Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery by Jyoti Wadhwa, Abhay Asthana, Gyati Shilakari, Arun Kumar Chopra, Ranjit Singh

“…Study demonstrated that the nanoemulsifying preconcentrate can be a promising system for the colon specific delivery of curcumin to treat local pathologies.…”
Get full text

Cardiac sound classification using a hybrid approach: MFCC-based feature fusion and CNN deep features by Mahbubeh Bahreini, Ramin Barati, Abbas Kamali

“…Conventional feature extraction methods often face challenges in distinguishing non-stationary signals like healthy and pathological PCG signals. Our research addresses these challenges by adopting a hybrid feature extraction scheme that leverages deep learning and handcrafted techniques. …”
Get full text

Delayed Manifestation of Shunt Nephritis: A Case Report and Review of the Literature by Michael Babigumira, Benjamin Huang, Sherry Werner, Wajeh Qunibi

“…In this review, we comment on the presentation, lab findings, pathological features, and management of this rare, potentially fatal, but curable disease entity.…”
Get full text

Maternal Hypertension and Early Atherosclerotic Lesions in Aortas of Deceased Fetuses and Neonates by Janet María Capote-Santa Cruz Pacheco, Carmen Teresa Peraza Méndez, Marlene Ferrer Arrocha, Lisandra Álvarez de la Nuez, Belkis Ortega de la Campa, Mirian Castro Ortega

“…<br /><strong>Method:</strong> a descriptive cross-sectional study was carried out that included fetuses older than 22 weeks and deceased neonates born to hypertensive mothers, who underwent autopsy in the pathological anatomy department of the Eusebio Hernández Pérez Gynecobstetric University Hospital, in the period between January 2021 and December 2022, with a total of 18. …”
Get full text

Protective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis by Fugang Huang, Shuo Huang, Ke Sun, Yanhao Chen, Guanqun Xie, Jie Bao, Yongsheng Fan

“…CK remarkably restored mitochondrial homeostasis by attenuating pathological mitochondrial fission and enhancing mitophagy, thereby rebalancing the delicate mitochondrial network. …”
Get full text

Integrated Analysis of microRNA Targets Reveals New Insights into Transcriptional–Post-Transcriptional Regulatory Cross-Talk by Simona Panni, Roberto Pizzolotto

“…Despite their undeniable relevance and the substantial body of literature demonstrating their role in cancer and other pathologies, the identification of functional interactions is still challenging. …”
Get full text

Osteoporosis in Rett Syndrome: A Study on Normal Values by Lilit Zysman, Meir Lotan, Bruria Ben-Zeev

“…This condition may cause pathological fractures, inflict pain, and seriously damage mobility. …”
Get full text

STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis by Jianfen Zhu, Yijing Chen, Yulan Chen, Yinqiu Lv, Tianxin Chen

“…However, the specific therapy and mechanisms of AKI in DPLN remain to be explored.Methods The correlation between AKI and clinical pathological changes in DPLN patients was analyzed. Expression of STAT3 signaling was detected in MRL/lpr mice with DPLN using immunohistochemical staining and immunoblotting. …”
Get full text

The Role of Oral Biomarkers in the Assessment of Noncommunicable Diseases by Gustavo Sáenz-Ravello, Marcela Hernández, Mauricio Baeza, Patricia Hernández-Ríos

“…<b>Background/Objectives</b>: Oral biomarkers have gained attention as non-invasive tools for assessing systemic diseases due to their potential to reflect physiological and pathological conditions. This review aims to explore the role of oral biomarkers in diagnosing and monitoring systemic diseases, emphasizing their diagnostic relevance and predictive capabilities in clinical practice. …”
Get full text

Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices by Raffaella Molteni, Andrea C. Rossetti, Elisa Savino, Giorgio Racagni, Francesca Calabrese

“…Although activity-dependent transcription represents a crucial mechanism for long-lasting experience-dependent changes in the hippocampus, limited data exist on its contribution to pathological conditions. We aim to investigate the influence of chronic stress on the activity-dependent transcription of brain-derived neurotrophic factor (BDNF). …”
Get full text

New Predictive Factors in the Development of Type 2 Diabetes Mellitus by Maurio González Hernández

