Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS) by Alessandra Trojani, Alessandro Beghini, Luca Emanuele Bossi, Marta Rachele Stefanucci, Cassandra Palumbo, Antonino Greco, Annamaria Frustaci, Barbara Di Camillo, Roberto Cairoli

“…Interestingly, we identified new mutated genes, including WNK2 somatic mutations affecting 46% of WM/sWM patients, for which a recurrent allelic variant (V1635Ter) was observed in this cohort. Moreover, sequencing evaluation revealed recurrently frameshift or missense mutations involving NFKB2 (L473Afs) in 60% of IgM MGUS and 20% of WM/sWM, PTPN13 (P1546Tfs) in 20% of IgM MGUS and 7% of WM/sWM, CARD11 (S622del) in 20% of IgM MGUS and 20% of WM/sWM, KMT2C (I823T) in all IgM MGUS and 93% of WM/sWM, and ATM in 20% of IgM MGUS and 47% of WM/sWM patients. …”
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Is the flipped classroom more effective than the traditional classroom in clinical medical education: a systematic review and meta-analysis by Xu-Ying Shi, Qing Yin, Qiu-Wen Wang, Bing-Rui Lu, Guo-Xiang Li, Shu-Hong Huang, Zhi-Gang Sun

“…However, no statistically significant difference was observed in student satisfaction (SMD = −0.195, 95% CI: −1.081 to 0.691, p = 0.667).ConclusionThe flipped classroom teaching method is more effective in enhancing the theoretical scores, composite scores, and skill scores of clinical medicine students compared to the traditional classroom teaching method. …”
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The challenges of evidence-based prehabilitation in a real-life context for patients preparing for colorectal surgery—a cohort study and multiple case analysis by A. D. Talen, N. L. U. van Meeteren, J. A. Barten, I. Pereboom, W. P. Krijnen, H. Jager-Wittenaar, B. C. Bongers, G. van der Sluis

“…This study aimed to investigate the implementation fidelity of an evidence-based prehabilitation program in the real-life context of a Dutch regional hospital. Methods In this observational cohort study with multiple case analyses, all patients who underwent colorectal surgery from January 2023 to June 2023 were enrolled. …”
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Unfolding insights about resilience and its coping strategies by medical academics and healthcare professionals at their workplaces: a thematic qualitative analysis by Salman Yousuf Guraya, Jacqueline Maria Dias, Mohamed Ahmed Eladl, Ayah Mohammad Rajai Rustom, Fatima Audi Saleem Alalawi, Majid Hassan Saleh Alhammadi, Yusra Ahmed Mohammed Ahmed, Amna Ali Omran Taryam Al Shamsi, Sarah Juman Bilalaga, Alfred Nicholson, Hani Malik, Shaista Salman Guraya

“…The guide was validated by content experts and was piloted on a small group of MHAs of the University of Sharjah (UoS) and HCPs from different hospitals of the United Arab Emirates to test its relevance, internal consistency, and inter-observer validity. The validated interview guide was then administered for in-person interviews. …”
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Associations of social isolation with sociodemographic aspects and health indicators in Brazilian middle-aged and older adults: ELSI-Brazil by Paulo Afonso Sandy Júnior, Flávia Silva Arbex Borim, Daniela de Assumpção, Anita Liberalesso Neri

“…Significant positive associations were observed between high level of social isolation and male sex (PR 1.27; 95%CI 1.16–1.40); being 70 to 79 years old (PR 1.22; 95%CI 1.07–1.39) or 80 years or older (PR 1.56; 95%CI 1.32–1.85); having no formal education (PR 3.15; 95%CI 2.69–3.68) or having a maximum of 4 years (PR 2.11; 95%CI 1.82–2.46) or 5 to 8 years of formal education (PR 1.54; 95%CI 1.30–1.84); fair self-rated health (PR 1.25; 95%CI 1.12–1.39); depressive symptoms (PR 1.22; 95%CI 1.07–1.40); and poor-quality diet (PR 1.37; 95%CI 1.19–1.58). …”
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Trends in the prevalence of antenatal and postnatal depression in Bangladesh: A systematic review and meta-analysis by Mohammad Injamul Hoq, Md Mohotasin Hossain, Mohammad Aktar Sayeed, Md Jakaria

“…Conclusion: A rising trend in the prevalence of maternal depression has been observed in Bangladesh. Health policymakers need to prioritize addressing maternal depression. …”
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The value of thrombus markers applied in patients with respiratory failure by Yingqun Chen, Zihan Yin, Junshi Wang, Cunliang Yan, Xuwei Lin, Lei Huang

“…In correlation analysis, a positive correlation was observed between TT, PCT, and the fraction of inspired oxygen (FiO2). …”
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The endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 3 attenuates the unfolded protein response and has pro-survival and pro-viral roles in hepatoma cells and... by Alina-Veronica Ghionescu, Mihaela Uta, Andrei Sorop, Catalin Lazar, Petruta R. Flintoaca-Alexandru, Gabriela Chiritoiu, Livia Sima, Stefana-Maria Petrescu, Simona Olimpia Dima, Norica Branza-Nichita

“…Results Our work revealed significantly elevated EDEM3 expression in HCC tissues irrespective of HBV infection, while the highest levels were observed in tissues from HBV-infected patients. Investigation of published transcriptomic data sets confirmed EDEM3 upregulation in independent HCC patient cohorts, associated with tumor progression, poor survival prognosis and resistance to therapy. …”
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Approaches for difficult-to-induce-seizures electroconvulsive therapy cases (DEC): a Japanese expert consensus by Yoshiteru Takekita, Taro Suwa, Kazuyuki Yasuda, Hirotsugu Kawashima, Wataru Omori, Naoki Kurimoto, Takashi Tsuboi, Takamasa Noda, Nobuatsu Aoki, Ken Wada, Ken Inada, Minoru Takebayash, Expert Consensus Development Working Group, Electroconvulsive Therapy Committee, Japanese Society of General Hospital Psychiatry

