Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth by Hao Wang, Ruixue Huo, Kexin He, Weihan Li, Yuan Gao, Wei He, Minhao Yu, Shu-Heng Jiang, Junli Xue

“…The average nerve diameter was 28.14 ± 6.04 μm, with no significant difference between intratumoral (28.2 ± 7.65 μm) and extratumoral regions (27.86 ± 6.72 μm). PNI was observed in 65 patients (50.4%). PNI and high normalized nerve density (NND) were associated with shorter overall survival and disease-free survival in CRC patients, with PNI identified as an independent prognostic factor. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…Continuous glucose monitoring was conducted to evaluate parameters for glycemic variability.Results: Sixteen weeks after imeglimin administration, the HbA1c level improved from 7.5%± 1.3% to 6.5%± 0.5% (p < 0.05), the casual blood glucose level significantly improved from 168.2± 55.4 to 127.8± 20.0 mg/dL (p=0.027), time in range increased from 65.0%± 0.34% to 90.0%± 0.08% (p < 0.05), and time above range reduced from 34.0%± 0.034% to 9.0%± 0.08% (p < 0.05). During MTT, we observed significantly reduced area under the curve (AUC)0– 180 glucose, increased AUC0-180 CPR/AUC0-180 glucose, CPR index, and HOMA-β (p< 0.05). …”
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An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced bi... by Shaker Hassan S. Alshehri, Mastour Saeed Alshahrani, Saeed Y. Al Adal, Faisal M. Alyazedi, Hani Hassan Alnakhli, Ravi Shankar Reddy

“…Results Significant differences were observed in AJPS accuracy between groups, with plantar fasciitis patients showing higher AJPS error in plantarflexion (mean difference = 1.22°, p < 0.001) and dorsiflexion (mean difference = 1.31°, p < 0.001). …”
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Association of composite dietary antioxidant index with circadian syndrome: evidence from NHANES by Chen Chen, Chenyu Zhao, Hongyu Jin, Zhiping Jiang, Wei Wang, Wen-Yang Li

“…Subgroup analysis showed BMI modified the inverse association between CDAI and CircS (p for interaction = 0.003).ConclusionThis study revealed a non-linear and negative association between CDAI and CircS risk, with a U-shaped correlation observed between Zinc and CircS. Obese individuals might not benefit from excessively high CDAI. …”
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Thrombotic vs. Bleeding Events of Interruption of Dual Antiplatelet Therapy within 12 Months among Patients with Stent-Driven High Ischemic Risk Definition following PCI by Hao-Yu Wang, Bo Xu, Chen-Xi Song, Chang-Dong Guan, Li-Hua Xie, Yan-Yan Zhao, Zhong-Xing Cai, Sheng Yuan, Ke-Fei Dou

“…Furthermore, the rate of net adverse clinical events (4.9% vs. 3.2%; Cox-adjusted HR: 1.581 [1.128–2.216]; PS matching-HR: 1.639 [1.075–2.499]; IPTW-adjusted HR: 1.554 [1.110–2.177]) was also higher in patients with DAPT interruption (≤12 months), whereas no significant differences between groups were observed in terms of BARC 2, 3, or 5 bleeding. These findings were consistent across various stent-driven high-ischemic risk subsets with respect to the primary ischemic endpoints, with a greater magnitude of harm among patients with diffuse multivessel diabetic coronary artery disease. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…Thin and uniform NFs with a smooth surface and standard size (<400 nm) were observed by SEM at the optimized 5:5 (GEL:PVA) volumetric ratio. …”
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Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids by Janesh Pillay, Antine W. Flikweert, Matijs van Meurs, Marco J. Grootenboers, Simone van der Sar-van der Brugge, Peter H. J. van der Voort, Morten A. Karsdal, Jannie M. B. Sand, Diana J. Leeming, Janette K. Burgess, Jill Moser

“…Further studies are needed to confirm these observations and better understand the role of ECM remodeling in COVID-19 and the potential therapeutic impact of corticosteroids.…”
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Association of serum uric acid, morning home blood pressure and cardiovascular risk factors in a population with previous prehypertension: a cross-sectional study by Lucky Aziza Bawazier, Mochammad Sja'bani, Fredie Irijanto, Zulaela Zulaela, Agus Widiatmoko, Abdul Kholiq, Yasuhiko Tomino

“…Objective To observe the changes in blood pressure (BP) over 10 years and to investigate current BP association to serum uric acid (SUA) levels and cardiovascular risk factors in the epidemiological data of a target group of patients with prehypertension in 2007.Design Cross-sectional study.Setting Mlati Subdistrict, Sleman District, Yogyakarta Province, Indonesia.Participants A total of 733 patients from ‘Mlati Study Database’ in 2007 were selected by simple random sampling using statistical software. …”
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Game-thinking; utilizing serious games and gamification in nursing education – a systematic review and meta-analysis by Mats Nylén-Eriksen, Marko Stojiljkovic, Daniela Lillekroken, Katrin Lindeflaten, Elisabeth Hessevaagbakke, Tone Nygaard Flølo, Olav Johannes Hovland, Ada Marie Svarstad Solberg, Sylvia Hansen, Ann Kristin Bjørnnes, Christine Tørris

