The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines by Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab

“…However, a consensus of studies agrees that the dominant form of this response is due to innate reactivity by macrophages to implant debris where both danger (DAMP) and pathogen (PAMP) signalling elicit cytokine-based inflammatory responses. …”
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Effectiveness of a commercial LAMP technology-based kit for rapid detection of Bursaphelenchus xylophilus in Pinus pinaster by María Menéndez-Gutiérrez, Lucía Villar, Raquel Díaz

“…Don under field conditions, thus contributing to the advancement of efficient surveillance and management strategies to combat this pathogen. Material and methods: In three different experiments, the detection rate of the B. xylophilus LAMP kit was compared to the traditional Baermann funnel technique for nematode extraction. …”
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Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes by Biigba Yakubu, Edwin Moses Appiah, Andrews Frimpong Adu

“…As a result, this study compared the genomes of selected H. pylori isolates from selected areas of Africa and evaluated their virulence and antibiotic drug resistance, those that are highly pathogenic and are associated with specific clinical outcomes and those that are less virulent and rarely associated with clinical outcomes. 146 genomes of H. pylori isolated from selected locations of Africa were sampled, and bioinformatic tools such as Abricate, CARD RGI, MLST, Prokka, Roary, Phandango, Google Sheets, and iTOLS were used to compare the isolates and their antibiotic resistance or susceptibility. …”
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease by Zhu J, Zhang Z, Chu Y, Xie Z, Zeng D, Jin L, Li L

“…Jiamin Zhu,1,* Zhen Zhang,1,2,* Yanhui Chu,1,* Zhongyin Xie,1 Dongmei Zeng,1 Lijiao Jin,1 Luxin Li1 1Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 2School of First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luxin Li, Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157000, People’s Republic of China, Tel +86 13763617174, Email liluxin@mdjmu.edu.cnAbstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. Currently, therapies and their efficacy for kidney diseases are limited. …”
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Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea by Patthanasak Rungsirivanich, Elvina Parlindungan, Jennifer Mahony, Witsanu Supandee, Narumol Thongwai, Douwe van Sinderen

“…The ML061-4 genome was evaluated for genes associated with complex carbohydrate metabolism, bacterial adhesion, virulence factors, pathogenicity, bacteriophages, antiviral defence systems as well as toxin- and antibiotic-resistance associated genes, and genes involved in toxin production, secondary metabolite biosynthesis and xenobiotics biodegradation. …”
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Microcephalic osteodysplastic primordial dwarfism type II in four Indian children with PCNT variants by Amit Singh, Mahak Garg, Mohammed Shariq, Preeti Khetarpal, Inusha Panigrahi

“…Conclusion All four patients had significant microcephaly and growth retardation and the new variants were found to be likely pathogenic by in silico analysis. Early detection of the syndrome is essential for early interventions, proper genetic counseling and prenatal diagnosis.…”
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Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulate SpTransformer gene expression and immune responsiveness by Ryley S. Crow, Leon Grayfer, L. Courtney Smith

“…IntroductionThe California purple sea urchin, Strongylocentrotus purpuratus, relies exclusively on an innate immune system to survive in its pathogen rich marine environment. Central to this defense is the SpTransformer (SpTrf) gene family that is unique to the euechinoid group of echinoderms. …”
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Expression of Helicobacter pylori hspA Gene in Lactococcus lactis NICE System and Experimental Study on Its Immunoreactivity by Xiao-Juan Zhang, Shu-Ying Feng, Zhi-Tao Li, Yan-Ming Feng

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Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…Bingquan Li,1,* Boyang Dong,1,* Liangzhen Xie,2 Yan Li2 1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Ear-Nose-Throat Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liangzhen Xie; Yan Li, Email xieliangzhen888111@163.com; liyan888111@163.comAbstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, and society, particularly in the context of accelerating globalization and increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, and several decongestants. …”
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A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. …”
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Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis by Dongmei Xu, Yaoyao Wang, Hongzhen Li, Bing Wang, Libin Chai, Li Feng, Fengzhi Ren, Xuejin Zhao, Xuexia Zhang

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Evaluation of serum leptin and adiponectin and their associations with obesity-related renal injury among Egyptian adolescents by Azza A El-Shaheed, Reham F. Fahmy, Nermine N. Mahfouz, Salwa R El-Zayat, Hiba Sibaii, Rehab S.I. Moustafa

“…Conclusion Leptin and adiponectin are the main pathogenic factors for renal injury in obese adolescents.…”
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Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis by Xin-Yu Pan, Meng Wang, Yi-Dan Xu, Lin-Nong Wang

“…A total of 287 patients with IK admitted to the Department of Ophthalmology of Nanjing First Hospital between August 2018 and December 2022 were analyzed retrospectively, and the pathogenic causes, etiological characteristics, detection, treatment methods, and efficacy were summarized. …”
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Study of the vaccination effects against <i>Staphylococcus aureus</i>, causing mastitis and endometritis in cows by E. V. Ivanov, A. V. Kapustin, N. N. Avduevskaya

“…In the test group, the pathogen was detected in 20% of cases, which is 2.5 times lower than in the control group.…”
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SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject by R. Wumba, M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, J. M. Kayembe

“…Background. The pathogenic mechanisms and immune response of COVID-19 are far from clear. …”
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Dual Control of Host Actin Polymerization by a Legionella Effector Pair by M. Pillon, C. Michard, N. Baïlo, J. Bougnon, K. Picq, O. Dubois, C. Andrea, L. Attaiech, V. Daubin, S. Jarraud, E. Kay, P. Doublet

“…Host actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. …”
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Antibiogram Pattern of Uropathogenic Escherichia Coli in Baghdad Province, Iraq by Nuha Abd Al.rheem Saad, Raghad Hassan Hussein, Nadia M.M. Al-Shakir

“…Conclusions: It was concluded from this study that E. coli is the main pathogen inflicting UTIs on patients. Amoxicillin, ceftriaxone, cefotaxime, Nalidixic acid, Trimethoprim/Slfamethoxazole & tetracycline were among the antibiotics with the highest rates of resistance. …”
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Selective cultivation of bacterial strains with lipolytic and hydrocarbon-oxidizing activity from bottom sediments of the Ob River, Western Siberia by A. I. Gerasimchuk, D. A. Ivasenko, A. A. Kasymova, Yu. A. Frank

“…The phylogenetic and metabolic diversity of the cultivated non-pathogenic bacterial strains with lipolytic and oil-oxidizing activity revealed in the study indicates the biotechnological potential of the isolates. …”
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Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis by Zhijun Jiao, Wenhong Wang, Jie Ma, Shengjun Wang, Zhaoliang Su, Huaxi Xu

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The Trends of Staphylococcus aureus Antibiotics Resistance in Iraq: A Narrative Review by Nawfal R. Hussein, Masood Ahmed Hameed, Qusay Nawaf Resho

“…Staphylococcus aureus (S. aureus) is a major human pathogen that is able to develop resistance to multiple antibiotics with significant challenges in clinical treatment. …”
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