Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

“…These microbial exometabolites predominantly comprised aliphatic/peptide-like and carboxyl-rich alicyclic molecule (CRAM)-like compounds. …”
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Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis by Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U. Joseph Schoepf, Jian Li, Yining Wang

“…T >44 ms, extracellular volume fraction (ECV) >47%, and native T1 >1468 ms were significantly prognostic (all, P < 0.05) but non-significant after adjustment for N-terminal pro-B-type natriuretic peptide (all, P > 0.05) in AL amyloidosis. T2 >44 ms was independently prognostic after correcting for left ventricle (LV) late gadolinium enhancement, LV ejection fraction, LV longitudinal strain, and therapeutic response (all, P < 0.05). …”
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Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

“…Cholemia also blunted the light entrainment response and light-induced phase change of SCN mediated by the neurons expressing gastrin releasing peptide through Tgr5-Per2 axis. BA sequestrant or CK1 inhibitor reversed the CRSDs in cholemic mice by restoring Per2 distribution. …”
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Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis by Ruomei Cheng, Xiaopeng Tang, Qiyu Zhao, Yuming Wang, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, Dawit Adisu Tadese, Xudong Zhao, Caiwen Ou, Ren Lai

“…Immune recognition and activation by the peptide-laden major histocompatibility complex–T cell receptor (TCR)–CD3 complex is essential for anti-tumor immunity. …”
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The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity by Ying Wang, Shuyi Yang, Suming Zhang, Suming Zhang, Ye Yang, Siqing Li, Siqing Li, Meiyu Zhang, Meiyu Zhang, Xiaona Li, Hua Bai, Peiliang Luo, Yingdi Yuan, Yingdi Yuan

“…Children in the MAFLD group had higher levels of height[(159.49 ± 12.73)cm vs.(155.55 ± 10.50)cm], weight[(82.32 ± 18.75)kg vs.(68.28 ± 15.00)kg], BMI[(32.08 ± 4.49)kg/m2 vs.(27.85 ± 4.21)kg/m2],fasting insulin[33.42(24.07,43.93)uIU/ml vs.23.91(15.72,31.52)uIU/ml],HOMA-IR[7.27(5.26,10.71) vs.4.87(3.27,6.86)],fastingC-peptide[1409.00(1175.00,1668.00)pmol/L vs.1020.00(849.05,1303.00)pmol/L], WBC[(7.85 ± 1.80)×109/L vs.(7.15 ± 1.42)×109/L], HbA1c[5.40(5.30,5.70)% vs.(5.30(5.20,5.60)%],ALT[48.00(27.00,80.00)U/L vs.19.00(15.00,26.50)U/L], and AST[31.00(24.00,60.00)U/L vs.21.00(18.50, 26.00)U/L] compared to the simple obesity group (P&lt;0.05). …”
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Changes in clinical and imaging variables during withdrawal of heart failure therapy in recovered dilated cardiomyopathy by Brian P. Halliday, Ruth Owen, John Gregson, Ali Vazir, Rebecca Wassall, Zohya Khalique, Amrit S. Lota, Upasana Tayal, Daniel J. Hammersley, Richard E. Jones, Dudley J. Pennell, Martin R. Cowie, John G.F. Cleland, Sanjay K. Prasad

“…Plasma N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) fell immediately after withdrawing beta‐blockers and only tended to increase 6 months after beginning therapy withdrawal [mean change in log NT‐proBNP at 6 months: 0.2 (95% CI −0.1, 0.4)]. …”
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The Importance of Dose Escalation in the Treatment of Pulmonary Arterial Hypertension with Treprostinil by Piotr Kędzierski, Marta Banaszkiewicz, Michał Florczyk, Michał Piłka, Rafał Mańczak, Maria Wieteska-Miłek, Piotr Szwed, Krzysztof Kasperowicz, Katarzyna Wrona, Szymon Darocha, Adam Torbicki, Marcin Kurzyna