“…The results of rating approaches for patients with mood disorders and schizophrenia were similar, with differences observed among the approaches for patients with catatonia, high risk of cognitive impairment, and cardiovascular events. …”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…These findings demonstrate that distance manipulation influences visual behavior and decision-making processes in dynamic sports situations. The gaze patterns observed between the monitoring and execution phases suggest phase-specific visual strategies. …”
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Comparison of integrated versus parallel continuous renal replacement therapy combined with veno-venous extracorporeal membrane oxygenation in patients with COVID-19 ARDS by Kristina Schönfelder, Felix Helmenstein, Frank Herbstreit, Johanna Reinold, Andreas Kribben, Michael Jahn, Justa Friebus-Kardash

“…Thromboembolism occurred in four cases in the integrated group, while one pneumothorax was observed in the parallel group. No cases of air embolism, device associated haemolysis or blood leakage was documented. …”
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The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Secondly, an adjuvant-induced arthritis rat model was established to directly observe the anti-inflammatory and anticoagulant effects of XFC in vivo. …”
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Integrative application of licorice root extract and melatonin improves faba bean growth and production in Cd-contaminated saline soil by Shimaa A. Abd El Mageed, Ali A. S. Sayed, Ahmed Shaaban, Khaulood A. Hemida, Abdelsattar Abdelkhalik, Wael M. Semida, Ibrahim A. A. Mohamed, Mohammed A. H. Gyushi, Yasmine H. Abd Elmohsen, Taia A. Abd El Mageed

“…However, the application of LRE + Mt considerably improved these negative effects, with higher improvements were observed due to application of LRE + Mt100. Application of LRE + Mt significantly reduced hydrogen peroxide (H2O2) accumulation, lipid peroxidation and Cd content in leaves and seeds, all of which had increased due to Cd stress. …”
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Assessment of rainfed wheat productivity in a changing climate in Irbid, Jordan using statistical downscaling and Random Forest Regression prediction under RCP4.5 & 8.5 pathway... by Tasnim Dheif Allah Althalaj, Fayha Muhammed Al-Shibli, Amani Abdullah Alassaf

“…Taylor diagram was utilized to choose the best model to represent observed data. Cumulative Distribution Function and Probability Density Function Curves were plotted to describe the changes over decades based on climate models. …”
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Health-related Quality of Life and Exercise Capacity in Double Lung Transplant Recipients With Baseline Lung Allograft Dysfunction by Alisha Rullay, BSc, Karina Kaur, BSc, Jennifer Holman, PT, Laura C. van den Bosch, MD, Justin G. Weinkauf, MD, Jayan Nagendran, MD, PhD, Rhea A. Varughese, MD, Alim S. Hirji, MD, Dale C. Lien, MD, Jason C. Weatherald, MD, Kieran M. Halloran, MD

“…BLAD was associated with lower SF-36 scores (P = 0.0025) and 6MWD (P = 0.0008) in adjusted regression models at 1 y posttransplant. We did not observe differences in Beck Depression Inventory or Borg scores. …”
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Postoperative symptom changes following uterine artery embolization for uterine fibroid based on FIGO classification by Yoshimi Nozaki, Shiori Takeuchi, Masafumi Arai, Yoshiki Kuwatsuru, Hiroshi Toei, Shingo Okada, Hitomi Kato, Naoko Saito, Takamichi Nobushima, Keisuke Murakami, Mari Kitade, Ryohei Kuwatsuru

“…Level of evidence 3B, Retrospective observational study.…”
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Death trends for 2010 - 2022 for members of a large private medical scheme in South Africa by L Steenkamp, S Collie, T A Moultrie, H Moultrie, G Gray

“…When COVID-19 -related deaths are excluded, the age-standardised rates for both females and males in 2022 was lower than observed in the pre-pandemic years. While the low mortality experience could be related to competing causes and mortality displacement, further analysis over a longer period is needed to confirm this. …”
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The association between bone density of lumbar spines and different daily protein intake in different renal function by Chia-Lin Lee, Kun-Hui Chen, Wei‑Ju Liu, Ching-Hsien Chen, Shang-Feng Tsai

“…However, a higher risk of osteoporosis was observed only in the non-CKD group. There was an apparent trend of higher DPI coexisting with lower BMD and T scores in patients with CKD. …”
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The impact of an integrated intervention program combining drug therapy with water, sanitation, and hygiene (WASH) education on reinfection with intestinal parasitic infections amo... by Woottichai Nachaiwieng, Sangob Sanit, Nattharinee Kongta, Jassada Saingamsook, Suwit Duangmano, Sakorn Pornprasert, Pradya Somboon, Jintana Yanola

“…In contrast, no significant changes in the prevalence of IPIs were observed in the control group. The intervention group showed significant improvements in KAP scores, which were significantly higher than those in the control group. …”
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Modified single-incision MIS-TLIF with expandable tubular assistance for degenerative lumbar spine diseases by Wenlong Hu, Wenlong Hu, Fei He, Fei He, Kai Sun, Kai Sun, Haiwu Wan, Sijun Ruan, Bo Huang

“…However, significant differences were observed in intraoperative blood loss, postoperative drainage, and complication rates. …”
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