Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages. by Girish Ramachandran, Darren J Perkins, Patrick J Schmidlein, Mohan E Tulapurkar, Sharon M Tennant

“…Typhimurium ST313 strains are phenotypically different to ST19 strains and instead share similar pathogenic characteristics with typhoidal Salmonella serovars.…”
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Serological Investigation of Akabane Virus Infection in Cattle and Sheep in Nigeria by Daniel Oladimeji Oluwayelu, Comfort Oluladun Aiki-Raji, Emmanuel Chibuzor Umeh, Samat Odunayo Mustapha, Adebowale Idris Adebiyi

“…Akabane virus (AKAV) is recognized as an important pathogen that causes abortions and congenital malformations in ruminants. …”
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Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) by Narendra Kumar Chaudhary, Parashuram Mishra

“…The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin.…”
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Phenotypic and molecular characterization of the largest worldwide cluster of hereditary angioedema type 1. by Juan Sebastian Arias-Flórez, Sandra Ximena Ramirez, Bibiana Bayona-Gomez, Lina Castro-Castillo, Valeria Correa-Martinez, Yasmín Sanchez-Gomez, William Usaquén-Martínez, Lilian Andrea Casas-Vargas, Carlos Eduardo Olmos Olmos, Nora Contreras Bravo, Camilo Andres Velandia-Piedrahita, Adrien Morel, Rodrigo Cabrera-Perez, Natalia Santiago-Tovar, Cristian Camilo Gaviria-Sabogal, Ingrid Tatyana Bernal, Dora Janeth Fonseca-Mendoza, Carlos M Restrepo

“…It is a highly variable, insidious, and potentially life-threatening condition, characterized by sudden local, often asymmetric, and episodic subcutaneous and submucosal swelling, caused by pathogenic molecular variants in the SERPING1 gene, which codes for C1-Inhibitor protein. …”
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Microbiological tests of fresh bull semen collected at breeding establishment by M. A. Sushkova, I. Ya. Stroganova, S. А. Schislenko

“…Other test parameters (total microbial count, coliform count) were within admissible limits. № anaerobes and pathogenic fungi were detected. Four Pseudomonas aeruginosa isolates and three Proteus vulgaris isolates recovered during the test have demonstrated susceptibility to ciprofloxacin that can be used for etiotropic treatment of bulls identified as bacteria carriers.…”
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Using fecal microbiota transplantation for animal health (review) by H. Yu. Drobot, S. K. Shebeko, A. M. Ermakov

“…Thus, the procedure makes it possible to stabilize and maintain a healthy gut microbiome that inhibits the pathogen growth. In veterinary medicine, fecal microbiota transplantation is considered as a potential alternative to traditional antibiotics amid rising antibiotic resistance. …”
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Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production by Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh

“…Results The engineering targets included the deletion of the lacZ gene to prevent lactose metabolism interference, introduction of α-1,2-fucosyltransferase derived from the non-pathogenic strain, and optimization of the GDP-L-fucose biosynthesis pathway through the overexpression of manA and manC. …”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Moreover, dysbiosis in MS involves more pathogenic bacteria and fewer beneficial taxa, further influencing disease progression. …”
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Epigenetic regulation of the nuclear genome associated with mitochondrial dysfunction in Leber’s hereditary optic neuropathy (LHON) by Aswathy P. Nair, Ambika Selvakumar, Janani Gopalarethinam, B. Abishek Kumar, Balachandar Vellingiri, Mohana Devi Subramaniam

“…One of the most common locations for deadly pathogenic mutations in humans is the human complex I accessory NDUFS4 subunit gene. …”
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Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients by Rokeya Begum, Arindita Das, Md. Jahangir Alam, Gazi Nurun Nahar Sultana

“…This study aims to analyze the complete mutation spectrum of the OCT1 gene in metformin poor responders and to explore the potential pathogenic effects of the identified mutations. Clinical features of 56 Bangladeshi T2DM patients (who showed altered response to metformin) were analyzed, and genomic DNA was extracted from their blood samples. …”
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Genetic tracking of Crimean-Congo haemorrhagic orthonairovirus in Hyalomma population infesting cattle in Nigeria. by Oluwafemi Babatunde Daodu, Joseph Ojonugwa Shaibu, Rosemary Ajuma Audu, Daniel Oladimeji Oluwayelu

