A rare splice site mutation in the gene encoding glucokinase/hexokinase 4 in a patient with MODY type 2 by D. E. Ivanoshchuk, E. V. Shakhtshneider, A. K. Ovsyannikova, S. V. Mikhailova, O. D. Rymar, V. I. Oblaukhova, A. A. Yurchenko, M. I. Voevoda

“…When nonclassical diabetes mellitus is being diagnosed in young people and pregnant women, genetic testing is needed to verify the diagnosis and to select the optimal treatment method.…”
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A new process for extracting vanadium by direct calcification using the heat of molten vanadium slag by Qu J.-W., Zhang T.-A., Lv G.-Z., Chen Y.

“…When the mass ratio of Ca to V was 0.75, under the optimal acid leaching conditions (particle size of calcified vanadium slag less than 0.075 mm, leaching temperature 90 ℃, H2SO4 concentration 200 g.L-1, liquid-to-solid ratio 6:1 ml.g-1, leaching time 60 min, and stirring speed 300r.min-1), the leaching rate of vanadium from calcified vanadium slag could exceed 90%. …”
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Major and minor perineural invasion in salivary gland cancer by Fei Liu, Yinglin Chu, Qizhe Zheng, Yunshuang Hu, Yiyi Wang, Lu Qin, Shuaikun Fu, Suping Wang

“…ObjectiveTo delineate the distribution of perineural invasion (PNI), evaluate its impact on patient survival, and identify optimal criteria for initiating adjuvant radiation therapy (RT) in cases of PNI associated with salivary gland cancer (SGC).MethodsThis retrospective study categorized enrolled patients into three groups based on PNI status (none, minor, or major), defined by the extent of nerve involvement. …”
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Direct anterior and direct lateral approach in patients with femoral neck fractures receiving a total hip arthroplasty: a randomized controlled trial by John Magne Hoseth, Tommy Frøseth Aae, Øystein Bjerkestrand Lian, Tor Åge Myklebust, Otto Schnell Husby

“… Background and purpose: The optimal approach to the hip joint in patients with displaced femoral neck fractures (dFNF) receiving a total hip arthroplasty (THA) remains controversial. …”
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Predicting the exposure of mycophenolic acid in children with autoimmune diseases using a limited sampling strategy: A retrospective study by Ping Zheng, Ting Pan, Ya Gao, Juan Chen, Liren Li, Yan Chen, Dandan Fang, Xuechun Li, Fei Gao, Yilei Li

“…This study aims to use machine learning and deep learning algorithms to develop a prediction model of MPA exposure for pediatric autoimmune diseases with optimizing sampling frequency. Pediatric autoimmune patients' data were collected at Nanfang Hospital between June 2018 and June 2023. …”
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In Vitro Bioaccessibility of Edible Seaweed Proteins from the Chilean Coast and Proteins from the Novel Seaweed-Derived Mycoprotein by Catalina Landeta-Salgado, Javiera Munizaga, María Paz González-Troncoso, Anamaría Daza-Sanchez, Irene Martínez, María Elena Lienqueo

“…These findings highlight the need to characterize the nutritional properties of edible seaweeds in Chile further and emphasize the importance of optimized processing techniques, such as fermentation or bioconversion, to improve the nutritional potential of seaweeds and develop high-quality food ingredients for diverse applications.…”
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Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extra... by Yun Zuo, Jie Wang, Xiaoju Huang, Yuan Liu, Zhiwu Zeng, Ruiqing Xu, Yawen Chen, Kui Liu, Hongkang You, Jingang Wang

“…Four defects with different corrosion levels were classified using the optimized SVM model, with an accuracy rate of 95%. …”
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Genome-Wide Identification and In Silico Expression Analysis of <i>CCO</i> Gene Family in <i>Citrus clementina</i> (Citrus) in Response to Abiotic Stress by Sadaf Sarwar, Adnan Sami, Muhammad Zeshan Haider, Layba Tasawar, Jannat Akram, Arsalan Ahmad, Muhammad Shafiq, Haitham E. M. Zaki, Gabrijel Ondrasek, Muhammad Shafiq Shahid

“…Notably, two genes, <i>CcNCED1</i> and <i>CcNCED3</i>, were significantly expressed among the <i>CCO</i> genes, and these were found to be expressed during stress and played a crucial role in enabling optimal plant development. Furthermore, a comprehensive genome-wide comparison of <i>CCO</i> genes in <i>C. …”
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Composting of chicken manure with a mixture of sawdust and wood shavings under forced aeration in a closed reactor system by Waqas Qasim, Min Ho Lee, Byeong Eun Moon, Frank Gyan Okyere, Fawad Khan, Mohammad Nafees, Hyeon Tae Kim

