Biomarkers as Diagnostic and Prognostic Tools in Cardiac Disorders: A Comprehensive Review by Rabinarayan Parhi, Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula

“…Among the well-established biomarkers, cardiac troponins (cardiac troponin I and cardiac troponin T) exhibit high sensitivity and specificity in the detection of myocardial infarction, and recent advances have improved early diagnosis and risk evaluation. B-type natriuretic peptide and its precursor N-terminal pro-B-type natriuretic peptide play critical roles in the diagnosis and management of heart failure; elevated levels of these factors indicate poor prognosis and can guide therapeutic decision-making. …”
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B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody by Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández

“…Using bioinformatics, a MHC class I-binding peptide from P3 VH region was identified. P3 mAb was able to induce a specific CTL response in vivo against cells presenting this peptide. …”
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions by Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano

“…Objective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells. …”
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Noninvasive Optical Imaging of Ovarian Metastases Using Cy5-labeled RAFT-c(-RGDfK-) by Zhao-hui Jin, Veronique Josserand, Jesus Razkin, Elisabeth Garanger, Didier Boturyn, Marie-Christine Favrot, Pascal Dumy, Jean-luc Coll

“…Human ovarian adenocarcinoma IGROV1 cells expressing low levels of integrin α v β 3 (the main receptor for the cRGD peptide) were used for in vitro and in vivo assays in combination with Cy5-labeled RAFT-c(-RGDfK-) 4 , cRGD, or RAFT-c(-RβADfK-) 4 . …”
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Exploring associations between the FTO rs9939609 genotype and plasma concentrations of appetite-related hormones in adults with obesity. by Ann Kristin Hjelle de Soysa, Mette Langaas, Valdemar Grill, Catia Martins, Ingrid Løvold Mostad

“…This study explored associations of the rs9939609 genotypes to plasma concentrations of acylated ghrelin, active glucagon-like peptide 1 (GLP-1), and total peptide YY (PYY), and moderating effects of fat mass (FM), in 96 adults (69% female) with BMI ≥35 kg/m2, using a cross sectional observation study designed to have 1/3 of participants each with genotypes TT, AT and AA, respectively. …”
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Drug discovery: a multifactorial ecosystem by Fernando Albericio

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Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciproc... by Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng

“…EBI3 blocking peptide promoted antitumor cytotoxic T lymphocyte (CTL) response by inducing Granzyme B, IFN-γ production, and p-STAT3 expression and inhibited CRC cell proliferation and tumor growth to associate with suppressing gp130 and p-STAT3 expression. …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…In addition, the 32-aa peptide and its short derivatives were investigated for effects on cancer cell viability. …”
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Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and In situ remineralization properties for dental caries prevention by Jiayi Shi, Xuekai Qi, Ying Ran, Qiang Zhou, Yiqin Ding, Lujian Li, Youyun Zeng, Dongchao Qiu, Zhibin Cai, Xiaojun Cai, Yihuai Pan

“…This formulation employed peptide dendrimer nanogels (PDN) as a carrier for the photosensitizer Ce6, further functionalized with saliva-acquired peptide (SAP) to confer wet adhesion properties. …”
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Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

“…This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid‐targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. …”
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GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism by Tian Qiu, Tian Qiu, Ou Fu, Ou Fu

“…We also discuss recent findings that highlight the interaction of distinct peptide-GPCR systems in modulating complex feeding behaviors.…”
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Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis by Jessica Anne Douglas, Kevin Deighton, Jan Maria Atkinson, Vahid Sari-Sarraf, David John Stensel, Greg Atkinson

“…In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. …”
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The Effects of C. lacerata on Insulin Resistance in Type 2 Diabetes Patients by Arim Choi, Jung Hye Kim, Hye-Kyung Chung, Chul Woo Ahn, Hee Joon Choi, Yu-Sik Kim, Ji Sun Nam

“…Fasting, postprandial c-peptide, and insulin levels decreased at week 12 in the C. lacerata group (p<0.05). …”
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Evaluation of the Presentation of Newly Diagnosed Type 1 Diabetes Mellitus in Children During and After the COVID-19 Pandemic by Semine Özdemir Dilek, Fatma Özgüç Çömlek

“…In the pandemic period, admissions with autoantibody positivity, low C-peptide and severe acidosis were more common.…”
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Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. by Elayoni E Igomu, Paul H Mamman, Jibril Adamu, Maryam Muhammad, Abubarkar O Woziri, Manasa Y Sugun, John A Benshak, Kingsley C Anyika, Rhoda Sam-Gyang, David O Ehizibolo

“…To boost the immunogenicity of the peptide construct, fliC from S. Typhimurium was included at the N-terminal. …”
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Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11 by Rebeka Nazareth, Pius Horumpende, Tolbert Sonda, Arnold Ndaro, Edson Mollel, Eliakim Paul, Emmanuel Athanase, Jaffu Chilongola

“…To characterize naturally acquired Immunoglobulin G (IgG) responses to the synthetic peptide AS202.11, a malaria vaccine candidate. Methodology. …”
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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…This study not only presents more potent small non-peptide activators of the HslV protease but also enhances the understanding regarding the mechanism of HslVU complex activation via small non-peptidic molecules.…”
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H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…SG-1002 also decreased the expression of hypertrophic/HF protein markers such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), galectin-3, TIMP1, collagen type III, and TGF-β1 in stressed HL-1 cells. …”
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Wheat Leaf Rust Effector Pt48115 Localized in the Chloroplasts and Suppressed Wheat Immunity by Lulu Song, Liping Cui, Hao Li, Na Zhang, Wenxiang Yang

“…Pt48115 contains a signal peptide with a secretory function and a transit peptide that can translocate Pt48115 to the host chloroplasts. …”
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Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient by Christine A Hughes, Constance L Chik, Geoffrey D Taylor

“…Blood glucose levels were repeatedly low, with elevated insulin and C-peptide levels despite multiple intravenous bolus doses and infusions of dextrose. …”
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