Dietary Alpha-Lipoic Acid Alleviated Hepatic Glycogen Deposition and Improved Inflammation Response of Largemouth Bass (<i>Micropterus salmoides</i>) Fed on High Dietary Carbohydra... by Zishuo Fang, Xianwei Pan, Ye Gong, Nihe Zhang, Shiwen Chen, Ning Liu, Naisong Chen, Songlin Li

“…In order to mitigate the adverse effects of high carbohydrates on largemouth bass and to investigate the feasibility of LA as a feed additive, the present study observed the effects of added α-lipoic acid (LA) on growth performance, glucose metabolism and immunity in largemouth bass fed on high dietary carbohydrates (10% α-cassava starch inclusion). …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…The increased expression of NUAK1 and PD-L1 proteins were observed in the rat livers of diethylnitrosamine-induced HCC model. …”
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Pengaruh Pemberian Diet Tinggi Minyak Sawit terhadap Kadar Malondialdehid Darah Tikus Wistar by Maressya Silvia Eszy, Susila Sastri, Machdawaty Masri

“…After one month treatment, malondialdehyde concentrations were observed. The result of this study revealed significant defference (p&lt;0.05) between MDA concentration in treatment group rats (2.494±0.504 nmol/ml) and control group rats (3.152±0.237 nmol/ml). …”
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Efficacy of dietary supplementation with 1α-hydroxycholecalciferol on performance, eggshell quality, serum metabolites, jejunal morphology and bone characteristics of laying hens a... by Maryam Ghaderi Nik, Reza Mahdavi, Shahab Ghazi, Kourosh Gholami

“…In addition, the linear tendency to increase was observed (linear P = 0.062) in total protein. Dietary supplementation of 1αOHD3 increased the tibia diameter (linear P = 0.053), tibia calcium (linear P = 0.004 and quadratic P = 0.014) and tibia strength (linear and quadratic P < 0.001). …”
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AI-Assisted Compressed Sensing Enables Faster Brain MRI for the Elderly: Image Quality and Diagnostic Equivalence with Conventional Imaging by Gu W, Yang C, Wang Y, Hu W, Wu D, Cai S, Hong G, Hu P, Zhang Q, Dai Y

“…Additionally, Cohen’s weighted kappa statistic was used to assess inter-protocol intra-observer agreement.Results: The ACS images demonstrated superior quality across all qualitative features compared to the conventional ones. …”
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Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study by Xiao Ma, Xiao Ma, Lan Gao, Siying Che, Chaofeng Tao

“…This study amid to evaluate the correlation between dose exposure intensity and efficacy and safety of apatinib in the treatment of advanced gastric cancer.MethodsWe conducted an observational, retrospective cohort study of patients with advanced gastric cancer who received apatinib targeted therapy in Beijing Friendship Hospital affiliated to Capital Medical University between June 1, 2018, and June 30, 2021. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…H84T CAR T cells exhibited improved T-cell infiltration in multicellular spheroids and had potent antitumor effects in the xenograft models. We observed no adverse effects against normal tissues.Conclusions T cells expressing H84T CAR target malignant cells and their stroma in PDAC tumor models. …”
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Effectiveness, cost-effectiveness and return on investment of individual placement and support compared with traditional vocational rehabilitation for individuals with severe menta... by Johanna Maria van Dongen, Philippe Delespaul, Frederieke Schaafsma, Jaap van Weeghel, Johannes Anema, Miljana Vukadin, Wim Zwinkels, Marcel Spijkerman, Marloes de Graaf-Zijl

“…Objectives To assess the effectiveness, cost-effectiveness and return on investment of individual placement and support (IPS) implemented through a reimbursement strategy on a nationwide scale compared with traditional vocational rehabilitation (TVR) regarding sustainable participation in competitive employment in individuals with severe mental illness receiving sickness or disability benefits.Methods An observational study was conducted using administrative data regarding all Dutch individuals receiving sickness or disability benefits in the period 2012–2019. …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…Therefore, based on the observed trends of decreased streamflow volume, recommendations for the study area include the development of water sources such as microdams, ponds, and water wells, implementation of water harvesting techniques, improvement of land use and land cover practices, proper utilization and management of available discharge, drought assessment, and environmental impact assessment. …”
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Inequalities in utilization of maternal health services in Ethiopia: evidence from the PMA Ethiopia longitudinal survey by Asebe Hagos, Misganaw Guadie Tiruneh, Melak Jejaw, Kaleb Assegid Demissie, Lemlem Daniel Baffa, Demiss Mulatu Geberu, Getachew Teshale, Tesfahun Zemene Tafere

