Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics by Mikhail T. Silk, Nina Mikkilineni, Tarik C. Silk, Emily C. Zabor, Irina Ostrovnaya, Ari A. Hakimi, James J. Hsieh, Etay Ziv, Natasha Rekhtman, Stephen B. Solomon, Jeremy C. Durack

“…Since non-formalin-fixed DNA is advantageous for molecular studies, workflows that optimize core needle biopsy yield for molecular characterization should be explored.…”
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Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling by Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David T.W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

“…Therefore, gene and/or protein expression analyses for this molecular marker could be adopted for ST-EPN ZFTA-RELA prognostication and may help assign patients to optimal therapies in prospective clinical trials.…”
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Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer r... by А. А. Timofeeva, V. I. Minina, A. V. Torgunakova, О. А. Soboleva, R. А. Тitov, Ya. А. Zakharova, M. L. Bakanova, А. N. Glushkov

“…Using MDR analysis, the most optimal statistically significant 3-locus model of gene-gene interactions in the development of luminal B Her2-negative subtype breast cancer was found. …”
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Machine learning model and nomogram to predict the risk of heart failure hospitalization in peritoneal dialysis patients by Liping Xu, Fang Cao, Lian Wang, Weihua Liu, Meizhu Gao, Li Zhang, Fuyuan Hong, Miao Lin

“…The performance was validated using fivefold cross-validation. The optimal ML algorithm was used to construct the models to predictive the risk of the HF and all-cause mortality. …”
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Multiple Dimensions Define Thresholds for Population Resilience of the Eastern Oyster, Crassostrea virginica by Megan K. La Peyre, Hongqing Wang, Shaye E. Sable, Wei Wu, Bin Li, Devin Comba, Carlos Perez, Melanie Bates, Lauren M. Swam

“…These conditions are defined by a minimum, maximum, and optimal ranges of single and combined factors. Forays into environmental conditions outside the minimum or maximum tolerance of a species (i.e., thresholds) are predicted to have large effects on a species' population and may help predict population resilience in the face of changing conditions. …”
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Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. …”
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Can Caffeine Be an Effective Ergogenic Aid in Combat Sports? A Comprehensive Review by Marcin Komorowski, Michał Janiszewski, Aleksandra Pelczarska, Rafal Kaczorowski, Tomasz Forenc, Jaromir Hunia, Julia Górny, Jonasz Jurek, Alicja Kapciak

“…Aim of Study: The primary aim of this study is to analyze the effects of caffeine on performance in combat sports, considering various factors such as optimal dosage, timing, and the impact of habitual caffeine consumption. …”
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Can “LITE” Procedure Combined With a Short Course Antibiotic Treatment Be Effective in Treating the Chronic PJI?—A Prospective Randomized Controlled Trial by Yang Chen, Haiqi Ding, Qijin Wang, Zida Huang, Chaofan Zhang, Wenbo Li, Yansheng Lin, Yufeng Guo, Xinyu Fang, Wenming Zhang

“…ABSTRACT Objective The prevailing treatment for chronic periprosthetic joint infection (PJI) is a two‐stage exchange, yet the optimal duration of antibiotic therapy following this procedure remains a topic of debate. …”
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An AI recognition method for children's clinical operative pain by skin potential (SP) signal by Mingxuan Huang, Cangcang Fu, Linbo Chui, Jiadong He, Xiaozhi Wang, Jikui Luo, Bin Wu, Yonggang Chen, Shaohua Hu, Jihua Zhu, Yubo Li

“…Then, we applied wavelet transform (WT) to capture the time-frequency characteristics of the signals and extract energy features and created a feature set comprising 30 features and selected 10 most relevant ones using the “SelectKBest” function.We compared six algorithms, optimized their parameters, and evaluated the stability and fitting performance of each algorithm. …”
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Identification and Functional Analysis of miRNAs in Extracellular Vesicles of Semen Plasma from High- and Low-Fertility Boars by Weidong Chen, Yanshe Xie, Zhiqian Xu, Yijun Shang, Wenzheng Yang, Pengyao Wang, Zhenfang Wu, Gengyuan Cai, Linjun Hong

“…Artificial insemination (AI), as an efficient assisted reproduction technology, can help the livestock industry to improve livestock and poultry breeds, optimize production performance and improve reproductive efficiency. …”
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Integrative machine learning frameworks to uncover specific protein signature in neuroendocrine cervical carcinoma by Tao Shen, Tingting Dong, Haiyang Wang, Yi Ding, Jianuo Zhang, Xinyi Zhu, Yeping Ding, Wen Cai, Yalan Wei, Qiao Wang, Sufen Wang, Feiyun Jiang, Bin Tang

