Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid by Eleane de Oyarzabal, Lourdes García-García, Claudia Rangel-Escareño, Leticia Ferreyra-Reyes, Lorena Orozco, María Teresa Herrera, Claudia Carranza, Eduardo Sada, Esmeralda Juárez, Alfredo Ponce-de-León, José Sifuentes-Osornio, Robert J. Wilkinson, Martha Torres

“…Expression of chemokine ligand 4 (CCL4), chemokine ligand 10 (CXCL10), chemokine ligand 11 (CXCL11), interferon alpha (IFNA), radical S-adenosyl methionine domain-containing 2 (RSAD2), ubiquitin-specific peptidase 18 (USP18), interferon-induced protein 44 (IFI44), interferon-induced protein 44 like (IFI44L), interferon-induced protein tetratricopeptide repeats 1(IFIT1), and interleukin 2 receptor subunit alpha (IL2RA) mRNA levels were assessed by qPCR before, during, and after INH treatment. Results. We observed significantly lower relative abundances of USP18, IFI44L, IFNA, and IL2RA transcripts in PBMC from IGRA-positive individuals compared to levels in IGRA-negative individuals before INH therapy. …”
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Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses by Yu-Wei Lin, Yu-Wei Lin, Yu-Wei Lin, Yu-Wei Lin, Yu-Wei Lin, Anna Largajolli, Anna Largajolli, A. Yin Edwards, A. Yin Edwards, S. Y. Amy Cheung, S. Y. Amy Cheung, Kashyap Patel, Stefanie Hennig, Stefanie Hennig

“…., the time of the events with respect to observational period, the level of dose reduction/interruption) should be considered in the choice of the exposure metric. …”
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Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surfa... by Zhao Chen, Enrique J. Delgado Suárez, Raquel R. Bonelli, Celso J. B. Oliveira, Andrea I. Moreno-Switt, Aiko D. Adell, Angélica Reyes-Jara, Christopher J. Grim, Marc W. Allard, Sandra M. Tallent, Eric W. Brown, Rebecca L. Bell, Magaly Toro, Jianghong Meng

“…However, a notable exception was observed with one S. Agona isolate from Brazil closely related to two isolates from Chile, differing by only 18 and 19 single-nucleotide polymorphisms, respectively.IMPORTANCEThis comprehensive study explored the intricate genomic landscapes of S. …”
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The agronomic mechanism of root lodging resistance and yield stability for sweet corn in response to planting density and nitrogen rates at different planting dates by Qinggan Liang, Qinggan Liang, Qinggan Liang, Qinggan Liang, Hailong Chang, Hailong Chang, Hongrong Chen, Hongrong Chen, Qingdan Wu, Qingdan Wu, Yuanxia Qin, Zhuqing Wang, Gang Wang, Xuhui Li, Weiwei Chen, Jiantao Wu, Jiantao Wu, Qinnan Wang, Jianqiang Wang, Jianqiang Wang

“…This further improved the development of plant crown architecture, including stem nodes and ear leaf traits, and further coordinated dry matter dynamics and lignin metabolism between the root and shoot organs. These observations may account for the resistance of the roots to lodging in this treatment. …”
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Impaired hemodynamic forces assessed by routine CMR and its determinants in different duration T2DM patients with normal LV function and myocardial strain by Guozhu Shao, Guozhu Shao, Guozhu Shao, Yukun Cao, Yukun Cao, Yukun Cao, Yue Cui, Yue Cui, Yue Cui, Hongyan Li, Heshui Shi, Heshui Shi, Heshui Shi

“…LV deformation parameters, global circumferential strain (LVGCS), radial strain (LVGRS), longitudinal strain (LVGLS) and HDFs parameters such as longitudinal (apical-basal/A-B), transversal (lateral-septal/L-S) HDF strength (RMS) were measured and compared among the three groups.ResultsCompared with healthy volunteers, no significant differences in LV function and strains were observed (P > 0.05), while HDF Strength (RMS) L-S (%) were significantly higher in T2DM patients (p < 0.001). …”
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A sea ice deformation and rotation rate dataset (2017–2023) from the Environment and Climate Change Canada automated sea ice tracking system (ECCC-ASITS) by M. Plante, J.-F. Lemieux, L. B. Tremblay, A. Bouchat, D. Ringeisen, D. Ringeisen, P. Blain, S. Howell, M. Brady, A. S. Komarov, B. Duval, L. Yakuden, F. Labelle

“…The heterogeneity and localization of these sea ice deformations are important characteristics of the sea ice cover that can be used to evaluate the performance of dynamical sea ice models against observations across multiple spatial and temporal scales. …”
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An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…Patients with any HAI had a longer mean stay in ICU (10.1 days v. 6.7 days (p<0.01) and a higher mortality of 48/59 (81%) v. 19/31 (61%) (p=0.05). Conclusion. We observed a very significant rise in HAIs in the COVID-19 ICU during the third wave compared with the first, with almost three times as many patients developing HAIs. …”
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Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…Moreover, significant increases in intra- and inter-network RSFC were observed, particularly within the visual, default mode, dorsal attention, frontoparietal (FPN), and somatosensory (SMN) networks. …”
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From fear to food: predation risk shapes deer behaviour, their resources and forest vegetation by Martin, Jean-Louis, Chamaillé-Jammes, Simon, Salomon, Anne, Gomez Pourroy, Devana Veronica, Schlaeflin, Mathilde, Le Saout, Soizic, Lucas, Annick, Bentaleb, Ilham, Chollet, Simon, Pattison, Jake, Martin-Blangy, Soline, Gaston, Anthony James

