Clinical significance of Helicobacter pylori infection in iron-deficiency anemia: features of comprehensive treatment approach by I. V. Mayev, S. A. Kochetov

“…At control examination in 28 days after iron supplementation onset positive changes were observed, that were more prominent in the subgroup 1a: Hb 117,8 g/l, RBC 3,9×1012, RBC color index 0,83, serum iron 17,7 µmol/l, TIBC 74,4 µmol/l, transferrin saturation percent 20,8 %, ferritin of 20,7 µg/l; in the subgroup 1B: 104,2 g/l, 3,6×1012, 0,81, 12,6 µmol/l, 79,2 µmol/l, 16,6 %, 17,9 µg/l respectively. …”
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Contribution à l’étude de la mobilité de l’hallux et de la phylogénie des primates actuels by J Norbert Kuhlmann

“…Many animals have been observed in semi-liberty or in wide aviaries. Also, 436 foot skeletons of primates have been measured and the measurements converted to a percentage relative to the length of the 3rd metacarpal, in order to compare them, despite their difference in size (collections of the Museum d’Histoire Naturelle of Paris)Results: The hallux column is always very developed and often twice longer than that of the pollex. …”
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Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Here, we assessed changes in lung inhomogeneity in patients with type-2 high asthma treated with biological therapy and explored the relationship between inhomogeneity measures and conventional asthma disease markers.Methods This was an observational study of 91 severe type-2 high asthma patients recruited from a tertiary asthma clinic, of whom 67 subsequently started anti-IL5 or anti-IL5R biologics. …”
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Hurdle Approach to Simulate Corn Wet Milling Inactivation of Undesirable Microorganisms: A Pilot Scale Microbial Challenge Study Using Salmonella Surrogate Enterococcus faecium by Erin Kealey, Madeline Shick, Minho Kim, Ruben Chavez, Gordon Shetley, David Stenger, Kirk A. Perreau, Allison Cooke, Cecil Barnett-Neefs, Matthew J. Stasiewicz

“…The peroxide step had a reduction range from 0.03 log CFU/mL in the control group (0% H2O2 added) to >6 log CFU/mL observed in the high-intensity treatment of corn starch slurry. …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…However, this was not observed in those with confirmed ACS (9.9% of the females vs 9.3% of the males, p=0.881). …”
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Polysaccharides of Atractylodes Macrocephala Koidz Alleviate LPS-Induced Bursa of Fabricius Injury in Goslings by Inhibiting EREG Expression by Shuying Gong, Bingqi Zhang, Xiang Sun, Weijun Liang, Longsheng Hong, Xiang Zhou, Wanyan Li, Yunbo Tian, Danning Xu, Zhongping Wu, Bingxin Li

“…On the 28th day, 1 h after the LPS injection, the BF and serum were collected and analyzed for organ indices, cytokines, antioxidant indicators, and histological observations. Histological examination and HE staining demonstrated that the PAMK treatment ameliorated the LPS-induced BF atrophy, structural damage, increased cellular exudation, and reticulocyte hyperplasia in the goslings. …”
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Overground robotic exoskeleton vs conventional therapy in inpatient stroke rehabilitation: results from a pragmatic, multicentre implementation programme by Pui Kit Tam, Ning Tang, Nur Shafawati Binte Kamsani, Thian Yong Yap, Ita Coffey-Aladdin, Shi Min Goh, Jean Pei Pei Tan, Yook Cing Lui, Rui Ling Lee, Ramaswamy Suresh, Effie Chew

“…The difference was not observed for FAC 2 to 3 (162.9 [SD 29.2]m vs 134.2 [SD 87.5]m, 95% CI −22.2 to 79.7, d = 0.41, p = 0.252). …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Structural Equation Modeling (SEM) explored the pathways linking DAS to ageism via mediators.Results: A moderate level of ageism was observed, with significant variations across socio-demographic factors like academic year, physical health, and contact with older adults. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…This raises the question of how prepared we are serologically and whether seasonal vaccines are capable of inducing protective immunity against these influenza subtypes. An observational study was conducted in which sera from people born between years 1925–1967, 1968–1977, and 1978–1997 were collected before or after 28 days or 6 months post-vaccination with an inactivated seasonal influenza vaccine. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…These increases were also observable 48 h post sialidase treatment. While CD86 and PD-L1 showed significant increases after 48 h of cytokine maturation, 48 h post sialidase treatment showed a higher increase in CD86 and shorter increase in PD-L1. …”
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m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus by Lijiu Zhao, Xiangyu Wei, Fengyue Chen, Baoshan Chen, Ru Li