“…The treatment efficacy was assessed as improvement in 6 min walk distance (6MWD) and WHO functional class (WHO FC), a reduction in N-terminal prohormone of brain natriuretic peptide (NTproBNP), and the percentage of patients achieving low-risk status after 12 months of treatment. …”
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Effect of Xingbi Gel Nasal Drops on Rats with Allergic Rhinitis Based on the Nasal Mucosa-Hippocampus Neuroimmune Mechanism by FAN Xueqi, QIU Caixia, YAN Shuiping, ZHUANG Xiangli, AI Si, GUO Lihua, ZHENG Jian

“…The AR rat behavioral scoring criteria was used to evaluate rhinitis behavior of rats; Morris water maze test was used to evaluate learning and memory function of rats; enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of immunoglobulin E (IgE) and transforming growth factor-β1 (TGF-β1); hematoxylin-eosin (HE) staining was used to observe pathological changes of nasal mucosa and eosinophil (EOS) count; immunohistochemistry method was used to detect expression levels of non-receptor tyrosine kinases Fyn, substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in the hippocampus; and real-time polymerase chain reaction (RT-PCR) was used to detect mRNA transcription levels of Fyn, SP, VIP and NPY in the hippocampus.Results(1) Behavioral scores of rhinitis: compared with the normal group, behavioral scores of rhinitis were significantly higher in the model group, the traditional Chinese medicine group and the western medicine group before treatment (<italic>P</italic>&lt;0.05). …”
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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…In contrast, MS patients who underwent apheresis (nmax=27) showed strong immunoglobulin reduction rates, especially for IgG, and decreased antibody reactivities against all tested peptides. EBNA1 (amino acids 391-410) was the only peptide that also reached the significance level in NMOSD patients (n=9). …”
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Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from J... by Xin Huang, Xin Huang, Xin Huang, Xin Huang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Chao Wang, Chao Wang, Chao Wang, Chao Wang, Guotai Sheng, Guotai Sheng, Yang Zou, Guobo Xie

“…Additionally, the results of receiver operating characteristic curve analysis indicated that PWR had high predictive accuracy for mortality events within 30 days of hospitalization in ADHF patients and is significantly better than the traditional HF marker N-Terminal Pro-Brain Natriuretic Peptide (AUC: NT-proBNP 0.69, PWR 0.76; Delong test P &lt; 0.05). …”
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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…IMA202 consists of autologous genetically modified cytotoxic CD8+ T cells expressing a T cell receptor (TCR), which is specific for a nine amino acid peptide derived from MAGEA1. Eligible patients underwent leukapheresis, T cells were isolated, transduced with lentiviral vector carrying MAGEA1-specific TCR and following lymphodepletion (fludarabine/cyclophosphamide), infused with a median of 1.4×109 specific T cells (range, 0.086×109–2.57×109) followed by interleukin 2.Safety of IMA202 No DLT was observed. …”
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STRUCTURAL AND FUNCTIONAL STATE OF THE MYOCARDIUM AND SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE PRESENCE OF ARTERIAL H... by Rostyslav Kovalchuk, Uliana Bahan

“…In addition, the blood levels of natriuretic peptide (NT-proBNP) and C-reactive protein were determined, and an ultrasound examination of the heart was performed at the inpatient stage of treatment and after 6 weeks of follow-up. …”
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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective... by Yukitaka Ueki, Tom W J Huizinga, René E M Toes, Shoichi Fukui, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami, Tomohiro Koga, Naoki Matsuoka, Toshihiko Hidaka, Naoki Iwamoto, Mami Tamai, Shin-ya Kawashiri, Akitomo Okada, Ayako Nishino, Tamami Yoshitama, Takahisa Suzuki, Toshimasa Shimizu, Shimpei Morimoto, Tomomi Tsuru, Karin A J van Schie, Masahiro Ayano, Remi Sumiyoshi, Yushiro Endo, Tohru Michitsuji, Kaori Furukawa, Masataka Umeda, Nobutaka Eiraku, Hiroaki Hamada

