Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Additionally, we investigated downstream molecular pathways using western blot, Co-immunoprecipitation, immunofluorescence, and mass spectrometry techniques. Results We observed that Mfsd2a expression is reduced in LM compared to PT, and higher Mfsd2a levels are associated with better prognosis in CRLM patients. …”
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Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains by Xia-Li Lyu, Ting-Ting Lin, Jing-Tao Gao, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Jing Dong, Qi Sun, Wei Shu, Sai-Sai Wang, Li-Ping Pan, Hai-Rong Huang, Zong-De Zhang, Qi Li

“…Results. (1) 100% of Bdq-treated macrophages (all doses applied over 4–48 h) survived with 0% inhibition of proliferation observed. (2) Intracellular CFUs of Bdq-treated MDR-MTBs-infected macrophages decreased over 4–48 h of treatment, were lower than preadministration and control CFUs, decreased with increasing Bdq dose, and resembled H37Rv-infected group CFUs (48 h). (3) For MDR-MTBs-infected macrophages (various Bdq doses), IL-12/23 p40 levels resembled preadministration group levels and exceeded controls (4 h); TNF-α levels exceeded preadministration group levels (24 h/48 h) and controls (24 h); IL-12/23 p40 and TNF-α levels resembled H37Rv-infected group levels (4 h/8 h/24 h/48 h); IL-6 levels exceeded preadministration and H37Rv-infected group levels (24 h/48 h) and controls (24 h); IL-10 levels resembled preadministration and H37Rv-infected group levels (4 h/8 h/24 h/48 h) and were lower than controls (24 h/48 h); IL-12/23 p40 and IL-10 levels remained unchanged as intracellular CFUs changed, with IL-12/23 p40 levels exceeding controls (4 h) and IL-10 levels remaining lower than controls (24 h/48 h); TNF-α and IL-6 levels increased as intracellular CFUs decreased (24 h/48 h) and exceed controls (24 h). …”
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Clinical And Molecular-Genetic Features Of Congenital Aniridia by T.A. Vasilieva, Voskresenskaya A. A, V.V. Kadyshev, N.A. Pozdeeva, A.V. Marakhonov, R.A. Zinchenko

“…A milder phenotype is observed in patients with deletions of the 3′ cis-regulatory region.…”
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Three-dimensional omnidirectional characterization methods of rock anisotropic wave velocity and acoustic emission location optimization by Shengjun MIAO, Wenxuan YU, Mingchun LIANG, Pengjin YANG, Conghao LI, Zejing LIU

“…Lastly, siltstone demonstrates stronger wave velocity anisotropy, with inconsistent variation trends observed across different stages. Compared with traditional simplex and Geiger methods, the positioning accuracy of the proposed method improves by more than 58% in both rock types, validating the effectiveness of the proposed location method. …”
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Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

“…Lighting difficulties were observed at similar rates in both earthquakes (19.0% in Maraş, 19.5% in Marmara; p = 1.000). …”
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Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study by Simonsen MR, Maksten EF, Jakobsen LH, Severinsen MT, Dann EJ, Frederiksen H, Niemann CU, Jørgensen JM, Clausen MR, Starklint J, Johnsen SP, El-Galaly TC, Baech J

“…However, no total causal effect of immigration status on OS was observed overall (HR: 0.94 [0.79– 1.12]) and within subtype-specific analyses, except for classical Hodgkin lymphoma.Conclusion: No significant differences in OS between non-Western immigrant patients and Danish-born patients were discovered.Plain Language Summary: Non-Western immigrant lymphoma patients in Western countries may face multiple challenges, including lower socioeconomic status and insufficient language proficiency, which can make navigating the complexity of modern lymphoma treatment difficult. …”
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USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway by Ming-chen Yu, Xiao-lin Li, Ming-liang Ning, Zhen-zhong Yan, Wan-tao Yu

“…Besides, there was a notable reduction in the levels of TNF-α and IL-1 β in the cell culture medium, while a remarkable increase was observed in the level of IL-10. Additionally, the level of iNOS-positive cells was significantly decreased, while the level of Arg1-positive cells was considerably increased. …”
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Evaluasi Tata Kelola Teknologi Informasi PT Pertamina Hulu Energi Menggunakan Framework COBIT 4.1 Fokus Domain Plan and Organise (PO) dan Acquire and Implement (AI) Khusus pada Imp... by Muhammad Ghiffari, Yusi Tyroni Mursityo, Suprapto Suprapto

“…Evaluation is an activity that starts from observing the object, then analyzes it to produce an output that changes the original form. …”
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Automated Video Assistant Referee in Lead Climbing by Eliane Künzler, David Roder, Urs Stöcker, Peter Wolf

