Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…The innate arm also communicates this message with more specialized adaptive forces represented by pathogen-specific B cells and T cells. Interestingly, B cells also express some innate sensors, like TLR7 and TLR9, and may respond to bacterial hypomethylated CpG motifs and single-stranded RNA viruses. …”
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Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…Combined treatment of UDCA and budesonide is proposed.Conclusion. UDCA is pathogenicly proved treatment of PBC.…”
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Microbiological Study of Cast Posts before Cementation by Maricela Vallejo-Labrada, Juan Carlos Ojeda-Garces

“…The disinfection process worked out in a high percentage and demonstrated that the sterilization by autoclaving eliminated completely the pathogenic microbiota without affecting the cast post shape and integrity that could compromise their final fitting.…”
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Updates on the development of vaccines and therapeutic options against rabies by Roshan Arjun Ananda, Hooi-Leng Ser, Vengadesh Letchumanan

“…Further studies on the pathogenic mechanism of RABV and therapeutic approaches are still required to prevent the deathly infection following clinical manifestation. …”
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Guidance for Processing Reduced Oxygen Packaged (ROP) of Raw, Frozen Seafood in Retail Operations by Keith R. Schneider, Victor Garrido, W. Steve Otwell, Ray Mobley

“…These packaging methods can provide the benefit of protecting the product during frozen storage while providing attractive, easy to handle packages with odor control, but in certain circumstances it can also present anaerobic conditions that are favorable for growth and toxin production by a potentially lethal pathogen, Clostridium botulinum. This document is FSHN05-04, one of a series of the Food Science and Human Nutrition Department, Florida Cooperative Extension Service, IFAS, University of Florida, Gainesville, FL 32611. …”
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An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system by Meiqin Mao, Li He, Qingpi Yan

“…Finally, we investigate the coordinated role of the PhoP/PhoQ system in acquiring pathogenic virulence.…”
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Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…Furthermore, viral and bacterial infections interfere with the chronic inflammation seen in stable COPD and exacerbations via pathogen-associated molecular patterns (PAMPs). Finally, autoimmunity is another novel aspect that may play a critical role in the pathogenesis of COPD. …”
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Genome Architecture and Its Roles in Human Copy Number Variation by Lu Chen, Weichen Zhou, Ling Zhang, Feng Zhang

“…Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. …”
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Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM) by Swati Jaiswal, Sanjay Kumar

“…Unlike <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, NTM species exhibit different pathogenic characteristics and drug resistance mechanisms, making them increasingly relevant in clinical settings. …”
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Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies by Diana-Maria Bunu, Cristian-Eugen Timofte, Manuela Ciocoiu, Mariana Floria, Claudia-Cristina Tarniceriu, Oana-Bogdana Barboi, Daniela-Maria Tanase

“…The aim of this article is to review the available literature about the possible pathogenic mechanisms and determine preventive measures capable of reducing the incidence and severity of the cardiovascular manifestations. …”
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Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models by Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Menghao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

“…Notably, one homolog, EphcCasλ, is experimentally validated for self-processing pre-crRNA, DNA cleavage, and trans-cleavage, showing promise for CRISPR-based pathogen detection. This study highlights an innovative approach for discovering CRISPR-Cas systems with specific functions, emphasizing their potential in gene editing.…”
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Preserving Darwin’s fox: genomic tools for the conservation of South America’s most endangered canid by Cristóbal Valenzuela-Turner, José Horacio Grau, Jörns Fickel, Jörns Fickel, Daniel W. Förster

“…Here we highlight the potential of HTS to address these challenges, such as clarifying its taxonomy, demographic history, geographic distribution, population structure, genetic diversity, and pathogen exposure. Integrating molecular data into conservation planning will be pivotal in ensuring the long-term survival of Darwin’s fox by identifying priorities for targeted management interventions, highlighting areas of critical habitat for conservation, and guiding genetic rescue efforts to enhance genetic diversity and resilience.…”
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Bridging gaps and leveraging opportunities for One Health: Feedback from the 8th World One Health Congress by Alexandre Caron, Michel de Garine-Wichatitsky, Muriel Figuié, Julie Meunier, Prisca Mugabe, Jakob Zinsstag

“…The One Health approach still needs to go beyond diseases and to embrace a truly holistic definition of health in both its pathogenic and salutogenic components. This broader definition of health should be applied to all human groups with more equity and inclusivity, to non-human animals, as sentient beings, and to ecosystems and the environment in a more integrated way. …”
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Investigation of virulence factors in resistance and sensitive pseudomonas aeruginosa clinical isolates by Zeinab Waheed kadim, Hala Mouayed Radif

“… The pathogen "Pseudomonas aeruginosa" is extremely hazardous for people with weak immune systems because it has several virulence factors and can resist antibiotics. …”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Our findings identify a conserved cellular component essential for IB maturation and suggest a mechanism by which cells may detoxify the pathogenic protein aggregates through forming mitochondrion-associated IBs.…”
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Protection against SHIV-KB9 Infection by Combining rDNA and rFPV Vaccines Based on HIV Multiepitope and p24 Protein in Chinese Rhesus Macaques by Chang Li, Zhenwei Shen, Xiao Li, Jieying Bai, Lin Zeng, Mingyao Tian, Ying Jin Song, Ming Ye, Shouwen Du, Dayong Ren, Cunxia Liu, Na Zhu, Dandan Sun, Yi Li, Ningyi Jin

“…The animals were challenged intramuscularly with pathogenic molecularly cloned SHIV-KB9. Immunogenicity and protective efficacy of vaccines were investigated by measuring IFN-γ levels, monitoring HIV-specific binding antibodies, examining viral load, and analyzing CD4/CD8 ratio. …”
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Cardiovascular Risk Factors in the Antiphospholipid Syndrome by Felipe Freire da Silva, Roger Abramino Levy, Jozélio Freire de Carvalho

“…A major cause of morbidity and mortality in the context of the antiphospholipid syndrome (APS) is the occurrence of thrombotic events. Besides the pathogenic roles of antiphospholipid antibodies (aPL), other risk factors and medical conditions, which are conditions for traditional risk of an individual without the APS, can coexist in this patient, raising their risk of developing thrombosis. …”
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Case report: a rare concurrence of dense deposit disease in an adolescent patient with IgA nephropathy by Jian-Hui Zhang, Hong-Ping Yu, Ying Chen, Qian Chen, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang

“…The presence of both in a single patient may result in more intricate pathogenic pathways. Conclusions This specific case elucidates the pathological characteristics of both diseases while investigating the intricate connections and lesion correlations that may occur between them, offering novel insights into their pathogenesis.…”
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SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature by Prajwal Boddu, Abdul S. Mohammed, Chandrahasa Annem, Winston Sequeira

“…The cause and effect relationships of lymphoma in SLE have been subject to extensive scrutiny with several studies reporting on clinic-pathologic characteristics and risk factors predicting lymphoma development in SLE. However, the pathogenic role of immunosuppressives in SLE-related lymphoma still remains unclear, and indices to help guide diagnosis, prognostication, therapy, and posttreatment monitoring are yet to be established. …”
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The Role of Cell Surface Architecture of Lactobacilli in Host-Microbe Interactions in the Gastrointestinal Tract by Ranjita Sengupta, Eric Altermann, Rachel C. Anderson, Warren C. McNabb, Paul J. Moughan, Nicole C. Roy

“…Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. …”
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