ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells by Lara Hundsdorfer, Marie Muenkel, Raul Aparicio-Yuste, Julio Cesar Sanchez-Rendon, Maria Jose Gomez-Benito, Aylin Balmes, Tilman E. Schäffer, Ana Velic, Yi-Ting Yeh, Iordania Constantinou, Kathryn Wright, Gizem Özbaykal Güler, Dominik Brokatzky, Boris Maček, Serge Mostowy, Effie E. Bastounis

“…Summary: Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collective infected cell extrusion (CICE) and limit infection spread across cell monolayers. …”
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The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins by Minkiewicz Piotr, Sokolowska Jolanta, Darewicz Malgorzata

“…The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins.…”
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Geographic variation in abundance and diversity of Acinetobacter baumannii Vieuvirus bacteriophages by Dafne Arellano-Maciel, Juan Manuel Hurtado-Ramírez, Laura Carolina Camelo-Valera, Santiago Castillo-Ramírez, Alejandro Reyes, Gamaliel López-Leal

“…IntroductionProphages play a crucial role in the genomic diversity of Acinetobacter baumannii, contributing to its pathogenicity and adaptation.MethodsIn this study, we induced and sequenced seven prophages from five isolates of A. baumannii. …”
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Porphyric encephalopathy in a 15-year-old girl: A case report by Saihari S Dukkipati, Jordan Terschluse, Drew Thodeson, Angela Beavers, Melissa Muff-Luett, Claire Ives, Sookyong Koh

“…A hydroxymethylbilane synthase (porphobilinogen deaminase) pathogenic variant was found in porphyria gene panel confirming the diagnosis of acute intermittent porphyria. …”
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Disorder of intracellular cobalamin metabolism: Importance of rapid diagnostic illustrated by a case report of early-onset methylmalonic aciduria and homocystinuria, cobalamin C ty... by Etienne Mondesert, Bastien Baud, Agathe Roubertie, Jean-François Benoist, Pierre-Edouard Grillet, Jean-Paul Cristol, Marie Céline Francois-Heude, Manuel Schiff, Stéphanie Badiou

“…Diagnosis was later confirmed by genetic analysis which identified two pathogenic variants on the MMACHC gene: c.271dupA (p.Arg91lysfs∗14) paternal allele and c.388T > C (p.Tyr130His) maternal allele. …”
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Gas Gangrene in Orthopaedic Patients by Zhimin Ying, Min Zhang, Shigui Yan, Zhong Zhu

“…Several factors, if available, were analyzed for each case: age, cause of injury, fracture location, pathogen, and outcome. Based on our case report and the literature review, emergency clinicians should be aware of this severe and potentially fatal infectious disease and should not delay treatment or prompt orthopedic surgery consultation.…”
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Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots by Dos Santos Delair Silveira, Oberger Júlia Vieira, Niero Rivaldo, Wagner Theodoro, Delle Monache Franco, Cruz Alexandre Bella, Martin-Quintal Zhelmy, Cechinel Filho Valdir

“…The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. …”
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Dysphoric spectrum of emotional disorders at irritable bowel syndrome by M. A. Morozova, G. Ye. Rupchev, A. A. Alekseyev, A. G. Beniashvili, M. V. Mayevskaya, Ye. A. Poluektova, O. Z. Okhlobystina, V. T. Ivashkin

“…Somatic manifestations of IBS are associated to dysphoric experience indicating their potential pathogenic value. Imbalance between the scope of data on emotional disorders at IBS and the number of studies devoted to psychopharmacotherapy efficacy assessment at emotional disorders was revealed. …”
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Attempts to identify the molecular cause of autoinflammatory recurrent fever by Oksana Boyarchuk, Diana Savkiv

“…We present the molecular diagnosis results of 12 children with recurrent fever, analyzing the correlation between molecular findings and clinical symptoms. No pathogenic variants confirming autoinflammatory disease were found. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling. Taken together, our findings reveal a macrophage-specific ubiquitination signaling axis in colitis and CAC development and suggest that Pellino1 is a potential candidate for treating chronic inflammation and inflammation-related cancer.…”
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The Promise of Human Induced Pluripotent Stem Cells in Dental Research by Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim, Vijayendran Govindasamy

“…Indeed, this has provided a perfect cell source for disease modeling and a better understanding of genetic aberrations, pathogenicity, and drug screening. In this paper, we will summarize the recent progress of the disease-specific iPSC development for various human diseases and try to evaluate the possibility of application of iPS technology in dentistry, including its capacity for reprogramming some genetic orodental diseases. …”
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Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…Along with traditional concepts on the risk factors of atherosclerosis and cardio-vascular diseases development one should take into account data on the new pathogenic mechanisms for these diseases. According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
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Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry by Qingping Liang, Wei Zhou, Siyuan Peng, Ziyu Liang, Zhemin Liu, Changliang Zhu, Haijin Mou

“…Bacteriocins produced by LAB have attracted the attentions for application in the food industry as natural food bio-preservatives because of their antimicrobial activity against the food spoilage and pathogenic bacteria. With the increasing demands of consumers for more healthier food and investigations on natural food preservatives, the bioactivity of bacteriocins allows them to give the application values to the bacteriocin-producing LAB. …”
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Impact of population screening for Lynch syndrome insights from the All of Us data by Jiheum Park, Hemanth Karnati, Sheila D. Rustgi, Chin Hur, Xiao-Fei Kong, Fay Kastrinos

“…LS affects about 1 in 354 individuals in this U.S. cohort, where pathogenic variants in the genes MSH6 and PMS2 account for the majority of cases. …”
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Effectiveness of the California Mastitis Test (CMT), Reductase Test, and Alcohol Test for Dairy Cows Subclinical Mastitis Detection by Eriza Rosalina Rochmah, Dadik Raharjo, Sri Hidanah, Mustofa Helmi Effendi, Adiana Mutamsari Witaningrum, Sunaryo Hadi Warsito

“…Mastitis is an inflammation of the mammary glands caused by pathogenic bacteria Mastitis divided into 2 types, clinical mastitis which has symptoms of swelling and changes in the shape of the mammary gland, while subclinical mastitis does not indicate clear symptoms. …”
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases by Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi, Anwar Abdelnaser

“…In addition, gut microbial metabolites play crucial roles in infectious disease susceptibility and resilience, mediating immune pathways that impact pathogen resistance. By consolidating recent insights into the gut microbiota’s role in shaping disease and health, this review underscores the therapeutic potential of targeting microbiome-derived metabolites for treating GI cancers and infectious diseases and calls for further research into microbiome-based interventions.…”
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Follicular T cells and the control of IgE responses by Pablo F. Cañete, Di Yu

“…Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. …”
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Schistosome-Derived Molecules as Modulating Actors of the Immune System and Promising Candidates to Treat Autoimmune and Inflammatory Diseases by Luis Janssen, Gisele Lorranna Silva Santos, Herick Sampaio Muller, Anderson Rodrigues Araújo Vieira, Tatiana Amabile de Campos, Vicente de Paulo Martins

“…This modulation is not only important in order to understand the host-pathogen interactions and to develop treatments against the parasites themselves but also important in the development of treatments against autoimmune and inflammatory diseases. …”
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How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). …”
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Viral diversity and phloem transcriptional changes in grapevine Shiraz disease infected vines by Cristobal Onetto, Dilrukshi Nagahatenna, Yeniu Mickey Wang, Vinay Pagay, Anthony Borneman

“…Similar to other plant pathogen infections, SD upregulated genes associated with the systemic acquired resistance (SAR) mechanism and downregulated genes related to vine immunity. …”
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