Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population by Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak

“…Peptides longer than 10 amino acids are trimmed by the endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 to fit the peptide binding groove of the HLA-I molecule. …”
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sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction by Maëlle Plawecki, Marion Morena, Nils Kuster, Leila Chenine, Hélène Leray-Moragues, Bernard Jover, Pierre Fesler, Manuela Lotierzo, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol

“…Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). …”
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Suitability of Commercial Transport Media for Biological Pathogens under Nonideal Conditions by Kyle Hubbard, Gregory Pellar, Peter Emanuel

“…This study evaluates commercial off-the-shelf (COTS) transport media based on sample recovery, viability, and quality of nucleic acids and peptides for nonpathogenic strains of Bacillus anthracis, Yersinia pestis, and Venezuelan equine encephalitis virus, in addition to ricin toxin. …”
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Microbiome role in pancreatic diseases development by Yu. V. Evsyutina, V. T. Ivashkin

“…Taking into account the ability of probiotics to stimulate production of antimicrobial peptides, normalize epithelial barrier function, limit bacterial translocation, their the application may be promising for pancreatic diseases treatment.…”
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Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges by Yangjie Gao, Zhe Ji, Jingyu Zhao, Julin Gu

“…In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair. …”
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Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…PTHrP is a polyhormone undergoing proteolytic processing into smaller bioactive forms, comprising an N-terminal peptide, which is the mediator of the “classical” PTH-like effect, as well as midregion and C-terminal peptides. …”
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Recent advances in polymeric nanoparticles for the treatment of hepatic diseases by Feng Gao, Xuefei Feng, Xinyu Li

“…Furthermore, this paper reviewed the application of polymeric nanoparticles -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) and poly (lactic-co-glycolic acid) (PLGA)-in liver disease treatment, focusing on their use in various delivery systems for pure bioactive compounds of natural origin, drugs, nucleic acids, peptides, and others. Finally, the challenges and future perspectives of the NPs were discussed to provide guidance for further research directions, with the aim of promoting the clinical application of nanotherapeutics in treating hepatic diseases.…”
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Venom of the Endoparasitoid Wasp Pteromalus puparum: An Overview by Jia-Ying Zhu, Gong-Yin Ye, Cui Hu

“…Even great achievements have been made, further research is required to uncover the sophisticated bioactivity of the venom and isolate more novel toxic peptides/proteins.…”
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The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis by Danuta Nowicka, Ewelina Grywalska

“…A deficiency in the endogenous antimicrobial peptides may be partly responsible for the susceptibility to colonization by and skin infection with S. aureus in patients with AD. …”
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The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review by Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia

“…Gram-negative bacteria produce N-acyl-L-homoserine lactones as autoinducer, while quorum sensing in Gram-positive bacteria produces autoinducing peptides. By looking at quorum sensing responses in bacterial pathogenesis and resistance, the study of natural antibiotic agents became a particular concern for researchers. …”
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The Role of Intracellular Organisms in the Pathogenesis of Inflammatory Arthritis by Animesh Singh, Sarah Karrar

“…., anticitrullinated peptides in rheumatoid arthritis), but the absence of these, in the seronegative arthritides, for example, raises question as to the underlying pathogenesis. …”
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Seaweed nutraceuticals and their therapeutic role in disease prevention by Abirami R. Ganesan, Uma Tiwari, Gaurav Rajauria

“…Seaweed bioactives including polysaccharides, pigments, fatty acids, polyphenols and peptides have been proven to possess various beneficial biological properties that could potentially contribute to functional food and nutraceutical development. …”
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Energetics of substrate transport in proton-dependent oligopeptide transporters by Balaji Selvam, Nicole Chiang, Diwakar Shukla

“…Abstract The PepTSo transporter mediates the transport of peptides across biological membranes. Despite advancements in structural biology, including cryogenic electron microscopy structures resolving PepTSo in different states, the molecular basis of peptide recognition and transport by PepTSo is not fully elucidated. …”
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An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system by Meiqin Mao, Li He, Qingpi Yan

“…It regulates the expression of bacterial environmental tolerance genes, virulence factors, adhesion, and invasion-related genes by sensing various environmental signals in the host, including Mg2+, low pH, antimicrobial peptides, and osmotic pressure. In this review, we describe the PhoP/PhoQ system-induced signal composition and its feedback mechanism, and the abundance of PhoP phosphorylation in the activated state directly or indirectly controls the transcription and expression of related genes, regulating bacterial stability. …”
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Learning predictive signatures of HLA type from T-cell repertoires. by María Ruiz Ortega, Mikhail V Pogorelyy, Anastasia A Minervina, Paul G Thomas, Thierry Mora, Aleksandra M Walczak

“…T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. …”
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Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N by Julius Bogomolovas, Ju Chen

“…Our method identified a new PKN substrate peptide that we optimized for use in a fluorescent biosensor design. …”
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, Barbara Brandao, Maikel L. Colli, Decio L. Eizirik, Jahnavi Aluri, Deep Patel, Marcus Göransson, Orlando Burgos Morales, Amanda Anderson, Laurie Landry, Farah Kobaisi, Raphael Scharfmann, Lorella Marselli, Piero Marchetti, Sylvaine You, Maki Nakayama, Sine R. Hadrup, Sally C. Kent, Sarah J. Richardson, Nicola Ternette, Roberto Mallone

“…While the resting β-cell immunopeptidome is dominated by HLA-A-restricted peptides, IFN-α largely favors HLA-B and only marginally upregulates HLA-A, translating into increased HLA-B-restricted peptide presentation and activation of HLA-B-restricted CD8+ T cells. …”
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Targeting Drug Delivery to the Lungs by Inhalation by C. O'Callaghan

“…This route of administration may be particularly attractive if it avoids the metabolic destruction encountered when some drugs are administered by alternative routes (for instance, peptides and proteins are rapidly destroyed by peptidases when Oven by the oral route). …”
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Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes by Enéas R. M. Gomes, Robson A. S. Santos, Silvia Guatimosim

“…Actually, it is well known that besides Ang II, the RAS has other active peptides. Of particular interest is the heptapeptide Ang-(1-7) that has been shown to exert cardioprotective effects. …”
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D-Amino Acids in the Nervous and Endocrine Systems by Yoshimitsu Kiriyama, Hiromi Nochi

“…Amino acids are important components for peptides and proteins and act as signal transmitters. …”
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