ARV1 p.Gln62Ter, a novel mutation linked to developmental and epileptic encephalopathy-38 by Mostafa Neissi, Ayoob Radhi Al-Zaalan, Misagh Mohammadi-Asl, Mojdeh Roghani, Javad Mohammadi-Asl, Kamele Jorfi

“…The use of whole exome sequencing revealed a rare and likely pathogenic ARV1 gene mutation, emphasizing the significance of this genetic screening method in unraveling the complexities of developmental and epileptic encephalopathies.…”
Get full text

Involvement of Toll -like receptor 9 signaling in neutrophil extracellular traps-induced epithelial-to-mesenchymal transition in myositis-associated interstitial lung disease by Feng Yingyue, Zhuo Cui, Su Qiyan, Cui Xi, Guo Jin, Zhu Jiarui, Zhang Sigong

“…Conclusion NETs-induced EMT may serve as a key pathogenic mechanism in IIM-ILD, with TLR9 signaling playing a key role. …”
Get full text

Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) by So-Yoon Park, Van-Long Truong, Su-Gyeong Jeon, So-Young Choe, Razanamanana H. G. Rarison, Byoung-Hoon Yoon, Ji-Won Park, Hye-Jeong Jeong, Woo-Sik Jeong

“…Furthermore, the adhesion assays using Caco-2 intestinal epithelial cells revealed that these polysaccharides promoted probiotic adhesion while inhibiting the adhesion of pathogenic bacteria. These findings highlight the bioactive potential of ethanol extracts and mucilage polysaccharides from Korean yams, emphasizing their promising applications as anti-inflammatory, immune-modulating, and prebiotic agents for functional food and nutraceutical development.…”
Get full text

Effects of phosvitin phosphopeptide-Ca complex prepared by efficient enzymatic hydrolysis on calcium absorption and bone deposition of mice by Mengdie Zhao, Dong Uk Ahn, Songming Li, Wei Liu, Shengwei Yi, Xi Huang

“…The low-calcium specific pathogen free-Kunming (SPF-KM) mice were used to determine the effect of PPP-Ca complexes on intestinal calcium absorption and their utilization for bone formation. …”
Get full text

A lethal disease of the European bison – posthitis is conditionally determined by its genomics by Sazia Kunvar, Sylwia Czarnomska, Cino Pertoldi, Astrid V. Stronen, Iwona Ruczyńska, Małgorzata Tokarska

“…Multiple attempts have been undertaken over the last 30 years to identify a source of infection and a primary pathogen. Studies indicated the disease could have a genetic background after tools developed for cattle (Bos taurus) revealed genomic regions that could be associated with its occurrence. …”
Get full text

Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome by Yue Liu, Ping Ren, Hailong Li, Yingying Liu, Yiting Yang, Wanting Wang, Jiaming Zhou, Ling Su, Lili Guan, Hongxia Ma

“…Specifically, Pb decreased the proportion of pathogenic species (g_Fusarium, p_Basidiomycota, g_Alternaria, g_Aspergillus, and g_Candida) while NCVP increased the abundance of probiotics species (g_Kazachstania and p_Ascomycota). …”
Get full text

Analysis and validation of serum biomarkers in brucellosis patients through proteomics and bioinformatics by Xiao Li, Bo Wang, Xiaocong Li, Juan He, Yue Shi, Rui Wang, Dongwei Li, Ding Haitao, Ding Haitao

“…After ELISA validation, five proteins were ultimately selected.DiscussionThese five proteins are implicated in the innate immune processes of brucellosis, potentially associated with its pathogenic mechanisms and chronicity. Furthermore, we highlighted their potential as diagnostic biomarkers for brucellosis. …”
Get full text

Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules by João Victor Marcelino de Souza, Natalia C. S. Costa, Maria C. O. Arruda Brasil, Luana Ribeiro dos Anjos, Renata Priscila Barros de Menezes, Eduardo Henrique Zampieri, Jhonatan Santos de Lima, Angela Maria Arenas Velasquez, Luciana Scotti, Marcus Tullius Scotti, Marcia A. S. Graminha, Eduardo R. Pérez Gonzalez, Eduardo Maffud Cilli

“…In addition, the current compounds have low selectivity for the pathogen, leading to various side effects, which results in lower adherence to treatment. …”
Get full text

IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome by Shujuan Li, Ming Yu, Haifeng Li, Hongliang Zhang, Yanfang Jiang

“…These cytokines display pathogenic potential and may serve as useful biomarkers for GBS.…”
Get full text

Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

“…Furthermore, the combination of both RNase T and LCCR4 systems can be used to investigate and dissect the effects of pathogenic mutations on C- and A-addition.…”
Get full text

