Cervical Thymic Cyst: A Rare Differential Diagnosis in Lateral Neck Swelling by Vijendra Shenoy, M. Panduranga Kamath, Mahesh Chandra Hegde, Raghavendra Rao Aroor, Vijetha V. Maller

“…Greater awareness among the pathologists may decrease misdiagnosis.…”
Get full text

The “Endothelialized Muscularis Mucosae”: A Case Report Describing a Large Cavernous Hemangioma at the Terminal Ileum and a New Histologic Clue for Preoperative Diagnosis from Endo... by Erin K. Purdy-Payne, Jean F. Miner, Brandon Foles, Tien-Anh N. Tran

“…Therefore, gastroenterologists, pathologists, and surgeons should be aware of the “endothelialized muscularis mucosae” which can be very helpful in diagnosing GI cavernous hemangiomas from endoscopic biopsies.…”
Get full text

Application of HPLC Combined with Laser Induced Fluorescence for Protein Profile Analysis of Tissue Homogenates in Cervical Cancer by Sujatha Bhat, Ajeetkumar Patil, Lavanya Rai, V. B. Kartha, Santhosh Chidangil

“…The statistical analysis has shown that the differences in protein profiles can be used to diagnose biochemical changes in the tissue, and thus can be readily applied for the detection of cervical cancer, even in situations where a histopathology examination is not easy because of nonavailability of experienced pathologists.…”
Get full text

Exploring diagnostic frontiers in oral squamous cell carcinoma: A comprehensive review from immunohistochemistry to genomic profiling by Hema Suryawanshi, Alka Hande, Kaladhar Reddy Aileni, Manisha Sahu, Santosh R. Patil, Mohmed Isaqali Karobari

“…A multidisciplinary approach involving collaboration between surgeons, pathologists, and researchers is crucial for advancing the field and optimizing OSCC management. …”
Get full text

Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis by Varun Mamidi, Manikantan Shekar, Jaiju James Chakola, Vamsi Krishna Makkena, Jayakumar Matcha

“…Due to its rarity and diagnostic difficulty, treatment is challenging for clinicians, pathologists and radiologists. Treatment of choice for symptomatic patients is steroid therapy. …”
Get full text

Evaluation of the significance of tumor stromal patterns and peri-tumoral inflammation in head and neck squamous cell carcinoma with special reference to the Yamamoto–Kohama classi... by Geet Bhuyan, Prabir Hazarika, Anju M. Rabha

“…The hematoxylin and eosin (H and E)-stained sections from all cases were examined by two experienced pathologists for the grade, nature of stomal reaction (SR), peri-tumoral inflammatory infiltration, Yamamoto–Kohama classification grade, worst pattern of invasion (WPOI), depth of invasion (DOI), and other histopathological parameters. …”
Get full text

Gastric Carcinoma with Osteoclast-Like Giant Cells Coexisting with Gastrointestinal Spindle Cell Tumor by Christos Poulios, Triantafyllia Koletsa, Antonis Goulas, Georgia Karayannopoulou, Eleni Vrettou, Ioannis Kostopoulos

“…Due to the limited number of the reported cases, the prognostic value of OGCs is under discussion. Furthermore, pathologists should be aware that incidental GIST may accompany any tumor.…”
Get full text

Image Analysis Based Grading of Bladder Carcinoma. Comparison of Object, Texture and Graph Based Methods and Their Reproducibility by Heung‐Kook Choi, Torsten Jarkrans, Ewert Bengtsson, Janos Vasko, Kenneth Wester, Per-Uno Malmström, Christer Busch

“…The possibility that computerized image analysis could increase the reproducibility of grading of bladder carcinoma as compared to conventional subjective grading made by pathologists was investigated. Object, texture and graph based analysis were carried out from Feulgen stained histological tissue sections. …”
Get full text

Malignant glomus tumor of jejunum with liver and peritoneum metastasis: a rare case report by Shilan Peng, Nan Yang, Zifan Xu, Guomiao Su, Xiaoyu Tuo, Shiyue Liu, Zi Lei, Guoqing Pan

“…This report summarizes the clinical and histopathological features of jejunal MGTs with the aim of increasing awareness among clinicians and pathologists regarding this disease.…”
Get full text

A re-look at the modified Ryan regression scoring system in esophageal cancer—validation of prognostic significance and comparison with other less commonly used systems by Paromita Roy, Rupanita Biswal, Sayali N. Honap, Robin Thambudorai, Tapesh Bhattacharyya, Indranil Mallick

“…Materials and Methods: Two pathologists independently reviewed all cases of post-NACRT (CROSS) EC, to score TRGs and other histological parameters. …”
Get full text

Assessment of endometrial carcinoma on biopsy as a predictor of final surgical pathology: Are we doing it right? A completed audit cycle and recommendations by Aneeta Jassar, Nour Hemali, Anjali Bhatnagar

“…Settings and Design: The audit was approved by the Clinical Effectiveness Team of the Royal College of Pathologists (UK) as meeting all the criteria and standards set out by the College. …”
Get full text