“…However, there was no age-related inequality in the use of maternal health services.ConclusionA high level of socioeconomic and geographic area related inequality was observed in the utilization of ANC four, SBA, and PNC services in Ethiopia. …”
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Counting the cost of hospitalised injury using administrative data in Australia: three considerations from a retrospective cohort data linkage study by Jacelle Warren, Kirsten Vallmuur, Victoria McCreanor, Steven M McPhail, Shahera Banu, Michael Schuetz, Clifford Afoakwah

“…CPI-inflated costs were significantly lower than health group index-inflated estimates, with observed differences between 7.7% (95% CI 6.9% to 8.7%) and 11.9% (95% CI 10.8% to 13.1%) for the same AR-DRG. …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Through gain- and loss-of-function approaches, miR-199a-5p over-expression significantly increased expression of VSMC marker genes and inhibited VSMC proliferation and migration, whilst the opposite effect was observed when endogenous miR-199a-5p was knocked down. …”
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Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment by Jingwen Yang, Chenquan Qiu, Renhai Tang, Wenbin Dong, Enlong Yao, Huyunzhao Wang, Shuwen Lin, Minyang Xiao, Zuyang Zhang, Jin Niu, Liru Fu, Lijun Song, Xuehua Li, Yuhua Shi, Xiaowen Wang

“…The participants in our study showed a preference for confidentiality regarding the testing status (β = 1.82, p < 0.001), for the test being available at hospitals (β = 0.72, p < 0.001), and for the test being administered by physicians (β = 0.74, p < 0.001). We also observed that having support services was preferable (β = 0.50, p < 0.01) to support services not being available. …”
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Collagenase Chemonucleolysis for Treating Cervical Disc Herniation: An Exploratory, Single-Arm, Open-Label, Multicenter Clinical Trial by Zhijian Wang, Bifa Fan, Lili Gu, Xuexue Zhang, Tao Sun, Hui Liu, Rongchun Li, Likui Wang, Kaiqiang Wang, Shun Li, Yong Ma, Haibo You, Daying Zhang

“…A significant difference was observed in the pre- and postoperative CDH index (109.6 ± 119.1 vs. 70.8 ± 74.8, P < 0.001). …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Safety (exposure-adjusted incidence rates/100 patient-years (EAIRs)) and efficacy outcomes (binary: non-responder imputation (NRI) and observed case (OC); continuous: multiple imputation (MI)) are presented through 256 weeks.Results From Weeks 0–256, 289/303 (95.4%) patients had ≥1 treatment-emergent adverse event (TEAE); most frequent were nasopharyngitis (21.8%) and upper respiratory tract infection (14.5%). …”
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Sacubitril/valsartan on right ventricular-pulmonary artery coupling and albumin-bilirubin score in heart failure in Chinese patients with reduced ejection fraction by Yanan Shi, Chuanyu Gao, Yu Xu, Fang Yuan

“…Methods A retrospective observational study was conducted on 305 patients with HFrEF and RVD who were hospitalized between June 2020 and December 2021. …”
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Black posterior vitreous detachment: A 10-year historical cohort of pigmented uveal tumors by Vicktoria Vishnevskia-Dai, Hila Goldberg, Michael Ostrovsky, Ofira Zloto, Rachel Shemesh

“…A pigmentary PVD was observed on presentation in one case (1/8; 12.5 %); the remaining cases had pigmentary PVD documented during follow-up. …”
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Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…The results showed no statistically significant differences were observed between fusion and non-fusion group of GBM and LGG. …”
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Promotional tone in reviews of menopausal hormone therapy after the Women's Health Initiative: an analysis of published articles. by Adriane Fugh-Berman, Christina Pike McDonald, Alicia M Bell, Emily Catherine Bethards, Anthony R Scialli

“…Themes that were common in articles considered promotional included attacks on the methodology of the WHI, arguments that clinical trial results should not guide treatment for individuals, and arguments that observational studies are as good as or better than randomized clinical trials for guiding clinical decisions. …”
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Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma by Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H

“…Additionally, the diagnostic performance of various indicators were evaluated using ROC analysis.Results: Among the qualitative data, significant differences (P< 0.05) were observed between the MVI-positive and MVI-negative groups in 5 items such as peritumoral enhancement. …”
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