ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 Inversely Regulates Programmed Death-Ligand 1 Through Negative Feedback of Phosphorylated Epithelial Growth Factor Recept... by Chiba N, Menju T, Shimazu Y, Toyazaki T, Sumitomo R, Miyamoto H, Tamari S, Nishikawa S, Date H

“…Following a semi-comprehensive phosphorylated RTK assay, we observed the upregulation of phosphorylated EGFR (pEGFR) led by the downregulation of AMAP1. …”
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The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention by Botey Katamu Benjamin, Chunguang Qiu, Zhanying Han, Wenjie Lu, Guoju Sun, Xiaofei Qin, Xule Wang, Xi Wang, Ran Li, Liang Pan

“…A significantly higher rate of myocardial infarction (MI) in diabetic patients with the longest diabetes duration (7.7% vs. 0% and 0.6%, P=0.001) was observed compared with groups of shorter duration. …”
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Baseline Smartphone App Survey Return in the Electronic Framingham Heart Study Offspring and Omni 1 Study: eCohort Study by Jian Rong, Chathurangi H Pathiravasan, Yuankai Zhang, Jamie M Faro, Xuzhi Wang, Eric Schramm, Belinda Borrelli, Emelia J Benjamin, Chunyu Liu, Joanne M Murabito

“…High app survey return rates and very high app survey completion rates were observed along with high participant rating of this study’s app.…”
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A Pragmatic Clinical Trial to Compare the Real-World Effectiveness of V-Go versus Standard Delivery of Insulin in Patients with Advanced Type 2 Diabetes by Mark J. Cziraky, Scott Abbott, Matt Nguyen, Kay Larholt, Elizabeth Apgar, Thomas Wasser, Poul Strange, Leon Shi, H. Courtenay Harrison, Beverly Everitt, Lynn Nowak

“…**Conclusions:** This pragmatic clinical trial demonstrated improved HbA1c levels, lower cost, and decreased insulin dose in patients with T2DM initiating V-Go vs STO in a real-world community-based practice setting. Observed baseline HbAlc indicated use of V-Go in more difficult to manage diabetes patients.…”
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Dietary supplementation with Epimedium contributes to the improvement of hormone levels, gut microbiota, and serum metabolite composition in the Chinese forest musk deer (Moschus b... by Shan Xie, Shan Xie, Qinlin Yang, Zaixiang Ying, Zaixiang Ying, Mingcheng Cai, Wenqiao Fan, Hanyu Gao, Hanyu Gao, Xiaolan Feng, Yongjiang Wu

“…Significant alterations were observed in key metabolic pathways related to lipid metabolism, hormone regulation, and antioxidation, such as ovarian steroidogenesis, tyrosine metabolism, and glycerophospholipid metabolism. …”
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Serum metabolic profiles in quails: Effects of age, breed, and sex by Qin He, Hanle Shang, Yizhong Huang, Lizhi Li, Zhuomin Wu, Huihui Ran, Jiguo Xu, Xinwei Xiong

“…Differences in energy metabolism and amino acid biosynthesis and metabolism were observed between males and females. These findings enhance our understanding of the dynamic changes in quail serum metabolites influenced by various factors and address the knowledge gap regarding serum metabolic changes at different stages in quails.…”
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Efficacy and Acceptability of a Mobile App for Monitoring the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease Receiving Home Oxygen Therapy: Randomized Contr... by Anisbed Naranjo-Rojas, Luis Ángel Perula-de Torres, Freiser Eccehomo Cruz-Mosquera, Guillermo Molina-Recio

“…However, a significant decrease was observed in the IG (baseline median CAT 27, IQR 23-31 vs final median CAT 22, IQR 14-28; P<.001). …”
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Temperature, violent crime, climate change, and vulnerability factors in 44 United States cities by Seulkee Heo, Hayon Michelle Choi, Jesse D. Berman, Michelle L. Bell

“…Evidence is needed on daily impacts of temperature on crime, applying non-linear models across different locations. This observational study examined non-linear relationships between daily summer temperature (May–September) and violent crime in 44 cities across 33 US states, 2005–2022. …”
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CHANNELING: SEARCH OF THE METAANTHROPOLOGIC MEAS-UREMENTS OF MIND BEING IN THE UNIVERSE (based on the World Wide Web) by Anatoly T. Tshedrin

“…The features of channeling as cultural practices aimed at solving the problem of finding meta an-thropological dimensions of existence in the universe of the mind, as an attempt to resolve the contradiction between the theoretical ideas about extraterrestrial civilizations and the lack of empirically observable, the expected signs of their activities. …”
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The criteria for choice of myocardial revascularization method in patients with stable coronary artery disease in routine clinical practice by O.A. Yepanchintseva, O.J. Zharinov, K.O. Mikhaliev, A.V. Khokhlov, B.M. Todurov

