Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…The increased reduction of cell viability upon the same combination was also observed in patient‐derived metastatic melanoma cells. …”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Survival rates were observed. Bacterial clearance, neutrophil infiltration, tissue damage, and the induction of hepatic and systemic inflammatory responses were determined 2 h and 12 h after the septic insult. …”
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Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury by Sin Yin Lim, Cameron O. Scarlett, Sefer Yapici, Peter Ferrazzano, Peter Ferrazzano, Pelin Cengiz, Pelin Cengiz

“…However, the neuroprotective effect of 7,8-DHF was only observed in female, but not male, neonatal mice with HI brain injury. …”
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Pharmacognostic analysis and antimalarial evaluation of quercetin in Ilex umbellulata bark using HPTLC, in vitro screening, molecular docking, and network pharmacology by James H. Zothantluanga, Dipak Chetia, Yasangam Umbon, T. C. Lalhriatpuii, Dhritiman Roy, Nidahun Lamare, Salem Lalvenhimi

“…JazQSAR web tool previously developed by us predicts the IC50 of quercetin against Plasmodium falciparum as 3.88 ± 0.35 µM, which was not far from the practically observed value for quercetin. Multi-target molecular docking with a validated docking protocol revealed that quercetin could potentially interact with 20 proteins of P. falciparum that are highly expressed during the schizont and trophozoite stages. …”
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Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes by Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

“…Fewer significant differences were observed in participants of non-white ethnic background. …”
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Predictors of the Short‐Term Outcomes of Guillain–Barré Syndrome: Exploring Electrodiagnostic and Clinical Features by Yi‐Hsiang Chen, Chia‐Lun Wu, Wei‐Chieh Weng, Yi‐Chia Wei

“…The clinical features that differentiate between good and poor outcomes in the AIDP subgroup were similar to those observed in all GBS patients. Notably, the motor conduction features, including distal and proximal CMAP and MNCV of the median and tibial nerves (all p < 0.05), were particularly important electrodiagnostic features of outcome discrimination in the AIDP subgroup. …”
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Preparation, Modification, Characterization and Antioxidant Activities of Apigenin Liposomes by Siyu DAI, Ying TANG, Nian LIU, Lu HE, Miao GU, Chenbo FENG, Jin REN, Zhengjie FANG

“…The appearance, microstructure, particle size and distribution, potential, encapsulation efficiency and stability of the liposomes were observed before and after chitosan modification. The antioxidant capacity of apigenin dispersion (AP-D), AP-L and CS-AP-L was investigated by DPPH and ABTS+ free radical scavenging assays. …”
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Synergistic antimicrobial activity of essential oils mixture of Moringa oleifera, Cinnamomum verum and Nigella sativa against Staphylococcus aureus using L-optimal mixture design by Samah H. Abu-Hussien, Antony R. Nasry, Ziad Samy, Salwa M. El-Sayed, Ashraf Bakry, Naglaa Ebeed, Hesham Elhariry, Thanaa ElNoby

“…Gas chromatography mass spectrometry (GC/MS) identified abundant bioactive phytochemicals like cinnamaldehyde, linoleic acid, and palmitic acid methyl esters underlying the observed antimicrobial effects. This rationally designed, synergistic phytochemical combination presents a promising natural therapeutic against antibiotic-resistant S. aureus while exhibiting minimal cytotoxicity. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…A novel OTBI classification was proposed, categorizing patients based on a combination of intracranial hematoma and midline shift observed on imaging, and logistic regression analyses were performed to identify risk factors associated with poor prognosis and to investigate the association between the novel OTBI classification and prognosis. …”
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Sensorimotor Robotic Measures of tDCS- and HD-tDCS-Enhanced Motor Learning in Children by Lauran Cole, Sean P. Dukelow, Adrianna Giuffre, Alberto Nettel-Aguirre, Megan J. Metzler, Adam Kirton

“…No changes with training or stimulation were observed for position sense. For the object hit task, the HD-tDCS group moved more quickly with the right hand compared to sham at posttraining (χ2(2) = 6.255, p=0.044). …”
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Accumulation Characteristics and Hydrological Effects of Litter in Mixed Robinia pseudoacacia Plantations by CAO Zetao, DENG Yangxu, TIAN Jing, WANG Bing, LIU Guobin, YANG Yanfen

“…The evaporation amount and rate followed the same trend as water-holding capacity, in the order of leaf > grass > fruit > branch. (4) During the water-holding and evaporation coupling process, a significant logarithmic relationship existed in the water-holding phase (R2≥0.84, p<0.01), while a significant power function relationship was observed in the evaporation phase (R2≥0.94, p<0.01). …”
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Hubungan Faktor Risiko dengan Kejadian Pre-Eklampsia Berat di RSUP Dr. M. Djamil Padang by Nurulia Muthi Karima, Rizanda Machmud, Yusrawati .

