Clinical and genetic analysis of a Chinese family with GM1 gangliosidosis caused by a novel mutation in GLB1 gene by Biao Zhang, Xiao-li Huang, Xin-xin Lu, Heng-bin Huang, Yan-an Wu

“…ObjectiveTo describe the clinical presentation and novel mutation in the ganglioside-beta-galactosidase gene (GLB1) gene in a Chinese family with GM1 gangliosidosis.MethodsWe collected clinical data from a Chinese family with GM1 gangliosidosis, and performed whole exon sequencing (WES) of the proband and his parents. The pathogenic sites of candidate genes were targeted, and the detected exon mutations were verified by Sanger sequencing. …”
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The Effect of the Use of the Beneficial Acetic Acid Bacteria Starter Cultures on the Microbiological and Physicochemical Quality of Raw Ripening Sausages by Anna Okoń, Anna Łepecka, Piotr Szymański, Katarzyna Neffe-Skocińska

“…All variants of study sausages showed good microbiological quality concerning the total number of microorganisms, lactic acid bacteria, and the absence of pathogenic microorganisms. The synergistic effect of lactic acid bacteria and acetic acid bacteria was observed and a positive effect on the survivability of the native lactic microbiota of study sausages was shown. …”
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Analysis of cases of severe streptococcal infection in children and adults in Khmelnytskyi region by L.V. Pypa, K.Yu. Kreniov, L.V. Dudikova, N.O. Zymak, Yu.M. Lysytsia, V.I. Ruda, K.A. Demyanyk

“…Group A beta-hemolytic streptococcus (Streptococcus pyogenes) is a widespread bacterial pathogen that can cause many clinical variants of diseases in humans and be a trigger factor for the development of various autoimmune conditions. …”
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Noncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner by Fabian Giska, Wojciech Rymaszewski, Malgorzata Lichocka, Marcin Piechocki, Jakub Kwiatkowski, Jarosław Poznański, Magdalena Górecka, Magdalena Krzymowska

“…To pass through the conduit of secretion machinery the effectors need to acquire an extended conformation, and in many bacterial species specific chaperones assist in this process. In plant pathogenic bacterium Pseudomonas syringae, secretion of only few effectors requires the function of chaperones. …”
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<i>Candida auris</i> Antifungal Resistance, Virulence and Susceptibility to a Novel Nitric Oxide-Releasing Microparticle and Its Correlations to Clade Identification by Alessandro F. Valdez, Flora Bohner, Joshua P. Goldman, Ali B. Jaquiery, Eduardo V. C. do Amaral, Dario Correa-Junior, Andrew Draganski, Leonardo Nimrichter, Joshua D. Nosanchuk, Daniel Zamith-Miranda

“…<i>Candida auris</i> is a globally emerging pathogenic fungus described in Japan in 2009. This fungus has been identified mainly in nosocomial environments, associated with a high frequency of multidrug-resistant strains, and mortality rates reach 60%. …”
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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…Growing evidence suggests that inflammation is an important pathogenic mediator in the development of diabetes mellitus. …”
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Primeras citas de dos especies de mosquitos antropófilos en Segovia. Implicación en la transmisión de patógenos by Josué Martínez-de la Puente, Mikel A. González

“…Abstract: The aim of this field note is to report the presence of new mosquito species (Diptera: Culicidae) in the province of Segovia and discuss their potential role in pathogen transmission. In August 2024, two female mosquitoes were captured and identified as Aedes geniculatus (Olivier, 1791) and Anopheles petragnani (Del Vecchio, 1939) through a combination of traditional morphological identification and molecular analysis of their COI gene sequences. …”
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Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition by Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, Susu M. Zughaier

“…Pseudomonas aeruginosa is the most common pathogen that persists in the cystic fibrosis lungs. …”
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Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood by Klara Mareckova, Ana Paula Mendes-Silva, Martin Jáni, Anna Pacinkova, Pavel Piler, Vanessa F. Gonçalves, Yuliya S. Nikolova

“…The novel FI score was calculated based on 7 potentially pathogenic mtDNA variants. Greater FI score of mtDNA variants was associated with older epigenetic age in the early 20s and older biological age in the late 20s. …”
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Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae by Sangeetha Prakash, Sudhanshu Agrawal, Dandan Ma, Sudhir Gupta, Ellena M. Peterson, Anshu Agrawal

“…Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection. …”
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Multiple Adenomatous Duodenal Polyposis by Zdena Zádorová, Jan Hajer, Václav Mandys

