T cell receptors specific for an imatinib-induced mutation in BCR-ABL for adoptive T cell therapy by Meng-Tung Hsu, Gerald Willimsky, Gerald Willimsky, Gerald Willimsky, Leo Hansmann, Leo Hansmann, Leo Hansmann, Leo Hansmann, Thomas Blankenstein

“…By immunizing transgenic mice that express a diverse human T cell receptor (TCR) repertoire restricted to HLA-A2, we detected CD8+ T cell responses against the ABL-E255V, but not the ABL-T315I peptide. From immune responding mice, two E255V-specific TCRs were isolated. …”
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Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection by V. S. Priyadharshini, F. Ramírez-Jiménez, M. Molina-Macip, C. Renteria-Rosales, J. Santiago-Cruz, Paola Zarate-Segura, E. Lara-Padilla, Luis M. Teran

“…Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. Human neutrophil peptides (HNPs) have been found to exhibit antiadenoviral activity. …”
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Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs by María Sancho-Albero, Alessandra Decio, Reha Akpinar, Ada De Luigi, Raffaella Giavazzi, Luigi M. Terracciano, Luisa De Cola

“…Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). …”
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In Vitro Bioaccessibility of Edible Seaweed Proteins from the Chilean Coast and Proteins from the Novel Seaweed-Derived Mycoprotein by Catalina Landeta-Salgado, Javiera Munizaga, María Paz González-Troncoso, Anamaría Daza-Sanchez, Irene Martínez, María Elena Lienqueo

“…SDS-PAGE revealed soluble peptides (<25 kDa) in <i>Durvillaea</i> spp., <i>Macrocystis pyrifera</i>, and mycoproteins, whereas <i>Ulva</i> spp. proteins exhibited limited solubility due to structural aggregation. …”
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Tear Film Proteome of Healthy Domestic Cats by Jéssica Fontes Veloso, Paula Elisa Brandão Guedes, Luciana Carvalho Lacerda, Juliano Oliveira Santana, Irma Yuliana Mora-Ocampo, Carlos Priminho Pirovani, Arianne Pontes Oriá, Alexandre Dias Munhoz, Renata Santiago Alberto Carlos

“…The resulting spectra were analyzed and compared with the Swiss-Prot search tool. Forty peptides were detected in the analyzed protein fragments of 90 spots, with 16 proteins identified. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…Seeking to refine the vaccine antigenic target and achieve scalable manufacturing compatible with Good Manufacturing Practices, we mapped linear B-cell epitopes spanning the entire VirG protein sequence by probing the immune reactivity of 10-mer peptides (overlapping 4–8 aa) with sera from Shigella-infected rhesus monkeys. …”
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Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review by Taoufik Alsaadi, AbuBakar Al Madani, Mohammed Alhatou, Mona Nada, Abdulrazaq Albilali, Ahmed Al-Qassabi, Hegab Mohamed, Haytham Mohamed, Rowan El Masry, Ghaidaa Ahmed Saifuddin, Suhail Abdullah AlRukn

“…The current treatment landscape for acute migraines encompasses anti-inflammatory agents, analgesics, triptans, ditans, calcitonin-gene-related peptides, and antiemetics. However, migraines in the region are often underestimated, underreported, and undertreated. …”
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Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules by Lisa M. James, Apostolos P. Georgopoulos

“…Since the binding of a peptide to an HLA-II molecule is the first and necessary step in initiating the production of antibodies, the findings above support our hypothesis that the severity of GWI symptomatology is partly due to a lack of HLA-II protection. …”
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Scavenger Receptor Class B, Type I, a CD36 Related Protein in Macrobrachium nipponense: Characterization, RNA Interference, and Expression Analysis with Different Dietary Lipid Sou... by Zhili Ding, Na Luo, Youqin Kong, Jingfen Li, Yixiang Zhang, Fang Cao, Jinyun Ye

“…The complete MnSR-BI coding sequence was 1545 bp, encoding 514 amino acid peptides. The MnSR-BI primary structure consisted of a CD36 domain that contained two transmembrane regions at the N- and C-terminals of the protein. …”
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Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of <i>Mycobacterium bovis</i>-Infected Domestic Dogs (<i>Canis lupus familiaris</i>) by Conor O’Halloran, Paul Burr, Danielle A. Gunn-Moore, Jayne C. Hope

