The European summer heatwave of 2019 – a regional storyline perspective by T. Klimiuk, P. Ludwig, A. Sanchez-Benitez, H. F. Goessling, P. Braesicke, P. Braesicke, J. G. Pinto

“…We provide evidence that the downscaling of global storyline integrations significantly improved the representation of present-day temperature patterns and reduced errors in daily 2 m temperatures relative to observations from central Europe. The magnitude of the heatwave temperature response significantly exceeds the globally modelled background warming, with distinct spatial and temporal variations in the regional increments. …”
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The prevalence and associated disability burden of mental disorders in children and adolescents in China: a systematic analysis of data from the Global Burden of Disease StudyResea... by Wanyue Dong, Yunning Liu, Ruhai Bai, Lei Zhang, Maigeng Zhou

“…Although disparities in the distribution of mental disorder burden were observed across provinces, there was a reduction in income-related inequality, where the gap in the age-standardized DALY rates between the highest and lowest income provinces decreased by 61.7% between 1990 and 2021. …”
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Fostering positive affective exercise experiences and affect-related competencies for a physically active lifestyle: The FEEL Project – Results of the Pilot-Study by Martin Robert Bührer, Stephanie Rosenstiel, Gorden Sudeck, Julia Schmid

“…Similar results were observed in the focus group discussion. Additionally participants also expressed that they valued the safe space atmosphere, the encouragement to reflect on their affect during exercise and sport and the opportunity to experience different activities. …”
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Aux sources de la spécialisation hémisphérique cérébrale du langage : l'intérêt de l'IRM anatomique chez le babouin by Adrien Meguerditchian, Damien Marie, Muriel Roth, Romain Lacoste, Bruno Nazarian, Ivan Balansard, Jean-Luc Anton, Olivier Coulon, Alice Bertello, Jean-Noël Benoit, Scott A. Love, Thomas Brochier, Martine Meunier, Sandrine Melot‑Dusseau, Jean‑Christophe Marin, William D Hopkins

“…Ces recherches visent à constituer une base de données la plus large possible d'images cérébrales anatomiques auprès de sujets hébergés et observés à la station de primatologie de Rousset. Nous ferons le point sur les méthodes que nous avons développées pour collecter des images auprès de sujets in vivo au Centre IRMf de l'Institut des Neurosciences de la Timone à Marseille. …”
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Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China by Bangfeng Han, Liu Liu, Zhishen Jiang, Li Ye, Yubin Cao, Jian Pan

“…Our findings underscore the importance of RCT in transplanted teeth with closed or semi-closed apices. Multi-center observational studies with larger sample size and extended follow-up duration may be needed to validate the conclusion.…”
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Digital Twin Technology in Resolving Polycystic Ovary Syndrome and Improving Metabolic Health: A Comprehensive Case Study by Paramesh Shamanna, MD, Anuj Maheshwari, MD, Ashok Keshavamurthy, MD, Sanjay Bhat, DM, Abhijit Kulkarni, DM, Shivakumar R, MD, Kumar K, MD, Mukulesh Gupta, MD, Mohamed Thajudeen, MD, Ranjita Kulkarni, MD, Shashikiran Patil, MD, Shashank Joshi, DM

“…After 360 days, significant improvements were observed. Weight decreased from 65.4 kg to 57.3 kg (−12.4%); body mass index lowered from 26.2 to 22.96 (−12.4%); Waist circumference reduced from 104 cm to 86.3 cm (−17.0%); clinic systolic blood pressure/diastolic blood pressure reduced from 144/93 to 102/80 mmHg (−29.17%/-13.98%); fasting insulin dropped from 27.6 to 15.5 μIU/mL (−43.8%); postprandial insulin decreased from 182.4 to 23.8 μIU/mL (−87.0%); Homeostatic Model Assessment of Insulin Resistance reduced from 6.47 to 3.48 (−46.2%); estimated glomerular filteration rate improved from 116 to 128 mL/min/1.73m2 (+10.3%); urine microalbumin creatinine ratio decreased from 596 to 73 mg/g (−87.8%). …”
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AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecogniz... by Raquel M. Zimmerman, Edgar J. Hernandez, Mark Yandell, Martin Tristani-Firouzi, Robert M. Silver, William Grobman, David Haas, George Saade, Jonathan Steller, Nathan R. Blue

“…Our objective was to use data from a large, deeply phenotyped observational obstetric cohort to develop a probabilistic graphical model (PGM), a type of “explainable artificial intelligence (AI)”, as a potential framework to better understand how interrelated variables contribute to perinatal morbidity risk in FGR. …”
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In Vitro Antibacterial and Antioxidant Activities and Molecular Docking Analysis of Phytochemicals from Cadia purpurea Roots by Tsegu Kiros, Rajalakshmanan Eswaramoorthy, Yadessa Melaku, Aman Dekebo

“…The compounds, however, indicated a weak ferric ion reduction power even at higher amount. In general, the observed antibacterial and antioxidant activities of isolated compounds and extracts were found to be dose-dependent. …”
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The articular wrist complex in Miocene and Plio-Pleistocene African hominoids: anatomofunctional and morphometric comparative approach by Guillaume Daver

