Vaccarin suppresses diabetic nephropathy through <?A3B2 pi6?>inhibiting the EGFR/ERK1/2 signaling pathway by Zhu Xuexue, Meng Xinyu, Du Xinyao, Zhao Chenyang, Ma Xinyu, Wen Yuanyuan, Zhang Shijie, Hou Bao, Cai Weiwei, Du Bin, Han Zhijun, Xu Fei, Qiu Liying, Sun Haijian

“…Notably, blocking either EGFR or ERK1/2 yields renal benefits similar to those observed with VAC treatment. Therefore, this study reveals that VAC attenuates renal damage via inactivation of the EGFR/ERK1/2 signaling axis in T2DM patients…”
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Dietary protein intake and PM2.5 on ovarian cancer survival: A prospective cohort study by He-Li Xu, Yi-Fan Wei, Qi Bao, Ya-Li Wang, Xiao-Ying Li, Dong-Hui Huang, Fang-Hua Liu, Yi-Zi Li, Yue-Yang Zhao, Xin-Xin Zhao, Qian Xiao, Song Gao, Ren-Jie Chen, Ling Ouyang, Xia Meng, Xue Qin, Ting-Ting Gong, Qi-Jun Wu

“…A positive association between PM2.5 exposure and all-cause mortality was observed (HR=1.52; 95 % CI: 1.13–2.05, per interquartile range increment). …”
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Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients by Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Xiao-Jun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li

“…A significant reduction of Chinese medicine symptom complex score was only observed in T-Group. The study of mechanism showed that, compared with healthy controls, Th1 and DC frequencies were decreased in all CHB patients, while Treg frequency was increased only in treatment-naïve patients. …”
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Prevalence of overweight and obesity among preschool children in Hainan: a cross-sectional study in China's largest free-trade zone by Wei-Jia Wu, Wei-Jia Wu, Ping-Hao Chen, Ping-Hao Chen, Zhen-Ning Huang, Zhen-Ning Huang, Xue-Lu Lei, Xue-Lu Lei, Chen Wang, Chen Wang, Chun-hui Zhang, Chun-hui Zhang, Ping Wang, Ping Wang, Chui-can Huang, Qing Luo, Qing Luo, Li-Chun Fan, Li-Chun Fan

“…Additionally, potential factors affecting overweight and obesity were analyzed using a multifactor binary logistic regression model.ResultsThe prevalence of overweight and obesity among preschool children in Hainan Island was 11.30% based on the Chinese criteria, significantly higher than the rates of 5.80% and 5.40% observed according to the WHO and IOTF criteria, respectively (χ2 = 12,870.368, P &lt; 0.001). …”
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Anxiety and depression in people with epilepsy during and one year after the COVID‐19 pandemic by Iris E. Martínez‐Juárez, Jimena Gonzalez‐Salido, Jimena Colado‐Martinez, Irving Fuentes‐Calvo, Santiago Philibert‐Rosas, E. Rodrigo Velásquez‐Coria, Salvador Martínez‐Medina, Mijail A. Rivas‐Cruz, Eithel Valenzuela‐Mendivil, Karen E. Guzmán‐Sánchez, Elizabeth M. Ruiz‐Peñaflor, Arnold R. Thomson‐Cerna, Emilia M. González‐Villagómez, Jimena Armenta‐Báez, Andrea Santos‐Peyret, Aurelio Jara‐Prado, Adriana Ochoa‐Morales, Daniel Crail‐Meléndez, Ángel Ruiz‐Chow, Mario A. Sebastián‐Díaz

“…Methods We conducted a prospective, observational, and analytical study at the Epilepsy Clinic of the National Institute of Neurology and Neurosurgery (NINN) in Mexico City during the COVID‐19 pandemic. …”
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Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…A higher proportion of FAPs was observed in the skeletal muscle of 245-day-old pigs. …”
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Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…Promoter activity assays showed that the transcriptional repressor RstR protected against CTXΦ superinfection by preventing the replication and integration of CTXΦ/pre-CTXΦ phages containing the same <i>rstR</i> allele, supporting the co-integration of the diverse CTXΦ/pre-CTXΦ members observed. The numbers and types of prophages and their co-integration arrangements in serogroup O139 strains were more complex than those in serogroup O1 strains. …”
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Prevalence and predictors of permanent pacemaker implantation in patients with aortic stenosis undergoing transcatheter aortic valve implantation: a prospective cohort study by Erlend Eriksen, Ronak Rajani, Sahrai Saeed, Svein Rotevatn, Daanyaal Wasim, Øyvind Bleie, Abukar Mohamed Ali, Erik Jerome Stene Packer, Håvard Keilegavlen

“…The secondary objectives were to investigate the temporal changes in permanent pacemaker implantation following TAVI and its impact on long-term prognosis.Design Prospective observational cohort study of patients with AS undergoing TAVI.Setting Single-centre study conducted at a tertiary hospital in Western Norway between 2012 and 2019.Participants Among 600 consecutive patients with severe AS who were treated with TAVI, 52 patients with permanent pacemaker prior to TAVI were excluded. …”
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Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data. by Laura Slade, Maya Blackman, Hiten D Mistry, Jeffrey N Bone, Milly Wilson, Nuhaat Syeda, Lucilla Poston, Peter von Dadelszen, Laura A Magee, SCOPE Consortium

