CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

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Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients by Yirou Zhang, Hong Zhang, Xingyu Zhu, Han Ye, Kan Yang, Xujiao Zhou, Jiaxu Hong

Subjects: “…calcitonin gene-related peptide…”
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A 7-Amino Acid Peptide Mimic from Hepatitis C Virus Hypervariable Region 1 Inhibits Mouse Lung Th9 Cell Differentiation by Blocking CD81 Signaling during Allergic Lung Inflammation by Wanzhou Zhao, Conghao Tan, Xi Yu, Ruihe Yu, Qibing Mei, Yun Cheng

“…Th9 is a novel Th cell subset that mainly produces IL-9, a potent proinflammatory cytokine in asthma. A 7-amino acid peptide (7P) of the hypervariable region 1 (HVR1) of hepatitis C virus has been identified as an important regulator in the type 2 cytokine (IL-4, IL-5, and IL-13) immune response. …”
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Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy, and Single-Photon Emission Computed Tomography Using a Cyclic RGD Peptide Labeled with a Near-Infrared Fluorescent Dye and a Radionuclide by W. Barry Edwards, Walter J. Akers, Yunpeng Ye, Philip P. Cheney, Sharon Bloch, Baogang Xu, Richard Laforest, Samuel Achilefu

“…To image the expression pattern of the α v β 3 integrin in tumors through a multimodality imaging paradigm, we prepared a cyclic RGDyK peptide analogue (LS308) bearing a tetraazamacrocycle 1,4,7,10-tetraazacyclododecane- N, N′, N″, N‴ -tetraacetic acid (DOTA) and a lipophilic near-infrared (NIR) fluorescent dye cypate. …”
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Imaging the Met Receptor Tyrosine Kinase (Met) and Assessing Tumor Responses to a Met Tyrosine Kinase Inhibitor in Human Xenograft Mouse Models with a [Tc] (AH-113018) or CY 5** (AH-112543) Labeled Peptide by Elaine M. Jagoda, Sibaprasad Bhattacharyya, Joseph Kalen, Lisa Riffle, Avrum Leeder, Stephanie Histed, Mark Williams, Karen J. Wong, Biying Xu, Lawrence P. Szajek, Osama Elbuluk, Fabiola Cecchi, Kristen Raffensperger, Meghana Golla, Donald P. Bottaro, Peter Choyke

“…These results were comparable to Cy5**-Met peptide (AH-112543) fluorescence imaging using the same treatment model. [ 99m Tc] or Cy5**-Met peptide tumor uptake was further validated by histologic (necrosis, apoptosis) and immunoassay (total Met, p Met, and plasma shed Met) assessments in imaged and nonimaged cohorts. …”
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The Comparison of the Kidney Effects of Dipeptidyl Peptidase 4 Inhibitors and Glucagon-Like Peptide 1 Agonist-Administered Concomitant with Sodium-Glucose Cotransporter 2 Inhibitors in Japanese Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease by Kazuo Kobayashi, Masao Toyoda, Nobuo Hatori, Kazuyoshi Sato, Masaaki Miyakawa, Kouichi Tamura, Akira Kanamori

“…Only 8% of patients were treated with SGLT2is alone, and more than 70% of them additionally received incretin-related agents, such as dipeptidyl peptidase 4 inhibitor (DPP4i) and glucagon-like peptide 1 agonist (GLP1Ra). Both agents reduce the plasma glucose level with an incretin effect, but the differences in the renoprotective effects between these agents are poorly understood. …”
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Comparing the Efficacy and Safety of Glucagon-Like Peptide 1 Receptor Agonists with Sodium-Glucose Cotransporter 2 Inhibitors for Obese Type 2 Diabetes Patients Uncontrolled on Metformin: A Systematic Review and Meta-Analysis of Randomized Clinical Trials by Lu Ding, Bang Sun, Xinhua Xiao

“…To conduct the first meta-analysis of randomized controlled trials (RCTs) comparing glucagon-like peptide 1 receptor agonists (GLP-1RAs) with sodium-glucose cotransporter 2 inhibitors (SGLT-2is) for obese type 2 diabetes (T2D) patients uncontrolled on metformin. …”
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A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…IL-1β is a strong regulator of Brain Natriuretic Peptide (BNP), a hormone involved in cardiovascular homeostasis by guanylyl cyclase Natriuretic Peptide Receptor (NPR-1). …”
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Heterologous Expression of Laccase1 from Cryphonectria parasitica in Saccharomyces cerevisiae by Kum-Kang So, Fatima Alejandra Hernandez Alvarado, Gui-Hwan Han, Jeong-Won Kim, Tae-Geum Kim, Dae-Hyuk Kim

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Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

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Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

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Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy by Hongxia Zhang, Ming Ji, Yamei Wang, Mengmeng Jiang, Zongyu Lv, Gongyu Li, Lulu Wang, Zhen Zheng

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The Role of NT-proBNP Levels in the Diagnosis of Hypertensive Heart Disease by Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Despo Melanarkiti, Theodora Eleni Plakomyti

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Viral entry mechanisms: the role of molecular simulation in unlocking a key step in viral infections by Mariana Valério, Carolina C. Buga, Manuel N. Melo, Cláudio M. Soares, Diana Lousa

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Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial by Lauren Powell, Fiona O’Sullivan, Pramoda Jayasinghe, Basia Rogula, Feng Dai, Jessica Cirillo, Samantha Sweeney, Lucy Abraham, Jessica Ailani

Subjects: “…Calcitonin gene-related peptide…”
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Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells by Markus Bergqvist, Kyong-Su Park, Nasibeh Karimi, Lijuan Yu, Cecilia Lässer, Jan Lötvall

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Impact of Myo-Inositol-Chiro Inositol Combination on the improvement of Polycystic Ovary Syndrome Condition by Zuhair Assi Hussein, Maysaa Jalal Majeed, Lubna Amer Al-Anbari

Subjects: “…d-inositol-insulin-like peptide 5…”
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Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice by Kazuki Harada, Eiji Wada, Yuri Osuga, Kie Shimizu, Reiko Uenoyama, Masami Yokota Hirai, Fumihiko Maekawa, Masao Miyazaki, Yukiko K. Hayashi, Kazuaki Nakamura, Takashi Tsuboi

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Safety of Rimegepant in Adults with Migraine and Anxiety, Depression, or Using Antidepressants: Analysis of a Multicenter, Long-Term, Open-Label Study by David Kudrow, Susan Hutchinson, Glenn C. Pixton, Terence Fullerton

Subjects: “…Calcitonin gene-related peptide receptor antagonist…”
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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential by Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei

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