APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence by Jingyi Xie, Daniel G. Chen, William Chour, Rachel H. Ng, Rongyu Zhang, Dan Yuan, Jongchan Choi, Michaela McKasson, Pamela Troisch, Brett Smith, Lesley Jones, Andrew Webster, Yusuf Rasheed, Sarah Li, Rick Edmark, Sunga Hong, Kim M. Murray, Jennifer K. Logue, Nicholas M. Franko, Christopher G. Lausted, Brian Piening, Heather Algren, Julie Wallick, Andrew T. Magis, Kino Watanabe, Phil Mease, Philip D. Greenberg, Helen Chu, Jason D. Goldman, Yapeng Su, James R. Heath

“…Abstract Elucidating the relationships between a class I peptide antigen, a CD8 T cell receptor (TCR) specific to that antigen, and the T cell phenotype that emerges following antigen stimulation, remains a mostly unsolved problem, largely due to the lack of large data sets that can be mined to resolve such relationships. …”
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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity by Evelyn F Okal, Philip A. Romero, Pete Heinzelman

“…Abstract Background Angiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1–7), which activates the Mas receptor and elicits vasodilation, increased blood flow, reduced inflammation, and decreased pathological tissue remodeling. …”
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Effect of Interleukin and Hepcidin in Anemia of Chronic Diseases by Maha F. Yacoub, Hala Fouad Ferwiz, Fadwa Said

“…Recent studies revealed that interleukin-6 (IL-6), a proinflammatory cytokine, and hepcidin, an antimicrobial hepatic peptide, play a key role in ACD pathogenesis. Patients and Methods. …”
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Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis by Chao Li, Yali Cui, Wenjie Zhou, Yiduo Zhang, Xiaocui Huang, Fan Yu

“…The search formula is as follows: “nonalcoholic fatty liver disease” combined with the terms that bone turnover markers such as “osteocalcin,” “collagen type I trimeric cross-linked peptide,” and “procollagen type I N-terminal peptide.” …”
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Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2 by Niti Yashvardhini, Amit Kumar, Deepak Kumar Jha

“…Altogether, our study revealed that RdRp of SARS-CoV-2 (an epitope-based peptide fragment) can be a potentially good candidate for the development of a vaccine against SARS-CoV-2.…”
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Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy by Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg

“…These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). …”
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Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation by Khalaf Reema Abu, Alwarafi Ebtisam, Sabbah Dima

“…Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP), leading to insulin secretion from pancreatic beta cells. …”
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diaTracer enables spectrum-centric analysis of diaPASEF proteomics data by Kai Li, Guo Ci Teo, Kevin L. Yang, Fengchao Yu, Alexey I. Nesvizhskii

“…Abstract Data-independent acquisition has become a widely used strategy for peptide and protein quantification in liquid chromatography-tandem mass spectrometry-based proteomics studies. …”
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Survodutide - Novel Anti Obesity Drug by Irtiqa Ayani Rathore, Sana Malik, Amarjeet Singh, Vishal R Tandon, Annil Mahajan

“… Survodutide (BI 456906) is a novel, dual agonist of glucagon and glucagon-like peptide-1 (GLP-1) receptors developed as a once-weekly subcutaneous injection for the management of obesity. …”
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Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C by Robert P Myers, Djamila Messous, Thierry Poynard, Francoise Imbert-Bismut

“…BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. …”
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Maillard reaction products in plant-based dairy alternatives and their release during simulated gastrointestinal digestion by Kira Bieck, Franziska Ebert, Tilman Grune, Jana Raupbach

“…During simulated gastrointestinal digestion, CML and MG-H1 were released either as modified amino acid or in peptide-bound form, respectively. CEL was released to a significantly lesser extent in peptide-bound form. …”
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Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol by Alessandro D. Genazzani, Christian Battipaglia, Martina Foschi, Elisa Semprini, Claudia Aio, Eleonora Spelta, Anna Kostrzak, Maria Laura Rusce, Anna Szeliga, Blazej Meczekalski

“…The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). …”
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Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…These results suggest that islet α-cells may contain insulin and/or other insulin-like proteins (proinsulin, C-peptide). Future studies are needed to evaluate the role of α-cells in insulin secretion and diabetes pathogenesis.…”
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Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers by Zhenyu Qian, Yan Jia, Guanghong Wei

“…Peptide-lipid interaction analyses show that the different binding features of hIAPP at POPC and POPG bilayers are attributed to different magnitudes of electrostatic and hydrogen-bonding interactions with lipids. …”
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Characterization of Human Colorectal Cancer MDR1/P-gp Fab Antibody by Xuemei Zhang, Gary Guishan Xiao, Ying Gao

“…In this study, the peptide sized 21 kDa covering P-gp transmembrane region was first prepared for generating a novel mouse monoclonal antibody Fab fragment with biological activity against multiple drug resistance protein P-gp21 by phage display technology. …”
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Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study by Nermeen El-Moataz Bellah Ahmed, Masashi Murakami, Yujiro Hirose, Misako Nakashima

“…Moreover, treatment with DPSC secretome significantly decreased the cytotoxicity of Aβ peptide by increasing cell viability compared to nontreated cells. …”
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Phosphorylation of S‐S‐S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses by Xiaokun Liu, Cha Yang, Xian Lin, Xiaomei Sun, Huanchun Chen, Qiang Zhang, Meilin Jin

“…Moreover, treatment of NEP peptide mimics containing the S‐S‐S motif to competitively block NEP binding to the kinases reduces influenza virus replication in cells and mice. …”
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Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema by Takuya Oyakawa, Keita Miura, Nao Muraoka, Kei Iida, Ayano Fujita, Tateaki Naito, Toshiaki Takahashi

“…In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of empagliflozin to loop diuretics reduced the edema. …”
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Somatostatin in inflammatory bowel disease by J. D. Van Bergeijk, J. H. P. Wilson

“…Somatostatin is the main inhibitory peptide in inflammatory processes, and its possible role in IBD is discussed.…”
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Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica. by Simran Preet, Sanjay Bharati, Geeta Shukla, Ashwani Koul, Praveen Rishi

“…N-phenyl napthylamine (NPN) uptake assay in presence of sulethal, lethal as well as twice the lethal concentrations further confirmed the membrane-dependent mode of action of cryptdin-2 and suggested that the peptide could permeabilize the plasma membrane of E. histolytica. …”
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