The Zn- or Cu-Thionein Character of a Metallothionein Determines Its Metal Load When Synthesized in Physiological (Metal-Unsupplemented) Conditions by Mercè Capdevila, Òscar Palacios, Sílvia Atrian

“…Therefore, intrinsically different roles can be hypothesized for the constitutively-produced MT peptides in the absence of any metal overload, depending on their Zn- or Cu-thionein character.…”
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Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment by Liu Hanqing, Tu Zhigang, Feng Fan, Shi Haifeng, Chen Keping, Xu Ximing

“…Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. …”
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Extensive Differences in Antifungal Immune Response in Two Drosophila Species Revealed by Comparative Transcriptome Analysis by Yosuke Seto, Koichiro Tamura

“…In response to the fungal infection, a transcriptome profile of immune-related genes was considerably different between D. melanogaster and D. virilis: the genes encoding antifungal peptides, Drosomycin and Metchnikowin, were highly expressed in D. melanogaster whereas, the genes encoding Diptericin and Defensin were highly expressed in D. virilis. …”
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A Narrative Review of Biomarkers and Imaging in the Diagnosis of Acute Aortic Syndrome by Ümit Arslan, Izatullah Jalalzai

“…Because AAS can be asymptomatic or present with diverse symptoms, its diagnosis requires clinical evaluation, risk scoring, and biomarkers such as D-dimer (DD), C-reactive protein (CRP), homocysteine, natriuretic peptides (BNP), and imaging modalities like computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography. …”
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Surface Modification of Biomaterials: A Quest for Blood Compatibility by Achala de Mel, Brian G. Cousins, Alexander M. Seifalian

“…Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.…”
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A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System by Mario García-Domínguez

“…One explanation for the emergence of disrupted pain modulation in individuals with fibromyalgia is a significant reduction in opioid receptor activity or an imbalance in the levels of endogenous opioid peptides. Further research is essential to clarify the complex details of the mechanisms underlying this abnormality. …”
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Marine fungi as a goldmine for novel antibiotics: a 2024 perspective by Chengqian Pan, Syed Shams ul Hassan, Ishaq Muhammad, Huizi Jin

“…These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities. …”
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Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes by Zijun Ma, Kaiqin Jin, Mengmeng Yue, Xin Chen, Jun Chen

“…In addition, the very concept of synthetic peptides opens up many unknown possibilities for tirzepatide. …”
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Emirates consensus recommendations on cardiovascular risk management in type 2 diabetes by Hani Sabbour, Hani Sabbour, Hani Sabbour, Wael Almahmeed, Wael Almahmeed, Fatheya Alawadi, Fatheya Alawadi, Abdullah Shehab, Abdulamjeed Al Zubaidi, Alaaeldin Bashier, Abdul Rauf Ghulam, Fauzia Rashid, Hosam Zaky, Hussien Heshmat Kassemn, Hussien Heshmat Kassemn, Jamila Bin Adi, Juwairia Tahir, Khadija Hafidh, Mohammed Farghali, Mohamed Hassanien, Mohamed Hassanien, James Januzzi

“…Routine measurement (at least yearly) of natriuretic peptides and high-sensitivity troponins can help identify patients requiring cardiac imaging referrals. …”
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Influence of Physical Activity and Nutrition on Obesity-Related Immune Function by Chun-Jung Huang, Michael C. Zourdos, Edward Jo, Michael J. Ormsbee

“…These include inflammatory peptides, such as TNF-α, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. …”
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How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies by Sofia Miranda Fernandes, Johanna Mayer, Per Nilsson, Makoto Shimozawa

“…A pathological hallmark of AD is the accumulation of aberrant protein/peptide aggregates such as extracellular amyloid plaques containing amyloid-beta peptides and intracellular neurofibrillary tangles composed of hyperphosphorylated tau. …”
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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. …”
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Vitamin D in Early Childhood and the Effect on Immunity to Mycobacterium tuberculosis by Anna Jane Battersby, Beate Kampmann, Sarah Burl

“…Recent studies have begun to explain the mechanisms by which vitamin D affects immunity. Antimicrobial peptides are induced in conjunction with stimulation of innate pattern recognition receptors enhancing immunity to particular infections. …”
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Hereditary Angioedema and Gastrointestinal Complications: An Extensive Review of the Literature by Napoleon Patel, Lisbet D. Suarez, Sakshi Kapur, Leonard Bielory

“…The angioedema is caused by the activation of the kallikrein-kinin system that leads to the release of vasoactive peptides, followed by edema, which in severe cases can be life threatening. …”
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Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells by A. Jiménez-Periáñez, B. Abos Gracia, J. López Relaño, C. M. Diez-Rivero, P. A. Reche, E. Martínez-Naves, E. Matveyeva, M. Gómez del Moral

“…We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.…”
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Recent Advances in Biosensors Using Enzyme-Stabilized Gold Nanoclusters by Myeong-Jun Lee, Jeong-Hyeop Shin, Seung-Hun Jung, Byung-Keun Oh

“…However, because they are unstable in solution, AuNCs require stabilization by using ligands such as dendrimers, peptides, DNA, and proteins. As a result, the properties of AuNCs and their formation are determined by the ligand, so the selection of the ligand is important. …”
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Targeting TLR/IL-1R Signalling in Human Diseases by Maria Loiarro, Vito Ruggiero, Claudio Sette

“…In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily. …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…The pharmacological targeting of nAChRs, using small molecules or peptides, is a promising approach for the development of compounds for the treatment of various human diseases including inflammatory and neurogenerative disorders such as Alzheimer’s disease. …”
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Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain. Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. …”
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Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM by Matthew Cook, Christian Freniere, Chunxiang Wu, Faith Lozano, Yong Xiong

“…By templating the assembly of HIV-2 CA on functionalized liposomes, we report high-resolution structures of the HIV-2 CA lattice, including both CA hexamers and pentamers, alone and with peptides of host phenylalanine-glycine (FG)-motif proteins Nup153 and CPSF6. …”
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