Case Report: Ehrlichiosis and Anaplasmosis in Timber Wolf Crossbreed (Canis lupus) in Bali, Indonesia by Ni Wayan Helpina Widyasanti, I Putu Cahyadi Putra, Ni Ketut Suwiti

“…Pathogenic bacteria from the Anaplasmataceae family cause ehrlichiosis and anaplasmosis in animals, including dogs and wild carnivores (wolves, foxes, raccoons, and others). …”
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Subtilases: a major prospect to the genome editing in horticultural crops by Umashankar Chandrasekaran, Umashankar Chandrasekaran, Woo Jong Hong, Hyeran Kim, Hyeran Kim

“…Given this, leveraging SBTs for horticultural crop improvement through advanced gene-editing tools is critical for enhancing crop resilience to stress and pathogens. Over the past five years, research on proteolytic enzymes, especially SBTs, has increased markedly, yet reports involving loss- or gain-of function analyses aimed at improving crop yield and quality are still limited. …”
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Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis by Kazuhiko Umazume, Jun Suzuki, Yoshihiko Usui, Yoshihiro Wakabayashi, Hiroshi Goto

“…Endogenous endophthalmitis (EE) is a rare ocular disease caused by bacterial or fungal infection of intraocular spaces by hematogenous spread of pathogens from distant infectious loci in the body. …”
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Comparative Analysis of the Full-Length Genome Sequence of a Clinical Isolate of Human Parainfluenza Virus 4B by John A. Lednicky, Thomas B. Waltzek, Micah D. Halpern, Sara B. Hamilton

“…We are engaged in airborne transmission and epidemiology studies of respiratory pathogens, with particular interest in human parainfluenza virus type 4 (hPIV-4) and other lesser studied viruses. …”
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Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1 by Zhen-Shun Gan, Qian-Qian Wang, Jia-Hui Li, Xu-Liang Wang, Yi-Zhen Wang, Hua-Hua Du

“…Iron metabolism in inflammation has been mostly characterized in macrophages exposed to pathogens or inflammatory conditions. The aim of this study is to investigate the cross-regulatory interactions between M1 macrophage polarization and iron metabolism. …”
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Occurrence of antibiotics and antibiotic resistance genes at various stages of different aquaculture modes surrounding Tai Lake, China by Congcong Wu, Congcong Wu, Haitao Ye, Mingzhu Xu, Xuan Zhao, Xuejie Zhao, Lina Li, Mingzhi Li, Yanfei Wei, Yuru Li, Baolan Hu, Baolan Hu

“…Microbial diversity also varies seasonally, especially with a gradual increase in the abundance of some pathogenic bacteria (Flavobacterium). Antibiotics and resistance genes were found at higher levels in fish ponds compared to shrimp and crab ponds, while they were lower in shrimp and crab ponds that utilized the ecological mode ponds than in the traditional culture mode ponds.ConclusionOur study presents a comprehensive characterization of antibiotics and ARGs in aquaculture waters from various perspectives. …”
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Production of an Extract with β-1,4-Xylanase Activity by <i>Fusarium oxysporum</i> f. sp. <i>melonis</i> on a Sonicated Brewer’s Spent Grain Substrate by Irma A. Arreola-Cruz, Rosalba Troncoso-Rojas, Francisco Vásquez-Lara, Nina G. Heredia-Sandoval, Alma R. Islas-Rubio

“…The <i>Fusarium oxysporum</i> species commonly found in soil include plant and human pathogens, and nonpathogenic species. <i>F. oxysporum</i> grown on lignocellulosic substrates under submerged conditions produces an extracellular enzyme profile with hemicellulolytic and cellulolytic activities. …”
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Chemical cross‐linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual‐antigen subunit vaccine by Long Chen, Chao Shang, Zihao Wang, Mengzhu Zheng, Cuiling Zhang, Dapeng Li, Zhanqun Yang, Yuchao Dong, Yuru Xu, Yunsheng Yuan, Shiyong Fan, Wu Zhong, Jian Lin, Xiao Li

“…In consideration of the current threats from the monkeypox virus and potential future emerging pathogens, the chemical cross‐linking strategy provide powerful tools.…”
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Anti-biofilm and anti-virulence potential of cell free supernatant of Akkermansia muciniphila against Salmonella by Jiaxiu Liu, Wenxiu Zhu, Huanhuan Liu, Xiaomeng Ren, Ningbo Qin, Xiaodong Xia