“…We performed retrospective observational single-center study and analyzed data from the patients with stable CAD (n = 341), suitable for both methods of MR – percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), according to the pre-specified anatomical criteria. …”
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Rehabilitation Efficacy of Gait Induced Functional Electrical Stimulation Combined with Body-Weight Supported Treadmill Training on Children with Spastic Cerebral Palsy by SONG Wei, ZHONG Yue, KE Xiaohua, HUANG Dunbing, ZHANG Anren, DONG Xiaoli

“…ObjectiveTo observe the effect of gait induced functional electrical stimulation (FES) combined with body-weight supported treadmill training (BWSTT) on gross motor function and walking function of children with spastic cerebral palsy (SCP).MethodsA total of 60 children with spastic cerebral palsy in the Shanghai Fourth People's Hospital Affiliated to Tongji University from March 2022 to March 2023 were randomly divided into control group, BWSTT group and combined intervention group according to a randomized sequence by SAS software, with 20 cases in each group. …”
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Enhancing Soil Moisture Prediction in Drought-Prone Agricultural Regions Using Remote Sensing and Machine Learning Approaches by Xizhuoma Zha, Shaofeng Jia, Yan Han, Wenbin Zhu, Aifeng Lv

“…Singular spectrum analysis (SSA) was first applied to reconstruct site-specific time series, filling in missing and singular values. Leveraging observational data from 617 monitoring sites across the North China Plain and multiple spatial covariates, we developed a machine learning model to estimate near-surface soil moisture at a 1 km resolution. …”
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Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome by Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

“…TF and renin upregulation observed in the BMI- and IR-matched limited sample PCOS subgroup indicates their potential risk of CVD.…”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. …”
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Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey by Ekin Kurtul, Esra Küpeli Akkol, Büşra Karpuz Ağören, Büşra Yaylacı, Özlem Bahadır Acıkara, Eduardo Sobarzo-Sánchez, Eduardo Sobarzo-Sánchez

“…The correlation between the highest inhibitory activity observed in H. sphondylium subsp. cyclocarpum roots and the elevated levels of coumarins, particularly bergapten and imperatorin, suggests a potential link between coumarin concentration and anti-inflammatory effects. …”
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Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential? by Carla C. G. Pinheiro, Alessander Leyendecker Junior, Daniela Y. S. Tanikawa, José Ricardo Muniz Ferreira, Reza Jarrahy, Daniela F. Bueno

“…These results suggest that deciduous dental pulp and orbicularis oris muscle stem cells demonstrate superior osteogenic differentiation potential relative to umbilical cord-derived stem cells and that this increased potential is related to their neural crest origins. Based on these observations, and the distinct translational advantage of incorporating stem cells from noninvasive tissue sources into tissue engineering protocols, greater study of these specific cell lines in the setting of alveolar cleft repair is indicated.…”
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Genetic divergence of hot pepper lines (Capsicum spp.) in hybrid combinations by Šević Biljana, Cvikić Dejan, Slađana Savić, Tupajić Ivan, Ugirnović Milan, Bajagić Marija, Luković Kristina, Stojiljković Jelena

“…The number of fruits per plant (11.40-16.80) and the number of chambers (2) were consistent across hybrids, with no statistically significant differences observed. By comparing market-available varieties with hybrids, which are still limited in number, the results of this study highlight the superiority of hybrids for cultivation in greenhouse. …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…Superior PFS was also observed in the HAIC-L-P group, with an HR of 0.64 (95% CI: 0.55-0.75; p &lt; 0.0001), and higher 1-year and 2-year PFS rates. …”
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The Malayan Landscape Paintings by Sarena Abdullah, Yuen Beng Lee

“…Traveller artists who arrived in Malaya and Singapore during the 18th and 19th centuries illustrated various subject matters that they observed. The most common examples included tropical flora and fauna, various views and landscapes, British residences, and so on. …”
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Impact of subgingival periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome: a systematic review of randomized clinical trials by Marie Chavez, Asshly Ramirez, Akram Hernández-Vásquez, Daniel Comandé, Diego Azañedo

“…Only Montero et al. reported on interleukin 1β and TNF-α, observing significant reductions at 3 months for interleukin 1β (0.9 pg/dl ± SE: 0.1 vs. 2.3 pg/dl ± SE: 0.5; p = 0.046) and TNF-α (6.4 pg/dl ± SE: 0.8 vs. 10.0 pg/dl ± SE: 2.3; p = 0.037).DiscussionThe evidence is limited by the small number of comparative RCTs. …”
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