Improving protein hydrolysis and digestibility in Arthrospira platensis biomass through recombinant peptidases (EC 3.4): Opportunities for monogastric animal diets by Maria P. Spínola, Mónica M. Costa, Rita S. Simões, Vânia O. Fernandes, Vânia Cardoso, Virgínia M.R. Pires, Cláudia Afonso, Carlos Cardoso, Narcisa M. Bandarra, Carlos M.G.A. Fontes, José A.M. Prates

“…Protein content was determined using the Bradford method and potential peptide formation was measured via an o-phthaldialdehyde (OPA) assay. …”
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Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…Here, we integrated genetic engineering and bone-targeting peptide modification to develop innovative bone-targeting engineered exosomes. …”
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Heterologous Expression and Transglycosylation of Acarviosyltransferase by XUE Zhenglian, WANG Yuqing, LI Chuang, LI Dandan, ZHU Sibao, LI Xiangfei

“…Bioinformatics analysis showed that the conserved domains of ATase, the expression product of acbD, were highly similar to those of cyclodextrin glycosyltransferase, which belongs to the glycoside hydrolase 13 (GH13) family, and ATase possessed a signal peptide and a transmembrane domain. After removal of the coding sequences in the signal peptide, the soluble expression level of acbD increased by 23.4 times as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). …”
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Comparative analysis of the Streptococcus pneumoniae competence development in vitro versus in vivo during pneumonia-derived sepsis by Sook Yin Chong, Shi Qian Lew, Tauqeer Alam, Christopher A. Gaulke, Gee W. Lau

“…Some pneumococcal strains can enter a transient competent state for genetic transformation in an optimized competence-inducing medium when the threshold level of the peptide pheromone competence stimulating peptide is attained; upregulating the expression of three distinct phases of “early”, “late” and “delayed” competence genes. …”
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Micro-MRI at 11.7 T of a Murine Brain Tumor Model Using Delayed Contrast Enhancement by Rex A. Moats, Sendhil Velan-Mullan, Russell Jacobs, Ignacio Gonzalez-Gomez, David J. Dubowitz, Takashi Taga, Vazgen Khankaldyyan, Linda Schultz, Scott Fraser, Marvin D. Nelson, Walter E. Laug

“…These strategies were applied to monitor the growth of brain tumors xenotransplanted into nude mice and either treated with the antiangiogenic peptide EMD 121974 or an inactive control peptide. …”
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Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. by Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas

“…By inactivation of the nonribosomal peptide synthetase SidC, we demonstrate that the intracellular siderophores are required for germ tube formation, asexual sporulation, resistance to oxidative stress, catalase A activity, and virulence. …”
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Factors Affecting the Readmission of Patients with Pancreatic Cancer after Surgery by Xiaojing Gu, Wei Zhou, Juan Han

“…At 7, 14, and 21 days postsurgery, the levels of gastrointestinal hormones motilin, gastrin, calcitonin gene-related peptide, and growth hormone-releasing peptide of the observation group were lower than the control group, while the levels of adrenocorticotropin, renin, angiotensin, and plasma aldosterone of the observation group were significantly higher than the control group. …”
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Giese-type alkylation of dehydroalanine derivatives via silane-mediated alkyl bromide activation by Perry van der Heide, Michele Retini, Fabiola Fanini, Giovanni Piersanti, Francesco Secci, Daniele Mazzarella, Timothy Noël, Alberto Luridiana

“…The reaction can be performed in a phosphate-buffered saline (PBS) solution and shows post-functionalization prospects through pathways involving classical peptide chemistry.…”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Amit Pithadia, Jeffrey R. Brender, Carol A. Fierke, Ayyalusamy Ramamoorthy

“…Furthermore, we have outlined possible mechanistic discoveries of the interaction of these small molecules with the peptide and how they may mitigate toxicity associated with peptide aggregation. …”
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Side-Stream Based Marine Solubles From Atlantic Cod (Gadus morhua) Modulate Appetite and Dietary Nutrient Utilization in Atlantic Salmon (Salmo salar L.) and can Replace Fish Meal by Hanne Jorun Sixten, Ivar Rønnestad, André S. Bogevik, Tone Aspevik, Åge Oterhals, Ana S. Gomes, Floriana Lai, Ingvill Tolås, Virginie Gelebard, Marie Hillestad, Katerina Kousoulaki

