Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees by Pramod Nehete, Elizabeth R. Magden, Bharti Nehete, Patrick W. Hanley, Christian R. Abee

“…We also observed increased levels of metabolic hormones glucagon-like-peptide-1, glucagon, connecting peptide, insulin, pancreatic peptide YY3–36, and leptin in the plasma of overweight and obese chimpanzees. …”
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Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides by Ji Eun Lee

“…While each neuropeptide could have its own biological function, mass spectrometry (MS) allows for the identification of the precise molecular forms of each peptide without a priori knowledge of the peptide identity and for the quantitation of neuropeptides in different conditions of the samples. …”
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Protein Repair and Degradation during Aging by Bertrand Friguet

“…Arguments for the implication of peptide methionine sulfoxide reductase in the age-related accumulation of oxidized protein are also discussed.…”
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body by Luis Leon-Mercado, Ivan Menendez-Montes, Jonathan Tao, Bandy Chen, David P. Olson, C. Mackaaij, C.G.J. Cleypool, Laurent Gautron

“…Agouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily expressed in hypothalamic neurons. …”
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Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome by Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor

“…The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. …”
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Integrated analysis of ATAC-seq and RNA-seq reveals ADSCP2 regulates oxidative phosphorylation pathway in hypertrophic scar fibroblasts by Qian Li, Zhe Quan, Ling Chen, Yiliang Yin, Xin Chen, Jingyun Li

“…The primary effector cells involved in the formation of hypertrophic scars are fibroblasts. A potential peptide, ADSCP2 (adipose-derived stem cell peptide 2, the peptide fragment of ALCAM protein), derived from adipose-derived stem cell-conditioned medium, has been identified as having the potential to mitigate hypertrophic scar formation by targeting pyruvate carboxylase. …”
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Characterization of Streptomyces Isolates Associated with Estuarine Fish Chanos chanos and Profiling of Their Antibacterial Metabolites-Crude-Extract by Muhammad A. Kurnianto, Harsi D. Kusumaningrum, Hanifah N. Lioe

“…The results of this study indicated that some Streptomyces isolated from new environmental niches, i.e., gut of estuarine fish Chanos chanos, produce promising peptide-containing bioactive compounds.…”
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Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression by Michela Cioni, Christian Mittelholzer, Marion Wernli, Hans H. Hirsch

“…Effects of agnoprotein on viral peptide-dependent T-cell killing were investigated using 51Cr release. …”
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Cloning, expression analysis, and the photoperiodic response of CHH gene in Panulirus homarus by Zhimin Ju, Jiajun Luo, Charles Brighton Ndandala, Chongqing Wen, Zhao Yanfei, Huafang Liang

“…PhCHH-A and PhCHH-B possess most of the characteristics of eyestalk type-I CHH/MIH/GIH family neuropeptides. Both have a “signal peptide, CPRP, and mature peptide” structure. Their mature peptide comprised 74 amino acids and 6 cysteine residues in a conserved position. …”
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Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…The identification and prioritization of patient-specific tumor neoantigens are based on advanced computational algorithms taking advantage of the profiling with next-generation sequencing considering factors involved in human leukocyte antigen (HLA)-peptide-T-cell receptor (TCR) complex formation, including peptide presentation, HLA-peptide affinity, and TCR recognition. …”
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Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu

“…The results of HbA1c and fasting C-peptide levels were extracted for further quantitative assessment. …”
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Prolonged Honeymoon Phase in Adult-Onset Type 1 Diabetes Mellitus: A Case Study by Pranjali Shah

“…Laboratory results showed uncontrolled hyperglycemia, absence of C-peptide, and positive for anti-GAD. Treatment involved CGMS fixation and insulin degludec/aspart, leading to excellent sugar control. …”
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A membrane permeability database for nonpeptidic macrocycles by Qiushi Feng, Danjo De Chavez, Jan Kihlberg, Vasanthanathan Poongavanam

“…In addition, we present a new descriptor, the “amide ratio” (AR), that quantifies the peptidic nature of macrocyclic compounds, enabling the classification of peptidic, semipeptidic, and nonpeptidic macrocycles. …”
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An Exceedingly Rare Case of Liraglutide-Induced Liver Injury by Swetha Parvataneni, Rajarajeshwari Ramachandran, Eric Then, Tyler Grantham, Vinaya Gaduputi

“…Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes mellitus. …”
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Organizing Pneumonia Preceding Rheumatoid Arthritis by Yoshiaki Kinoshita, Atsuhiko Sakamoto, Kouko Hidaka

“…We suggest that patients with organizing pneumonia and positive for either rheumatoid factor or anticyclic citrullinated peptide antibody should be cautiously followed up regarding the development of rheumatoid arthritis, particularly during the first year after the diagnosis of organizing pneumonia.…”
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TT Mutant Homozygote of Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children by Jung Ran Choi, In-Su Kwon, Dae Young Kwon, Myung-Sunny Kim, Myoungsook Lee

“…In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p = 0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust r2 = 1.000, p < 0.001, respectively). …”
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Are Trends in Economic Modeling of Pediatric Diabetes Mellitus up to Date with the Clinical Practice Guidelines and the Latest Scientific Findings? by Roque Cardona-Hernandez, Alberto de la Cuadra-Grande, Julen Monje, María Echave, Itziar Oyagüez, María Álvarez, Isabel Leiva-Gea

“…Eight models included diabetic ketoacidosis (42.1%), 16 included hypoglycemia (84.2%), 2 included C-peptide (1 of those as prognostic factor) (10.5%) and 1 included legacy effect (5.3%). …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC0–0.5, AUC0–1, AUC0–3 (P<0.05). …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

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Role Of Cgrp In Sensitization Of Dura Mater by K. Messlinger

“…The mammalian dura mater encephali is richly supplied by trigeminal nerve fibers, a considerable proportion of which contains calcitonin gene-related peptide (CGRP). As plasma levels of CGRP are increased in some forms of headaches, the question is in which way CGRP is involved in nociceptive mechanisms within the peripheral and the central trigeminovascular system.…”
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