Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease by Nour Rahnama, MD, Arthur Colson, MD, PhD, Pamela Baldin, MD, PhD, Agnès Pasquet, MD, PhD, Damien Gruson, MD, PhD, David Vancraeynest, MD, PhD, Christophe Beauloye, MD, PhD, Frédéric Debiève, MD, PhD, Sophie Pierard, MD, PhD

“…N-terminal pro b-type natriuretic peptide assays in the second trimester and echocardiography in the third trimester were performed to evaluate maternal cardiovascular health. …”
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Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells by Ming Wang, Shuhong An, Diyi Wang, Haizhen Ji, Xingjing Guo, Zhaojin Wang

“…ESCC cell lines (EC109 and TE-1) were treated with PAR4-activating peptide (PAR4-AP). Immunohistochemistry for DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) was performed in 26 cases of ESCC tissues. …”
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From the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential by Ocky K. Radjasa, Ray Steven, Yosua Natanael, Husna Nugrahapraja, Septhy K. Radjasa, Tati Kristianti, Maelita R. Moeis, Joko P. Trinugroho, Haekal B. Suharya, Alfito O. Rachmatsyah, Ari Dwijayanti, Mutiara R. Putri, Charlie E. de Fretes, Zen L. Siallagan, Muhammad Fadli, Rafidha D. A. Opier, Jandinta D. Farahyah, Viana Rahmawati, Meirifa Rizanti, Zalfa Humaira, Ary S. Prihatmanto, Nugroho D. Hananto, R. Dwi Susanto, Agus Chahyadi, Elfahmi, Neil Priharto, Kamarisima, Fenny M. Dwivany

“…Moreover, our analysis uncovered eight biosynthetic gene clusters (BGCs) using the common genome mining pipeline, antiSMASH. Two non-ribosomal peptide synthetase (NRPS) BGCs within these clusters exhibited the potential to generate novel biological compounds. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…Notably, the GsMTx-4 venom peptide effectively countered mechanically induced responses, particularly by inhibiting OS cell migration, without harming healthy cells. …”
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Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus by Liangfang Liu, Tangsong Feng, Mengmeng Shi, Huafeng Zou, Weiqun Lu

“…In addition, Gene Ontology (GO) enrichment analysis revealed that DEGs enriched in peptide biosynthetic process, translation procession were down-regulated in the AG flounder. …”
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Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

“…Our results emphasise that robust identification of T1D cases and appropriate clinical care may require routine measurement of diabetes autoantibodies and C-peptide.…”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Medications like metformin, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), aspirin, statins, and selective serotonin reuptake inhibitors reduce HCC risk, while acid suppressive agents, particularly proton pump inhibitors, elevate it. …”
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Evaluating NfL and NTproBNP as predictive biomarkers of intracranial injuries after mild traumatic brain injury in children presenting to emergency departments by Anne-Cécile Chiollaz, Virginie Pouillard, Michelle Seiler, Céline Habre, Fabrizio Romano, Céline Ritter Schenck, Fabian Spigariol, Christian Korff, Fabienne Maréchal, Verena Wyss, Lyssia Gruaz, Joan Montaner, Jean-Charles Sanchez, Sergio Manzano

“…We aim to assess the performances of two routinely used biomarkers in other fields: the neurofilament light chain protein (NfL), and the N-terminal prohormone of brain natriuretic peptide (NTproBNP), to safely discharge children without intracranial injuries (ICIs).MethodsA prospective multicenter cohort study was conducted, enrolling children suffering from mTBI, both with and without imaging during their acute management in the PED. …”
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Cardioprotective effect of crocin in patients with breast cancer receiving anthracycline-based chemotherapy: A randomized, double-blind, placebo-controlled study by Xinye Li, Xin Su, Wanping Liang, Li Wang, Chao Yuan, Juping Xu, Yijun Zhang, Yan Liu, Ning Ma, Fan Yang, Yiyuan Yang, Liyuan Tao, Shipeng Sun, Hongcai Shang, Yanwei Xing

“…At 6 months, there were significant differences in the mean change of N-terminal pro–brain natriuretic peptide (NT-pro BNP) between the groups (3.06 [-25.18–6.95] vs. 3.06 [-4.85–24.98] pg/ml; P = 0.017). …”
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Ionized and total magnesium levels and health outcomes in patients with type 2 diabetes mellitus by Juhaina Salim Al-Maqbali, Salwa Al Harasi, Qasim Al Mamary, Henrik Falhammar, Ibrahim Al-Zakwani, Mohammed Al Za’abi, Abdullah M. Al Alawi

“…The study included adult patients with T2DM treated with oral hypoglycemic agents (OHA), insulin, glucagon-like-peptide 1 (GLP-1) injections or their combinations. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