“…Crimean-Congo haemorrhagic fever virus (CCHFV), a Biosafety level 4 pathogen transmitted by ticks, causes severe haemorrhagic diseases in humans but remains clinically silent in animals. …”
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Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt by Shaymaa H. Abdel-Rhman, Rehab M. Elbargisy, Dina E. Rizk

“…Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged. …”
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…At the moment, there are neither approved vaccines nor effective drugs for the treatment of human leishmaniasis for any of its three typical clinical manifestations, and, importantly, the drugs of clinical use have several side effects, require complex administration regimens, present high cost, and are ineffective in many populations due to pathogen resistance. Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly. …”
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A Comprehensive Study of the Relationship between the Production of β-Lactamase Enzymes and Iron/Siderophore Uptake Regulatory Genes in Clinical Isolates of Acinetobacter baumannii... by Mahyar Porbaran, Hamed Tahmasebi, MohammadReza Arabestani

“…Background.The iron/siderophore uptake system (IUS) involved in the Acinetobacter baumannii pathogenicity. However, IUS’s role in antibiotic resistance and the production of β-lactamase enzymes of A. baumannii are unclear. …”
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Improving neonatal outcome by studying the incidence of maternal group B streptococcus colonization among pregnant women: A prospective observational study by Priyank Rajan, Mukesh Sanklecha, Saloni Gandhi, Kaushal Soni, Mayur Wanjari, Gaurav Mittal

“…Also, empiric treatment with antibiotics for GBS in symptomatic mothers cannot be justified, and hence, GBS should be considered as an insignificant pathogen.…”
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12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens by Din L. Lin, Kevin M. Magnaye, Cara E. Porsche, Sophia R. Levan, Elze Rackaityte, Mustafa Özçam, Susan V. Lynch

“…These observations offer plausible mechanisms by which this lipid promotes early-life pathogenic microbiome development and innate immune dysfunction associated with childhood allergic sensitization.…”
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Investigating the Causes of Blindness and Vision Impairment in Children Younger Than 15 Years Old by Abbas Riazi, Fatemeh Riazi

“…Retinitis pigmentosa 9%, Leber congenital amaurosis (LCA) 8%, albinism <1%, refractive errors 9.5%, cortical visual impairment 13.6%, cataract and glaucoma each alone 7%, corneal opacity 1.7% and non-pathogenic causes, such as trauma <1% were diagnosed. …”
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Basic reproduction number for certain infectious porcine diseases: estimation of required level of vaccination or depopulation of susceptible animals by V. M. Gulenkin, F. I. Korennoy, A. K. Karaulov

“…A systematic analysis has been undertaken with respect to the publications available on the estimation of R 0 for various virus isolates of African swine fever, classical swine fever, foot-and-mouth disease, porcine reproductive and respiratory syndrome, Aujeszky’s disease, hepatitis E, encephalomyocarditis, porcine circovirus type 2, as well as pleuropneumonia associated with Actinobacillus pleuropneumoniae, and diseases caused by pathogenic isolates of Mycoplasma hyopneumoniae. Based on the obtained R0 values, recommendations for the veterinary services are made on preventive vaccination of pigs against the above mentioned diseases in the areas at risk of infection spread. …”
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An Atypical Presentation of a Male with Oral-Facial-Digital Syndrome Type 1 Related Ciliopathy by Sheena Sharma, Jennifer M. Kalish, Ethan M. Goldberg, Francis Jeshira Reynoso, Madhura Pradhan

“…A Ciliopathy Panel showed a novel and likely pathogenic deletion, approximately 7.9 kb, in the OFD1 gene encompassing exons 16, 17, and 19 (c.1654+833_2599+423del). …”
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Autophagy: A New Avenue and Biochemical Mechanisms to Mitigate the Climate Change by Muhammad Abubakkar Azmat, Malaika Zaheer, Muhammad Shaban, Saman Arshad, Muhammad Hasan, Alyan Ashraf, Muhammad Naeem, Aftab Ahmad, Nayla Munawar

“…Several biotic and abiotic stresses, i.e., pathogen infection, nutrient deficiency, plant senescence, heat stress, drought, osmotic stress, and hypoxia induce autophagy in plants. …”
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