Prevalence of Transfusion Transmitted Virus Infection in Hemodialysis Patients and Injection Drug Users Compared to Healthy Blood Donors in Isfahan, Iran by Behrooz Ataei, Alireza Emami Naeini, Farzin Khorvash, Mohammad Reza Yazdani, Abbas-Ali Javadi

“…Introduction. The pathogenicity and transmission routes of Transfusion Transmitted Virus (TTV) remain unclear. …”
Get full text

Bioconversion of Poultry Litter into Insect Meal and Organic Frasstilizer Using Black Soldier Fly Larvae as a Circular Economy Model for the Poultry Industry: A Review by Anand Raj Kumar Kullan, Arumuganainar Suresh, Hong Lim Choi, Elke Gabriel Neumann, Fatima Hassan

“…Poultry litter waste management poses a significant global challenge, attributed to its characteristics (odorous, organic, pathogenic, attracting flies). Conventional approaches to managing poultry litter involve composting, biogas generation, or direct field application. …”
Get full text

Resistance of cayenne pepper varieties (Capsicum frutescens) to anthracnose disease (Colletotrichum gloeosporioides) isolates from swampy areas by Ismed Setya Budi, Mariana Mariana, Amalia Fauziah

“… Anthracnose, a primary disease in chili plants caused by the pathogen fungus Colletotrichum sp., has proven significant losses by affecting harvests and inducing fruit decay. …”
Get full text

Rotavirus in Calves and Its Zoonotic Importance by Umer Seid Geletu, Munera Ahmednur Usmael, Fufa Dawo Bari

“…Rotavirus is a major pathogen responsible for diarrheal disease in calves, resulting in loss of productivity and economy of farmers. …”
Get full text

Case Report: Ehrlichiosis and Anaplasmosis in Timber Wolf Crossbreed (Canis lupus) in Bali, Indonesia by Ni Wayan Helpina Widyasanti, I Putu Cahyadi Putra, Ni Ketut Suwiti

“…Pathogenic bacteria from the Anaplasmataceae family cause ehrlichiosis and anaplasmosis in animals, including dogs and wild carnivores (wolves, foxes, raccoons, and others). …”
Get full text

Purification and Characterization of a New Lectin from Loach Skin Mucus by Peng-peng Sun, Yuan-yuan Ren, Jie Zheng, Ai-jun Hu

“…Lectin from loach skin mucus plays an important role in pathogen defense. However, hardly can any paper relevant to the character of lectin from loach skin mucus be found in recent years. …”
Get full text

Drug Target Identification and Elucidation of Natural Inhibitors for : An Study by Surya Narayan Rath, Manisha Ray, Animesh Pattnaik, Sukanta Kumar Pradhan

“…Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. …”
Get full text

Occurrence of antibiotics and antibiotic resistance genes at various stages of different aquaculture modes surrounding Tai Lake, China by Congcong Wu, Congcong Wu, Haitao Ye, Mingzhu Xu, Xuan Zhao, Xuejie Zhao, Lina Li, Mingzhi Li, Yanfei Wei, Yuru Li, Baolan Hu, Baolan Hu

“…Microbial diversity also varies seasonally, especially with a gradual increase in the abundance of some pathogenic bacteria (Flavobacterium). Antibiotics and resistance genes were found at higher levels in fish ponds compared to shrimp and crab ponds, while they were lower in shrimp and crab ponds that utilized the ecological mode ponds than in the traditional culture mode ponds.ConclusionOur study presents a comprehensive characterization of antibiotics and ARGs in aquaculture waters from various perspectives. …”
Get full text

Modern approaches to production of safe and effective genetically modified rabies vaccines for animals by M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin

“…Taking into account that there is a lack of affordable high-quality vaccines to globally prevent and control the disease, stable, attenuated production strains of rabies virus with broad cross-activity against various variants of the pathogen shall be considered as ideal candidates to produce high-quality, safe and effective vaccines. …”
Get full text

Analysis of the Control Effect of <i>Bacillus amyloliquefaciens</i> C4 Wettable Powder on Potato Bacterial Wilt Caused by <i>Ralstonia solanacearum</i> by Zhixiang Xing, Dan Liu, Meng Luo, Zelin Yang, Wenyuan Pang, Yexing Feng, Jiani Yan, Fumeng He, Xu Feng, Qiang Yuan, Yingnan Wang, Fenglan Li

“…The physiological and biochemical results showed that C4 wettable powder could induce rapid defense enzyme responses in leaves and enhance plant resistance to pathogenic bacteria. The results showed that C4 wettable powder effectively controlled potato bacterial wilt, and its application method was determined.…”
Get full text