“…<strong><br />Conclusions:</strong> among the new predictive factors for the development of type 2 diabetes mellitus are: the value of microalbuminuria, periodontal disease, sensitivity disorders in the lower limbs, a pathological history of hypothyroidism and eye fundus alterations.…”
Get full text

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease by Ilenia Pellarin, Alessandra Dall’Acqua, Andrea Favero, Ilenia Segatto, Valentina Rossi, Nicole Crestan, Javad Karimbayli, Barbara Belletti, Gustavo Baldassarre

“…We then discuss the potential roles and deregulation of CDKs in human pathologies, with a particular focus on cancer, the human disease in which CDKs have been most extensively studied and explored as therapeutic targets. …”
Get full text

Bile Reflux Gastritis: Insights into Pathogenesis, Relevant Factors, Carcinomatous Risk, Diagnosis, and Management by Xiaolan Shi, Zijiao Chen, Yi Yang, Su Yan

“…Nevertheless, advances in techniques, especially extensive applications of endoscopy and chemical analysis of reflux contents, have improved our ability to identify the occurrence of this disease as well as distinguishing physiological reflux from pathological reflux. Finally, it is fortunate for patients that more and more importance has been attached to the treatment of BRG. …”
Get full text

Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation by Gui-Hua Tian, Shan-Shan Tao, Man-Tang Chen, Yu-Sang Li, You-Ping Li, Hong-Cai Shang, Xiao-Yi Tang, Jian-Xin Chen, He-Bin Tang

“…Together, these findings suggest that CPSP is closely related to pathological changes of the neocortex and hippocampus. …”
Get full text

Case report: Watch-and-wait strategy in resectable esophageal cancer following neoadjuvant chemoimmunotherapy: a case series by Lingyu Tan, Lingyu Tan, Guozhen Yang, Guozhen Yang, Chufeng Zeng, Chufeng Zeng, Xu Zhang, Xu Zhang, Xu Zhang

“…Neoadjuvant chemoimmunotherapy (NCIT) has improved pathological complete response and conferred survival benefits in patients with locally advanced esophageal cancer. …”
Get full text

The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction by Hongliang Zu, Huiling Wang, Chunfeng Li, Wendian Zhu, Yingwei Xue

“…The patients with distal gastric cancer with GOO generally presented more aggressive pathologic features, a poorer nutritional status, more duodenal infiltration, and peritoneal dissemination than those with cancer without GOO. …”
Get full text

Neurochemical Plasticity of the Coeliac-Superior Mesenteric Ganglion Complex Neurons Projecting to the Prepyloric Area of the Porcine Stomach following Hyperacidity by Katarzyna Palus, Jarosław Całka

“…These findings enrich existing knowledge about the participation of these active substances in adaptive mechanism(s) of the sympathetic neurons during pathological processes within the gastrointestinal tract.…”
Get full text

Association of Premature Ventricular Contraction (PVC) with hematological parameters: a data mining approach by Nafiseh Hosseini, Sara Saffar Soflaei, Pooria Salehi-Sangani, Mahdiyeh Yaghooti-Khorasani, Bahram Shahri, Helia Rezaeifard, Habibollah Esmaily, Gordon A. Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan

“…However, it may be associated with some pathological conditions. In this research the association between hematological factors and PVC was studied. …”
Get full text

The Efficacy of Denosumab in the Management of a Tibial Paediatric Aneurysmal Bone Cyst Compromised by Rebound Hypercalcaemia by Matthew Harcus, Samantha Aldridge, Adesegun Abudu, Lee Jeys, Senthil Senniappan, Henry Morgan, Barry Pizer

“…The patient had ongoing severe pain, was unable to weight-bear, and was at significant risk of pathological fracture. En bloc resection and embolization were not deemed viable, and a decision to use denosumab was made. …”
Get full text

Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination by Anurag Maheshwari, Kris Janssens, Jeroen Bogie, Chris Van Den Haute, Tom Struys, Ivo Lambrichts, Veerle Baekelandt, Piet Stinissen, Jerome J. A. Hendriks, Helena Slaets, Niels Hellings

“…Demyelination is one of the pathological hallmarks of multiple sclerosis (MS). To date, no therapy is available which directly potentiates endogenous remyelination. …”
Get full text