“…The objective of this study was to determine relationship between the risk factors and the incidence of severe pre-eclampsia The design of this research is case-control study with observational analytic methods. The data was collected in January 2013 by using secondary data, maternal medical record data with severe pre-eclampsia and without pre-eclampsia of the obstetrics and gynecology department Dr. …”
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Metode COPRAS untuk Menentukan Kain Terbaik dalam Pembuatan Pakaian pada Butik Batik Hatta Semarang by Saifur Rohman Cholil, Mohamad Adi Setyawan

“…The decision making process can be minimized so that errors do not occur, it requires accurate observations and several considerations from decision makers in terms of texture, color quality, quality of materials, and others in determining the best fabric for making clothing in a fast time quantitatively. …”
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Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response by Jing Wang, Jin Wang, Yi-Na Wang, Yuan-Yuan Wang, Wen-Juan Bai, Nai-Jun Miao

“…Background Massive tumor-associated macrophage (TAM) infiltration is observed in many tumors, which usually display the immune-suppressive M2-like phenotype but can also be converted to an M1-like antitumor phenotype due to their high degree of plasticity. …”
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A MALDI-TOF MS-based multiple detection panel of drug resistance-associated multiple single-nucleotide polymorphisms in Candida tropicalis by Feifei Wan, Min Zhang, Jian Guo, Huiping Lin, Xiaoguang Zhou, Lixin Wang, Wenjuan Wu

“…Although resistance to echinocandins and amphotericin B remains low, multi-resistance to echinocandins and azoles has been observed. Current methods for detecting drug resistance are limited by the long turnaround time of antifungal susceptibility testing, low throughput of Sanger sequence to target resistance mutations, complex data analysis, and high costs of second-generation sequencing. …”
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Prolonged ICU Stay in Severe and Critically-Ill COVID-19 Patients Who Received Convalescent Plasma Therapy by Bambang Pujo Semedi, Nadya Noor Ramadhania, Betty Agustina Tambunan, Siprianus Ugroseno Yudho Bintoro, Soedarsono Soedarsono, Cita Rosita Sigit Prakoeswa

“…There was no effect of convalescent plasma in ICU mortality and no improvement was observed in terms of oxygen support requirements.…”
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Burden of type 2 diabetes due to high body mass index in different SDI regions and projections of future trends: insights from the Global Burden of Disease 2021 study by Yun-fa Ding, An-xia Deng, Teng-fei Qi, Hao Yu, Liang-ping Wu, Hong-bing Zhang

“…The results of the analysis emphasized the geographic variability of T2DM disease burden associated with SDI Within the area covered by the study, a decreasing trend in ASMR for T2DM was observed in high SDI areas, with an EAPC value of − 1.07 and a confidence interval ranging from − 1.39 to − 0.76. …”
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Transport into the polar stratosphere from the Asian monsoon region by X. Yan, P. Konopka, F. Ploeger, F. Ploeger, A. Podglajen

“…We use SF<span class="inline-formula">₆</span> observations and the Lagrangian chemistry transport model Chemical Lagrangian Model of the Stratosphere (CLaMS), driven by the ERA5 reanalysis data for the period 2010–2014, to assess the impact of the Asian monsoon (AM) region (15–45° N, 30–120° E) as a significant source of pollutants for the stratosphere, in particular in polar regions. …”
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Investigating the Effects of Optimized Mineral Fertilization on Plant Growth, Physiological Traits, Tuber Yield, and Biochemical Contents of Potato Crop by Hadjer Chabani, Neji Tarchoun, Roua Amami, Wassim Saadaoui, Najla Mezghani, Alexios A. Alexopoulos, Spyridon A. Petropoulos

“…The highest yield per plant (615.4 g of tubers) and average number of tubers/plant (6.44) were observed in cv. ‘Spunta’ subjected to optimal fertilizer rate (T1), while more than 50% of tubers of this variety were classified as size C1 (>50 mm). …”
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Analysis of Lens Thickness Distribution Based on Swept-Source Optical Coherence Tomography (SS-OCT) by Xi Feng, Yong Wang, Jianheng Liang, Yali Xu, Julio Ortega-Usobiaga, Danmin Cao

“…The values of LT : AL, AS : AL, and VCD : AL in different AL groups and their changes are the main outcome measures used to observe the proportion of the anterior and posterior segments of the eye. …”
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