“…Their serum levels of multiple cytokines and chemokines, rheumatoid factors, and serum autoantibodies (anti-cyclic citrullinated peptide-2 (anti-CCP2) and anti-carbamylated protein antibodies) were measured at baseline, 3 months and 12 months.Results Dimensionality reduction using 38 cytokines and chemokines demonstrated four distinct clusters that differed significantly regarding the frequencies of remission defined by clinical composite measures and ultrasound evaluations. …”
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Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling by Vera Fortmeier, MD, Mark Lachmann, MD, Lukas Stolz, MD, Jennifer von Stein, MD, Karl-Philipp Rommel, MD, Mohammad Kassar, MD, Muhammed Gerçek, MD, Anne R. Schöber, MD, Thomas J. Stocker, MD, Hazem Omran, MD, Michelle Fett, Jule Tervooren, Maria I. Körber, MD, Amelie Hesse, Gerhard Harmsen, PhD, Kai Peter Friedrichs, MD, Shinsuke Yuasa, MD, PhD, Tanja K. Rudolph, MD, Michael Joner, MD, Roman Pfister, MD, Stephan Baldus, MD, Karl-Ludwig Laugwitz, MD, Stephan Windecker, MD, Fabien Praz, MD, Philipp Lurz, MD, Jörg Hausleiter, MD, Volker Rudolph, MD

“…Patients from the low-risk category (n = 261) were defined by mean pulmonary artery pressure ≤28 mm Hg and N-terminal pro–B-type natriuretic peptide ≤2,728 pg/mL, and they exhibited a 2-year survival rate of 85.5%. …”
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Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma by Fan Wu, Xin Kuang, Sanlin Deng, Shuo Qi, Jian Xiong, Bibo Zhao, Chuanfu Li, Senyou Tan, Qiang Kang, Hao Xiao, Xiaofeng Tan, Gui-long Wu, Qinglai Yang, Guodong Chen

“…Conjugating the HCC-specific targeting molecule GPC3 peptide and the MRI agent DOTA-Gd through click chemistry. …”
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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant by Yingshuai Wang, Lihua Shi, Junna Lu, Fengyuan Wang, Zihan Zhou, Yuexuan Wang, Xiangyu Du, Di Qin, Fangman Chen, Dan Shao, Yuanyuan Gao, Cheng Gao, Tongyi Sun

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Effect of Low-Frequency Ultrasonic-Assisted Enzymolysis on the Physicochemical and Antioxidant Properties of Corn Protein Hydrolysates by Qiufang Liang, Xiaofeng Ren, Haile Ma, Suyun Li, Kangkang Xu, Ayobami Olayemi Oladejo

“…Molecular weight distribution and amino acid profile analysis showed that ultrasound pretreatment enhanced the formation of short-chain peptides with molecular weight of 200–3000 Da, especially the peptides containing hydrophobic amino acids. …”
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Dynamic changes of peptidome and release of polysaccharide in sea cucumber (Apostichopus japonicus) hydrolysates depending on enzymatic hydrolysis approaches by Yanchao Wang, Yan Song, Yaoguang Chang, Yanyan Liu, Guangning Chen, Changhu Xue

“…A portfolio of 216 shared peptides were detected in the peptidome by papain with different hydrolysis time, while 32 shared peptides were detected in the peptidome by differing proteases. …”
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Preparation, characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken, porcine and bovine by Liwei Qi, Hongru Zhang, Yujie Guo, Hong Liu, Chunhui Zhang

“…The free amino groups loss, browning intensity, and fluorescence intensity of G-Cbcp (glycosylated chicken bone collagen hydrolysates (peptides)) were the heaviest, followed by G-Pbcp (glycosylated porcine bone collagen hydrolysates (peptides)) and G-Bbcp (glycosylated bovine bone collagen hydrolysates (peptides)). …”
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IgM against Merozoite Surface Protein 1-Block 2 Haplotypes as New Tools for Plasmodium vivax Infections by Fernanda de Almeida Batalha, Elizangela Farias da Silva, Paula Taquita Serra, Rafaella Oliveira dos Santos, Zeca Manuel Salimo, Yury de Oliveira Chaves, Mirian Ívens Fagundes, Paulo Emílio Feuser, Victor Costa de Souza, Felipe Gomes Naveca, Ricardo A. Machado de Ávila, Paulo Afonso Nogueira

“…We evaluated seroprevalence against sets of specific peptides to the block 2 region of Plasmodium vivax-merozoite surface protein-1 (PvMSP1) to detect parasite clones. …”
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