“…Abstract Purpose This study aimed to achieve successful composting and aeration rate and to optimize the carbon:nitrogen (C:N) ratio to provide favourable conditions for the process. …”
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Multimodality Treatment Including Triplet Regimen as First-Line Chemotherapy May Improve Prognosis of Serum AFP-Elevated Gastric Cancer with Liver Metastasis by Yakun Wang, Lin Shen, Ming Lu, Zhi Ji, Xiaotian Zhang

“…This study sought to investigate the optimal treatment modality. A total of 319 gastric cancer patients with liver metastasis (GCLM) whose serum AFP levels were tested before treatment were enrolled in this study. …”
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THE POSSIBILITIES OF TREATMENT OF PATIENTS WITH MALIGNANT NEOPLASMS OF THE FEMALE REPRODUCTIVE SYSTEM WITH METASTATIC BRAIN LESION by A. M. Zaytsev, E. G. Novikova, O. N. Kirsanova, M. I. Kurzhupov, E. A. Potapova

“…Genital tumor metastasis in the brain is around 5%. The optimal treatment strategy of intracerebral metastases in this case is still an unsolved problem: the presence of foci of more than 3 cm surgery and then chemotherapy and radiation therapy is recommended; with smaller foci method of choice is a stereotactic brain radiosurgery followed by chemotherapy.Purpose. …”
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A multicenter micro-costing analysis of flexible cystoscopic procedures in Korea by Uiemo Je, Woong Kyu Han, Hee-Kyo Jeong, Hankil Lee, Kwang Suk Lee, Sung Ku Kang, Byeong-Ju Kwon, Sung-Uk Kuh

“…Given the results, reevaluating these rates is essential to ensure fair compensation for healthcare providers and to deliver optimal patient care." …”
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Regional differences in triage decisions affect hospital mortality among frail COVID-19 patients in the COvid MEdicaTion study by Julia Minnema, Roos Sablerolles, Janneke van Kempen, Hugo van der Kuy, Harmke Polinder-Bos, Bob van de Loo, Jorie Versmissen, Miriam L. Haaksma, Melvin Lafeber, Miriam C. Faes, on behalf of the COMET research team^

“…Conclusion Our study shows that, despite variation in rates of ICU admission between northern and southern countries for frail patients, no difference in in-hospital mortality was observed. This might help optimize prioritization of resources in a pandemic setting while offering options for palliative care instead of ICU admission.…”
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Radiomics analysis of thoracic vertebral bone marrow microenvironment changes before bone metastasis of breast cancer based on chest CT by Hao-Nan Zhu, Yi-Fan Guo, YingMin Lin, Zhi-Chao Sun, Xi Zhu, YuanZhe Li

“…Multiple machine learning algorithms were utilized to construct various radiomics models for predicting the risk of bone metastasis, and the model with optimal performance was integrated with clinical features to develop a nomogram. …”
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Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer by Birte Valentin, Lars Schimmöller, Matthias Boschheidgen, Tim Ullrich, Thomas Andreas Thiel, Alexandra Ljimani, Jan Philipp Radtke, Thomas Benkert, Peter Albers, Gerald Antoch, Hans-Jörg Wittsack, Michael Quentin

“…Abstract Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. …”
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Evaluation of urban water cycle health status based on DPSIRM framework and AHP-FCE-Cloud model by Jiageng Hu, Fuqiang Wang, Peiheng Liu, Subing Lü, Cheng Lü, Furong Yu

“…This study employs the Driving force-Pressure-State-Impact-Response-Management (DPSIRM) framework, using key policy implementation milestones as benchmarks to divide the timeline into three evaluation phases, thereby optimizing the urban water cycle health evaluation system. …”
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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

“…Furthermore, we collected an additional set of malignant cytological and matched tumor samples from 84 NSCLC patients, cfDNA & cfRNA extraction and double detection for driver gene mutations was validated using the multi‐gene mutations detection by RT‐qPCR. Results Under the optimal protection system, 91.0% (101/111) of cfRNA were protected effectively. …”
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Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages by Cong Chen, Zhengfeng Liang, Yuqi He, Yan Gao, Shuhui Ouyang, Lili Wang, Jianghua Liu, Jingsong Cao

“…The findings provide a new theoretical and experimental bases for optimizing the strategies for prevention and treatment of T2D VC.…”
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Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start by Marta Arrigoni, Nitash Zwaveling-Soonawala, Stephen H LaFranchi, A S Paul van Trotsenburg, Christiaan F Mooij

“…Europe, North America, Oceania, China, Japan and Israel have efficient programs with optimal coverage. Recently, some countries of Central and Western Asia have implemented NBS programs for CH, and coverage has increased in several Asian countries. …”
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GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer by Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang, Pengju Wang

“…Then, VVL-DD was armed with an optimal combination of immunomodulatory molecules, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-21 (IL-21), to produce VVL-GL21. …”
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