Disease Association and Diagnosis of Human Herpesvirus 6 by JM Weber, GAR Wilson

Get full text

Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites by Hong Zheng, Zhangping Tan, Wenyue Xu

Get full text

Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells by Shanti Klingspor, Angelika Bondzio, Holger Martens, Jörg R. Aschenbach, Katharina Bratz, Karsten Tedin, Ralf Einspanier, Ulrike Lodemann

“…Probiotics have shown positive effects on gastrointestinal diseases; they have barrier-modulating effects and change the inflammatory response towards pathogens in studies in vitro. The aim of this investigation has been to examine the response of intestinal epithelial cells to Enterococcus faecium NCIMB 10415 (E. faecium), a probiotic positively affecting diarrhea incidence in piglets, and two pathogenic Escherichia coli (E. coli) strains, with specific focus on the probiotic modulation of the response to the pathogenic challenge. …”
Get full text

Optimized production and antiviral activity evaluation of recombinant chicken interferon-alpha using an improved Baculovirus expression system by Yuxia Zhang, Wenwen Dong, Feng Li, Kai Meng, Guiming Li, Xiaoyuan Yuan

“…Despite extensive vaccination efforts, certain pathogens continue to pose significant challenges to the poultry industry. …”
Get full text

Physiological and sanitary quality of lima bean seeds treated with essential oils by Maria Geisa da Silva Soares, Hilderlande Florêncio da Silva, Edcarlos Camilo da Silva, Raví Emanoel de Melo, Luciana Cordeiro do Nascimento

“…Pathogens in lima bean seeds grown by family farmers in the Northeast region of Brazil cause great losses and can make planting areas unviable, making it essential to search for control alternatives that do not harm the environment. …”
Get full text

Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer by Wen Wen, Sen Zhao, Yiwen Jiang, Chengzhu Ou, Changyuan Guo, Ziqi Jia, Jiayi Li, Yansong Huang, Hengyi Xu, Pengming Pu, Tongxuan Shang, Lin Cong, Xiang Wang, Nan Wu, Jiaqi Liu

“…Initial screening targeted BRCA1/2 variants followed by GS to identify pathogenic/likely pathogenic germline variants through a 3-tiered classification. …”
Get full text

Case Report: A 3’ splice site variation in RORB exon 3 associated with idiopathic generalized epilepsy in a child by Dandan Shi, Nannan Li, Caifang Fan, Qiang Luo

“…According to ACMG guidelines, this variant is classified as “likely pathogenic”. Additionally, we provide a comprehensive summary of previously reported pathogenic or likely pathogenic variants in RORB, contributing to the growing body of evidence linking this gene to epilepsy. …”
Get full text

Management of Major Seed-Borne Fungi of Cowpea (Vigna unguiculata (L.) Walp) with Four Selected Botanical Extracts by Eric Gyasi, Daniel A. Kotey, Barnabas A. Adongo, Fuleratu K. Adams, Edmund O. Owusu, Abdul Mohammed

“…Seed-borne fungal pathogens present significant constrain to the production and conservation of many seed crops including cowpea. …”
Get full text

Deterrent Effects of Clary Sage Oil and Two Major Constituents against <em>Drosophila suzukii</em> (Diptera: Drosophilidae) by Yu Wang, Fengyi Wen, Xiangyi Zhou, Guoxing Chen, Chunxia Tian, Jiali Qian, Huiming Wu, Mengli Chen

Get full text

Virulence potential of faecal <i>Escherichia coli</i> strains isolated from healthy cows and calves on farms in Perm Krai by V. S. Mihailovskaya, N. B. Remezovskaya, I. N. Zhdanova, M. Starčič Erjavec, M. V. Kuznetsova

“…Cattle are a reservoir of pathogenic and potentially pathogenic Escherichia coli (E. coli) strains, which can pose a threat to human and animal health. …”
Get full text

Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella by Devon W. Kavanaugh, Adeline Sivignon, Yannick Rossez, Zina Chouit, Christophe Chambon, Christophe Chambon, Louane Béal, Mathilde Bonnet, Michel Hébraud, Michel Hébraud, Yann Guérardel, Hang Thi Thu Nguyen, Nicolas Barnich

“…Recent studies are accumulating which demonstrate the glycosylation of surface proteins or virulence factors in pathogens, including E. coli. Using biochemical and glycobiological techniques, including biotin-hydrazide labeling of glycans and chemical and glycosidase treatments, we demonstrate (i) the presence of a well-defined and chemically resistant FimA oligomer in several strains of pathogenic and non-pathogenic E. coli, (ii) the major subunit of type I fimbriae, FimA, in pathogenic and laboratory strains is recognized by concanavalin A, (iii) standard methods to remove N-glycans (PNGase F) or a broad-specificity mannosidase fail to remove the glycan structure, despite the treatments resulting in altered migration in SDS-PAGE, (iv) PNGase F treatment results in a novel 32 kDa band recognized by anti-FliC antiserum. …”
Get full text

Fungal Biodiversity of Apple Bark, Leaves, Stems, and Fruit Under Rain Shelters with Reduced Fungicide Schedule by Claudia Maria Oliveira Longa, Lidia Nicola, Massimo Pindo, Elisa Bozza, Carmela Sicher, Daniel Bondesan, Ilaria Pertot, Michele Perazzolli

“…The use of rain shelters is a promising agronomic practice to protect crops from rainfall, reducing the need for fungicides to control certain pathogens that take advantage of leaf wetness. However, the combined condition of absence of rain and reduced fungicide schedule can affect the fungal populations, possibly favoring biocontrol agents and/or other pathogens. …”
Get full text

Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

“…These nanodelivery systems demonstrate remarkable specificity against target pathogens and effectively localize to bacteria‐infected lungs in vivo. …”
Get full text

A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae by Zhicheng Huang, Qing Wang, Yan Li, Pengyun Huang, Jian Liao, Jing Wang, Hui Li, Yingying Cai, Jiaoyu Wang, Xiaohong Liu, Fu-Cheng Lin, Jianping Lu

“…Abstract Carbon catabolite repression (CCR) and de-repression (CCDR) are critical for fungal development and pathogenicity, yet the underlying regulatory mechanisms remain poorly understood in pathogenic fungi. …”
Get full text

Uterine Necrosis Associated with Fusobacterium necrophorum Infection by T. Widelock, R. Elkattah, S. Gibbs, Z. Mashak, S. Mohling, S. DePasquale

“…Fusobacterium necrophorum is infrequently implicated as a pathogenic organism. When pathogenic, the typical clinical presentation is that of pharyngitis, cervical adenopathy, and unilateral thrombophlebitis of the internal jugular vein. …”
Get full text

Modulation of Host Cell Signal Transduction Pathways by Helicobacter Pylori Infection by Peter JM Ceponis, Nicola L Jones

“…Bacterial pathogens modulate host cell signal transduction responses to establish infection and cause disease. …”
Get full text

Innate Immune Cells in Liver Inflammation by Evaggelia Liaskou, Daisy V. Wilson, Ye H. Oo

“…Innate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host. …”
Get full text

The genus Nocardia as a source of new antimicrobials by Napawit Nonthakaew, Liam K. R. Sharkey, Sacha J. Pidot

“…Abstract The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimicrobial secondary metabolites. …”
Get full text

Microbial Contamination, an Increasing Threat to the Consumption of Fresh Fruits and Vegetables in Today’s World by Gadafi Iddrisu Balali, Denis Dekugmen Yar, Vera Gobe Afua Dela, Priscilla Adjei-Kusi

“…Thus, many pathogenic microbes have found their way into fresh fruits and vegetables which are a great source of a healthy diet for humans. …”
Get full text

Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. by Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson

“…Understanding the genetic pathways that regulate how pathogenic fungi respond to their environment is paramount to developing effective mitigation strategies against disease. …”
Get full text