“…The production of antigen-specific tumour necrosis factor-alpha (TNF-α) by PBMC in response to a cocktail of ESAT-6 and CFP-10 peptides correlated very strongly with the overall IGRA results, suggesting future diagnostic potential. …”
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Can serum orexin levels be used as a marker in childhood epilepsy? by Mutluay Arslan, Canan Üstün, Ayşe Nur Coşkun, Hasan Çelik, Hacı Nadir Yalçın, Eda Karaismailoğlu, Erdim Sertoğlu, Bülent Ünay

“…Orexins are excitatory peptides and associated with energy homeostasis, eating and drinking behaviors, sleep regulation, sleep-wake periods, analgesia, and cognitive activities such as attention, learning, and memory. …”
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Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I by Yukitoshi Takahashi, Kazumi Matsuda, Yuko Kubota, Jiro Shimomura, Etsuko Yamasaki, Tatsuya Kudo, Katsuyuki Fukushima, Hitoshi Osaka, Noriyuki Akasaka, Atsushi Imamura, Shinji Yamada, Naomi Kondo, Tateki Fujiwara

“…Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). …”
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Discovery of a broad-spectrum monoclonal antibody recognizing a conserved, linear epitope WFYDGYPT on VP1 protein of Enterovirus A species by Lie Fu, Wei-Ping Jin, Wen-Hui Wang, Chen Wang, Sha-Sha Qian, Meng-Jun Wang, Rui-Lun Liu, Song-Zhuang Li, Ya-Xin Du, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Xiao-Qi Chen, Shuo Shen

“…A linear epitope 202WFYDGYPT209 was identified as the minimal binding region of 1H4 by indirect ELISAs with overlapped and truncated peptides of VP1. Alanine scanning test found that W202, F203, D205, G206, Y207, P208, and T209 were key residues in the epitope region. …”
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Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4+CD8+ thymocytes by Tianlai Wang, Boyu Wang, Xiaowu Fan, Yixin Cai, Lequn Li, Shengling Fu

“…The expression of the Helios transcription factor is induced during negative selection and marks a group of T cells that have undergone negative selection and are likely to be deleted due to strong TCR binding with self-peptides/MHC ligands. We observed that the percentage of Helios-positive CD4SP T cells was greater in MG (−) than in MG (+) thymomas. …”
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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…Post-mortem mass spectrometry and proteomic analysis of her cerebrospinal fluid show several T. gondii peptides. A literature review suggests that risks associated with anti-TNF-α therapy for patients who are seropositive for T. gondii have not been adequately recognized. …”
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Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Finally, we demonstrate that Fic proteins are synthesized by F. animalis as Fic peptides are detectable in F. animalis monoculture supernatants. …”
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Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation by Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok

“…Refined sample preparation and analysis conditions across four embryonic and prenatal time points resulted in the identification of 21,498 peptides with high-confidence mapping to 1,502 proteins. …”
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Use of α-Lactalbumin and Caseinoglycomacropeptide as Biopeptide Precursors and as Functional Additives in Milk Beverages Fermented by L. helveticus by Katarzyna Skrzypczak, Emilia Fornal, Dorota Domagała, Waldemar Gustaw, Ewa Jabłońska-Ryś, Aneta Sławińska, Wojciech Radzki, Anna Kononiuk, Adam Waśko

“…The objective of this investigation was to verify whether biologically active peptides (BAPs) could be obtained from water solutions of α-lactalbumin (α-la) and caseinoglycomacropeptide (CGMP) through an application of the new Lactobacillus helveticus strains. …”
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Virus-inspired biogenic delivery system for advancing cancer therapy by Di Sun, Hao Liang, Qianwen Mu, Chengchao Chu, Gang Liu, Chao Liu

“…Among them, the components comprised of virus-like particles (VLPs) derive from the proteins or peptides of the viruses; the glycoproteins on their surface exert significant function as specific targeting. …”
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CKD patients comorbid with hypertension are associated with imbalanced gut microbiome by Pan Wang, Yang Shen, Kaixin Yan, Siyuan Wang, Jie Jiao, Hongjie Chi, Jiuchang Zhong, Qianmei Sun, Ying Dong, Jing Li

“…Enhanced phenylalanine metabolism and siderophore group nonribosomal peptides biosynthesis from non-CKD to CKD were observed, particularly in CKD with hypertension. …”
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