Three-way relationships between gut microbiota, helminth assemblages and bacterial infections in wild rodent populations by Bouilloud, Marie, Galan, Maxime, Dubois, Adelaide, Diagne, Christophe, Marianneau, Philippe, Roche, Benjamin, Charbonnel, Nathalie

“…We applied analyses of community and microbial ecology to evaluate the interactions between the gut bacteriota, the gastro-intestinal helminths and the pathogenic bacteria detected in the spleen. We identified important variations of the gut bacteriota composition and diversity among bank voles. …”
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<i>Bacillus cabrialesii</i> subsp. <i>cabrialesii</i> Strain TE5: A Promising Biological Control Bacterium Against the Causal Agent of Spot Blotch in Wheat by Ixchel Campos-Avelar, Michelle Fabiela García Jaime, Pamela Helué Morales Sandoval, Fannie Isela Parra-Cota, Sergio de los Santos Villalobos

“…<i>cabrialesii</i> strain TE5 as a promising biological control agent against the wheat pathogen <i>Bipolaris sorokiniana</i> while suggesting lipopeptides as the potential mode of action, together with plant growth and defense stimulation.…”
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Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study by Muqiu Zhang, Xinyao Liu, Xin Ran, Runyan Gao, Jitong Sun, Kaiwen Zhuang, Zimeng You, Zhi Zhang, Yuping Ran

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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…The innate diversity and adaptability of this pathogen pose significant challenges to effective control measures. …”
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox... by Kristina N. Delgado, Crystal F. Vicente, Christopher M. Hennelly, Farhang Aghakhanian, Jonathan B. Parr, Kevin P. Claffey, Justin D. Radolf, Kelly L. Hawley, Melissa J. Caimano

“…ABSTRACT Syphilis is a sexually transmitted infection caused by the highly invasive and immunoevasive spirochetal pathogen Treponema pallidum subsp. pallidum (TPA). …”
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Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…However, it showed promise, mostly in patients with a pathogenic variant in the MTOR gene, highlighting the need for further research into patient‐specific factors influencing treatment response. …”
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Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a compara... by Xiaolin Ma, Yuting Wu, Ri De, Hailan Yao, Feng He, Yi Wang, Wei Wang, Chao Yan, Qinwei Song, Chunjie Guo, Li Wen, Linqing Zhao, Ling Cao, Chunmei Zhu

“…BackgroundThe pathogenic distribution of co-infections and immunological status of patients infected with human adenovirus serotypes 3 or 7 (HAdV-3 or HAdV-7) were poorly understood.MethodsThis study involved a retrospective analysis of respiratory specimens collected from enrolled children with lower respiratory tract infections (LRTIs), positive for HAdV-3 or HAdV-7 from January 2017 to December 2019. …”
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Competence induction of homologous recombination genes protects pneumococcal cells from genotoxic stress by David De Lemos, Anne-Lise Soulet, Violette Morales, Mathieu Berge, Patrice Polard, Calum Johnston

“…Transformation involves the capture and internalization of exogenous DNA in the form of single strands, followed by HR-mediated chromosomal integration. In the human pathogen Streptococcus pneumoniae, transformation occurs during a transient, stress-induced differentiation state called competence. …”
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Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…Tier I TGVs, interpreted as pathogenic/likely pathogenic (P/LP) and found in most- or standard-actionable genes with high germline conversion rates (GCRs) in any context, were more likely to be considered germline relevant (p-value < 0.05). …”
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Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…ABSTRACT Staphylococcus aureus is an important human pathogen due to its vast array of virulence factors regulated by multiple regulatory mechanisms, including the accessory gene regulator. …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Genomic DNA from family members was extracted and initially screened for pathogenic mutations in APP, PSEN1, and PSEN2, and screened for 77 genes associated with neurodegenerative conditions using NeuroX array assay. …”
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Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…In this study, we characterized pathogen kinetics and evaluated the physiologic, immunologic, and pathologic responses in this model of septic shock induced by the clinically relevant pathogen Klebsiella pneumoniae across a three-log dose range. …”
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Studying a collection of common-wheat varieties for leaf rust resistance, crop yield and grain quality in the environmental conditions of Novosibirsk region by L. P. Sochalova, V. A. Aparina, N. I. Boyko, E. V. Zuev, E. V. Morozova, E. V. Musinov, N. A. Vinichenko, I. N. Leonova, V. V. Piskarev

“…The study of leaf rust resistance in 49 common wheat varieties was carried out in the field against the natural pathogen background and under laboratory conditions using single-pustule isolates with virulence to Lr9 and Lr24. …”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…Yet, how this opportunistic pathogen adapts to the various metabolically distinct host cellular niches remains poorly understood. …”
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Neglected Case of Human Balantidiasis: Presumed as Antibiotic-Associated Diarrhoea by Sreska Shrestha, Priyatam Khadka

“…Balantidiasis, due to its rare human incidence and nonspecific clinical presentations often neglected from the diagnosis considerations; however, a potent pathogen. Herein, we report a case of neglected balantidiasis presumed as antibiotic-associated diarrhoea. …”
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Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome by Kishan Kumar Nyati, Kashi Nath Prasad

“…Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system, mostly triggered by an aberrant immune response to an infectious pathogen. Although several infections have been implicated in the pathogenesis of GBS, not all such infected individuals develop this disease. …”
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Anaerobic Digesters for Manure Management at Livestock Operations by Rishi Prasad, George Hochmuth, Ann C. Wilkie

“…The stabilization process reduces the organic matter and water contents, unpleasant odors, concentrations of pathogenic microorganisms, and weed seeds. Anaerobic digestion (AD), which is the topic of this fact sheet, also results in the production of renewable energy in the form of methane-rich biogas. …”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. …”
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Engineering Saccharomyces cerevisiae for medical applications by Carla Maneira, Alexandre Chamas, Gerald Lackner

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ANALYZING THE CHARACTERISTICS AND BIOLOGICAL ACTIVITIES OF METHANOLIC EXTRACTS FROM STACHYS BYZANTINE LEAVES by Ali Q. Khazaal, Zainab F. Mahmood, Sanaa A. Hammood

“… This study was aimed to examine the suppressive effects of Stachys byzantine leaf methanolic extracts on cancer cell lines and pathogenic microbes. Five concentrations of S. byzantine methanolic extract, from 25 to 400 µg/ml, were applied to HepG1 and HCT116 cells. …”
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