“…The most significant effect of game-thinking on academic achievement was observed in the academic knowledge performance of nursing students (Pooled ES = 1.06, [95%CI 0.55, 1.57]), followed by academic skill performance (Pooled ES = 0.54, [95%CI 0.06, 1.03]). …”
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Optimization of Preparation of Bioactive Peptide by Enzymatic Hydrolysis in <italic>Katsuwonus pelamis </italic>Using Response Surface Methodology and its Anti-fatigue Effect on Mi... by LI Shoujiang, KONG Xiangjia, LIU Zhiyu, ZHAO Feng, SU Yongchang, CHEN Xiaoting

“…ObjectiveTo optimize the enzymatic hydrolysis technology of bioactive peptide in <italic>Katsuwonus pelamis</italic> and observe the anti-fatigue effect of bioactive peptide on mice.MethodsWith the yield of bioactive peptide in <italic>Katsuwonus pelamis</italic> as the evaluation index, the papain, neutral protease, flavor protease, alkaline protease and acid protease were used to screen out the best enzymes for <italic>Katsuwonus pelamis</italic> surimi. …”
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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…Toxicities were recorded and immune responses assayed by ELIspot.Results CD8+ T cell responses to transdermal vaccination in DMSO occurred in 83% of participants in group 3 and 86% in group 4, and responses to vaccination in IFA were observed in 29% of participants in group 1 and 14% in group 2. …”
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A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast by Mary E. Edgerton, Yao-Li Chuang, Paul Macklin, Wei Yang, Elaine L. Bearer, Vittorio Cristini

“…In accordance with biological observations, our model simulates the diffusion-limited in situ tumors with a relatively short phase of fast initial growth, followed by a prolonged slow-growth phase where tumor size is constrained primarily by the relative weight of cell mitosis and death. …”
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Mangrove biomass productivity and sediment carbon storage assessment at selected sites in Mauritius: the effect of tidal inundation, forest age and mineral availability by M D D Doodee, S D D V Rughooputh, S Jawaheer

“…Using 25m x 25m quadrats and a simple random sampling technique, plant height and diameter at breast height (DBH) were measured in situ with the GLOBE Observer application (The Globe Program, NASA-sponsored) and a measuring tape, respectively. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…The estrous cycle was observed, and HE staining was performed for pathological changes in the ovary and uterus. …”
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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Results Our findings demonstrated that MDS-MSCs exhibited significant functional impairments, including reduced proliferation, impaired differentiation, diminished support for hematopoiesis, and increased apoptosis. Notably, we observed an upregulation of lipid metabolism in these MSCs, which appears to contribute to their dysfunction. …”
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Peran Asupan Zat Gizi Makronutrien Ibu Hamil terhadap Berat Badan Lahir Bayi di Kota Padang by Mila Syari, Joserizal Serudji, Ulvi Mariati

“…This study was an observational analytic study with case control design. …”
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Perfusion index as a predictor of successful PNS-guided supraclavicular block: A prospective study by Monika Gandhi, Khushboo Ranpise, Aseem Sharma, Manish Banjare

“…Results: Significant increases in PI were observed in the blocked limb at multiple intervals compared to the unblocked limb (P < 0.05). …”
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Prognosis and factors related to severe secondary hyperparathyroidism in long-term peritoneal dialysis patients by Yanmei Li, Xiaonan Feng, Na Chen, Shuhua Song, Min Yu, Yan Wang, Hongxia Zhang, Li Wang, Menghua Chen, Na Tian

“…The sSHPT and non-sSHPT groups comprised 75 (9.7%) (median progression, 35 months) and 696 patients, respectively. sSHPT was defined as a serum intact parathyroid hormone (PTH) level >800 pg/mL observed three times after active vitamin D pulse therapy. …”
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Emulation of ARISTOTLE and ROCKET AF trials in real-world atrial fibrillation patients results in similar efficacy and safety as original landmark trials: insights from the GARFIEL... by Ralf E Harskamp, Karen Pieper, A John Camm, Ajay K Kakkar, Jelle C L Himmelreich, Saverio Virdone, Jean-Pierre Bassand, Frank Misselwitz, Freek W A Verheugt, Frank Cools, Harry Gibbs, Antônio C Pereira-Barretto

“…Aims This study aimed to determine the robustness, reproducibility and representativeness of the landmark Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (AF) (ARISTOTLE) and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in AF (ROCKET AF) randomised trials through replication in an observational AF patient registry.Methods and results Patients from the Global Anticoagulant Registry in the FIELD (GARFIELD)-AF registry treated with apixaban, rivaroxaban or vitamin K antagonist (VKA) were assessed for eligibility for the ARISTOTLE and ROCKET AF trials. …”
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Evaluating the Performance of Artificial Intelligence-Based Large Language Models in Orthodontics—A Systematic Review and Meta-Analysis by Farraj Albalawi, Sanjeev B. Khanagar, Kiran Iyer, Nora Alhazmi, Afnan Alayyash, Anwar S. Alhazmi, Mohammed Awawdeh, Oinam Gokulchandra Singh

“…No heterogeneity was observed between the experimental group (ChatGPT-3.5, Gemini, and Copilot) and the control group (ChatGPT-4). …”
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