Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial by Federica Sordelli, Antonio Desai, Filippo Dagnino, Roberto Contieri, Sofia Giuriolo, Marco Paciotti, Vittorio Fasulo, Stefano Mancon, Davide Maffei, Pier Paolo Avolio, Giorgio Da Rin, Federica Maura, Elena Vanni, Davide Federico, Piergiuseppe Colombo, Giovanni Lughezzani, Nicolò Maria Buffi, Paolo Casale, Alberto Saita, Massiomo Lazzeri, Rodolfo Hurle, Antonio Voza

“…Methods: We conducted a prospective single-centre observational study in the ED of a tertiary university hospital. …”
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Cultivatable Bacteriota of Chronic Wound of Patients with Diabetic Foot Syndrome with Critical Limb Ischemia Based on Wound Biopsy in Peri-Revascularization Period by Syedah Sarah Hussaini, Fran Dominic Grubesa, Mateusz Gajda, Martyna Schönborn, Katarzyna Bogucka, Mikołaj Maga, Paweł Maga, Jadwiga Wójkowska-Mach

“…No cases of reocclusion or restenosis were observed during the study; however, small amputations were performed in two patients (8.7%). …”
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Scenario Simulation of Ecosystem Services Based on Land Use/Land Cover Change in the Bailong River Basin, in China by Shuangying Li, Yanyan Zhou, Dongxia Yue, Zhongling Guo, Zhi Li

“…Built-up land and farmland increased, and ESs decreased significantly under the SSP5-8.5 scenario. (2) Synergistic effects were identified among the ESs, with the most pronounced synergy observed between CS and HQ. Spatially, six pairs of ESs under the SSP1-2.6 scenario showed synergistic effects. …”
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Genetic Association and Expression Correlation between Colony-Stimulating Factor 1 Gene Encoding M-CSF and Adult-Onset Still’s Disease by Yi-Ming Chen, Wei-Ting Hung, Wan-Chun Chang, Chia-Wei Hsieh, Wen-Hung Chung, Joung-Liang Lan, Ning-Rong Gung, Yun-Shien Lee, Der-Yuan Chen, Shuen-Iu Hung

“…Patients with systemic pattern outcome were associated with elevated M-CSF and frequently observed in TT carriers. Our data suggest that genetic variants near CSF1 are associated with AOSD and the rs11102024 T allele links to higher M-CSF levels and systemic outcome. …”
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Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment by Haiyi Zhang, Lu Zhang, Juan Lu, Jiajun Yue, Zhengzhen Yuan, Jidan Hu, Qi Yao, Yuting Fu, Guiquan Chen, Jiliang Fang, Jie Zhao

“…In summary, the results of our study suggest that patients diagnosed with BD-MCI display atypical activity across several brain regions. The observed changes in these areas encompass a range of functional networks. …”
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Phytolith assemblages from palm leaves and palm-leaf manuscripts: what is the difference and what it could mean? by Anastasia Poliakova, Anastasia Poliakova, Anastasia Poliakova, Giovanni Ciotti, Giovanni Ciotti, Giovanni Ciotti, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Agnieszka Helman-Wazny, Jörg Fromm, Jörg Fromm

“…Fifty-three phytolith types described for PLM material were not observed in any of the fresh, dry or herbarized palm-leaf samples. …”
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Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province by Zichen Feng, Long Sun, Shu Niu, Bin Liu, Ruijie Ba, Guoqing Wang, Qing Sun, Chunxiang Li, Yan Wang, Fangfang Yu, Guoyu Zhou, Yue Ba

“…Thus, this study explored the relationships among fluoride exposure, genetic factors, physiological characteristics, lifestyle, and OAD risk, as well as the potential interactions among contributors in 593 adults from a cross-sectional study conducted in 2017. We observed that the OAD (n = 175) risk was increased with increasing urinary fluoride (UF) levels (OR=1.484; 95 %CI: 1.043, 2.111), age (OR=1.065; 95 %CI: 1.033, 1.098), and hip circumference (OR=1.069; 95 %CI: 1.014, 1.127), as well as a poor night sleep quality (OR=1.818; 95 %CI: 1.072, 3.084). …”
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Molecular and biological characterization of infectious full-length cDNA clones of two viruses in Paris yunnanensis, including a novel potyvirus by Pingxiu Lan, Peng He, Aiqiu Mu, Mengji Cao, Yun Wang, Guohua Zhou, Xiaojiao Chen, Hong Cai, Fan Li

“…However, except mild leaf deformation exhibited on the PpCMV-inoculated C. moschata plants, no obvious symptom were observed in these plants including P. yunnanensis. …”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

