The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock by Gennaro De Pascale, Salvatore Lucio Cutuli, Mariano Alberto Pennisi, Massimo Antonelli

“…Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens. Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway. …”
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Modulation of virulence and metabolic profiles in Klebsiella pneumoniae under indole-mediated stress response by Xueyao Fang, Yanhui Chen, Longhua Hu, Shumin Gu, Junqi Zhu, Yaping Hang, Xingwei Cao, Yanping Xiao, Hong Luo, Chuwen Zhao, Lianhua Xiao, Qiaoshi Zhong

“…In this study, we demonstrate that indole enhances the pathogenicity and viability of Klebsiella pneumoniae using the Galleria mellonella infection model and serum killing assay. …”
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Novel MFSD8 Variants in a Chinese Family with Nonsyndromic Macular Dystrophy by Qin Xiang, Yanna Cao, Hongbo Xu, Zhijian Yang, Liang Tang, Ju Xiang, Jianming Li, Hao Deng, Lamei Yuan

“…The novel c.1102+2T>C variant in the MFSD8 gene was likely to affect the splicing form and predicted to be “pathogenic.” Conclusion. The novel compound heterozygous variants, c.1066C>T (p.Pro356Ser) and c.1102+2T>C, in the MFSD8 gene are likely responsible for the isolated macular dystrophy phenotype in this family. …”
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Prevalence and Characterization of Staphylococcus aureus Isolated from Meat and Milk in Northeastern Italy by Debora Pinamonti, Marisa Manzano, Michela Maifreni, Silvia Bianco, Beki Domi, Alessia Ferrin, Jamila Anba-Mondoloni, Julien Dechamps, Roman Briandet, Jasmina Vidic

“…Staphylococcus aureus is a pathogenic microorganism often found in animal-derived foods and is known for its ability to readily develop resistance to antibiotic treatments. …”
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An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytom... by Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Ryu Watanabe, Tomonori Ishii, Hideo Harigae

“…Autoantibodies against integral membrane proteins are usually pathogenic. Although anti-endothelial cell antibodies (AECAs) are considered to be critical, especially for vascular lesions in collagen diseases, most molecules identified as autoantigens for AECAs are localized within the cell and not expressed on the cell surface. …”
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Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis by Yewei Jia, Rui Li, Yixuan Li, Katerina Kachler, Xianyi Meng, Andreas Gießl, Yi Qin, Fulin Zhang, Ning Liu, Darja Andreev, Georg Schett, Aline Bozec

“…Here, we investigated the pathogenic mechanisms driving melanoma-induced osteocyte death. …”
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Oxidative impact on lipoprotein structure: Insights from dynamic light scattering by Nickolette Kong, Natalia Penaloza, Gustavo Agreda, Angela B. Nguyen, Joseph Gutheinz, Alison Tran, Nhi Nguyen, Tuong Vi Ho, Ana Marin, Birgit Mellis, Richa Chandra

“…Our work highlights the value of DLS in advancing our understanding of the pathogenic mechanisms underlying CVD development, while also providing a foundational framework to study other biological processes and their effects on lipoproteins, ultimately guiding the development of therapies to address these harmful processes.…”
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Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis by Marielle Garcia Silva, Juliana Santana de Curcio, Mirelle Garcia Silva-Bailão, Raisa Melo Lima, Mariana Vieira Tomazett, Aparecido Ferreira de Souza, Vanessa Rafaela Milhomem Cruz-Leite, Nicolau Sbaraini, Alexandre Melo Bailão, Fernando Rodrigues, Maristela Pereira, Relber Aguiar Gonçales, Célia Maria de Almeida Soares

“…Abstract Iron is an essential nutrient for all organisms. For pathogenic fungi, iron is essential for the success of infection. …”
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Dermatophytosis: Prevalence of Dermatophytes and Non-Dermatophyte Fungi from Patients Attending Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia by Adane Bitew

