A Pilot Study of Exosome Proteomic Profiling Reveals Dysregulated Metabolic Pathways in Endometrial Cancer by Feras Kharrat, Valeria Capaci, Andrea Conti, Valentina Golino, Pietro Campiglia, Nour Balasan, Michelangelo Aloisio, Danilo Licastro, Lorenzo Monasta, Federica Caponneto, Antonio Paolo Beltrami, Federico Romano, Giovanni di Lorenzo, Giuseppe Ricci, Blendi Ura

“…<b>Background/Objectives</b>: Endometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of the disease are still unknown. …”
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Data Mining Models in Prediction of Vancomycin-Intermediate <i>Staphylococcus aureus</i> in Methicillin-Resistant <i>S. aureus</i> (MRSA) Bacteremia Patients in a Clinical Care Set... by Wei-Chuan Chen, Jiun-Ling Wang, Chi-Chuan Chang, Yusen Eason Lin

“…Vancomycin-intermediate <i>Staphylococcus aureus</i> (VISA) is a multi-drug-resistant pathogen of significant clinical concern. Various <i>S. aureus</i> strains can cause infections, from skin and soft tissue infections to life-threatening conditions such as bacteremia and pneumonia. …”
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Whole genome sequence of seaweed endophyte Bacillus halotolerans strain AUPP for antagonistic activity against Fusarium incarnatum causing chilli fruit rot by Hudson Ann Suji, Karuppiah Manikandan, Appusami Sudha, Arjunan Muthukumar, Chelladurai Jeyalakshmi, Muniyandi Charumathi, Manickam Rajesh, Thankaraj Suthin Raj

“…The endophytic bacteria were isolated from the seaweed (Sargassum wightii) to manage the chilli fruit rot pathogen Fusarium incarnatum. The antifungal activity of the isolated bacteria was tested by dual culture assay and plant growth-promoting activity was also tested by the standard paper towel method. …”
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Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge by René H. M. Raeven, Jeroen L. A. Pennings, Elly van Riet, Gideon F. A. Kersten, Bernard Metz

“…In this study the effects of priming, by either vaccination or infection, on a subsequent pathogen encounter were studied. To that end, three postchallenge transcriptome datasets of previously primed mice were combined and compared to the responses in unprimed control mice. …”
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Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma by Richard A. Peterson, Bhavani Kashyap, Pamala A. Pawloski, Anna C. Forsberg, Leah R. Hanson

“…Genetic testing revealed no pathogenic mutation in the TP53 gene. Ultimately, treatment was unsuccessful and the patient succumbed to glioma and sarcoma within 2 years of initial diagnosis. …”
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Biological properties of coronaviruses of farm, domestic animals and birds: comparative characterization of pathology they induce (review) by Kh. Z. Gaffarov, A. I. Yarullin, V. G. Gumerov, I. G. Karimullina

“…Members of the family Coronaviridae are characterized by the fact that they infect a wide range of animals and birds with expressed species-limited  pathogenicity.  One more coronavirus specificity involves their ability to simultaneously affect more than one organ. …”
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Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast by Jiayao Zhang, Juan Li, Jiehong Huang, Xuerui Xiang, Ruoyu Li, Yun Zhai, Shuxian Lin, Weicai Liu

“…In this study, we established and analyzed the chronic unpredictable mild stress (CUMS) mice to investigate the miRNA-related pathogenic mechanism involved in psychological stress-induced osteoporosis. …”
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Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model by Livia Aparecida Procópio Gomes, Lívia Mara Alves Figueiredo, Ana Luiza do Rosário Palma, Barbara Maria Corrêa Geraldo, Kelly Cristine Isler Castro, Luciana Ruano de Oliveira Fugisaki, Antônio Olavo Cardoso Jorge, Luciane Dias de Oliveira, Juliana Campos Junqueira

“…The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Abstract Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct‐acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. …”
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The relationship between kidney disease and mitochondria: a bibliometric study by Jueyi Mao, Cuifang Li, Feifeng Wu, Yang Wang, Junquan Zhu, Chuan Wen

“…We found that research in this field has shifted from disease-level studies to mechanism-based studies, with the most prominent disease being diabetic nephropathy and the most prominent pathogenic mechanism being related to mitochondrial ROS production.Conclusion The bibliometric analysis provided a comprehensive understanding of the progress of research on the role of mitochondria in kidney disease, enriching the review literature in this field.…”
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Prospects for the use of <i>Bacillus anthracis</i> toxin in cancer therapy by A. P. Rodionov, S. V. Ivanova, E. A. Artemeva, L. A. Melnikova

