Museomics of Carabus giant ground beetles shows an Oligocene origin and in situ alpine diversification by Pauli, Marie T., Gauthier, Jérémy, Labédan, Marjorie, Blanc, Mickael, Bilat, Julia, Toussaint, Emmanuel F. A.

“…The development of museomics represents a major paradigm shift in the use of natural history collection specimens for systematics and evolutionary biology. …”
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Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes by Leslie P. Cousens, Yan Su, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott, Anne S. De Groot

“…Implementation of these defined regulatory T cell epitopes for therapy of T1D and other autoimmune diseases may lead to a paradigm shift in disease management.…”
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Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment... by Polina Weitzenfeld, Nurit Meron, Tal Leibovich-Rivkin, Tsipi Meshel, Adit Ben-Baruch

“…These dramatic findings indicate that TNFα can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.…”
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Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage by Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, Federico Carrión, Brenda Iglesias, Kevin Madauss, Lucía Canclini

“…This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despite their identification in several other pathologies. …”
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Electromagnetic metamaterial agent by Shengguo Hu, Mingyi Li, Jiawen Xu, Hongrui Zhang, Shanghang Zhang, Tie Jun Cui, Philipp del Hougne, Lianlin Li

“…Here, we propose and experimentally prototype a paradigm shift toward a metamaterial agent (coined metaAgent) endowed with reasoning and cognitive capabilities enabling the autonomous planning and successful execution of diverse long-horizon tasks, including electromagnetic (EM) field manipulations and interactions with robots and humans. …”
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Molecularly redefining small bowel adenocarcinoma to accelerate precision patient care – protocol of a multicenter observational cohort biomarker study by Rasmus Haunstrup Døssing, Julia Johanna Almer Broman, Colm J. O’Rourke, Elizaveta Mitkina Tabaksblat, Jesper Bøje Andersen, Carsten Palnæs Hansen, Tim Svenstrup Poulsen, Estrid V. S. Høgdall, Jakob Hagen Vasehus Schou, Dan Høgdall

“…By identifying molecular subgroups, the research could enable the development of personalized treatment strategies, a paradigm shift within SBA. The study acknowledges the challenges of working with orphan diseases, including limited patient numbers and diverse clinical presentations. …”
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Science-based communication and education needed to improve forest carbon science, policy, and management outcomes by Chad C Papa, Kylie Clay, Lauren T Cooper, Scott C Stark

“…Because forests stand to play a significant role in reaching net-zero emission targets, politicians and policymakers must act decisively to engineer a rapid paradigm shift that maintains forests’ resilience and adaptive capacity. …”
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A cycle of invisibilisation: a qualitative study of Brazilian health system factors shaping access to long COVID care by Emma-Louise Aveling, Margareth Crisóstomo Portela, Letícia Soares, Bárbara Caldas, Brenda Sabaine, Flora Cornish

“…Doing so offers wider benefits beyond patients with LC. We call for a paradigm shift in clinical approaches to IACCs.…”
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A Chisel Generator for Standardized 3-D Die-to-Die Interconnects by Harrison Liew, Farhana Sheikh, Jong-Ru Guo, Zuoguo Wu, Borivoje Nikolic

“…The 3-D PHY generator framework and features detailed in this work can be used to produce a reference implementation for a standard like UCIe-3-D, representing a significant paradigm shift from current specification and design methodologies for 2.5-D D2D interconnect (e.g., UCIe) implementations. …”
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Mitigating antimicrobial resistance through effective hospital wastewater management in low- and middle-income countries by Yaovi Mahuton Gildas Hounmanou, Yaovi Mahuton Gildas Hounmanou, Adonias Houefonde, I-CRECT Consortium, Tram Thuy Nguyen, Anders Dalsgaard, Linh Viet Nguyen, Tung Xuan Nguyen, Troung Nhat My, Lan Thi Le, Huyen Thi Vu, Ngoc Thi Bich Hoang, Dien M. Tran, Thi Anh Mai Pham, Phuc D. Pham, Dennis Nurjadi, Flavie Goutard, Thirumalaisamy P. Velavan, Van Anh Thi Dinh, Bent Jörgensen, Le Huu Song, Nhung T.T. Nguyen, Etienne Loire, Åse Östholm, Lennart E. Nilsson, Tuyet Hanh T. Tran, Phuc H. Phan, Mattias Larsson, Linus Olson, Håkan Hanberger

“…This perspective calls for a paradigm shift in HWW management in LMIC, emphasizing the broader implementation of onsite treatment systems, which are currently rare. …”
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The youth mental health crisis: analysis and solutions by Patrick McGorry, Patrick McGorry, Hasini Gunasiri, Hasini Gunasiri, Cristina Mei, Cristina Mei, Simon Rice, Simon Rice, Caroline X. Gao, Caroline X. Gao

