Development of lateral flow immunochromatographic assay with Anti-Pythium insidiosum antibodies for point-of-care testing of vascular pythiosis by Panwad Tongchai, Ati Burassakarn, Nattapong Langsiri, Navaporn Worasilchai, Ariya Chindamporn

“…Abstract The pathogenic oomycete Pythium insidiosum causes a fatal infectious illness known as pythiosis, impacting humans and certain animals in numerous countries in the tropics and subtropics. …”
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Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) by Vladimir A. Marchenko, Irina N. Zhilinskaya

“…Thus, influenza A viruses, including subtypes A(H1N1)pdm09, A(H3N2), as well as highly pathogenic avian influenza viruses, can infect the vascular endothelium, leading to activation and subsequent dysfunction of these cells. …”
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Enhanced testing can substantially improve defense against several types of respiratory virus pandemic by James Petrie, James A. Hay, Oraya Srimokla, Jasmina Panovska-Griffiths, Charles Whittaker, Joanna Masel

“…To understand scenarios where mass testing might or might not be a viable intervention, here we modeled how effectiveness depends both on characteristics of the pathogen (R0, time to peak viral load) and on the testing strategy (limit of detection, testing frequency, test turnaround time, adherence). …”
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Congenital Glaucoma: a Novel Ocular Manifestation of Hajdu-Cheney Syndrome by L. Swan, G. Gole, V. Sabesan, J. Cardinal, D. Coman

“…We describe a hitherto undescribed missense mutation that is predicted to be pathogenic, with functional characterization remaining to be performed. …”
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Generation of a human induced pluripotent stem cell lines (UKJi003-A) from a patient with Fabry disease and healthy donor (UKJi004-A) by Mohamed M. Bekhite, Sascha Hübner, Tom Kretzschmar, Claudia Backsch, Anja Weise, Elisabeth Klein, Jürgen Bogoviku, Julian Westphal, P. Christian Schulze

“…Fabry disease (FD, OMIM #301500) is a rare metabolic disorder, X-linked glycosphingolipidosis that is characterized by pathogenic mutations in the GLA (Galactosidase Alpha) gene (OMIM *300644) that result in reduced α-galactosidase A (α-GAL) activity and accumulation of globotriaosylceramide (Gb3) in tissues and organs. …”
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Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications by Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song

“…Klebsiella pneumoniae is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. …”
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Inhibitory Effects of Litsea cubeba Oil and Its Active Components on Aspergillus flavus by Shiqi Xia, Hong Lin, Peilin Zhu, Peiling Wang, Shengliang Liao, Shangxing Chen, Zongde Wang, Guorong Fan

“…Aspergillus flavus (A. flavus) is a frequent harmful fungal pathogen. It can infect traditional Chinese medicine materials and release aflatoxin, to cause both economic and human health effects. …”
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Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases by Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin

“…These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. …”
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Human stem cell models for Marfan syndrome: a brief overview of the rising star in disease modelling by Jeffrey Aalders, Laura Muiño Mosquera, Laura Muiño Mosquera, Jolanda van Hengel

“…Marfan syndrome is caused by pathogenic variants in FBN1, the gene encoding for the extracellular matrix protein fibrillin-1 which ensembles into microfibrils. …”
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Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains by Maria Isabel Nogueira Di Azevedo, Frederico Kremer, Camila Ezepha, João Pedro Gomes Greco, Isadora Cosenza Vieira da Silva, Pascale Bourhy, Walter Lilenbaum

“…Important aspects of the interactions between the host and the pathogen during chronic leptospirosis have been well described in the kidney, but little is known about the genital infection mechanisms. …”
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A Novel Subspecies of Didymella acutilobae Causing Leaf Spot in East Asian Hogweed by Gyo-Bin Lee, Weon-Dae Cho, Wan-Gyu Kim

“…However, the morphological and cultural characteristics of the isolates exhibited somewhat distinct differences from those of D. acutilobae, suggesting that the isolates correspond to a novel subspecies. Pathogenicity tests revealed that the isolates caused leaf spot in East Asian hogweed plants. …”
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Synthesis of Silver Nanoparticles from the Aqueous Extract of Leaves of Ocimum sanctum for Enhanced Antibacterial Activity by Charusheela Ramteke, Tapan Chakrabarti, Bijaya Ketan Sarangi, Ram-Avatar Pandey