“…Lethal factor is the main virulence factor of the anthrax pathogen, which is a zinc-dependent metalloprotease, the substrate for which is intracellular MAPK signaling pathways widely present in cancer cells. …”
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Evaluation of Green Manure Amendments for the Management of Fusarium Basal Rot (Fusarium oxysporum f.sp. cepae) on Shallot by Assefa Sintayehu, Seid Ahmed, Chemeda Fininsa, P. K. Sakhuja

“…Under in vitro test condition it was confirmed that extracts of Ethiopian mustard and rapeseed showed higher inhibition on the growth of Foc pathogen compared to control. Data on seedling emergence, plant height, plant stand, disease incidence, severity, cull bulbs, and bulb weight were collected in greenhouse experiment. …”
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Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis by Valerie F. A. March, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Galo A. Goig, Sebastien Gagneux, Sonia Borrell

“…Here we provide evidence that drug exposure affects culturability on solid medium in diverse Mtb strains, which has implications for treatment monitoring and drug-pathogen interaction studies.…”
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Changes Related to Age in Natural and Acquired Systemic Self-IgG Responses in Malaria by Romuald Dassé, Didier Lefranc, Sylvain Dubucquoi, Patricia Dussart, Virginie Dutoit-Lefevre, Boualem Sendid, François Sombo Mambo, Patrick Vermersch, Lionel Prin

“…Such distortion might be due to evolutionary processes leading to pathogenic/protective events.…”
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Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…These results enhance our understanding of the pathogenicity of different USUV strains and provide guidance for the use of low doses for inoculation in an Ifnar−/− animal model.…”
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NIR‐II emissive biohybrid nanovesicles as mild‐temperature photothermal antibiofilm agents against acute bacterial skin and skin‐structure infections by Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao

“…Abstract The emergence of antibiotic‐resistant bacteria poses a significant challenge to the prompt and appropriate treatment of pathogenic bacteria infections, such as acute bacterial skin and skin‐structure infections (ABSSSI), especially in the presence of biofilms. …”
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Comparative Study of Antioxidant Status in Androgenic Embryos of Aesculus hippocastanum and Aesculus flava by Dubravka Štajner, Boris M. Popović, Dušica Ćalić, Marijana Štajner

“…Androgenic embryos of both species had low amount of antioxidants due to controlled in vitro environmental conditions (T, photoperiod, humidity, nutritive factors, and pathogen-free). Our results confirmed that we found optimal in vitro conditions for producing androgenic embryos of both Aesculus species. …”
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Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70 by Małgorzata Kowalska, Marzena Tylicka, Olga Martyna Koper-Lenkiewicz, Joanna Kamińska, Justyna Dorf, Ewa Matuszczak

“…The aim of this study was to explore the role of HSP-70, MMP-3, MMP-17 and IL-8 in possible pathogenic pathways connected with cryptorchidism. Cryptorchid patients with high scrotal and inguinal canal localization were included. …”
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Natural selection and adaptive traits in the Maniq, a nomadic hunter-gatherer society from Mainland Southeast Asia by Tobias Herzog, Maximilian Larena, Wibhu Kutanan, Helmut Lukas, Martin Fieder, Helmut Schaschl

“…Balancing selection was primarily detected in immune-related genes, particularly within the HLA region, underscoring the critical role of genetic diversity in surviving pathogen-rich environments. Additionally, balancing selection in olfactory receptor genes highlights their importance in environmental sensing and adaptation. …”
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Essential oils used in the poultry industry: Would it be an effective green alternative against Salmonella spp. dissemination and antimicrobial resistance? by Heitor Leocádio de Souza Rodrigues, Isis Mari Miyashiro Kolososki, Valdinete Pereira Benevides, Mauro M.S. Saraiva, Angelo Berchieri Junior

“…Thus, investigations related to the pharmacokinetics, mechanisms of action, and adverse effects of EOs in the poultry's body are important to elucidate the treatment with these alternative antimicrobials, as well as to understand their interactions with both pathogenic bacteria and the bacteria that naturally compose the poultry's microbiota.…”
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