“…Potential new explanatory factors and megatrends, potentially flowing from a paradigm shift in the global political economy which has largely passed under the radar, yet which has produced fragmentation and inequality, are identified, with the COVID-19 pandemic further intensifying these trends. …”
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Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex by Joyce Zhang, Deneen Argueta, Xiaoping Tong, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda

“…These abnormal cells emerge during early brain development as a result of a hyperactive mTOR pathway and may express both neuronal and glial markers. A paradigm shift occurred when our group demonstrated that BC/GC in pediatric cases of FCDIIb and TSC are unable to generate action potentials and lack synaptic inputs. …”
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Rainfed agriculture in Ethiopia: a systematic review of green water management pathways to improve water and food security by Ermias Teferi, Ermias Teferi, Tibebu Kassawmar, Tibebu Kassawmar, Woldeamlak Bewket, Woldeamlak Bewket, Gete Zeleke, Gebiaw T. Ayele, Greg O’Donnell, Claire Walsh

“…Increasing crop yields through better soil, water, and crop management practices can significantly improve water productivity, offering “windows of opportunity” to enhance food and water security. Thus, a paradigm shift from the traditional narrow focus on soil erosion control towards an integrated green-blue water management approach in water and agricultural policies and programs is urgently required. …”
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Liquid–Solid Triboelectric Nanogenerator‐Based DNA Barcode Detection Biosensor for Species Identification by Wenlong Ma, Jiawei Li, Xiaolin Qu, Shao‘e Sun, Yanan Zhou, Yitong Liu, Peng Wang, Zhongli Sha

“…The present work provides a paradigm‐shift way to develop an inexpensive and accurate technique to detect DNA barcode for species identification, and paves a novel way for the application of liquid–solid TENG.…”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…The novel approach of utilizing microbial-derived PDRN opens new avenues for therapeutic applications in oxidative stress management, tissue regeneration, and immune modulation, paving the way for a paradigm shift in PDRN sourcing and functionality.…”
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Adaption oder Anpassung? Umweltbewusstsein in der Region um den Plattensee/Balaton (Adaptation or a Change in Attitude? Environmental Awareness in the Region of Lake Balaton) by Magdolna Leveleki

“…If so, what could be the essence of this „paradigm shift” and whether any sign of change can be observed. …”
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Implementation of a program to strengthen oral hygiene in patient with cleft deformities: a prospective randomized controlled clinical trial by Camille Boeffard, Justine Loin, Roselyne Clouet, Alexis Gaudin, Pierre Corre, Tony Prud’Homme

“…Discussion This is a single-center study which, if conclusive, could lead to a paradigm shift in the dental care pathway for cleft patients. …”
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The evolutionary journey to a new normal for learning and capacity building of healthcare workers to prepare and respond to health emergencies across Africa by Boukaré Bonkoungou, Fausta Mosha, Amarachi Abianuru, Joseph Okeibunor, Heini Utunen, Giselle Balaciano, Ana C. Barbosa de Lima, Lauren Burke, Shannon McKenna, Sukriti Nag, Abdou Salam Gueye, Bruce Struminger

“…This initiative has reached more health professionals than pre-pandemic in-person training, facilitating more equitable access to essential knowledge and best practices.ConclusionThe WHO AFRO and Project ECHO partnership navigated a variety of challenges, while establishing a paradigm shift in learning strategies. Emphasizing a digital learning first approach, while retaining in-person elements, this collaborative initiative offers insights for future healthcare education, highlighting adaptability, cost-efficiency, equity, and new technologies in addressing global health challenges. …”
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Roads to remission: evolving treatment concepts in type 2 inflammatory diseases by Marek Lommatzsch, Katharina Blumchen, Lisa A. Beck, Jean Bousquet, Guy G. Brusselle, Wytske J. Fokkens, Eckard Hamelmann, Susanne Lau, Hagen Ott, Oliver Pfaar, Hugh A. Sampson, Josef S. Smolen, Christian Taube, Ingo H. Tarner, Martin Wagenmann, Thomas Werfel, Margitta Worm, Harald Renz

“…Currently, there is a major paradigm shift in the management of these diseases, towards the concept of disease modification and the treatment goal remission, regardless of severity and age. …”
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Comparative analysis of microsurgical clipping versus endovascular coiling for middle cerebral artery aneurysms: a prospective study at Ain Shams University hospitals by Mohamed Khamis, Hamdy Ibrahim, Ahmed M.Elsayed, Sameh R. Tawadros, Mohamed Helmy Abdelshafouk Mohamed, K. El-Bahy

“…The pivotal International Subarachnoid Aneurysm Trial (ISAT) of 2002 heralded a paradigm shift toward endovascular coiling as the preferred treatment modality for ruptured IAs, prompting a widespread adoption of this approach in neurosurgical centers worldwide. …”
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