Fatigue in Parkinson’s disease—A narrative review by Baikuntha Panigrahi, Kanchana S. Pillai, Divya M. Radhakrishnan, Roopa Rajan, Achal K. Srivastava

“…A deeper understanding of the patho-mechanisms of fatigue in PD is needed to establish evidence-based treatment guidelines. …”
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Il profilo del partner maltrattante by Luca Cimino

“…Although it is not possible to identify a prototypical psycho(patho)logical profile of the abusive partner, against whom in the vast majority of cases it is not possible to find a defined clinical condition, nevertheless it seems possible to detect in the IPV perpetrators a common denominator that feeds a “perverse” dimension of the interpersonal relationship in which, that is, it is possible to identify a distortion of the functioning of “object relations”, followed by problems in the formation of the ego and with the structuring of pathological forms of attachment that, by preventing the processing of abandonment issues, may also cause violent behaviors. …”
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WGAN-GP for Synthetic Retinal Image Generation: Enhancing Sensor-Based Medical Imaging for Classification Models by Héctor Anaya-Sánchez, Leopoldo Altamirano-Robles, Raquel Díaz-Hernández, Saúl Zapotecas-Martínez

“…The proposed method outperformed traditional generative models, such as conditional GANs and PathoGAN, achieving the best performance on key metrics: a Fréchet Inception Distance (FID) of 15.21, a Mean Squared Error (MSE) of 0.002025, and a Structural Similarity Index (SSIM) of 0.89 in the Kaggle dataset. …”
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Fungal and oomycete pathogens and heavy metals: an inglorious couple in the environment by Joanna Gajewska, Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Autar Mattoo, Magdalena Arasimowicz-Jelonek

“…Although the effects of HMs on plants, animals and humans have been extensively studied, yet little is known about their effects on the (patho)biology of the microorganisms belonging to a unique group of filamentous eukaryotic pathogens, i.e., fungi and oomycetes. …”
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Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? by Olivier Toussaint, Patrick Dumont, Jose Remacle, Jean-Francois Dierick, Thierry Pascal, Christophe Frippiat, Joao Pedro Magalhaes, Stephanie Zdanov, Florence Chainiaux

“…Examples are given suggesting these cells affect in vivo tissue (patho)physiology and aging.…”
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Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1 by Joanna Lecka, Michel Fausther, Beat Künzli, Jean Sévigny

“…Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), like other ectonucleotidases, controls extracellular nucleotide levels and consequently their (patho)physiological responses such as in thrombosis, inflammation, and cancer. …”
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Desensitization of delayed-type hypersensitivity in mice: suppressive environment by Takashi Katsura, Kazuo Kobayashi, Michio Hosaka, Sachiko Sugihara, Tsuyoshi Kasama, Keita Kasahara, Stanley Cohen, Takeshi Yoshida

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Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice by Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham

“…In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals. …”
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Detection of Amylin-β-amyloid Hetero-Oligomers by Enzyme-Linked Immunosorbent Assay by Noah Leibold, Deepak Kotiya, Nirmal Verma, Florin Despa

“…Parenchymal amylin-Aβ plaques are found in both sporadic and early-onset familial Alzheimer’s disease (AD), yet their (patho)physiological role remains elusive, particularly due to a lack of detection modalities for these mixed plaques. …”
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Role of intestinal mucin-2 in the effectiveness of the treatment of Helicobacter spp. infection in laboratory mice by E. A. Litvinova, M. D. Belyaev, A. V. Prokhortchouk, V. S. Korostina, E. B. Prokhortchouk, E. N. Kozhevnikova

“…In this study, we investigated the potential of antibiotics (clarithromycin, amoxicillin, and metronidazole) in elimination of patho­genic infection from Muc2 knockout mice (Muc2–/–). …”
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Grand Challenges at the Interface of Engineering and Medicine by Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller

“…We are at the nexus of creating “avatars” (herein defined as an extension of “digital twins”) of human patho/physiology to serve as paradigms for interrogation and potential intervention. …”
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Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…Understanding the sex-specific differences in fat metabolism may provide deeper insights into the patho-mechanisms associated with hypertension and lead to more comprehensive sex-specific care.…”
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A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts by Jessica Wiseman, Raja Haseeb Basit, Akihiro Suto, Sagnik Middya, Bushra Kabiri, Michael Evans, Vinoj George, Christopher Adams, George Malliaras, Divya Maitreyi Chari

“…To our knowledge, this is the first in vitro simulation of transecting injury in a two-dimensional multicellular cortical brain cell sheet, that allows for combined histological and electrophysiological readouts of damage/repair. The patho-mimicry and adaptability of this simplified model of brain injury could benefit the testing of biomaterial therapeutics in regenerative neurology, with the option for functional electrophysiological readouts.…”
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The Use of Voice Control in 3D Medical Data Visualization Implementation, Legal, and Ethical Issues by Miklos Vincze, Bela Molnar, Miklos Kozlovszky

“…During our research, we created a voice control module for an existing software called PathoVR, using a model taught by Google to interpret the voice commands given by the user. …”
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Impact of maternal prenatal stress by glucocorticoids on metabolic and cardiovascular outcomes in their offspring: A systematic scoping review. by Claudia Eberle, Teresa Fasig, Franziska Brüseke, Stefanie Stichling

“…<h4>Objective</h4>To review the evidence of in utero programming by focusing on the impact of maternal "stress", on adverse cardio-metabolic outcomes on their offspring later in life, by identifying underlying (patho-) physiological mechanisms (1) as well as adverse short and long-term cardio-metabolic outcomes (2).…”
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Anti-inflammatory effect of Plantago asiatica crude extract in rat gout arthritis model by Bingjun Qian, Jun Hu, Li Dai, Yue Zhou, Haixia Xu

“…PAE treatment significantly reversed patho- genic joint space narrowing and swelling, reversed the MSU-induced changes in inflammatory factors, and in general imparted effects very similar to those seen with colchicine (COL; known non-steroidal anti-inflammatory drug for clinical treatment of GA). …”
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Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains by Eslam Mohamed, Ines Zarak, Nick Vereecke, Sebastiaan Theuns, Kathlyn Laval, Hans Nauwynck

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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

“…Furthermore, 6-keto-PGF1alpha had its peak shortly before initiation of continuous veno-venous hemodialysis (at least in 5 of the observed patients), 2-AG was elevated in all our nine patients during (right) heart failure in the context of either re-opening patient’s chest, implementation of veno-arterial ECMO or at least while significantly increasing the amount of catecholamines.DiscussionIn this pilot trial we identified several evaluated lipids in critically ill patients representing either potentially (patho-) physiologically relevant mediators of the pro-inflammatory processes and during heart failure or possible markers preceding veno-venous hemodialysis.…”
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Personalized approach in the management of women with heart failure with preserved ejection fraction and carbohydrate metabolism disorders by L.R. Petrovska, I.O. Kostitska, T.R. Petrovskyy, R.V. Petrovskyy

“…Therefore, the main strategy for the treatment of comorbid patho­logy is the use of patient-oriented approaches taking into account gender characteristics and the search for alternative ways to achieve glycemic goals safely in individuals with HFpEF and carbohydrate metabolism disorders. …”
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Endocrine disruptors and cancers. [Perturbateurs endocriniens et cancers] by Souhila AOUICHAT BOUGUERRA, Saliha BOUMAZA, Khouloud HEMILA, Samia NEGGAZI, Nadjiba HAMLAT, Sihem BERDJA, Leïla SMAIL, Besma MOHAMMEDI, Kenza REGUOUAT, Amina BOUDJLIDA, Sofiane KACI, Fatima BOUACHRIA-BOUSMAHA

“…By modifying hormonal function, these compounds have potentially patho-logical consequences for the organism exposed to them or for its descendants. …”
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