“…These points are awarded immediately after an attempt by a judge who observed the athlete. Competition organisers are required to make video recordings, but these are only viewed by the head referee in case of an appeal. …”
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Computational analysis of Newtonian fluid in a 2-D square cavity with kinetic energy, enstrophy, and palinstrophy in the presence of bottom corner obstacle by Dalmalka Praveen Kumar, Yadagiri Rameshwar, Rifaqat Ali, S. Nazari, Mohamed Kallel, Ahmed M. Galal

“…The physics involved in KE and vortex dynamics is that increasing obstacle height progressively reduces the kinetic energy across all configurations, with the sharpest decline (38 %) observed in dual-corner obstacles due to amplified flow constriction and enhanced boundary layer effects. …”
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Identifikasi Malicious Host dalam Local Area Network Menggunakan Teknik Graph Clustering dan Filtering by Khafidzun Fadli, Achmad Basuki, Eko Setiawan

“…The results of graph visualization using graph clustering-filtering technique can display fewer nodes and edges, from 511 nodes and 4144 edges to 22 nodes and 328 edges observed and collected in a LAN within 3 hour in the campus LAN. …”
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Effect of Tiaoshen Patting Therapy Combined with Zhichan Granule on Patients with Parkinson's Disease by CAI Li, HAN Yue, WANG Taidong, GU Linyi, ZHU Kun, LIU Yi

“…ObjectiveTo observe the clinical effect of Tiaoshen patting therapy combine with Zhichan granule on tremor, stiffness and postural instability on patients with Parkinson's disease.MethodsA total of 228 patients with Parkinson's disease who were treated in the Shanghai Municipal Hospital of Traditional Chinese Medicine and it's medical consortium, which were randomly divided into Western medicine treatment group, traditional Chinese and Western medicine treatment group and combined treatment group,with 76 cases in each group. …”
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Effect of Bee Resin on Blood Profiles of Infected Carassius auratus by Aeromonas hydrophila by Sri Nuryati, Y. Kuswardani, Y. Hadiroseyani

“…In order to determine the effect of bee resin on blood profile of goldfish, Carassius auratus that had been infected by Aeromonas hydrophila, the numbers of hemoglobin, hetmaocrite, erythrocyte and leukocyte, and leukocyte differentiation were observed.   Fishes were divided into four groups: negative control, positive control, preventive and curative groups. …”
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Influence of substrate bias on the properties of CrAlN wear-resistant coating prepared by arc/magnetron composite technology by Xiaoyan NIU, Mingze LIU, Guoqiang DONG, Yujiang WANG, Haoliang TIAN

“…The CrN, AlN, and CrAlN phases with face-centered cubic structures were observed by XRD. In particular, the addition of Al elements caused the diffraction peak of the CrAlN phase to shift to higher angles. …”
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Evaluation of wheat products with high flavonoid content: justification of importance of marker-assisted development and production of flavonoid-rich wheat cultivars by E. K. Khlestkina, N. I. Usenko, E. I. Gordeeva, O. I. Stabrovskaya, I. B. Sharfunova, Y. S. Otmakhova

“…The use of such an accurate model has allowed relating the observed differences precisely with anthocyanin biosynthesis. …”
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Efficacy analysis of prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer: a retrospective study by Zhijie Gong, Zhijie Gong, Liping Zhou, Yinghao He, Yinghao He, Jun Zhou, Yanjie Deng, Zudong Huang, WeiWei Wang, Qiangbang Yang, Jian Pan, Yingze Li, Xiaolu Yuan, Minghui Ma

“…Furthermore, the impact of varying P-HIPEC frequencies and initiation timings was evaluated.ResultsNo significant differences in overall survival (OS) or postoperative complication rates were observed between the two groups in the original and PSM cohorts. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…The in vitro cellular uptake was observed via fluorescence microscope and flow cytometry. …”
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Ameliorating potential effects of natural biological formulations and biostimulants on plant health and quality attributes in coriander-fenugreek intercropped strawberry (Fragaria... by Priya Thakur, Pramod Kumar, CL Sharma, Uday Sharma, Nisha Sharma, Tanzin Ladon

“…This treatment application also observed maximum fruit yield (677.93 g/ plant) and yield efficiency (7.91 g/cm2 of leaf area) compared to all other bio-organic combinations applied. …”
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Artemia sp. as a DNA vaccine vector for common carp Cyprinus carpio larvae by Sri Nuryati, Sekar Sulistyaning Hadiwibowo, . Alimuddin

“…The expression of GP-11 in kidney in each treatment is also observed by the use of RT-PCR method, within ten days after vaccination. …”
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Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…Finally, we investigated the association between BATF expression and cell-cell communication within the AML cell population using single-cell sequencing.ResultsIn this study, we thoroughly investigated the role of BATF in AML. First, we observed a significant elevation in the expression of BATF in patients and cells in AML. …”
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