Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses by Mariangela Gennaro, Alessandro Mattiello, Tommaso Pizzorusso

“…Translational stroke research requires the use of animal models as they represent a reliable tool to understand the pathogenic mechanisms underlying the generation, progression, and pathological consequences of a stroke. …”
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Risk of Fungal Infection to Dental Patients by Jaqueline Lopes Damasceno, Rafael Aparecido dos Santos, Amir Horiquini Barbosa, Luciana Assirati Casemiro, Regina Helena Pires, Carlos Henrique Gomes Martins

“…Fungi can cause various diseases, and some pathogenic fungi have been detected in the water of dental equipment. …”
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Pyogenic Spondylodiscitis due to Streptococcus constellatus in an Immunocompromised Male Patient: A Case Report and Review of the Literature by Charalampos Potsios, Panagiota Xaplanteri, Vasileios Zoitopoulos, Panagiotis Patrinos, Iro Ioanna Giannakopoulou, Ilektra Tzivaki, Theodora Kafentzi, Konstantina Samanta, Konstantina Filioti, Panagiotis Sideris, Konstantinos Letsas, Konstantinos Koukios

“…S. constellatus is an extremely rare pathogen and to our knowledge only two other cases of pyogenic spondylodiscitis are reported in the literature. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…Establishing a significant role of adult neurogenesis in the pathogenicity of psychiatric disorders may hold the key to potential strategies toward effective treatment.…”
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TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells by L. Kui, G. C. Chan, P. P. W. Lee

“…Proinflammatory cytokines such as TNF-α and type I interferons (IFN) are pathogenic signatures of systemic lupus erythematosus, and plasmacytoid dendritic cells (pDCs) play a major role by predominantly producing IFN-α. …”
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Familial Russell–Silver Syndrome like Phenotype in the PCNA Domain of the CDKN1C Gene, a Further Case by A. H. Sabir, G. Ryan, Z. Mohammed, J. Kirk, N. Kiely, M. Thyagarajan, T. Cole

“…A maternally inherited pathogenic heterozygous CDKN1C variant was found in the PCNA (proliferating cell nuclear antigen) domain. …”
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Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel by Haonan Wang, Yingnan Xiao, Deli Zhuge, Genghe Shi, Chengping Liu, Hui Liang, Jing Wu, Yunxuan Huang, Yilin Xie, Chunnan Hu, Jiafeng Xie, Xinyi Wang, Yao Yao, Fang Wang, Xufei Zhang, Chengke Huang, Yingzheng Zhao, Weiyang Meng, Yijie Chen, Mengchun Chen

“…Overall, the nanoparticle-hydrogel superstructure shows promise for treating local pathogen-infected wounds.…”
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Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary by Ulises Urzua, Carlos Chacon, Renato Espinoza, Sebastián Martínez, Nicole Hernandez

“…Since lipofuscin is a widely accepted senescence marker and given the recently postulated role of lipofuscin-associated iron as a source of reactive oxygen species (ROS) in senescent cells, these findings suggest a possible pathogenic mechanism by which nulliparity contributes to an increased OC risk in the postmenopausal ovary.…”
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Gene Technology for Papaya Ringspot Virus Disease Management by Md. Abul Kalam Azad, Latifah Amin, Nik Marzuki Sidik

“…The genetic diversity of PRSV depends upon geographical distribution and the influence of PRSV disease management on a sequence of PRSV isolates. The concept of pathogen-derived resistance has been employed for the development of transgenic papaya, using a coat protein-mediated, RNA-silencing mechanism and replicase gene-mediated transformation for effective PRSV disease management. …”
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Substantiation of application and estimation of efficacy of probiotics at inflammatory bowel diseases by Ye. A. Poluektova, Yu. O. Sidorina, S. Yu. Kuchumova, A. V. Korolev, O. S. Shifrin