“…<h4>Conclusions</h4>In this study, we observed that 2017 ACC/AHA BP categories demonstrated a similar pattern of association and diagnostic test properties in nulliparous women, as seen in the general obstetric population. …”
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The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…Secondary outcomes included mean visual analog scale (VAS) scores every four hours within 24 hours, postoperative blood test results the day after surgery, and American Shoulder and Elbow Surgeons (ASES) score at 3 months postoperatively.Results: No significant differences in QoR-15 scores at 24 hours were observed among the groups [control, 127.0 (112.8, 138.0); TXA, 125.0 (116.5, 136.8); TXA+DEX, 132.0 (120.3, 140.8), p = 0.176]. …”
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Clinical efficacy and safety of acupuncture at Houtian Baguapoint around umbilicus combined with acupoint massage in the treatment of primary dysmenorrhea (针刺脐后天八卦穴联合穴位按摩治疗原发性痛经的临床... by HE Yan (何宴), DUI Minjie (杜敏杰)

“…Objective To observe the clinical efficacy and safety of acupuncture at the Houtian Bagua point around umbilicus combined with acupoint massage in the treatment of primary dysmenorrhea. …”
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Effect of supplemental dietary phytogenic blends on growth performance, jejunal histomorphometry, and jejunal immunity of broiler chickens by A. Ceylan, P. Saçaklı, Ö. Özgenç Çınar, M. S. Ramay, U. Ahsan, U. Ahsan, J. A. Harijaona, A. G. Bayraktaroğlu, F. Manghebati, A. Calik

“…Moreover, no major treatment effects were observed on mRNA abundances of cytokines (IL-1<span class="inline-formula"><i>β</i></span>, IL-6, and TNF<span class="inline-formula"><i>α</i></span>). …”
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Tax on Vacant Houses and Housing Price Bubble in Shiraz by Sara Parang, zahra dehghan shabani, Ebrahim Hadian, Ali Asgary

“…Findings The results of the research show that by applying a tax rate of 10%, if 70% of buyers are speculators, the highest growth rate of the housing price bubble was observed; that the decreasing growth rate was equal to 18%, that is, with application of tax on empty houses, the housing price bubble of Shiraz city in 2022 to the end of 2031 decreased by almost 19%, and after that the application of the tax rate of 15% in these conditions was approximately 17% which reduced the housing price bubble. …”
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Most prevalent jobs of doctoral degree graduates by detailed field of study by Marc Frenette, Tomasz Handler

“…While there are plenty of noteworthy results in the tables, the remainder of this article will simply highlight a few key observations. Readers are invited to examine the results based on their specific interests. …”
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Evaluation of the efficiency of Russian universities: Do we need to change the paradigm? by E. V. Romanov

“…A similar phenomenon is observed in higher education institutions, where the estimated number of vacancies is less than the full-time number of research and teaching staff (“vacancy manipulation effect”). …”
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Effects of Hypoxia Stress on Biochemical Indices and Expression of Hypoxia-Related Genes in the Heart of Rainbow Trout (Oncorhynchus mykiss) by Jiuju MA, Jinqiang HUANG, Yongjuan LI, Shenji WU, Lu ZHAO, Yue ZENG

“…No significant difference was observed between the control at 24 h and after reoxygenation (P > 0.05). …”
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The Use of Zeolit and Activated Carbon on Packing System of Corydoras aenus by E. Supriyono, E. Supendi, K. Nirmala

“…Dosage treatment of zeolit and activated carbon was 20 gram zeolit, 15 gram zeolit and 5 gram activated carbon, 10 gram zeolit and 10 gram activated carbon, 5 gram zeolit and 15 gram activated carbon, 20 gram activated carbon, and no added zeolit and no activated carbon as control.  Fish condition was observed every 6 hours, while water quality measurement was performed every 24 hours for 120 hours.  …”
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GIS-based modeling and analytical approaches for groundwater quality suitability for different purposes in the Egyptian Nile Valley, a case study in Wadi Qena by Hanaa A. Megahed, Abd El-Hay A. Farrag, Amira A. Mohamed, Mahmoud H. Darwish, Mohamed A. E. AbdelRahman, Heba El-Bagoury, Paola D’Antonio, Antonio Scopa, Mansour A. A. Saad

“…Maps of chemical variables are created using statistical tools by combining observations with interpolation models that can incorporate simple process relations. …”
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Development of the DO₃SE-Crop model to assess ozone effects on crop phenology, biomass, and yield by P. Pande, S. Bland, N. Booth, J. Cook, Z. Feng, L. Emberson

“…The DO<span class="inline-formula">₃</span>SE-Crop model was also able to simulate O<span class="inline-formula">₃</span>-induced yield losses of <span class="inline-formula">∼11 <i>%</i></span>–19 % compared to observed yield losses of 12 %–34 %, with an <span class="inline-formula"><i>R</i>²</span> of 0.68 (<span class="inline-formula"><i>n</i>=20</span>) and an RMSE of 76 g m<span class="inline-formula">⁻²</span>. …”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…The red blood cell (RBC) count of the control group was significantly different from that of T1 (p<0.05), with the highest RBC observed in T1. There were no significant differences in neutrophil percentages between the control group and T1 and T3. …”
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