“…Recent studies show the controlled release of vimentin into the extracellular environment, where it functions as a signaling molecule. Such observations are expanding our current knowledge of vimentin as a structural cellular component towards additional roles as an active participant in cell signaling. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…The overall incidence of Salmonella was 9.4 %, with a higher contamination rate observed in pork at 13.5 %, followed by the retail environment at 7.69 %. …”
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Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…Conclusion This meta-analysis revealed a moderate prevalence and a notable mortality rate for dengue and leptospirosis co-infections, with significant variability observed across different studies. Further research into the immunopathology and the implementation of integrated surveillance systems could enhance the effectiveness of diagnosis and treatment strategies in regions where these diseases are endemic.…”
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The Role of Inflammatory Parameters and Antibody Seroconversion on COVID-19 Outcomes in Patients with Central Obesity by Syahidatul Wafa, Dicky Levenus Tahapary, Evy Yunihastuti, Heri Wibowo, Cleopas Martin Rumende, Kuntjoro Harimurti, Ketut Suastika, Farid Kurniawan, Rona Kartika, Tika Pradnjaparamita, Dante Saksono Harbuwono

“…The poor clinical outcome of hospitalization was observed. We used the Mann-Whitney test to analyse non-normally distributed data, and T-test for normally-distributed data. …”
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Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway by Yingfu Chen, Burong Feng, Ye Yuan, Juan Hu, Wei Zhao, Huiwei Jiang, Wen Li, Ziyi Fan, Zhimin Du

“…We established a hyperlipidemia-induced cardiac inflammation model in rats and cells then administered AE and observed its effect on hyperlipidemia-induced cardiac inflammation. …”
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Physical Activity, Fatigue, and Sleep in People with Parkinson’s Disease: A Secondary per Protocol Analysis from an Intervention Trial by S. Coe, M. Franssen, J. Collett, D. Boyle, A. Meaney, R. Chantry, P. Esser, H. Izadi, H. Dawes

“…There was no impact on self-reported fatigue or sleep. Conclusion. The observed moderate effect on sedentary and light activities overnight could suggest an objective improvement in sleep patterns for individuals participating in both exercise and handwriting interventions. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…Functional experiments demonstrate the requirement of PLAC8 in SARS-CoV-2 pancreatic productive infection by pseudovirus and full SARS-CoV-2 infectious virus inoculum from Wuhan-1 and BA.1 strains. Finally, we observe an overlap between PLAC8 and SARS-CoV-2 immunoreactivities in the pancreas of deceased patients. …”
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Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis by Jian Zhang, Xiaomei Li, Ying Hu, Bin Dong, Yongning Jia, Ziyu Li, Xiaojing Cheng, Jinyao Shi, Jiafu Ji, Zhongwu Li, Hong Du, Ting Guo, Shuqin Jia, Xiaofang Xing, Yunsheng Dou

“…Then we performed multiplex fluorescence staining of a panel of immune markers (CD3, CD4, CD8, FOXP3 and PDL1) and T cell receptor β-chain sequencing to phenotype and enumerate T cell subpopulations and clonal expansion in paired GC samples (prechemotherapy and postchemotherapy) from another cohort of 30 cases of stage II/III GC patients.Results Infiltration of CD68+ macrophages in residual tumors after NAC was significantly decreased compared with treatment-naïve GC patients, while no significant difference observed with respect to other immune markers. In residual tumors, post-NAC CD8 +T cells and CD68+ macrophages levels were significantly associated with chemotherapy response. …”
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Exploring the physiological and biochemical mechanisms underlying growth rate variability in Hong Kong oyster (Crassostrea hongkongensis) by Na Hu, Wenhong Li, Pingping He, Pinyuan Wei, Ke Bai, Junliang Guan, Li Zhang, Yongxian Chen, Wei Li, Yusi Zheng, Qingsong He, Longcheng Liu, Xingzhi Zhang, Jinxia Peng

“…Significantly elevated activities of α-amylase and lipase (341.71 μg/min/mg prot and 363.83 nmol/min/mg prot) were observed in the SL group compared to the CL and CS groups (p < 0.05). …”
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Impact of bariatric surgery on liver fibrosis indices among type 2 diabetes patients in a national cohort by Arsalan Seyedi, Soghra Rabizadeh, Sahar Karimpour Reyhan, Sara Hobaby, Samira Amin Afshari, Mostafa Shomalzadeh, Seyed Ali Nabipoorashrafi, Nasrin Asgari Soran, Amirhossein Yadegar, Fatemeh Mohammadi, Fatemeh Moosaei, Elahe Saffari, Sajedeh Riazi, Fatemeh Sarv, Manouchehr Nakhjavani, Abdolreza Pazouki, Alireza Esteghamati

“…It showed an initial increase observed at the three-months visit, followed by a decline up to one year with a slight increase at the last follow-up (P-trend < 0.001). …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Similar results were observed for progression-free survival (PFS). Based on the results retrieved from organ-specific irAEs, ‘aggregated’ burden scores were developed to distinguish ‘protective’ (endocrine and musculoskeletal) and ‘harmful’ (gastrointestinal, pneumonitis, neurological, hepatic) irAEs showing prognostic effects on OS and PFS.Conclusions Our results demonstrate that not all irAEs could exert a protective effect on oncologic outcome. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. Methods: In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. …”
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