“…At patients with IBD the intestinal microbiome have quantitative and qualitative differences from microbiome of healthy patients aside of increase in contents of opportunistic and pathogenic microorganisms. Microbiome changes result in initiation of cascade of pathological immune reactions of the host in related to presence of genetical defects, that, in turn, promotes development of clinical symptoms and morphological changes in intestinal wall. …”
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Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells by Samanta Melgar-Rodríguez, Emilio A. Cafferata, Nicolás I. Díaz, Miguel A. Peña, Luis González-Osuna, Carolina Rojas, Alfredo Sierra-Cristancho, Angélica M. Cárdenas, Jaime Díaz-Zúñiga, Rolando Vernal

“…In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.…”
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Persistent Cutibacterium (Formerly Propionibacterium) acnes Bacteremia and Refractory Endocarditis in a Patient with Retained Implantable Pacemaker Leads by M. Freedman, J. O. Aflatooni, R. Foster, P. G. Haggerty, C. J. Derber

“…The patient in this report demonstrates how cardiac device-related endocarditis secondary to C. acnes can be overlooked due to the indolent nature of this pathogen. This patient presented with an implanted cardiac pacemaker device, as well as retained leads from a prior pacemaker. …”
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The Contribution of α-Synuclein Spreading to Parkinson’s Disease Synaptopathy by Francesca Longhena, Gaia Faustini, Cristina Missale, Marina Pizzi, PierFranco Spano, Arianna Bellucci

“…Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurodegenerative disorders such as Parkinson’s disease (PD). …”
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Retinitis Pigmentosa and Bilateral Idiopathic Demyelinating Optic Neuritis in a 6-Year-Old Boy with OFD1 Gene Mutation by Xun Wang, Cong Zheng, Wen Liu, Hui Yang

“…Nevertheless, the pathogenicity of the variant needs further confirmation.…”
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Integration of Transcriptomics and Metabolomics Provides Insight into the Growth-Promoting Functions of <i>Solanum khasianum</i> Endophyte in <i>Medicago sativa</i> by Jiahui Li, Shijia Zhou, Jiaru Fang, Qihang Cai, Yanbo Yang, Zhenghai Sun, Liping Li, Weiwei Li

“…<i>Alternaria alstroemeriae</i> has often been used as a pathogenic bacterium in previous studies, and studies on the growth-promoting effects of <i>A. alstroemeriae</i> are rare. …”
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Pioneering the use of micro-biomarkers in oral cancer detection by Namrutha D Shekar, L. Kayal, N. Aravindha Babu, Mukesh Kumar Dharmalingam Jothinathan, Iadalin Ryntathiang

“…It brings into light the multi-system interaction between the oral microbiota which not only look at the known pathogenic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum but the overall mechanism by which oral cancer develops. …”
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Differential Diagnosis of MutYH-Associated Polyposis from Sporadic Colon Polyps by A. S. Tsukanov, V. P. Shubin, A. M. Kuzminov, M. Kh. Toboeva, T. A. Savelyeva, V. N. Kashnikov, Yu. A. Shelygin

“…Mutations in the MutYH gene were not detected in patients with 4–19 polyps (p &lt;0.05). The pathogenic significance of the disease development was established not only for biallelic, but also for monoallelic mutations.Conclusion. …”
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A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus by Tao Zhou, Lu Huang, Min Wang, Daozhen Chen, Zhong Chen, Shi-Wen Jiang

“…It is urgent to screen for specific biomarkers for early diagnosis and precise treatment, as well as to identify key moleculars to better understand the pathogenic mechanisms. In the present review, we comprehensively summarized recent studies of gestational diabetes using mass spectrometry-based proteomic technologies. …”
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Septic Shock Induced by Bacterial Prostatitis with Morganella morganii subsp. morganii in a Posttransplantation Patient by Xiaofan Li, Jianhui Chen

“…Taken together, Morganella morganii should be considered a possible pathogen when immunocompromised patients develop prostatitis. …”
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Co-Cultivation Growth of Escherichia coli and Staphylococcus aureus as Two Common Dairy Contaminants by Alžbeta Medveďová, Romana Györiová, Veronika Lehotová, Ľubomír Valík

“…The overgrowth of spoilage and pathogenic bacteria may pose risk to consumers health and cause technological and economic losses. …”
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