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39021
Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment
Published 2025-01-01“…From 2 months of age, we observed mislocalized ANXA11 aggregates, SQSTM1/p62-positive inclusions, and cytoplasmic TDP-43 mislocalization, which intensified with disease progression. …”
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39022
Genome-wide identification of oat TCP gene family and expression patterns under abiotic stress
Published 2025-02-01“…After drought and salt stress treatments, significant differences in gene expression were observed among different oat cultivars and treatment periods. …”
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39023
Molecular investigation reveals three hemotropic mycoplasmas in cats and three tick species in China
Published 2025-01-01“…M. haemobos’ in the environment group, no significant differences were observed in the infection rates among the three tick species from anemic or healthy cats (p > 0.05, α = 0.05). …”
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39024
Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure
Published 2020-01-01“…During a 2-year follow-up, no significant association was observed of β-blocker use with all-cause mortality (with β-blockers 47/5,043 (0.9%) vs. without β-blocker use 8/588 (1.4%); hazard ratio (HR) 0.762, 95% confidence interval 0.36 to 1.64; P=0.485), cardiac death, myocardial infarction (MI), or major adverse cardiovascular and cerebrovascular events. …”
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39025
Molecular cloning and expression dynamics of Atrogin-1 in muscle tissue of Russian sturgeon (Acipenser gueldenstaedtii) under high salt stress
Published 2025-03-01“…A significant upregulation of atrogin-1 mRNA was observed at salinities of 16 ‰ and 24 ‰ compared to the control group. …”
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39026
Air temperature and precipitation constraining the modelled wetland methane emissions in a boreal region in northern Europe
Published 2025-01-01“…However, multi-model means, inversions, and upscaled eddy<span id="page324"/> covariance flux observations agree on the month of maximum emissions and are co-limited by temperature and precipitation. …”
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39027
Measurement of CP violation in B0 → D+D − and B s 0 $$ {\textrm{B}}_{\textrm{s}}^0 $$ → D s + D s − $$ {\textrm{D}}_{\textrm{s}}^{+}{\textrm{D}}_{\textrm{s}}^{-} $$ decays
Published 2025-01-01“…For the first time in a single measurement, CP symmetry is observed to be violated in B 0 → D + D − decays with a significance exceeding six standard deviations.…”
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39028
Barriers and facilitators to implementation of a home-based cardiac rehabilitation programme for patients with heart failure in the NHS: a mixed-methods study
Published 2022-07-01“…Different implementation contexts (urban/rural), timing (during the COVID-19 pandemic) and factors outside the healthcare team/system (quality of the REACH-HF training) were observed to negatively or positively impact the implementation process.Conclusions The findings are highly relevant to healthcare professionals involved in planning, delivering and commissioning of cardiac rehabilitation for patients with heart failure. …”
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39029
Clinical Characteristics, Laboratory Parameters, and Molecular Epidemiology of Neuroinvasive Flavivirus Infections in a Hotspot Region of Eastern Croatia
Published 2025-01-01“…No significant differences in the frequency of clinical symptoms were observed between WNV and TBEV-infected patients (fever 93.7 vs. 100%; malaise 78.1 vs. 100%; headache 75.0 vs. 100%; nausea 50.0 vs. 63.6%; vomiting 34.4 vs. 54.6%). …”
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39030
Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes
Published 2025-01-01“…Compared with the parental virus H120 strain, rH120-Δ5ab-gD-T/B showed similar growth kinetics. Clinical observations and scoring of clinical signs in the vaccination-challenge experiment showed that rH120-Δ5ab-gD-T/B provided 90% protection against virulent ILTV, effectively alleviating clinical signs caused by infection with a virulent strain of ILTV. …”
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39031
Rectal temperature and heat transfer dynamics in the eye, face, and breast of broiler chickens exposed to moderate heat stress
Published 2025-02-01“…Strong correlations were observed between Tr and Ts (r = 0.88, 0.89, and 0.92 for Tsb, Tse, and Tsf, respectively), suggesting Ts as a strong predictor of Tr. …”
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39032
Multi-decade northward shift of loggerhead sea turtle pelagic habitat as the eastern North Pacific Transition Zone becomes more oligotrophic
Published 2025-01-01“…Here, we integrate nearly 3 decades of satellite tracking data from a climate sentinel, the juvenile North Pacific loggerhead sea turtle (Caretta caretta), with concurrent observations of sea surface temperature (SST) and chlorophyll-a concentrations to examine higher trophic level response to climate-induced changes within the eastern bounds of the NPTZ. …”
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39033
Characteristics and contributing factors of adverse drug reactions: an analytical study of patients with tuberculosis receiving treatment under the National TB Program of India [ve...
Published 2024-07-01“…Although the National Tuberculosis Elimination Program (NTEP) is providing a wide range of interventions from early diagnosis to complete treatment to reduce morbidity and mortality from TB, adverse drug reactions (ADR) remain a challenge in treatment adherence and completion. Methods An observational cross-sectional study was conducted in selected districts of Gujarat state. …”
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39034
Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intes...
Published 2025-01-01“…The differences in the gut microbiota, as identified through 16S rRNA and ITS2 sequencing, were subsequently more pronounced than those observed in the bacterial microbiota of the model group. …”
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39035
The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult...
Published 2025-02-01“…Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease frequently complicated by gastro-oesophageal reflux disease. Although several observational studies and a pilot study have investigated the role of proton pump inhibitors (PPIs) in IPF, their efficacy is unknown and there is much debate in international IPF guidelines on their use. …”
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39036
Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics
Published 2024-12-01“…No significant relationships were observed between HER2 status and TyG levels, HOMA-IR, or HOMA-B. …”
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39037
HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis
Published 2025-03-01“…In addition, cardiac aging phenotypes and mitochondrial biogenesis were also analyzed in 25-month-old cardiac-specific Hint1 knockout mice, 24-month-old CAG-Caren Tg mice, and 24-month-old wild-type mice injected with AAV6-Caren. Results: We observed inactivation of mitochondrial biogenesis in hearts of aged mice. …”
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39038
A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection
Published 2025-01-01“…Moreover, histopathological changes of main tissues from all vaccinated mice were not observed.ConclusionThese data indicate that the L350–ferritin nanoparticle vaccine candidate has considerable potential application in preventing EBV infection and provides a promising basis for developing prophylactic EBV vaccines.…”
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39039
Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes
Published 2025-06-01“…In terms of mRNA expression, the overexpression of Mt-1, OGG1, APE1, Ku70, and Ku80 was observed. This finding suggests that DNA damage is primarily repaired via two mechanisms: base excision repair (BER) and nonhomologous end joining (NHEJ). …”
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39040
Supplementation of Parachlorella sp. in feed promote the gut microbiome colonization and fecal IgA response of broiler in both early and late period
Published 2025-01-01“…A significant positive correlation was observed between IgA, Clostridiaceae and Clostridium during the early and late periods. …”
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