Il-6 and MSH3 in colorectal carcinoma: Expression, relationship, and prognostic significance in 171 colorectal carcinoma cases by Elif Kolay Bayram, Betul Ogut, Mehmet Arda Inan, Ayse Dursun

“…Materials and Methods: IL-6 and MSH3 IHC and H and E slides were evaluated by two pathologists. Clinical data were obtained from the institution’s database. …”
Get full text

Evaluation of the histopathological spectrum of skin biopsies in patients with chronic kidney disease: A single-center experience by Amany A Fathaddin

“…The quality of life of CKD patients will be significantly improved by identifying and managing these conditions. Pathologists’ familiarity with this spectrum is important, as a correct histopathologic diagnosis will lead to a better outcome.…”
Get full text

Harnessing artificial intelligence role in oral cancer diagnosis and prediction: A comprehensive exploration by Archana Behera, N. Aravindha Babu, Remya Rajan Renuka, Mukesh Kumar Dharmalingam Jothinathan

“…The systems involving collaboration pathologists witness higher abnormality detection and treatment planning, thereby bettering the diagnosis precision and the quality of care. …”
Get full text

Papillary Thyroid Carcinoma Semantic Segmentation Using Multi-Scale Adaptive Convolutional Network With Dual Decoders by Thanat Payatsuporn, Pittipol Kantavat, Nichthida Tangnuntachai, Nopporn Tipparawong, Waratchanok Techapapa, Boonserm Kijsirikul, Somboon Keelawat

“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Currently, pathologists diagnose the PTC by interpreting their nuclei. …”
Get full text

A Gamut of Astounding Diagnosis as Paraganglioma of Urinary Bladder: A Retrospective Study from North India by Nazia Manzoor Walvir, Aiffa Aiman, Inara Abeer, Mohammad Iqbal Lone, Shadab Maqsood

“…This study aimed to describe the histopathology of UBPGL, emphasizing the histologic attributes that may help pathologists recognize this rare bladder tumor and aid in differentiation from urothelial malignancies and other tumors that may resemble paragangliomas. …”
Get full text

Impact of stain variation and color normalization for prognostic predictions in pathology by Siyu Lin, Haowen Zhou, Mark Watson, Ramaswamy Govindan, Richard J. Cote, Changhuei Yang

“…Abstract In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. …”
Get full text

Observer Performance in the Use of Digital and Optical Microscopy for the Interpretation of Tissue-Based Biomarkers by Marios A. Gavrielides, Catherine Conway, Neil O’Flaherty, Brandon D. Gallas, Stephen M. Hewitt

“…To examine observer agreement as a function of viewing modality (digital versus optical microscopy), whole slide versus tissue microarray (TMA) review, biomarker type (HER2 incorporating membranous staining and Ki-67 with nuclear staining), and data type (continuous and categorical). Methods. Eight pathologists reviewed 50 breast cancer whole slides (25 stained with HER2 and 25 with Ki-67) and 2 TMAs (1 stained with HER2, 1 with Ki-67, each containing 97 cores), using digital and optical microscopy. …”
Get full text

Label credibility correction based on cell morphological differences for cervical cells classification by Wenbo Pang, Yue Qiu, Shu Jin, Huiyan Jiang, Yi Ma

“…However, clinical definitions among different categories of lesion are complex and often characterized by fuzzy boundaries. In addition, pathologists can deduce different criteria for judgment based on The Bethesda System, leading to potential confusion during data labeling. …”
Get full text

A Study Comparing Immunohistochemistry, Fluorescence in situ hybridization, GeneXpert® Breast Cancer STRAT4 Assay for Determining Hormone Receptor, Human Epidermal Growth Factor Re... by Rajaa El Aje, Abdellah Naya, Ayoub Khoaja, Younes Zaid, Mounia Oudghiri, Jodi Weidler, Mehdi Karkouri

“…Immunohistochemistry, the most common method for evaluating these prognostic biomarkers, can be impacted by numerous variabilities due to pre-analytical/analytical factors and subjective interpretation by pathologists. The Xpert® Breast Cancer STRAT4, an RT-qPCR based system, can be used to classify invasive breast carcinomas based on the assessment of these four biomarkers; Methods: We evaluated ESR1, PGR, ERBB2, and MKi67 mRNA expression by Xpert Breast Cancer STRAT4 and ER, PR, HER2 and Ki67 by IHC (FISH for HER2 IHC 2+) in 200 formalin-fixed paraffin-embedded (FFPE) tissue blocks with invasive breast cancer, collected from the Pathology Department of Casablanca Ibn Rochd University Hospital; Results: Concordance between Xpert ® Breast Cancer STRAT4 and IHC was 93.5% for ER, 83.51% for PR, 95% for HER2 (92% for IHC+FISH), and 81.20% for Ki67 (excluding intermediate IHC Staining 10 ≤ %IHC <20). …”
Get full text