Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity of Candida albicans and Inflammatory Host Response In Vitro by Emily Chen, Bruna Benso, Dalia Seleem, Luiz Eduardo Nunes Ferreira, Silvana Pasetto, Vanessa Pardi, Ramiro Mendonça Murata

“…Thus, this study evaluated the modulatory effects of curcumin on major virulence factors associated with the pathogenicity of C. albicans. The minimum inhibitory concentration (MIC) of curcumin against C. albicans (SC5314) was determined. …”
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Bioactive Characteristics of Wild Berberis vulgaris and Berberis crataegina Fruits by Arzu Yaşar Eroğlu, Özlem Çakır, Mustafa Sağdıç, Enes Dertli

“…The water extracts of the Berberis fruits were tested against important foodborne pathogenic bacteria as potential antimicrobials. The extracts inhibited the growth of Bacillus cereus, Salmonella typhimurium, Yersinia enterocolitica, and Staphylococcus aureus at significant rates. …”
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Ocular Surface Disorders in Intensive Care Unit Patients by Tuba Berra Saritas, Banu Bozkurt, Baris Simsek, Zeynep Cakmak, Mehmet Ozdemir, Alper Yosunkaya

“…Patients in intensive care units (ICU) are at increased risk of corneal abrasions and infectious keratitis due to poor eyelid closure, decreased blink reflex, and increased exposure to pathogenic microorganisms. The aim of this retrospective study was to evaluate the ocular surface problems in patients who stayed in ICU more than 7 days and were consulted by an ophthalmologist. …”
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Wilson Disease in a Turkish Population: Molecular Insights into an Old Disease with Reported and Novel Variants by Abdullatif Bakır, Vehap Topçu, Büşranur Çavdarlı

“…WD is caused by homozygous or compound heterozygous pathogenic variants in the ATP7B gene. In this study, we aimed to contribute to the ATP7B gene variant spectrum in a Turkish population of WD patients. …”
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Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation by Léa Loison, Marion Huré, Benjamin Lefranc, Jérôme Leprince, Christine Bôle-Feysot, Moïse Coëffier, David Ribet

“…In contrast, several pathogenic bacteria were shown to dampen SUMOylation in order to promote infection. …”
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Long-term impact of tillage on microbial communities of an Eastern European Chernozem by Horia Domnariu, Kristin M. Trippe, Florina Botez, Elena Partal, Carmen Postolache

“…However, it also revealed higher numbers of pathogenic fungal taxa that are enriched in NT. Overall, our findings illustrate that tillage changes the structure of both prokaryotic and fungal communities, including distribution of functional groups, without necessarily changing diversity.…”
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Biochemical and Molecular Analysis of Staphylococcus aureus Clinical Isolates from Hospitalized Patients by Amit Karmakar, Parimal Dua, Chandradipa Ghosh

“…Staphylococcus aureus is opportunistic human as well as animal pathogen that causes a variety of diseases. A total of 100 Staphylococcus aureus isolates were obtained from clinical samples derived from hospitalized patients. …”
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Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages by Reziya Wumaier, Ke Zhang, Jing Zhou, Zilu Wen, Zihan Chen, Geyang Luo, Hao Wang, Juliang Qin, Bing Du, Hua Ren, Yanzheng Song, Qian Gao, Bo Yan

“…As a highly successful pathogen, <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) has evolved numerous strategies to evade host immune responses, making it essential to understand the interactions between <i>Mtb</i> and host cells. …”
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Production of Prodigiosin Using Tannery Fleshing and Evaluating Its Pharmacological Effects by C. Sumathi, D. MohanaPriya, S. Swarnalatha, M. G. Dinesh, G. Sekaran

“…Therapeutic efficacy was assessed by in vitro anticancer studies. Among the pathogenic bacteria Pseudomonas aeruginosa was most susceptible at the lowest concentration followed by Salmonella typhi. …”
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Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia by Nourchène Toukabri, Cyrine Dhieb, Dalenda El Euch, Mustapha Rouissi, Mourad Mokni, Najla Sadfi-Zouaoui

“…Dermatophytes were isolated in 70.5% and the most frequent pathogen was Trichophyton rubrum (98.1%), followed by yeasts (17.7%) commonly Candida parapsilosis. …”
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Developing a novel TaqMan qPCR assay for optimizing Salmonella Pullorum detection in chickens by Hao Wang, Xiamei Kang, Longhai Yu, Haijian Wang, Anja Müller, Corinna Kehrenberg, Yan Li, Min Yue

