The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain by Fatma Sarac, Sevgi Buyukbese Sarsu, Selman Yeniocak, Kamil Sahin, Esma Yucetas, Dogan Yildirim, Macit Koldas, Ozlem Uzun

“…The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diagnosis of pediatric patients with acute abdominal pain. …”
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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. …”
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Novel insights into the study of goblet cell hypersecretion in allergic rhinitis by Xiaojia Zhu, Xiaojia Zhu, Fengli Cheng, Hongying Duan, Hongying Duan, Sirui Fu, Sirui Fu, Changqing Zhao

“…The activation of enteric neurons promotes goblet cell degranulation by stimulating the calcitonin gene-related peptide (CGRP)–receptor active modification protein-1 (RAMP1) axis. …”
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Physician Perceptions of the Safety and Efficacy of GLP-1 Receptor Agonists: Underestimation of Cardiovascular Risk Reduction and Discrepancies with Clinical Evidence by Srikanth Krishnan, Pratyaksh K. Srivastava, Jayram Attaluri, Rebecca Nayeri, Dhananjay Chatterjee, Jay Patel, Ali Nsair, Matthew Budoff, Arash Nayeri

“…Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonists (GIP/GLP-1 RAs) are emerging as effective treatments for obesity and cardiometabolic disease. …”
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Ketogenic diets and Alzheimer’s disease by Klaus W. Lange, Katharina M. Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Shigehiko Kanaya, Joachim Hauser

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid β-peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD. …”
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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus by Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian

“…Mature hIAPP, a 37-aa peptide, is natively unfolded in its monomeric state but forms islet amyloid in T2DM. …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Meanwhile, CDC20 catalyzes K27 ubiquitination of PBRM1 and promotes its degradation via p62‐mediated selective autophagy. A bicyclic peptide (PB1‐p62) is designed and constructed to target PBRM1 and p62, thereby promoting the degradation of PBRM1. …”
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The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer by Marisa Rosso, Miguel Muñoz, Michael Berger

“…After binding to the specific neurokinin-1 (NK-1) receptor, the peptide substance P (SP), which is widely distributed in both the central and peripheral nervous systems, triggers a wide variety of functions. …”
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Potential and development of cellular vesicle vaccines in cancer immunotherapy by Wenxi Zhao, Xianjun Li, Jialu Guan, Shuai Yan, Lizhi Teng, Xitong Sun, Yuhan Dong, Hongyue Wang, Weiyang Tao

“…Tumor exosomes carry antigens and MHC-peptide complexes, which can provide tumor antigens to antigen-processing cells and increase the chances of recognition of tumor antigens by immune cells. …”
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Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…These cells were still responding to reactivation with HA-peptide in vitro. Our data support an idea about sufficient role of both the tumor-specific and -nonspecific mechanisms inducing immunosuppression in cancer patients.…”
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Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors by Riber Fabián Donoso Noroña, Nairovys Gómez Martínez, Adisnay Rodríguez Plasencia

“…The results showed that the treatment significantly reduced the risk of hospitalization for heart failure and cardiovascular mortality compared with placebo or standard care, and that sodium-glucose cotransporter type 2 inhibitors improved cardiac function and reduced levels of B-type natriuretic peptide, a biomarker of cardiac stress. The results of this study support the inclusion of sodium-glucose cotransporter type 2 inhibitors in the treatment of heart failure in patients with or without type 2 diabetes. …”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease by Benoît Leclerc, Abedelnasser Abulrob

“…The most promising diagnostic strategies in today’s world would consist in performing high diagnostic accuracy of combined modality imaging technologies using beta-amyloid 42 peptide-cerebrospinal fluid (CSF) positron emission tomography (PET), Pittsburgh compound B-PET, fluorodeoxyglucose-PET, total and phosphorylated tau-CSF, and volumetric magnetic resonance imaging hippocampus biomarkers for criteria evaluation and validation. …”
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Echocardiographic Assessment of Left Ventricular Function in Type 1 Gaucher's Disease by Mirta Koželj, Samo Zver, Vesna Zadnik

“…The obtained data was correlated with the levels of NT-proBNP (brain natriuretic peptide). None of the GD patients had clinical signs of heart disease. …”
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Distinguishing rheumatoid arthritis from psoriatic arthritis by Joseph F Merola, Luis R Espinoza, Roy Fleischmann

“…Patients with PsA typically have seronegative test findings for rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies, while approximately 80% of patients with RA have positive findings for RF and CCP antibodies. …”
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Musculoskeletal Ultrasonography in Detecting Disease Activity in Patients of Juvenile Idiopathic Arthritis: A Cross-Sectional Study by Sharad Dev, Ashish Verma, Anup Singh

“…A significant correlation between erosions and rheumatoid factor and anti-cyclic citrullinated peptide values was found. Conclusion: Our study found that MSUS has a definite role in assessing the disease activity in JIA patients and this modality may be considered as an adjunct in this context, as well as considered for future inclusion in classification criteria for JIA.…”
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Coexisting rheumatoid arthritis and sickle cell disease: case series and literature review by Abdallah Alqethami, Sabri Alsaeedi, Samera Felemban, Abdulelah Qadi

“…Most of the patients were positive for rheumatoid factor (6/7) or anticyclic citrullinated peptide (6/7). Four patients were treated with hydroxyurea. …”
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Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment by Karsten Buschard, Laurits J. Holm, Ulla Feldt-Rasmussen

“…She has now been insulin independent for one year and 9 months. Unstimulated C-peptide has increased by 51% (317 to 479 pmol/l), and IA-2 autoantibody level has decreased by 65% (49 to 17 × 103 arbitrary units). …”
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Thermosensitive Chitosan-β-Glycerophosphate Hydrogels as Targeted Drug Delivery Systems: An Overview on Preparation and Their Applications by Pouria Rahmanian-Devin, Vafa Baradaran Rahimi, Vahid Reza Askari

“…Hydrogels are used in many drug delivery systems and diseases, including nasal drug delivery, vaginal drug delivery, wound healing, peritoneal adhesion, ophthalmic drug delivery, tissue engineering, and peptide and protein delivery. Overall, the chitosan-β-glycerophosphate hydrogel is a suitable drug carrier for a wide range of drugs. …”
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Semaglutide Protects against 6-OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress by Dong-xing Liu, Chen-sheng Zhao, Xiao-na Wei, Yi-peng Ma, Jian-kun Wu

“…In addition, a neuroprotective effect of glucagon-like peptide-1 (GLP-1) receptor agonists was demonstrated in experimental models of PD. …”
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Clinical Pharmacokinetics of Atogepant in Healthy Japanese and White Adults by Ramesh R. Boinpally, Brian McNamee

“…Abstract Introduction Atogepant is a calcitonin gene-related peptide receptor antagonist approved for the preventive treatment of migraine in adults in the USA, EU, and several other countries. …”
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