Evaluation of Antifungal Analysis of Selected Food Products Obtained In the Local Markets of Peshawar KPK Pakistan by Shakir Ullah, Hayat Khan, Yasir Zubair, Muneeba Zubair, Usman Saeed, Maryam Bibi, Eidul Ahad, Zeeshan Ullah, Adam khan Gohar, Usman Shah, Sadiq Ur Rahman, Muhammad Iqbal Khan Rahman

“…The objective of this study was to isolate and evaluate the antifungal analysis of food-borne fungal pathogens. For the evaluation of pathogenic fungi Milk, Chutney, Apple, Spinach, Salad, Guava, Fish, and Peas were taken. …”
Get full text

The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…Abstract Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death and the effectors involved remain poorly characterized. …”
Get full text

Seasonal Variation in Antimicrobial Activity of Crude Extracts of Psammaplysilla sp. 1 from Phillips Reef, South Africa by Wasswa Cuthbert Kibungu, Justine Fri, Anna-Maria Clarke, Anthony Otigbu, Henry Akum Njom

“…The sponge crude extracts’ antimicrobial activity was evaluated using an agar well diffusion assay against 5 pathogens. Phytochemical screening was conducted to identify the presence of 7 critical phytochemical groups. …”
Get full text

Complete mitochondrial genomes of Culicoides brevitarsis and Culicoides imicola biting midge vectors of Bluetongue Virus by Khandaker Asif Ahmed, Anjana Karawita, Melissa J. Klein, Luana Fiorella Mincarelli, Barbara Secondini, Giuseppe Satta, Massimo Ancora, Cipriano Foxi, Marco Di Domenico, Michela Quaglia, Maria Goffredo, Alessio Lorusso, Cesare Cammà, Leon Court, Rahul V. Rane, Tom K. Walsh, Prasad N. Paradkar, Debbie Eagles, Gunjan Pandey, Christopher M. Hardy

Get full text

Gastrointestinal Microbiota and Some Children Diseases: A Review by Thabata Koester Weber, Isabel Polanco

“…There is emerging evidence indicating that quantitative and qualitative changes on gut microbiota contribute to alterations in the mucosal activation of immune system leading to intra- or extra-intestinal diseases. A balance between pathogenic and beneficial microbiota throughout childhood and adolescence is important to gastrointestinal health, including protection against pathogens, inhibition of pathogens, nutrient processing (synthesis of vitamin K), stimulation of angiogenesis, and regulation of host fat storage. …”
Get full text

Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella by Massimiliano Marvasi, George Hochmuth, Max Teplitski

“… Non-typhoidal Salmonella has emerged as one of the problematic human pathogens associated with fresh produce, nuts, and complex foods containing them. …”
Get full text

Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella by Massimiliano Marvasi, George Hochmuth, Max Teplitski

“… Non-typhoidal Salmonella has emerged as one of the problematic human pathogens associated with fresh produce, nuts, and complex foods containing them. …”
Get full text

Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells by Julio Aliberti

“…On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. …”
Get full text

A new atypical splice mutation in PKD2 leading to autosomal dominant polycystic kidney disease in a Chinese family by Junlin Zhang, Yiting Wang, Yingwang Zhao, Fang Liu

“…These findings suggested that the atypical splice site alteration, IVS6+5G>C, in the PKD2 gene was the potential pathogenic mutation leading to ADPKD in this Chinese family. …”
Get full text

Effect of fungal, oomycete and nematode interactions on apple root development in replant soil by Emma L. Tilston, Gregory Deakin, Julie Bennett, Thomas Passey, Nicola Harrison, Felicidad Fernández, Xiangming Xu

“…No single organism has been identified as the universal causal agent, but there is increasing evidence that multiple soil-borne plant pathogenic fungi and oomycetes form an ARD disease complex. …”
Get full text

Contribution of domestic animals’ feces to the occurrence of diarrhoea among children aged 6–48 months in Sidama region, Ethiopia: a laboratory-based matched case-control study by Argaw Ambelu, Gorfu Geremew Gunsa, Alemayehu Haddis

