Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…Our model is able to describe changes in the ratio of pathogenic T cells and regulatory T cells after the appearance of islet antibodies in the pancreas. …”
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Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells by Benjamin M. Nash, To Ha Loi, Milan Fernando, Amin Sabri, James Robinson, Anson Cheng, Steven S. Eamegdool, Elizabeth Farnsworth, Bruce Bennetts, John R. Grigg, Seo-Kyung Chung, Anai Gonzalez-Cordero, Robyn V. Jamieson

“…Human induced pluripotent stem cells (hiPSCs) generated from patients and the derivative retinal cells enable the investigation of pathological and novel variants in relevant cell populations. Biallelic pathogenic variants in RPE65 cause early-onset severe retinal dystrophy (EOSRD) or Leber congenital amaurosis (LCA). …”
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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…We identified 82 cases with pathogenic or likely pathogenic SNVs and 4 cases with pathogenic CNVs, of which one case with both SNV and CNV. …”
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Characterization of Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci and Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Intensive Care... by George G Zhanel, Mel DeCorby, Kim A Nichol, Patricia J Baudry, James A Karlowsky, Philippe RS Lagace-Wiens, Melissa McCracken, Michael R Mulvey, Daryl J Hoban, The Canadian Antimicrobial Resistance Alliance (CARA)

“…BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and vancomycin-resistant enterococci (VRE) are important hospital pathogens in Canada and worldwide.…”
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Current Views of Toll-Like Receptor Signaling Pathways by Masahiro Yamamoto, Kiyoshi Takeda

“…Recent studies have demonstrated that Toll-like receptors (TLRs) play crucial roles in innate responses that lead not only to the clearance of pathogens but also to the efficient establishment of acquired immunity by directly detecting molecules from microbes. …”
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Geosmithia Species in Florida: Common Fungal Symbionts of Wood-Boring Bark Beetles by Yin-Tse Huang, Jiri Hulcr

“…These native species look similar to the pathogenic fungus but are harmless to their plant hosts. …”
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Neurosyphilis with Concomitant Cryptococcal and Tuberculous Meningitis in a Patient with AIDS: Report of a Unique Case by Jose Armando Gonzales Zamora, Luis Alberto Espinoza, Rita N. Nwanyanwu

“…Meningitis in individuals living with acquired immunodeficiency syndrome (AIDS) is most frequently infectious in origin and usually due to opportunistic infections. The most common pathogens are Cryptococcus neoformans and Mycobacterium tuberculosis. …”
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RNA Biopesticides: A Cutting‐Edge Approach to Combatting Aquaculture Diseases and Ensuring Food Security by Qiu Li, Lixing Huang

“…RNA‐based biopesticides offer a promising solution by targeting specific mRNA sequences in pathogens, thereby inhibiting their growth and reproduction. …”
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Conductivity, Surface Tension, and Comparative Antibacterial Efficacy Study of Different Brands of Soaps of Nepal by Narendra Kumar Chaudhary, Arush Bhattarai, Biswash Guragain, Ajaya Bhattarai

“…The bioactive ingredients present in them provide antibacterial potency to cure various skin problems caused by bacterial pathogens. Similarly, the antibacterial potency of LFBY was found higher than other soaps. …”
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Depression and Anxiety among Patients with Epilepsy and Multiple Sclerosis: UAE Comparative Study by Taoufik Alsaadi, Khadija El Hammasi, Tarek M. Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof

“…This finding could point to the shared pathogenic mechanisms hypothesis between depression and epilepsy.…”
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The Benefits of Early versus Late Therapeutic Intervention in Fabry Disease by Mónica Furlano, Elisabet Ars, Anna Matamala, Vicens Brossa, Joan Martí, Maria del Prado-Venegas, Jaume Crespi, Esther Roe, Roser Torra

“…Fabry disease (FD) is an X-linked lysosomal storage disorder caused by pathogenic variants of the GLA gene. Heterozygous female patients may show much more variability in clinical manifestations, ranging from asymptomatic to full-blown disease. …”
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Microbial profile of some ready-to-cook frozen food items sold in Dhaka city, Bangladesh by Md. Shamimuzzaman, Rajib Kanti Roy, Toma Rani Majumder, Nirmal Chandra Barman, Nazia Nawshad Lina, Md. Tarek Hasan, Biplab Kumar Dash

“…Microbiological analyses were carried out to enumerate total aerobic counts of mesophilic bacteria, yeast and mold and to detect some common foodborne pathogens according to standard microbiological criteria. …”
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Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution by Jianchao Ying, Jun Ye, Teng Xu, Qian Wang, Qiyu Bao, Aifang Li

“…Rhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. …”
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Sympathetic Renal Innervation and Resistant Hypertension by Vito M. Campese, Elaine Ku, Jeanie Park

“…Hypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. …”
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Biofilm architecture and dynamics of the oral ecosystem by Rina Rani Ray

“…Noteworthy pathogenic bacteria, such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans , often initiate biofilm formation. …”
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The Contribution of the Airway Epithelial Cell to Host Defense by Frauke Stanke

“…This review describes how the epithelial cell senses the presence of pathogens and inflammatory conditions, which, in turn, facilitates the activation of CFTR and thus directly promotes pathogens clearance and innate immune defense on the surface of the epithelial cell. …”
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Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people by Franziska Meiners, Bernd Kreikemeyer, Patrick Newels, Ingmar Zude, Michael Walter, Alexander Hartmann, Daniel Palmer, Georg Fuellen, Israel Barrantes

“…Our findings suggest that a dietary intervention based on strawberries can positively alter the gut microbiota of healthy elderly people as seen in an enrichment of SCFA-producing genera, increased diversity, and a reduction in potentially pathogenic bacteria.IMPORTANCEAging is often associated with changes in the gut microbiome, including a decline in beneficial bacteria and an increase in potentially pathogenic species. …”
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Genome-wide identification of short-chain dehydrogenases/reductases genes and functional characterization of ApSDR53C2 in melanin biosynthesis in Arthrinium phaeospermum by Jiao Liao, Yisi Wang, Han Liu, Sijia Liu, Peng Yan, Hang Chen, Shujiang Li, Shujiang Li

“…Still, the relationship with melanin biosynthesis of A. phaeospermum is not clear.MethodsWe aimed to predict the biological function of the SDR gene family in A. phaeospermum, identify key ApSDR genes with pathogenic roles, and explore the pathogenic mechanism. …”
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Bacterial etiologies, antimicrobial susceptibility profiles and associated factors among patients with otitis media referred to Nekemte Public Health Research and Referral Laborato... by Endalu Tesfaye Guteta, Fedasan Alemu Abdi, Seifu Gizaw Feyisa, Betrearon Sileshi Kinfu, Tadese Bekele Tafesse

“…Currently, there is little information on the prevalence and antimicrobial susceptibility patterns of pathogenic bacterial isolates from patients with otitis media in Ethiopia. …”
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A Case of Congenital Nephrotic Syndrome with Crescents Caused by a Novel Compound Heterozygous Pairing of NPHS1 Genetic Variants by Kyle N. Goodman, Pongpratch Puapatanakul, Kevin T. Barton, Mai He, Jeffrey H. Miner, Joseph P. Gaut

“…These findings confirm the novel variant as pathogenic.…”
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