Prevalence of Toxoplasma gondii in retail venison in Montreal detected using a nested PCR method by Chi Zhao, Mengyu Zhang, Jiaxuan Lan, Xiaoqi Mi, Xiaonan Lu, Qian Liu

“…Toxoplasma gondii is a globally significant zoonotic pathogen responsible for congenital disorders and opportunistic infections, primarily transmitted through foodborne pathways. …”
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Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection by Elysse S. Tom, K. Matthew McKay, Steven S. Saraf

“…Ampiginous choroiditis is an inflammatory chorioretinopathy with an unknown pathogenic mechanism that often necessitates early immunomodulatory therapy. …”
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Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli by Gang Liu, Shuai Chen, Guiping Guan, Jun Tan, Naif A. Al-Dhabi, Hongbing Wang, Veeramuthu Duraipandiyan, Jun Fang

“…This study aims to investigate the effects of dietary chitosan (COS) on gastrointestinal pathogen resistance in mice model. For two weeks, a control group of ICR mice received a basal diet whilst the intervention group received the basal diet supplemented with 300 mg/kg COS. …”
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Modeling environmental transmission of MAP infection in dairy cows by Kokum R. De Silva, Shigetoshi Eda, Suzanne Lenhart

“…To investigate the effect of persistence of this bacteria on the farm on transmission in our model, we include environmental compartments, representing the pathogen input in an explicit way. The effect of indirect transmission from the bacteria in the environment and the culling of high-shedding adults can be seen in the numerical simulations. …”
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The large-scale whole-genome sequencing era expedited medical discovery and clinical translation by Qingxin Yang, Shuhan Duan, Yuguo Huang, Chao Liu, Mengge Wang, Guanglin He

“…This imbalance has hampered health equity and precision medicine, resulting in limited transferability of polygenic risk scores to underrepresented populations and misinterpretations of the pathogenicity of genomic variants. Recent advancements in sequencing technology have enabled the implementation of large-scale, high-quality, diverse, multi-omics, and engineered genomic projects, including the All of Us Research Program and the Trans-Omics for Precision Medicine Program. …”
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Identification of bapA in Strains of Salmonella enterica subsp. enterica Isolated from Wild Animals Kept in Captivity in Sinaloa, Mexico by Gabriela Silva-Hidalgo, Martin López-Valenzuela, Nora Cárcamo-Aréchiga, Silvia Cota-Guajardo, Mayra López-Salazar, Edith Montiel-Vázquez

“…Biofilm formation is associated with the ability to persist in different environments, which contributes to the pathogenicity of several species. We analyzed the presence of bapA in 83 strains belonging to 17 serovars of Salmonella enterica subsp. enterica from wildlife in captivity at Culiacan’s Zoo and Mazatlán’s Aquarium. …”
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G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD by Agata M. Parsons, Seth Byrne, Jesse Kooistra, John Dewey, Aaron L. Zebolsky, Gloria Alvarado, Gerrit J. Bouma, Gregory B. Vanden Heuvel, Erik D. Larson

“…Abstract The “secondhit” pathway is responsible for biallelic inactivation of many tumor suppressors, where a pathogenic germline allele is joined by somatic mutation of the remaining functional allele. …”
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Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…We use the model topredict disease progression scenarios, including primary, latency or clearance.Model analysis shows that occurrence of active disease is much attributedto the Mtb pathogen ability to persist outside the intracellular environmentand that high levels of CTLs result in latent TB, while low levels of CTLsresult in active TB. …”
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Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report by Lulu Wang, Yahui Feng, Sisi Wang, Leyao Shi, Yong Ren, Zhiya Yang, Dongmei Shi

“…The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. …”
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IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA? by Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano

“…MGUS and SMM are heterogeneous conditions with the presence of tumors with distinct pathogenic phenotypes and clinical outcomes. The identification of MGUS and SMM patients with a molecularly defined high risk of progression to MM offers the unique opportunity of early intervention with a therapeutic approach on a low tumor burden.   …”
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Genetic and audiological determinants of hearing loss in high-risk neonates by Yanan Shi, Naiyao Zhang, Na Du, Tongxi Zheng, Ying Yu, Youjin Li

“…Genetic analysis involved a deafness sequencing panel targeting 19 pathogenic variants across four genes (GJB2, GJB3, SLC26A4, and MT-RNR), applied to both the study cohort and a larger hearing screening cohort of 14863 neonates from our center and different medical centers in the same region. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…ABSTRACT The current situation with H5N1 highly pathogenic avian influenza virus (HPAI) is causing a worldwide concern due to multiple outbreaks in wild birds, poultry, and mammals. …”
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Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues by Saúl Rojas-Sánchez, Nikolay G. Kolev, Christian Tschudi

“…Abstract To regain infectivity, Trypanosoma brucei, the pathogen causing Human and Animal African trypanosomiasis, undergoes a complex developmental program within the tsetse fly known as metacyclogenesis. …”
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Prevalence of Brucellosis among Women Presenting with Abortion/Stillbirth in Huye, Rwanda by Nadine Rujeni, Léonidas Mbanzamihigo

“…More mechanistic studies will also demonstrate the pathogenicity of Brucella in human placentas.…”
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Theoretical Construction and Clinical Application of "Flaccidity Caused by Deficiency and Congestion" of Osteoporosis by YAO Xinmiao

“…Based on the basic theories such as "kidney governing bone" and "kidney deficiency", professor YAO Xinmiao of The Third Affiliated Hospital of Zhejiang Chinese Medical University creatively put forward the pathogenic theory of "flaccidity caused by deficiency and congestion" of OP, which holds that the pathogenesis of OP is the combination of deficiency and blood stasis, mixed with impotence. …”
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The growing challenge of autism spectrum disorder: a comprehensive review of etiology, diagnosis, and therapy in children by Chunyuan Wang, Hong Wang

“…Finally, this paper summarizes the current status of autism research, looks forward to future research directions, and calls for more research to explore the pathogenic mechanisms, diagnostic basis, and therapeutic methods of autism.…”
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The Management of Inflatable Penile Prosthesis Erosion and Infection following Iatrogenic Aspiration by Ali Baydoun, Alexander Benben, Matthew Skalak, Jordan Bilbrew, Mazen Abdelhady

“…Intraoperative cultures identified Escherichia cloacae as the causative pathogen. This case highlights the importance of thorough chart review to identify patients with IPPs before aspiration procedures and emphasizes the need for healthcare provider education regarding potential complications in this patient population. …”
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Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes by Amedeo Lonardo

“…Iron plays a key role in many of the key pathogenic steps concurring in the development and progression of MFLS, notably including genetics, intestinal dysbiosis, adipositis, insulin resistance, metaflammation, oxidative stress and ferroptosis, endoplasmic reticulum stress, and hepatic fibrosis. …”
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Preparation of Copper Nanoparticles/Diatomite Nanocomposite for Improvement in Water Quality of Fishponds by Truong Thi Hanh, Nguyen Thuy Lan Chi, Nguyen Ngoc Duy

“…Antibacterial activity of CuNPs/DA nanocomposite against pathogenous bacteria for catfish such as Aeromonas hydrophila and Edwardsiella ictaluri was estimated.…”
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Preventing Foodborne Illness: E. coli O157:H7 by Keith R. Schneider, Renée Goodrich Schneider, Ploy Kurdmongkoltham, Bruna Bertoldi

“… This seven-page fact sheet discusses the common foodborne pathogen E. coli O157:H7, especially as it concerns food handlers, processors and retailers. …”
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