“…Expression of stomach ghrelin-1 (ghrl1) was higher than ghrelin-2 (ghrl2) and membrane-bound O-acyltransferase domain-containing 4 (mboat4), and midgut peptide YYa-2 (pyya2) and glucagon-a (gcga) were higher than peptide YYb-1 (pyyb1). …”
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Synthesis and structural characterization of s-triazine derivatives and their photophysical properties by Hessa H. Al-Rasheed, Sizwe J. Zamisa, Ihab Shawish, Assem Barakat, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio, Anamika Sharma

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A reference genome for the eastern bettong (Bettongia gaimardi) [version 2; peer review: 2 approved, 1 approved with reservations] by Richard J Edwards, Luke W Silver, Sam Banks, Carolyn J Hogg, Adrian D. Manning, Linda Neaves

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Characterization and Synergistic Antimicrobial Evaluation of Lipopeptides from Bacillus amyloliquefaciens Isolated from Oil-Contaminated Soil by Pratiwi Sudarmono, Ahmad Wibisana, Lira W. Listriyani, Saleha Sungkar

“…By tandem mass spectrometry, five variants of surfactin with the same amino acid sequence in peptide moiety could be revealed. The peptide moiety contains seven amino acids identified as Glu-Leu/Ile-Leu-Val-Asp-Leu-Leu/Ile while the fatty acid moiety comprises a different length of chain from C12 to C16. …”
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N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19 by Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson

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Computational screening, synthesis and neuroprotective evaluation of small molecule for the treatment of alzheimer's disease by Nerlis Pajaro-Castro, Elkin Torres-Sierra, Edwar Cortes-Gonzalez, Margaret Paternina, Erwin Camacho, Pedro Blanco

“…Cytotoxicity and neuroprotective effects were assessed using the MTT assay in the presence of the Aβ25-35 peptide. RESULTS: Four candidate molecules showed strong binding affinity, ranging from -6.8 to -9.1 kcal/mol. …”
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Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…Prolonged administration of high-dose lipopeptides has neither adverse effects nor impairs peptide efficacy in subsequent SARS-CoV-2 challenges. …”
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A Full GMP Process to Select and Amplify Epitope-Specific T Lymphocytes for Adoptive Immunotherapy of Metastatic Melanoma by N. Labarriere, A. Fortun, A. Bellec, A. Khammari, B. Dreno, S. Saïagh, F. Lang

“…We have previously described a sorting method of epitope-specific T lymphocytes that uses magnetic beads coated with HLA/peptide complexes and we suggested that this method could be applied to a clinical setting. …”
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In Vitro Analyses Reveal the Effect of Synthetic Cytokinin Forchlorfenuron (FCF) on a Septin-Like Protein of Taeniid Cysticerci by Diana G. Rios-Valencia, Edgar O. López-Villegas, Dylan Diaz Chiguer, Adrian Marquez Navarro, Ruben D. Díaz-Martín, Benjamin Nogueda-Torres, Javier R. Ambrosio

“…The rabbit polyclonal antibody prepared against the synthetic peptide recognized a major band of 41 kDa in both parasites. …”
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Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice by Talero Elena, Di Paola Rosanna, Mazzon Emanuela, Emanuela Esposito, Motilva Virginia, Cuzzocrea Salvatore

“…Adrenomedullin (AM) is a 52 amino acid peptide that has shown predominant anti-inflammatory activities. …”
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Cryo-EM structure of the calcium-sensing receptor complexed with the kokumi substance γ-glutamyl-valyl-glycine by Hiroki Yamaguchi, Seiji Kitajima, Hiroshi Suzuki, Shota Suzuki, Kouki Nishikawa, Akiko Kamegawa, Yoshinori Fujiyoshi, Kazutoshi Takahashi, Uno Tagami, Yutaka Maruyama, Motonaka Kuroda, Masayuki Sugiki

“…These findings elucidate the molecular basis of kokumi peptide recognition by the CaSR and contribute to a better understanding of positive allosteric modulators of the CaSR. …”
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