“…Une approche transdisciplinaire a été conduite d’abord à l’aide de radiographies (n = 10), de dissections (n =14) et d’observations morphologiques (n = 392) puis à l’aide de la morphométrie géométrique 3D appliquée à l’étude des os du complexe fonctionnel capitatum-hamatum (n[capitatum] = 245 ; n[hamatum] = 222 ; n[capitatum fossiles] = 10 ; n[hamatum fossiles] = 6). …”
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Real-world study of phakic refractive lens for correction of high myopia by An-Peng Pan, Xu Shao, Yi-Ke Li, Zi-Yue Li, Qiong Yan, Wei-Yang Sun, A-Yong Yu

“…In both groups, no other major complications were observed up to 12-month follow-up. Conclusions PRL implantation was a safe, efficient, predictable and stable method for correcting high myopia. …”
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Mechanism of abnormal specification of spermatogonial stem cells after Rb1 knockout in mitotic-arrested prospermatogonia by CHEN Xinling, CHEN Xinling, LONG Yixuan, DU Guihua, DU Guihua

“…Results‍　‍① The results of scRNA-seq showed that in the two set clusters of prospermatogonia， the prospermatogonia that further specifies to generate SSCs had enriched genes that are associated with cell proliferation. ② Germ cell proliferation assay indicated that the average ratio of Ki67+ germ cells in the testicular cross-section of the cKO mice was significantly higher than that of the control mice at P2.5 ［（46.10±6.21）% vs （11.22±3.27）%， P<0.01］. ③ Flow cytometry revealed that， among the brightest community of ID4-GFP cells， the percentage of the cells at S phase was obviously higher in the testicular cells derived from the cKO mice when compared to the control mice at P2.5 ［（12.05±1.22）% vs （5.05±1.46）%， P<0.05］.④ TUNEL staining displayed that cell apoptosis was detected in the testicular cross-section of cKO mice rather than that of the control mice. ⑤ The results of SSCs specification exploration showed that statistical difference was observed in the percentage of cytoplasmic FOXO1 in the testicular cross-section between the control and cKO mice ［（20.57±2.15）% vs （45.08±2.45）%，P<0.01］. …”
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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…The antiparasitic effects triggered by P2Y2 activation were not observed when cells were pretreated with a caspase-1 inhibitor (Z-YVAD-FMK) or in macrophages from caspase-1/11 knockout mice (CASP-1,11−/−). …”
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Nutritional strategies for laying hens to address environmental challenges by reducing the nitrogen excretion by Vlaicu Petru Alexandru, Untea Arabela Elena, Panaite Tatiana Dumitra, Cornescu Gabriela Maria, Saracila Mihaela, Varzaru Iulia, Oancea Alexandra Gabriela

“…No significant effect on mineral excretion content was observed.…”
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Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2− Advanced Breast Cancer by Ram Patel, John Mathews, Caroline Hamm, Swati Kulkarni, Rasna Gupta, Tarquin Opperman, John Dean Chiong, Abdullah Nasser

“…Conclusion: In this real-world analysis, palbociclib demonstrated a median PFS consistent with the results from landmark trials, although the observed OS was shorter. The ribociclib-treated patients had a numerically longer PFS and OS compared with those treated with palbociclib, but the differences were not statistically significant. …”
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The use of Curcuma longa extract to control Edwardsiella tarda infection on Clarias sp. by Dinamella Wahjuningrum, Muharram Nur Ikhsan, , Sukenda, Yan Evan

“…Clinical signs such as swelling, hemoraghic, body ulcer, gastroentritis and gaseous captivity were observed on challenged fish. However, there were no significant different among treatments for specific growth, body weight, and absolute length parameters.    …”
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Validity and reliability of the brief form of the normative male alexithymia scale among Chinese patients after radical prostatectomy by F. Wang, X. Zhang, L. Huang, X. Zhang, W. Jie, X. Chang, Y. Chu, L. Wang, W. Jia, B. Zhang

“…Statistically significant differences in alexithymia levels were observed across patients with varying educational levels, family residence, household monthly income, and number of children. …”
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Exploring multi-level factors determining social participation of students with intellectual disabilities in inclusive physical education classes by Christoffer Klenk, Matthias Buser

“…Schluchter et al. (2024), observed that students with intellectual disabilities (SwID) show lower levels of SP, with fewer friendships, less engagement in social interactions and reduced peer acceptance compared to their non-disabled classmates. …”
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Involvement of Cholesterol Metabolic Pathways in Recovery from Noise-Induced Hearing Loss by Na Sai, Xi Shi, Yan Zhang, Qing-qing Jiang, Fei Ji, Shuo-long Yuan, Wei Sun, Wei-Wei Guo, Shi-Ming Yang, Wei-Ju Han

“…Proteomic Isobaric Tags for Relative and Absolute Quantification (iTRAQ) was used to observe changes in proteins of the miniature pig inner ear following noise exposure. …”
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Three-way relationships between gut microbiota, helminth assemblages and bacterial infections in wild rodent populations by Bouilloud, Marie, Galan, Maxime, Dubois, Adelaide, Diagne, Christophe, Marianneau, Philippe, Roche, Benjamin, Charbonnel, Nathalie

“…Abiotic features, as well as small mammal community composition and within host parasite coinfections, should now be considered to better understand the spatial variations observed in the relationships between gut bacteriota, gastro-intestinal helminths and bacterial infections. …”
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Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study by Johannes Pohl, Geert Verheyden, Jeremia Philipp Oskar Held, Andreas Ruediger Luft, Chris Easthope Awai, Janne Marieke Veerbeek

“…Criterion responsiveness was examined by correlating patient-reported Global Rating of Perceived Change (GRPC) scores and observed change in upper limb measures and AU metrics. …”
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