“…The presence of diarrhoea-causing pathogens (Campylobacteria, Escherichia coli, non-typhoidal salmonella, Shigella and Cryptosporidium) was detected using culture media, biochemical tests, gram stain, catalase and oxidase tests. …”
Get full text

Multigene Panel Testing in Turkish Hereditary Cancer Syndrome Patients by Esra ARSLAN ATES, Ayberk TURKYILMAZ, Ceren ALAVANDA, Ozlem YILDIRIM, Ahmet Ilter GUNEY

“…Objective: Hereditary cancer syndromes (HCSs) are a heterogenous group of disorders caused by germline pathogenic variations in various genes that function in cell growth and proliferation. …”
Get full text

Exploring Anti-Breast Cancer Effects of Live Pediococcus acidilactici and Its Cell-Free Supernatant Isolated from Human Breast Milk by Naa N. Adumuah, Jude T. Quarshie, Harry Danwonno, Anastasia R. Aikins, Elmer N. Ametefe

Get full text

Mixed Red-Complex Bacterial Infection in Periodontitis by N. Suzuki, M. Yoneda, T. Hirofuji

“…This article discusses the interspecies pathogenic interactions within the red complex.…”
Get full text

Investigation of potential Shiga toxin producing Escherichia coli (STEC) associated with a local foodborne outbreak using multidisciplinary approaches by Kristen A. Lozinak, Niketa Jani, Jayanthi Gangiredla, Isha Patel, Christopher A. Elkins, Zonglin Hu, Prince A. Kassim, Robert A. Myers, Pongpan Laksanalamai

“…However E. coli are generally innocuous commensal organisms, and there is a need to discriminate pathogenic from non-pathogenic isolates rapidly and accurately. …”
Get full text

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants by Aziz Ul Ikram, Muhammad Saad Shoaib Khan, Faisal Islam, Sulaiman Ahmed, Tengfang Ling, Feng Feng, Zongtao Sun, Huan Chen, Jian Chen

“…As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. …”
Get full text

Genetics of Primary Adrenal Insufficiency Beyond CAH in Saudi Arabian Population by Mohamed H. Al‐Hamed, Alya Qari, Lamya Alrayes, Mohammed Alotaibi, Zainab Al Masseri, Afaf Alotaibi, Abdullah AlAshwal, Zuhair N. AlHassnan, Afaf Alsagheir

“…Results In 30 unrelated families with PAI, pathogenic/likely pathogenic variants were detected in 27 families with a diagnostic yield of (90%). …”
Get full text

Limited transmission of avian influenza viruses, avulaviruses, coronaviruses and Chlamydia sp. at the interface between wild birds and a free-range duck farm by Chloé Le Gall-Ladevèze, Benjamin Vollot, Julien Hirschinger, Laëtitia Lèbre, Rachid Aaziz, Karine Laroucau, Jean-Luc Guérin, Mathilde Paul, Julien Cappelle, Guillaume Le Loc’h

“…Abstract Recent outbreaks of highly pathogenic avian influenza in Europe have raised questions regarding the epidemiological role of commensal wild birds on free-range poultry farms. …”
Get full text

Deep learning–based assessment of missense variants in the COG4 gene presented with bilateral congenital cataract by Shaohua Zhang, Yang Sun, Yinghong Ji, Li Ning, Binghe Xiao, Maierdanjiang Ainiwaer, Houyi Liu, Yingying Hong

“…Objective We compared the protein structure and pathogenicity of clinically relevant variants of the COG4 gene with AlphaFold2 (AF2), Alpha Missense (AM), and ThermoMPNN for the first time.Methods and analysis The sequences of clinically relevant Cog4 missense variants (one novel identified p.Y714F and three pre-existing p.G512R, p.R729W and p.L769R from Uniprot Q9H9E3) were imported into AF2 for protein structural prediction, and the pathogenicity was estimated using AM and ThermoMPNN. …”
Get full text

Genes related to neural tube defects and glioblastoma by Rui Cao, Yurong Liu, Kaixin Wei, Ning Jin, Yuxiang Liang, Ruifang Ao, Weiwei Pan, Xiang Wang, Xiuwei Wang, Li Zhang, Jun Xie

Get full text