Serotype Distribution and Antimicrobial Resistance Profile of Haemophilus influenzae Isolated from School Children with Acute Otitis Media by Dodi Safari, Daniel Joko Wahyono, Wisnu Tafroji, Anton Budhi Darmawan, Yayah Winarti, Wahyu Dwi Kusdaryanto, Wisiva Tofriska Paramaiswari, Hendro Pramono, Meyta Pratiwi, Muhamad Riza Chamadi

“…Haemophilus influenzae is a Gram-negative opportunistic bacterial pathogen of the human respiratory tract. This study describes the prevalence, serotype distribution, and susceptibility profiles of H. influenzae strains isolated from the nasopharynx of school children with acute otitis media (AOM) in Banyumas Regency, Central Java, Indonesia. …”
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HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response by Mudan Lu, Shanshan Yu, Wei Xu, Bo Gao, Sidong Xiong

“…HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute to the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, the precise mechanism of HMGB1 in the pathogenic process of SLE remains obscure. Method. The expression of HMGB1 was measured by ELISA and western blot. …”
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Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-κB Signals after Ischemic Reperfusion by Kang Chen, Wei Xie, Binyu Luo, Weidong Xiao, Daniel H. Teitelbaum, Hua Yang, Kebin Zhang, Chaojun Zhang

“…On the basis of these data, we conclude that BMP2/4 may act as the pathogenic basis for intestinal mucosal barrier dysfunction when the intestines suffer an I/R injury. …”
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Control of <i>Vibrio parahaemolyticus</i> in Seafood Using the Combination of Lytic Phages and Citric Acid by Xiaoshuang Zheng, Lu Gao, Lei Yuan, Caowei Chen, Zhenquan Yang

“…<i>Vibrio parahaemolyticus</i> is a key foodborne pathogen in seafood that poses health risks to consumers. …”
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Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis by Jingyi Hou, Yi Ouyang, Haiquan Deng, Zhong Chen, Bin Song, Zhongyu Xie, Peng Wang, Jinteng Li, Weiping Li, Rui Yang

“…Our study found that differentially expressed genes in the MAPK signaling, rheumatoid arthritis, and p53 signaling pathways may help to explain the pathogenic mechanism of RA and lead to therapeutic RA SMSC applications.…”
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Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells by Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner

“…Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. …”
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New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress by Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Constantin Caruntu, Maria Isabela Sarbu, Clara Matei, Ilinca Nicolae, Sandra Milena Tocut, Mircea Ioan Popa, Mircea Tampa

“…The host’s immunity plays a central role in the course of the infection; therefore, it may not be clinically manifest or may produce various benign or malignant lesions. The pathogenic mechanisms are complex and incompletely elucidated. …”
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Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection by Guadalupe Rivera-Torruco, Carolina A. Martínez-Mendiola, Tania Angeles-Floriano, Gustavo Alberto Jaimes-Ortega, José Luis Maravillas-Montero, Rodolfo García-Contreras, Yolanda González, Esmeralda Juárez, Porfirio Nava, Vianney Ortiz-Navarrete, Oscar Medina-Contreras, Paula Licona-Limón, Ricardo Valle-Rios

“…The process by which blood cells are generated has been widely studied in homeostasis and during pathogen-triggered inflammatory response. Recently, murine lungs have been shown to be a significant source of hematopoietic progenitors in a process known as extramedullary hematopoiesis. …”
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Enhanced early innate immunity and phagocytosis in grass carp (Ctenopharyngodon idella) induced by Aeromonas hydrophila fermentation broth during initial vaccine response by Xiaobo Yu, Qinglin Yang, Yanhong Jiang, Yanhong Li, Zhengli Wu

“…Aeromonas hydrophila is a significant fish pathogen responsible for substantial economic losses in the global aquaculture industry. …”
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Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis: A Single Centre, Six-Year Experience of 1981 Samples by Sara Sheikhbahaei, Alireza Abdollahi, Nima Hafezi-Nejad, Elham Zare

“…The most prevalent isolated pathogen was E. coli (33.8%), followed by staphylococcus aureus (8.9%) and Enterococcus (8.6%). …”
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Optimization and validation of a real-time PCR method for the simultaneous detection of Lactococcus garvieae and Streptococcus agalactiae in fish by Taona Zinyakasa, Farisai Chidzwondo, Tatenda Makawa, Sitokozile Sibanda, Exnevia Gomo, Tivapasi Musa, Elizabeth Gori

