Evidence Gaps and Lessons in the Early Detection of Atrial Fibrillation: A Prospective Study in a Primary Care Setting (PREFATE Study) by Josep L. Clua-Espuny, Alba Hernández-Pinilla, Delicia Gentille-Lorente, Eulàlia Muria-Subirats, Teresa Forcadell-Arenas, Cinta de Diego-Cabanes, Domingo Ribas-Seguí, Anna Diaz-Vilarasau, Cristina Molins-Rojas, Meritxell Palleja-Millan, Eva M. Satué-Gracia, Francisco Martín-Luján

“…However, inconsistencies in monitoring outcomes and limitations in current guidelines, particularly regarding AF burden, were observed. <b>Conclusions:</b> The study underscores the feasibility and utility of AF screening in primary care but identifies critical gaps in diagnostic criteria, anticoagulation thresholds, and guideline recommendations.…”
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Phytoplankton growth and succession driven by topography and hydrodynamics in seasonal ice-covered lakes by Ziyue Zhao, Yanfeng Wu, Y. Jun Xu, Yexiang Yu, Guangxin Zhang, Dehua Mao, Xuemei Liu, Changlei Dai

“…An integrated underwater topographic-hydrodynamic model was constructed based on topographic data from 597 exploration points and long-term hydrological and meteorological observational data. The dominant algal species and their three-dimensional distribution and succession processes during different periods were studied in detail. …”
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Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial by Péter Hegyi, Noémi Gede, Szilárd Váncsa, Barbara Tóth, András Jávorházy, Péter Nyirády, Boglárka Csupor-Löffler, Péter Birinyi, George Zhanel, Kurt Naber, Reinhard Länger, Nóra Vörhendi, Dezső Csupor

“…The antimicrobial activity of its extracts and some of its individual constituents has been observed in vitro; however, the efficacy of bearberry compared with standard antimicrobial therapy has not been assessed yet.Objective The objective of the study is to assess the safety and non-inferiority of bearberry as an alternative therapy in the treatment of acute uncomplicated cystitis in comparison with standard antibiotic therapy (fosfomycin).Methods and analysis This is a randomised controlled double-blinded multicentre trial. …”
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Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients by Amalia Azzariti, Simona De Summa, Tommaso M. Marvulli, Ivana De Risi, Giuseppe De Palma, Roberta Di Fonte, Rossella Fasano, Simona Serratì, Sabino Strippoli, Letizia Porcelli, Michele Guida

“…However, high number of significant correlations were observed among certain biomarkers in non-responders. …”
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Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students by Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang

“…Both groups demonstrated significant improvements in pull-up endurance and lat pull-down MVIC peak force after training, but no significant difference between the two groups was observed in the post-training test. Additionally, muscle activation of BR, PD, and PM decreased significantly in both groups, while the RT + tDCS group also demonstrated a significant reduction in TB coactivation after training. …”
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Attitudes toward healthy nutrition in Germany — results from an online-representative cross-sectional survey by Etienne Hanslian, Etienne Hanslian, Julia Katharina Schiele, Julia Katharina Schiele, Michael Jeitler, Andreas Michalsen, Andreas Michalsen, Manfred Wischnewsky, Manfred Wischnewsky, Maximilian Andreas Storz, Benno Brinkhaus, Miriam Ortiz, Mike R. Sigl, Rasmus Hoffmann, Judith Lehmann, Daniela A. Koppold, Daniela A. Koppold, Daniela A. Koppold, Daniela A. Koppold, Christian S. Keßler, Christian S. Keßler

“…Gender-specific dietary preferences were observed, with plant-based diets being much more popular among females. …”
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Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population by Helga Westerlind, Linda Mathsson-Alm, Alexandra Circiumaru, Aase Hensvold, Karin Lundberg, Jan Potempa, Yogan Kisten, Charlotte De Vries, Marina Dehara, Barbara Potempa