“…CpZap1 significantly influences the fungal phenotype and virulence, thereby restoring the abnormal phenotype observed in ∆CpALKBH mutants. Collectively, our findings highlight the essential role of CpALKBH as an m6A demethylase in the development and virulence of C. parasitica, while also elucidating the molecular mechanisms through which m6A modification impacts CpZap1 mRNA stability.IMPORTANCEN6-methyladenosine (m6A) is the most abundant eukaryotic mRNA modification and is involved in various biological processes. …”
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A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year by Eman A. Alraddadi, Eman A. Alraddadi, Hashim F. Alotaibi, Hashim F. Alotaibi, Yasser Alatawi, Ahmed Aljabri, Ahmed A. Alghamdi, Ahmed A. Alghamdi, Fahad Alturki, Fahad Alturki, Faisal F. Alamri, Faisal F. Alamri

“…BackgroundStroke recurrence is a serious and prevalent complication of ischemic stroke that warrants additional investigation.MethodsA hospital-based retrospective observational study included acute-subacute ischemic stroke adult patients. …”
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Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinic... by Anupama Kumari, Aarjvi Patel, Payal Berawala, Sara Mary Thomas

“…Haemodynamic parameters were comparable between the groups, with no significant side effects observed. Conclusion: Dexmedetomidine 1 μg/kg as an adjuvant to 0.2% ropivacaine in the TAP block provided a longer duration of analgesia and better quality of pain relief compared to dexamethasone 0.1 mg/kg for postoperative analgesia in infraumbilical surgeries.…”
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The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study by Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener

“…We explored the impact of gestational SSRI treatment on newborn thyroid function as measured by the National Newborn Screening (NBS) Program and identified contributory factors. Methods An observational large-scale study of mother-infant dyads of liveborn infants delivered between 2011 and 2022. …”
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Particle fluxes by subtropical pelagic communities under ocean alkalinity enhancement by P. Suessle, J. Taucher, S. U. Goldenberg, M. Baumann, K. Spilling, K. Spilling, A. Noche-Ferreira, A. Noche-Ferreira, M. Vanharanta, M. Vanharanta, U. Riebesell

“…The particle properties controlling the flux attenuation, including sinking velocities and remineralization rates, also remained unaffected by OAE. However, we observed abiotic mineral precipitation at high OAE levels (<span class="inline-formula">Δ</span>TA <span class="inline-formula">=</span> 1800 <span class="inline-formula">µ</span>mol kg<span class="inline-formula">⁻¹</span> and higher) that resulted in a substantial increase in particulate inorganic carbon (PIC) formation. …”
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Potential drug targets for asthma identified through mendelian randomization analysis by Xingxuan Chen, Yu Shang, Danting Shen, Si Shi, Zhe Wen, Lijuan Li, Hong Chen

“…Results Under Bonferroni significance conditions, Mendelian randomization analysis revealed causal relationships between seven proteins and asthma. In plasma, we observed that an increase of one standard deviation in IL1R1[1.30 (95% CI 1.20–1.42)], IL7R[1.07 (95% CI 1.04–1.11)], ECM1[1.03 (95% CI 1.02–1.05)], and CD200R1[1.18 (95% CI 1.09–1.27)] were associated with an increased risk of asthma, while an increase in ADAM19 [0.87 (95% CI 0.82–0.92)] was found to be protective. …”
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Potential diagnostic tools for intensive care unit acquired weakness: A systematic review by Chen Xin, Yubiao Gai, Lili Wei, Yanqiu Wang, Yuhong Luo, Binru Han

“…Results: A total of 38 observational studies were included in the study. In the included studies, the gold standard for intensive care unit-acquired weakness diagnosis include the Medical Research Council score, muscle biopsy and electrophysiologic testing, potential diagnostic tools include the manual muscle test, electrophysiologic testing, imaging, serum inflammatory markers, neuromuscular ultrasound, and other parameters. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…<i>Material and Methods:</i> This multicenter, retrospective, observational study included data from 193 consecutive patients from two centers from January 2020 to October 2022. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Single-cell data revealed that the abnormal overexpression of SLC7A11 in diffuse gastric cancer was primarily observed in tumor epithelial cells. Further validation using public data and immunohistochemical experiments confirmed the elevated expression of SLC7A11 in diffuse gastric cancer， which is associated with poor prognosis in gastric cancer patients. …”
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