“…Such AgNPs stabilized by Tulsi leaf extract were found to have enhanced antimicrobial activity against well-known pathogenic strains, namely Staphylococcus aureus and E. coli.…”
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Efficacy of mesalazine at ulcerative colitis with nutritional failure by A. V. Korolyov, O. S. Shifrin, O. Z. Okhlobystina, L. N. Androsova, Yu. O. Sidorina

“…On the other hand, overweight patients often have more severe course of UC, as it affects important pathogenic processes. This article discusses possible links between trophological status and achievement of clinical remission, as well as between nutritional failure at UC and efficacy of mesalazine monotherapy.Conclusion. …”
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Gas-Forming Pyogenic Liver Abscess with Septic Shock by Muhammad S. Khan, Muhammad K. Ishaq, Kellie R. Jones

“…The main virulence factor of this pathogen is its α-toxin (lecithinase), which decomposes the phospholipid in cell membranes leading to cell lysis. …”
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Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in a Child with Myelodysplastic Neoplasm with Complex Karyotype and ETV6 Variant: Challenges in Treatment by Elaiza Almeida Antônio de Kós, Viviane Lamim Lovatel, Rita de Cássia Barbosa Tavares, Gerson Moura Ferreira, Bernadete Evangelho Gomes, Ana Paula Silva Bueno, Elaine Sobral da Costa, Teresa de Souza Fernandez

“…At diagnosis, the patient showed a complex karyotype with chromosomal abnormalities not yet reported together in the same clone, and likely a pathogenic variant in the ETV6 gene. The patient was treated with HLA-matched sibling HSCT, but unfortunately relapsed after HSCT with clonal cytogenetic evolution. …”
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The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies by Hessam Yaghmaei, Amirhossein Bahanesteh, Masood Soltanipur, Sobhan Takaloo, Mahdi Rezaei, Seyed Davar Siadat

“…Therefore, the study of the effect of dysbiosis on the pathogenicity of NAFLD is important. European clinical guidelines state that the best advice for people with NAFLD is to lose weight and improve their lifestyle, but only 40% of people can achieve this goal. …”
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Fetal intracranial hemorrhage in second trimester: An ominous finding even after a normal array by Yu-Hong Long, Si-Qi Wu, Xin Wang, Li-Ping Wu, Yi-Min Xiong, Xin Yang, Feng-Xiang Wei

“…However, the whole exome sequencing (WES) identified a heterozygous missense mutation that was considered pathogenic in the COL4A1 (NM_001844.6) gene: c.3715G > A (p.Gly1239Arg). …”
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Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases by Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang

“…Abstract Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding of cellular prion proteins into pathogenic forms. The development of these diseases is intricately linked to oxidative stress and mitochondrial dysfunction. …”
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Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis by Zhiqiang Zha, Chunhong Jia, Ruisi Zhou, Qinlan Yin, Yu Hu, Zhipeng Huang, Linyu Peng, Yichi Zhang, Xiaowei Qiu, Ying Chen, Yawen Zhong, Yu Wang, Menglan Pang, Shijing Lu, Chao Sheng, Liping Huang

“…Clostridium difficile (C. difficile) is associated with fetal birth weight, and its membrane vesicles (MVs) are pathogenic vectors. However, the role of C. difficile and its MVs in FGR remains unclear. …”
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Antibiotic Susceptibility Patterns of Bacterial Isolates from Pus Samples in a Tertiary Care Hospital of Punjab, India by Rugira Trojan, Lovely Razdan, Nasib Singh

“…E. coli was the most prevalent pathogen (51.2%) followed by Staphylococcus aureus (21%), Klebsiella pneumoniae (11.6%), Pseudomonas aeruginosa (5.8%), Citrobacter spp. (3.5%), Acinetobacter baumannii (2.3%), Proteus mirabilis (2.3%), and Streptococcus spp. (2.3%). …”
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