“…Eleven machine-learning algorithms were packaged into 66 combinations, of which we selected the optimal algorithm, including randomForest, SVM-RFE, and LASSO, to select key NECC specific dysregulated proteins (kNsDEPs). …”
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Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

“…The present study aimed to prepare and optimize lamotrigine-loaded bovine serum albumin nanoparticles (LAM-NP) using the Quality by Design (QbD) approach and to investigate both the in vitro and ex vivo effects of different cross-linking agents glutaraldehyde (GLUT), glucose (GLUC) and 1-(3-dimethylaminutesopropyl)-3-ethylcarbodiimide hydrochloride (EDC) on intranasal applicability. …”
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Epidemiology and Treatment Patterns of Fistulizing Crohn’s Disease in a Large, Real-World Australasian Cohort by Jack McNamara, William Wilson, Joseph L. Pipicella, Simon Ghaly, Jakob Begun, Ian C. Lawrance, Richard Gearry, Jane M. Andrews, Susan J. Connor

“…Conclusion: People with fCD used more health-care resources, making this an important area for further research into care gaps to improve outcomes and optimal treatment approaches.…”
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Adaptation of an additively manufactured reactor concept for catalytic methanation with in-situ tar co-reforming of biogenic syngas by Jakob Müller, Alexander Feldner, Simon Markthaler, Peter Treiber, Jürgen Karl

“…ADDmeth3.1 uses a dedicated internal channel structure that serves as a counter-current heat exchanger for the feed gas, whereas ADDmeth3.2 is optimized to fill the triangular footprint of a scalable reactor module as best as possible. …”
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Technical Proficiency Analysis in Table Tennis: A Comparative Study Between Advanced and Intermediate Players by Benny Aprial, Denny Setyawan, George Danut Mocanu, Candra Brema Tarigan, Ghulam Mustafa, John Michael D. Aquino, Bilal Azmi Sarıtaş

“…Biomechanical analysis showed advanced players maintained more optimal arm angles (110.5° vs 95.8°) and faster bat swing speeds (17.8 m/s vs 12.4 m/s). …”
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Insights from the single-cell level: lineage trajectory and somatic-germline interactions during spermatogenesis in dwarf surfclam Mulinia lateralis by Yajuan Li, Huilan Wei, Xiaoting Dai, Lijing Zhang, Liangjie Liu, Xiaomei Chen, Tian Liu, Ya Shu, Yaxin Yang, Shi Wang, Zhenmin Bao, Lingling Zhang

“…The dwarf surfclam (Mulinia lateralis) is considered an optimal bivalve model due to its relatively short generation time and ease of breeding in laboratory settings. …”
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Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

“…The weighted k-means approach was linked to nine metrics covering the period 1990–2021 in three subnational jurisdictions of the Brazilian and Colombian Amazon: 1. baseline forest, 2. percentage forest loss, 3. remaining forest, 4. speed of forest loss, 5. active deforestation, 6. percentage forest degradation, 7. speed of forest degradation, 8. active degradation, and 9. percentage regrowth. Four optimal archetypes were chosen using k-means classification: a. consolidated frontier, b. vulnerable frontier, c. past gradual frontier and d. rampant frontier. …”
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Yield and Sensorial and Nutritional Quality of Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Fruits from Plants Grown Under Different Amounts of Irrigation in Soilless Culti... by Davide Raffaelli, Rohullah Qaderi, Luca Mazzoni, Bruno Mezzetti, Franco Capocasa

“…Effective, innovative solutions are crucial for optimizing water use for intensive crops such as cultivated strawberries (<i>Fragaria</i> × <i>ananassa</i>). …”
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From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…This innovative approach not only contributes to sustainability in healthcare by optimizing biological waste but also exemplifies efficient resource use in line with the circular economy, offering a cost-effective, biocompatible option that could benefit national health systems.…”
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<i>Zanthoxylum piperitum</i> Benn. Attenuates Monosodium Urate-Induced Gouty Arthritis: A Network Pharmacology Investigation of Its Anti-Inflammatory Mechanisms by Sung Wook Kim, Soo Hyun Jeong, Jong Uk Kim, Mi Hye Kim, Wonwoong Lee, Cheol-Jung Lee, Tae Han Yook, Gabsik Yang

“…Further research, including clinical trials, is required to confirm the safety of deZP, determine the optimal dosing, and evaluate its long-term effects.…”
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