“…This contrasted with the wary behaviour observed in the local deer born after the culls. Finally, deer in populations exposed to risk from hunters and/or predators were less likely to forage in the intertidal, although this trend might be, to some extent, affected by resources in the understory. …”
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Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…A distinct spatial relationship between increased vegetation and cooler areas was observed. For instance, Islamabad has greater vegetation cover and cool zones over 41.5 km2. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Neuropathological alterations of MEF2C-KD mice with mitochondrial dysfunction and motor neuronal damage were observed by confocal microscopy and transmission electron microscope (TEM). …”
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Assessment of psychological health effects of nurses during 2022–2023 of the COVID-19 pandemic: a descriptive study in Southern Taiwan by Hui-Ru Lin, Yung-Kuo Lee, Chen-Lin Chang, Ching-Hui Kuo, Hsin-Yun Ho, Chi-Jen Wu, Yi-Qian Chen, Cheng-Chun Wu, Yu-Cheng Ho, Tian-Huei Chu, Cheng-Hsin Chuang, Chou-Yuan Ko

“…Significant differences in work-related fatigue levels were observed based on working environments (52.78, p < 0.001), no beliefs regarding religion (46.53, p = 0.036), care for COVID-19 patients (47, p < 0.001) and previously diagnosed with COVID-19 (46.58, p = 0.005). …”
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Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Results Significant metabolic dysregulation was observed in TNs, IRs and INRs compared to HCs. In TNs, metabolomic analysis revealed increased levels of 3-hydroxyoctanoic acid, 3-oxododecanoic acid, 5-hydroxy-L-tryptophan, 5-hydroxyindoleacetic acid, L-kynurenine, oleoylcarnitine, and pseudouridine that were positively correlated with CD8 T cell activation and inflammation-related markers, and decreased levels of phosphorylcholine, ribothymidine, and thymine that were negatively correlated. …”
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Anthropometric measurements as markers of elevated blood pressure among Portuguese children and adolescents by Edmar Mendes, Paulo Farinatti, Alynne Andaki, Susana Vale, Andreia Pizarro, Maria Paula Santos, Clarice Martins, Jorge Mota

“…Results Elevated BP was observed in 32% of the sample. Partial correlations ranged from small to moderate (0.2–0.5, p < 0.05). …”
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LcProt: Proteomics‐based identification of plasma biomarkers for lung cancer multievent, a multicentre study by Hengrui Liang, Runchen Wang, Ran Cheng, Zhiming Ye, Na Zhao, Xiaohong Zhao, Ying Huang, Zhanpeng Jiang, Wangzhong Li, Jianqi Zheng, Hongsheng Deng, Yu Jiang, Yuechun Lin, Yun Yan, Lei Song, Jie Li, Xin Xu, Wenhua Liang, Jun Liu, Jianxing He

“…After integrating clinical factors, a significant increase diagnostic accuracy was observed with AUC of .91 (.85‒.98). For task #2, nine proteins panel achieved an AUC of .88 (.80‒.96), integration model showed an increase diagnostic accuracy with AUC of .90 (.85‒.97). …”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…There were no significant differences in cytokine concentration level between trial arms nor survivors and non-survivors over the duration of the observations from day 1 to day 4. Metabolomic analysis showed some separation in the levels of ceramides and cardiolipins between those who survived and those who died. …”
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Short‐term echocardiographic evaluation by global longitudinal strain in patients with heart failure treated with sacubitril/valsartan by Simone Mazzetti, Chiara Scifo, Raffaele Abete, Davide Margonato, Margherita Chioffi, Jessica Rossi, Matteo Pisani, Giovanni Passafaro, Massimiliano Grillo, Daniele Poggio, Andrea Mortara

“…Favourable effects on haemodynamic and functional parameters have been observed in patients with HFrEF undergoing ARNI therapy, using standard transthoracic echocardiography. …”
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Combined application of chemical and organic fertilizers enhances soil organic carbon sequestration and crop productivity by improving carbon stability and management index in a ri... by Hu Xu, Adnan Mustafa, Qudsia Saeed, Guiying Jiang, Nan Sun, Kailou Liu, Jiri Kucerik, Xueyun Yang, Minggang Xu

“…After 29 years of fertilization, we observed that NPKM resulted in the highest OC stocks (11.47 and 26.15 Mg ha−1, respectively) and distribution ratios (24 and 54%, respectively) in the less-labile fraction and passive pool. …”
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Co-creating a person-centered creative engagement intervention for Parkinson's care by Blanca T. M. Spee, Blanca T. M. Spee, Blanca T. M. Spee, Thieme B. Stap, Thieme B. Stap, Marjoke Plijnaer, Gert Pasman, Sara Zeggio, Annelien Duits, Annelien Duits, Julia S. Crone, Suzanne Haeyen, Suzanne Haeyen, Matthew Pelowski, Matthew Pelowski, Bastiaan R. Bloem, Jan-Jurjen Koksma

“…Qualitative data were collected through interviews, group reflections, and ethnographic observations. Data were analyzed using reflexive thematic analysis.ResultsThe co-creation process resulted in a 10-week creative engagement intervention delivered in a “creative playground” setting. …”
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The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling by Fangzhen Xia, Ziteng Zhang, Zhen Qian, Xiaoyu Fang, Junxue Wang, Yan Wang, Guoting Sun, Yuefeng Yu, Ninjian Wang, Junke Zhen, Yan Liu, Yingli Lu

“…Electron microscopy imaging was used to observe insulin secretory vesicles in pancreatic β cells. …”
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