“…Currently, available pathogen diagnostic tools use biochemical and microbiological methods beleaguered by very low accuracy, reproducibility and specificity. …”
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Prenatal diagnosis of mucopolysaccharidosis type I on hepatosplenomegaly and coarse features: a case-report by Maxime Agranier, Florence Demurger, Christele Dubourg, Jerome Fromageot, Anne-Sophie Cabaret Dufour, Erika Launay, Magalie Gournay, Charles Lefèvre, Roseline Froissart, Magali Pettazzoni, Paul Rollier

“…Whole exome sequencing after amniocentesis identified two likely pathogenic IDUA gene variants (in trans), raising suspicion of a diagnosis of MPS I. …”
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Adipose Tissue Remodeling as Homeostatic Inflammation by Michiko Itoh, Takayoshi Suganami, Rumi Hachiya, Yoshihiro Ogawa

“…Such a sustained interaction between endogenous ligands derived from parenchymal cells and pathogen sensors expressed in stromal immune cells should lead to chronic inflammatory responses ranging from the basal homeostatic state to diseased tissue remodeling, which may be referred to as “homeostatic inflammation”. …”
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Contribution of Phosphorylation Modification to Stability and Antibacterial Activity of Egg White Protein Nanogels Loaded with Cinnamon Bark Essential Oil by Sheng-Qi Rao, Xin-Ru Gao, Hui Liu, Zhi-Rong Wang, Zhen-Quan Yang

“…In addition, the results of the antibacterial experiments on <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Listeria monocytogenes</i> showed that the MIC values of P-EWP-CBEO nanogels were two times lower than those of EWP-CBEO nanogels and could completely inhibit the growth of pathogenic bacteria within 108 h. Hence, we have suggested that P-EWP-CBEO nanogels are successfully fabricated with improved physicochemical properties as novel potential natural preservatives in the food industry.…”
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Modeling the Combined Effects of Temperature, pH, and Sodium Chloride and Sodium Lactate Concentrations on the Growth Rate of Lactobacillus plantarum ATCC 8014 by Francieli Dalcanton, Elena Carrasco, Fernando Pérez-Rodríguez, Guiomar Denisse Posada-Izquierdo, Gláucia Maria Falcão de Aragão, Rosa María García-Gimeno

“…Lactic acid bacteria are able to synthetize compounds with antimicrobial activity against pathogenic and spoilage flora. Among them, Lactobacillus plantarum ATCC 8014 has exhibited this capacity, and further studies reveal that the microorganism is able to produce bacteriocins. …”
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Molecular Detection of FIPV among Imported Felines through Soekarno Hatta Airport, Indonesia by Fidyah Fitrawati, Suwarno, Ira Sari Yudaniayanti, Jola Rahmahani, Muchammad Yunus, Soeharsono, Desniwaty Karo-karo, Haeriah

“…Type I is a highly pathogenic strain, feline infectious peritonitis virus (FIPV). …”
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Myoclonic status epilepticus with dystonia-like symptoms in patients with dementia: Report of two cases by Rosario V. Rossi, Rosanna Melis, Noemi Murdeu, Sara Lizzos, Maria Luigia Piras, Loretta Racis, Silvia Serusi, Maria Valeria Saddi

“…A time-locked relationship between the frontocentral EEG activity and the EMG myoclonic potentials demonstrated the cortical origin of myoclonus and therefore the epileptic nature of the disorder, whereas the oromandibular and cervical dystonic-like postures suggested the pathogenic involvement of subcortical structures. The intravenous administration of diazepam suppressed the clinical symptoms and the EEG–EMG correlate of myoclonus. …”
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Structural and Functional Annotation of Hypothetical Proteins of O139 by Md. Saiful Islam, Shah Md. Shahik, Md. Sohel, Noman I. A. Patwary, Md. Anayet Hasan

“…V. cholerae O139 is the most common and pathogenic bacterial strain among various V. cholerae strains. …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…To date, the identification of C. burnetii as the causative pathogen of Q fever using targeted next-generation sequencing (tNGS) has not been previously documented. …”
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Comparative efficacy of Doppler-guided hemorrhoidal artery ligation with mucopexy and hemorrhoidectomy by A. Yu. Titov, Maryana V. Abritsova, L. P. Orlova, O. Yu. Fomenko, Yu. L. Trubacheva, D. A. Mtvralashvili

“…The Doppler-controlled hemorrhoid artery ligation with mucopexy is pathogenically justified surgical procedure with comparable efficacy to hemorrhoidectomy, that is confirmed by instrumental diagnostic tests. …”
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