“…Afterwards we screened the patient for germline MYH mutations using the denaturing high-performance liquid chromatography (DHPLC) in combination with sequencing. No novel pathogenic mutation has been identified. Large polyps were removed by means of endoscopic polypectomy and mucosectomy, while small polyps were removed by means of argon plasma coagulation.We conduct yearly checkups, removing only sporadic polyps. …”
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Metagenomic next-generation sequencing assists in the diagnosis of visceral leishmaniasis in non-endemic areas of China by Rui Zhao, Guilun He, Lin Xiang, Melinda Ji, Rongheng He, Xudong Wei

“…Direct identification of infected tissues is currently the primary method of diagnosis; however, the low sensitivity and inconvenience of microscopic examination in detecting amastigotes, parasitic manifestations of Leishmania, leads to the possibility of misdiagnosis, delayed diagnosis, and underdiagnosis.MethodsWith the development of metagenomic nextgeneration sequencing (mNGS) technology for pathogen identification, it is possible to detect specific nucleic acid sequences characteristic of Leishmania parasites, which opens new avenues for the more accurate diagnosis of leishmaniasis. …”
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Peptide hormones in plants by Zhenbiao Zhang, Huibin Han, Junxiang Zhao, Zhiwen Liu, Lei Deng, Liuji Wu, Junpeng Niu, Yongfeng Guo, Guodong Wang, Xiaoping Gou, Chao Li, Chuanyou Li, Chun-Ming Liu

“…The roles of peptide hormones are implicated in, but not limited to, processes such as self-incompatibility, pollination, fertilization, embryogenesis, endosperm development, stem cell regulation, plant architecture, tissue differentiation, organogenesis, dehiscence, senescence, plant-pathogen and plant-insect interactions, and stress responses. …”
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The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes by Mengying Xia, Lei Lei, Linyong Zhao, Wenqing Xu, Hongyu Zhang, Mingming Li, Jiankun Hu, Ran Cheng, Tao Hu

“…Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC and gastric dysbiosis in GC patients emphasize the potential role of other microbial factors. …”
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Study on the response mechanism of MicroRNA novel-13 and novel-44 to Vibrio parahaemolyticus infection in Pinctada fucata martensii by Chao Jie Li, Qi Yuan Zhang, Bin Zhang, Hai Ying Liang, Li Ning Ma, Muhammad Salman

“…However, it is highly susceptible to pathogen infection under intensive cultivation near the coast. …”
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Specialized contact sites regulate the fusion of chlamydial inclusion membranes by Christine Linton, Jordan Wesolowski, Anna Lobley, Toshiyuki Yamaji, Kentaro Hanada, Fabienne Paumet

“…Abstract The intracellular bacterial pathogen Chlamydia trachomatis replicates within a membrane-bound compartment called the inclusion. …”
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Fibrous dysplasia in the alveolar crest of edentulous site and the curettage for future implant placement: a case report by Hao Chen, Yuting Wen, Xueqi Guo, Shiyong Zhao

“…Conclusion We described an unreported pathogenic site of FD that occurred at the alveolar ridge of the edentulous site, which ended up with satisfactory oral implant rehabilitation through 5-year sequential diagnosis and treatment.…”
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Outer Membrane Proteome Analysis of Indian Strain of Pasteurella multocida Serotype B:2 by MALDI-TOF/MS Analysis by A. Prasannavadhana, Santosh Kumar, Prasad Thomas, Laxmi Narayan Sarangi, Santosh Kumar Gupta, Adyasha Priyadarshini, Viswas Konasagara Nagaleekar, Vijendra Pal Singh

“…Identification of outer membrane proteins (OMPs) is important to understand the bacteria structure and function, host-pathogen interaction, development of novel vaccine candidates, and diagnostic antigens. …”
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Stubble Management Plays a Greater Role than Tillage Practice in Shaping Soil Microbiome Structure and Function by Chang Xu, Ruey Toh, Jishun Li, Yi Zhou, Matthew D. Denton

“…Stubble retention increased the availability of carbon resources in the soil, resulting in a higher proportion of genes functional for metabolic activity and plant–pathogen interactions. However, tillage practice did not influence the structure or diversity of the soil prokaryote community. …”
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A systematic review of the neglected parasite cyclospora cayetanensis in türkiye from 2004 to 2023 by Fatih CAKIR, Alican BILDEN, Memiş BOLACALI, Muttalip CICEK

“…Cyclospora cayetanensis is a parasitic pathogen causing gastroenteritis, transmitted through contaminated food and water, and is prevalent in tropical and subtropical regions. …”
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