“…In contrast, treatment of the cells with the peptide at a higher concentration (1 nM) significantly augmented both cortisol production and cAMP content. …”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Based on a high-resolution 2.91 Å CP model that was constructed for the first time, this degradation process is likely driven by hydrophobic interactions between tCuinter-bCDs and CP residues MET1, VAL5, THR55, and THR58, along with hydrogen bonds formed with THR4, VAL5, GLY15, PRO57, and ALA59, thereby promoting degradation of adjacent peptide segments. This represents the first study demonstrating in situ Fenton-like reactions to combat pathogens in plant systems. …”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Beatriz Tavira, Hugo Barcenilla, Jeannette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Rosaura Casas

“…GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to promising results from other trials. …”
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Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…In this context, pairing an EGFR-targeting peptide with the emerging theranostic pair comprising the Auger electron emitter cobalt-58m (^58mCo) and the Positron Emission Tomography-isotope cobalt-55 (⁵⁵Co) would be of great interest for creating novel radiopharmaceuticals for prostate cancer and glioblastoma theranostics. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Among them, acetaminophen and pyridoxal phosphate significantly improved cardiac function in SCM moues, as demonstrated by the increased ejection fraction (EF) and fractional shortening (FS), and the reduced levels of cardiac injury biomarkers: B-type natriuretic peptide (BNP) and cardiac troponin I (cTn-I). In vitro assays revealed that acetaminophen inhibited prostaglandin synthesis, reducing inflammation, while pyridoxal phosphate restored amino acid balance, supporting cellular function. …”
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Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation by Yi-li Wang, Hai-yan Zhu, Xi-qian Lv, Xing-ying Ren, Ying-chun Peng, Jin-yu Qu, Xue-fang Shen, Ran Sun, Meng-lu Xiao, Hong Zhang, Zhao-hui Chen, Peng Cong

“…Importantly, EA effectively abrogated the promotion effect of DSS on ipsilateral lumbar 6 (L6) DRG sympathetic-sensory coupling, manifested as the sprouting of tyrosine hydroxylase- (TH-) positive sympathetic fibers into sensory neurons and colocalization of and calcitonin gene-related peptide (CGRP). Furthermore, EA at Zusanli (ST36) activated neurogenic inflammation, characterized by decreased expression of substance P (SP), hyaluronic acid (HA), bradykinin (BK), and prostacyclin (PGI2) in colitis rat skin tissues corresponding to the L6 DRG. …”
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Fasting Plasma Glucose Indicates Reversibility of the Acute Insulin Response after Short-Term Intensive Insulin Therapy in Patients with Various Duration of Type 2 Diabetes by Liehua Liu, Siyue Yang, Jianbin Liu, Hai Li, Juan Liu, Xiaopei Cao, Haipeng Xiao, Yanbing Li

“…In multivariate analyses, FPG after SIIT and baseline fasting C peptide were independent indicators of both AIR after the therapy and ∆AIR; HDL-C after the therapy also predicted AIR after the therapy. …”
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First-line combination therapy of immunotherapy plus anti-angiogenic drug for thoracic SMARCA4-deficient undifferentiated tumors in AIDS: a case report and review of the literature by Xiaoling Wei, Xiangju Xing, Wei Yao, Changzheng Wang, Yajie Xiao, Xianzhi Du

“…Additionally, serum biomarkers of lung cancer were abnormal as follows: carcinoembryonic antigen (CEA) at 13.74 ng/mL, cytokeratin 19 fragment (CYFRA21-1) at 6.82 ng/mL, neuron-specific enolase (NSE) at 25.49 ng/mL, and progastrin-releasing peptide precursor (ProGRP) at 89.35 pg/mL. Subsequent pathology confirmed SMARCA4-deficient undifferentiated tumors. …”
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PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy by Vineet Mohan MSc, Wouter V. Vogel MD, PhD, Gerlof D. Valk MD, PhD, Jan P. de Boer MD, PhD, Marnix G. E. H. Lam MD, PhD, Bart de Keizer MD, PhD

“…Methods: Five patients with differentiated thyroid cancer underwent [ 68 Ga]Ga-PSMA-11 PET/CT to evaluate their eligibility for peptide radioligand therapy with [ 177 Lu]Lu-PSMA-617. …”
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Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report by Elisa Dinoi, Giuseppe Daniele, Giuseppe Daniele, Angela Michelucci, Fulvia Baldinotti, Fabrizio Campi, Piero Marchetti, Stefano Del Prato, Angela Dardano, Angela Dardano

“…BackgroundThe treatment of obesity and type 2 diabetes (T2D) in Prader-Willi syndrome (PWS) is still a challenge. Glucagon-like peptide 1 receptor agonists (GLP-1 RA) are attractive options, since they effectively reduce weight and improve blood glucose, without increasing the risk of hypoglycemia. …”
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