“…Nail, skin, and scalp scrapings were collected from 318 patients and were used for microscopy and culture study. Fungal pathogens were identified by studying the macroscopic and microscopic characteristics of their colonies. …”
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Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…MTDS are clinical syndromes coupled with abnormalities of the ETC and OXPHOS, caused by pathogenic variants in mtDNA or nDNA. Many MTDS emerge from either homoplasmic or heteroplasmic mutations of the DNA, and include mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes. …”
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The inclusion of downy mildews in a multi-locus-dataset and its reanalysis reveals a high degree of paraphyly in Phytophthora by F. Runge, S. Telle, S. Ploch, E. Savory, B. Day, R. Sharma, M. Thines

“…Pathogens belonging to the Oomycota, a group of heterokont, fungal-like organisms, are amongst the most notorious pathogens in agriculture. …”
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Nuclear Factor Erythroid 2-Related Factor 2 Intervenes the Release of Neutrophil Extracellular Traps during Lipopolysaccharide-Induced Acute Lung Injury in Mice by Junying Lu, Guilan Xiong, Hongxiang Li, Dong Zhang, Xiaohao Zhang

“…To further investigate the NETs formation was pathogenic during LPS-induced ALI, the Nrf2-KO mice were treated with DNase I. …”
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Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential by Meng L, Wen W

“…We further delve into the connections between mitochondrial dysfunction and the pathogenic mechanisms of diabetic periodontitis, such as exacerbated inflammatory responses, decreased tissue repair capacity, and autophagy dysregulation. …”
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Complete genome of mangrove-derived anti-MRSA streptomycete, Streptomyces pluripotens MUSC 135T by Hooi-Leng Ser, Kok-Gan Chan, Wen-Si Tan, Wai-Fong Yin, Bey-Hing Goh, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…This strain exhibited broad spectrum bacteriocin against several pathogens including methicillin-resistant Staphylococcus aureus (MRSA) strain ATCC BAA-44, Salmonella typhi ATCC 19430T and Aeromonas hydrophila ATCC 7966T. …”
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Molecular Detection of Virulence Factors in Salmonella serovars Isolated from Poultry and Human Samples by Kelly Johanna Lozano-Villegas, María Paula Herrera-Sánchez, Mónica Alexandra Beltrán-Martínez, Stefany Cárdenas-Moscoso, Iang Schroniltgen Rondón-Barragán

“…These findings are beneficial for the pathogenic monitoring of Salmonella in Colombia.…”
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Non-albicans Candida Infection: An Emerging Threat by Sachin C. Deorukhkar, Santosh Saini, Stephen Mathew

“…Candida spp. are among the most common fungal pathogens. Candida albicans was the predominant cause of candidiasis. …”
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Immobilization of Paenibacillus polymyxa with biopolymers to enhance the production of 2,3-butanediol by Jnanada Joshi, Sarah Vanessa Langwald, Olaf Kruse, Anant Patel

“…Conclusion Carrageenan-chitosan immobilization enables non-pathogenic Paenibacillus polymyxa to be a capable 2,3-butanediol producer with increased product formation rate, which has not been previously reported. …”
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Bot Canker of Oak in Florida Caused by Diplodia corticola and D. quercivora by Sonja Mullerin, Jason A. Smith

“… This 6-page fact sheet describes the emergence of these two pathogens of oak and grapevine in North America and Florida; the signs and symptoms of infection; mechanism of host disease and death; fungal morphology; origin, host range, and classification; and management options. …”
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Preventing Foodborne Illness Associated with Clostridium perfringens by Keith R. Schneider, Renée M. Goodrich, Dirk M. Sampath

“… This is one in a series of facts sheets discussing common foodborne pathogens of interest to food handlers, processors and retailers. …”
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Bot Canker of Oak in Florida Caused by Diplodia corticola and D. quercivora by Sonja Mullerin, Jason A. Smith

“… This 6-page fact sheet describes the emergence of these two pathogens of oak and grapevine in North America and Florida; the signs and symptoms of infection; mechanism of host disease and death; fungal morphology; origin, host range, and classification; and management options. …”
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