Prevalence of Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates in Nepal by Ranjeeta Odari, Prabin Dawadi

“…In the meta-analysis, 14 studies were combined for determining the prevalence of K. pneumoniae in total positive clinical isolates which was 16% (95% CI: 0.11–0.20), while from 12 research studies, MDR status in the pathogen was found to be 64% (95% CI, 0.53–0.74). Conclusion. …”
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Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…Experimental models that mimic human disease have been developed in order to study pathogenic and therapeutic mechanisms, but have shown mixed success in clinical application. …”
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RECENT ADVANCES IN THE DEFINITION OF THE MOLECULAR ALTERATIONS OCCURRING IN MULTIPLE MYELOMA by Ugo Testa, Elvira Pelosi, Germana Castelli, Giuseppe Leone

“…MM initiation and progression are dependent upon complex genomic abnormalities. The current pathogenic model of MM includes two types of primary events, represented by chromosome translocations or chromosome number alterations resulting in hyperdiploidy. …”
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Bioactivity of Root Endophytic Freshwater Hyphomycetes Anguillospora longissima (Sacc. & Syd.) Ingold by S. C. Sati, Lokendra Singh

“…In preliminary antimicrobial assay, maximum zone of inhibition was recorded against Gram-negative human pathogenic bacterial strain Escherichia coli (23 mm) followed by Erwinia chrysanthemi (22 mm), Agrobacterium tumefaciens (21 mm), and Xanthomonas phaseoli (21 mm), while minimum zone of inhibition was observed against Bacillus subtilis (20 mm). …”
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Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside by Rajeshwari D. Koilkonda, John Guy

“…Half of the men and 10% of females who harbor the pathogenic mtDNA mutation actually develop the phenotype. …”
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Brown fat thermogenesis and branched-chain amino acids in metabolic disease by Zachary Brown, Takeshi Yoneshiro

“…The newly identified MBC offers new therapeutic avenues by which BAT activity may be enhanced to improve metabolic and cardiovascular health, as well as other diseases in which increases of circulating BCAA may play a role in pathogenicity.…”
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Inflammation in Diabetic Nephropathy by Andy K. H. Lim, Gregory H. Tesch

“…Lastly, we present the latest data on the pathogenic role of the stress-activated protein kinases in diabetic nephropathy, from studies on the p38 mitogen activated protein kinase and the c-Jun amino terminal kinase cell signalling pathways. …”
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A Mosquito Culex cedecei Stone and Hair (Insecta: Diptera: Culicidae) by Kristin Elizabeth Sloyer, Nathan Daniel Burkett-Cadena

“…Culex cedecei is therefore considered a vector of a zoonotic pathogen that can affect human health. …”
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Metabolomic analysis of murine tissues infected with Brucella melitensis. by Bárbara Ponzilacqua-Silva, Alexis S Dadelahi, Charles R Moley, Mostafa F N Abushahba, Jerod A Skyberg

“…Brucella is a gram negative, facultative intracellular bacterial pathogen that constitutes a substantial threat to human and animal health. …”
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A Maternal Loss‐of‐Function Variant in KHDC3L Gene Causes a Range of Adverse Pregnancy Outcomes: A Case Report by Zahra Anvar, Farnoosh Jafarpour, Bahia Namavar Jahromi, Andrea Riccio, Mohammad Hossein Nasr‐Esfahani, Maria Vittoria Cubellis

“…This case report broadens the understanding of KHDC3L's pathogenic variants and phenotypic spectrum, consistent with its crucial role during human pre‐ and post‐implantation development.…”
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Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb by Xinyue Wang, Ning Li, Lu Han, Ou Qiao, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao, Zichuan Liu, Yanhua Gong

“…Abstract Rhabdomyolysis or Crush syndrome-related AKI (RM/CS-AKI) has high mortality, and there is no effective early on-site treatment method. The critical pathogenic factor of RM/CS-AKI is the excessive free myoglobin (Mb) in blood circulation. …”
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Gene Expression during Survival of Escherichia coli O157:H7 in Soil and Water by Ashley D. Duffitt, Robert T. Reber, Andrew Whipple, Christian Chauret

“…These results suggest that E. coli O157:H7 may develop a different phenotype during transport through the environment. Furthermore, this pathogen may become more resistant to antibiotics making subsequent infections more difficult to treat.…”
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Probiotic Bacillus licheniformis DSMZ 28710 improves sow milk microbiota and enhances piglet health outcomes by Rungdawan Wongsamart, Naraporn Somboonna, Thanya Cheibchalard, Piriya Klankeo, Jakavat Ruampatana, Morakot Nuntapaitoon

“…Results indicated that the supplementation increased the abundances of beneficial bacteria, such as Lactobacillus, Pediococcus, Bacteroides, and Bifidobacterium, while decreasing the abundances of pathogenic bacteria, such as Staphylococcus aureus, Enterobacteriaceae, and Campylobacter in the colostrum. …”
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Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN by Jovita Patricija Druta, Gunda Petraitytė, Aušra Sasnauskienė, Eglė Preikšaitienė

“…The patient was initially diagnosed with secondary small fiber sensory polyneuropathy and myotonia, but further genetic testing revealed the homozygous pathogenic variant c.1578del in the WRN gene associated with Werner syndrome. …”
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Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice by Xiao Meng Zhang, Hao Deng, Jin Dong Tong, Yi Zhen Wang, Xu Chao Ning, Xiu Hong Yang, Fang Qiang Zhou, Hui Min Jin

“…Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice. …”
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Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy by Weiran Wang, Xiang Fu, Bolin Gu, Mengxin Hu, Jiaguo Liu

“…Duck hepatitis A virus type 1 (DHAV-1) is a significant pathogen affecting ducklings, capable of causing rapid mortality and adversely impacting the development of the duck industry. …”
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The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications by Ting Ding, Chang Liu, Zhengyu Li

“…Accumulating evidence suggests a possible involvement of commensal and pathogenic fungi in cancer initiation, progression, and treatment responsiveness. …”
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Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice by Takamune Takahashi, Raymond C. Harris

“…These studies clearly defined a critical role of eNOS in DN and developed a robust animal model of this disease, which enables us to study the pathogenic mechanisms of progressive DN. Further, recent studies with this animal model have explored the novel mechanisms by which eNOS deficiency causes advanced DN and provided many new insights into the pathogenesis of DN. …”
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Solitary Pyomyositis of the Left Rhomboideus Muscle Caused by Streptococcus anginosus and Streptococcus intermedius in an Immunocompetent Person by Yasuhiro Tanaka, Kenichi Takaya, Go Yamamoto, Isaku Shinzato, Toshiro Takafuta

“…Primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with Staphylococcus aureus most often isolated as a pathogen. However, pyomyositis caused by anaerobic bacteria is rare in adults. …”
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Enterococcus faecium HDRsEf1 Protects the Intestinal Epithelium and Attenuates ETEC-Induced IL-8 Secretion in Enterocytes by Zhongyuan Tian, Xiaofang Liu, Ran Dai, Yuncai Xiao, Xiliang Wang, Dingren Bi, Deshi Shi

“…In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal pathogen, the mechanism underlying Ef1 protection against an enteropathogen was investigated. …”
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