“…Overall, the T7 exonuclease-assisted TaqMan qPCR assay will not only upgrade the current detection for pullorum disease, but also exemplify the feasibility of targeting specific genomic deletions for pathogen detection.…”
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Protective Efficacy of the Calicivirus Valency of the Leucofeligen Vaccine against a Virulent Heterologous Challenge in Kittens by Cynthia Lesbros, Virginie Martin, Wojciech Najbar, Annaele Sanquer, David Mcgahie, Hyone-Myong Eun, Sylvie Gueguen

“…Feline calicivirus (FCV) is a common feline pathogen with a potential for antigenic diversity. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Remarkably, some well-known pathogenic proinflammatory mediators in RA, such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), may play a pivotal role in the development of CVD. …”
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Insights into the Genome Sequence of Chromobacterium amazonense Isolated from a Tropical Freshwater Lake by Alexandre Bueno Santos, Patrícia Silva Costa, Anderson Oliveira do Carmo, Gabriel da Rocha Fernandes, Larissa Lopes Silva Scholte, Jeronimo Ruiz, Evanguedes Kalapothakis, Edmar Chartone-Souza, Andréa Maria Amaral Nascimento

“…Members of the genus Chromobacterium have been isolated from geographically diverse ecosystems and exhibit considerable metabolic flexibility, as well as biotechnological and pathogenic properties in some species. This study reports the draft assembly and detailed sequence analysis of Chromobacterium amazonense strain 56AF. …”
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Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors by Hiroshi Kobayashi, Masahiro Shin, Naohiro Makise, Aya Shinozaki-Ushiku, Masachika Ikegami, Yuki Taniguchi, Yusuke Shinoda, Shinji Kohsaka, Tetsuo Ushiku, Katsutoshi Oda, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano, Sakae Tanaka

“…Next-generation sequencing revealed that these lesions harbored a common somatic mutation in epidermal growth factor receptor (EGFR), c.3617A>C, which is not considered a pathogenic chordoma mutation, thus indicating that these lesions were not multicentric but rather multiple metastatic tumors. …”
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Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship? by Farhad Salehzadeh, Hassan Anari, Sepehr Sarkhanloo

“…Blood samples of patients, who diagnosed as childhood idiopathic CRMO by imaging and pathologic study from June 2011 until September 2018, have been screened for the 12 common pathogenic variants of MEFV gene mutations. Result. …”
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Hepatic injury and metabolic perturbations in mice exposed to perfluorodecanoic acid revealed by metabolomics and lipidomics by Lvyun Sun, Shuling He, Jiali Chen, Amei Su, Qiuyao Mao, Wenyuan Zhang, Ying Pan, Jiaqian Hu, Disheng Feng, Yang Ouyang

“…However, research on the effects of PFDA exposure on organism metabolism and related pathogenic mechanisms is severely lacking. In this study, serum and liver samples of C57BL/6 J mice exposed to different doses of PFDA were analyzed by UPLC-HRMS-based metabolomics and lipidomics techniques. …”
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Effect of Stocking Density on Stress-Related Gene Expression of Pacific White Shrimp (Litopenaeus vannamei) Infected with Infectious Myonecrosis Virus (IMNV) by Moch. Nurhudah, Nur Komariah Baladrat, Sinung Rahardjo, Heny Budi Utari, Putu Angga Wiradana

“…The results showed that the expression of genes related to immunity in L. vannamei was upregulated after pathogen challenges such as lectin and TCTP, meanwhile, the Toll receptor gene was downregulated. …”
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Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease by Mahdi Bagherpoor Helabad, Irina Matlahov, Raj Kumar, Jan O. Daldrop, Greeshma Jain, Markus Weingarth, Patrick C. A. van der Wel, Markus S. Miettinen

“…Abstract Neurodegeneration in Huntington’s disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. …”
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Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations by Verena Vogi, David Haschka, Lukas Forer, Simon Schwendinger, Verena Petzer, Stefan Coassin, Ivan Tancevski, Thomas Sonnweber, Judith Löffler-Ragg, Elisabeth Puchhammer-Stöckl, Marianne Graninger, Dominik Wolf, Florian Kronenberg, Johannes Zschocke, Emina Jukic, Günter Weiss

“…We suggest that genetically determined enforced CRP formation may contribute to strengthening of innate immune responses and better initial pathogen control thereby reducing the risk of subsequent hyperinflammation and adverse course of COVID-19.…”
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