“…Numerous studies have demonstrated the benefits of A. muciniphila in ameliorating metabolic disorders, while little is known about the antimicrobial potential of A. muciniphila against pathogens. Here, we examined the antimicrobial and anti-virulence properties of cell free supernatant (CFS) of A. muciniphila against Salmonella Typhimurium. …”
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Analysis of the Control Effect of <i>Bacillus amyloliquefaciens</i> C4 Wettable Powder on Potato Bacterial Wilt Caused by <i>Ralstonia solanacearum</i> by Zhixiang Xing, Dan Liu, Meng Luo, Zelin Yang, Wenyuan Pang, Yexing Feng, Jiani Yan, Fumeng He, Xu Feng, Qiang Yuan, Yingnan Wang, Fenglan Li

“…The physiological and biochemical results showed that C4 wettable powder could induce rapid defense enzyme responses in leaves and enhance plant resistance to pathogenic bacteria. The results showed that C4 wettable powder effectively controlled potato bacterial wilt, and its application method was determined.…”
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Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study by Cheng-Wen Su, Yue-Cune Chang, Cheng-Li Lin, Hsin-Yi Chen

“…Based on the similar pathogenic mechanisms of NVG and ischemic stroke, we investigated the relationship between NVG and stroke by using a nationally representative sample. …”
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Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…Deep learning techniques have significantly advanced variant calling, pathogenicity prediction, splicing analysis, and MHC-peptide binding predictions in genetics. …”
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Peptide-Based Vaccination Therapy for Rheumatic Diseases by Bin Wang, Shiju Chen, Qing Zheng, Yuan Liu, Guixiu Shi

“…Peptide-based active vaccination against pathogenic cytokines such as TNF-α and interferon-α (IFN-α) is shown to be promising in treating RA or SLE. …”
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NLRP3 Is Expressed in the Spiral Ganglion Neurons and Associated with Both Syndromic and Nonsyndromic Sensorineural Deafness by Penghui Chen, Longxia He, Xiuhong Pang, Xiaowen Wang, Tao Yang, Hao Wu

“…In this study, we performed comprehensive genetic screening in a dominant family in which the proband was initially diagnosed with nonsyndromic deafness. No pathogenic mutation was identified by targeted NGS in 72 nonsyndromic and another 72 syndromic deafness genes. …”
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Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application by Federica Scalia, Alessandra Maria Vitale, Domiziana Picone, Noemi De Cesare, Maria Swiontek Brzezinska, Beata Kaczmarek-Szczepanska, Alfredo Ronca, Barbara Zavan, Fabio Bucchieri, Marta Anna Szychlinska, Ugo D’Amora

“…Kinetics release and antioxidant potential of TA and AA as well as antimicrobial activity against common pathogens <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> in accordance with ISO 22196:2011 are reported. …”
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Microbiological Hazard Identification and Exposure Assessment of Poultry Products Sold in Various Localities of Hyderabad, India by Rao V. Sudershan, R. Naveen Kumar, L. Kashinath, V. Bhaskar, K. Polasa

“…The most prevalent pathogenic bacteria isolated were S. aureus (3.4 log 10 cfu/g) and B. cereus (3.4 log 10 cfu/g). …”
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G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells by Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge

“…Neisseria meningitidis is the most frequent cause of bacterial meningitis and is one of the few bacterial pathogens that can breach the blood-brain barrier (BBB). …”
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Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…However, it remains unclear whether Hcy accumulation plays a pathogenic role in skin fibrosis. Here, we report that Hcy metabolism in fibroblasts plays a crucial role in regulating the pathogenesis of skin fibrosis. …”
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TACSTD2 in gelatinous drop-like corneal dystrophy: variant functional analysis and expression in the cornea after limbal stem cell transplantation by Liubov O. Skorodumova, Ekaterina N. Grafskaia, Daria D. Kharlampieva, Dmitry I. Maltsev, Tatiana V. Petrova, Alexandra V. Kanygina, Elena V. Fedoseeva, Pavel V. Makarov, Boris E. Malyugin

“…GDLD is characterized by the loss of barrier function in corneal epithelial cells (CECs) and amyloid deposition due to pathogenic variants in the TACSTD2 gene. Limbal stem cell transplantation (LSCT) has been suggested as an effective therapeutic alternative for patients with GDLD. …”
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Structural and functional analysis reveals the catalytic mechanism and substrate binding mode of the broad-spectrum endolysin Ply2741 by Shuang Wang, Xinxin Li, Jiahui Ma, Xiaochao Duan, Haiyan Wang, Linkang Wang, Dayue Hu, Wenwu Jiang, Xiangmin Li, Ping Qian

“…Our results demonstrated that Ply2741 could effectively eradicate multidrug-resistant gram-positive pathogens in vitro and in vivo. Structural analysis revealed that the bactericidal activity of Ply2741 depends on the classic “Cys-His-Asn” catalytic triad. …”
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