“…No changes in anti-Rgp IgG levels were observed during follow-up. The anti-Rgp IgG response at baseline did not associate with the development of arthritis; Cox-regression showed an HR of 0.95 (CI 0.80 to 1.13, p=0.6) for anti-Rgp IgG levels, and 0.82 (CI 0.55 to 1.23, p=0.3) for anti-Rgp IgG positivity.Conclusions Antibodies against the oral bacterium Pg are elevated during the RA-risk phase, both in individuals progressing to arthritis and in individuals remaining arthritis-free. …”
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Pattern of Disinfection of Root Canal Dentin by Alternated Acid-Base Irrigating Regimen by Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos Soares, Rodrigo Dantas Pereira, Manoel Brito-Júnior, Paula Prazeres Magalhães, Isabel Alessandra Miranda Nunes, Rudys Rodolpho de Jesus Tavarez, Claudia de Castro Rizzi, Rafaela Nogueira Moreira, Luiz de Macêdo Farias, Etevaldo Matos Maia Filho

“…Results. Biofilms were observed only in the control root canal walls. Topographically, the controls and CR showed similar distributions of E. faecalis in the dentin. …”
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TLR7: A Key Prognostic Biomarker and Immunotherapeutic Target in Lung Adenocarcinoma by Feiming Hu, Chenchen Hu, Yuanli He, Yuanjie Sun, Chenying Han, Xiyang Zhang, Lingying Yu, Daimei Shi, Yubo Sun, Junqi Zhang, Dongbo Jiang, Shuya Yang, Kun Yang

“…The response of the TLR7 subgroup to immunotherapy and drug sensitivity was observed. <b>Results:</b> We found significant associations between the immune and stromal components of LUAD TME and clinical features and prognosis. …”
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Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…The high expression levels were observed for LEF1 and DVL1. Inactive GSK3β and nuclear localization of β-catenin indicated Wnt signaling activation. …”
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Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort by Hui Wang, Dezheng Fu, Xiaoning Liu, Xiaochen Chang, Siyu Guo, Xiaomeng Cheng, Ying Tian, Jinjun Ran, Jun Zhang, Shengju Yin

“…When stratified by child sex, the statistically significant inverse associations were observed exclusively in girls. Results from BKMR showed that the overall effect of prenatal exposure to OPEs and OPPs mixtures was associated with some neurodevelopmental domains in girls. …”
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Spatiotemporal optimization of irrigation practices for winter wheat in China: Rationale, implications, and solutions by Luchen Zhang, Yuan Cao, Weihao Qian, Junning Tian, Shengshi Huang, Xiaolei Qiu, Bing Liu, Liang Tang, Liujun Xiao, Weixing Cao, Yan Zhu, Leilei Liu

“…Drought stress was most severe during the jointing to heading period; furthermore, the greatest increase in drought stress was also observed during this period. Over the past four decades, due to the intensification of drought stress, winter wheat yield in China has been declining at a rate of 0.36 % per year. …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…These effects are, at least in part, due to prevention of the expression of CD36 and may provide further evidence for a role of metabolic endotoxemia in the pathogenesis of metaflammation and ultimately T2DM. The observed increase in the levels of the endogenous AMP LL-37 in patients with T2DM may serve to limit the severity of the disease.…”
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Optimisation of controlled reproduction protocol in broadhead catfish (Clarias macrocephalus Günther, 1864) using Ovopel™: Effect of different hormonal treatment methods on reprodu... by Nguyễn Ngọc Quyến, Nguyễn Thanh Tâm, Thạch Anh Pha, Lý Anh Thuật, Nguyễn Ngọc Lợi, Nguyễn Thị Trúc Quyên, László Horváth, Tamás Müller

“…In hormone-induced groups, 71.43–100 % of fish ovulated, but no differences were observed in ovulation rates (P > 0.05). The mean latency periods (LT, hours: minutes) indicated significant differences among treated groups (P < 0.05); there was the shortest time in treatment OI-1.5 (7:19 ± 1:04, hours: minutes) and IP-1.5 (7:58 ± 1:01, hours: minutes). …”
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To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway by Jia-Rong Gao, Xiu-Juan Qin, Zhao-Hui Fang, Li-Shan, Li-Ping Han, Hui-Jiang, Ming-Fei Guo, Nan-Nan Jiang

“…In vivo aorta abdominalis of GK rats was observed with blood pressure, heart rate, hematoxylin and eosin (H&E), Masson, and Verhoeff staining. …”
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Detection of Circulating Tumor DNA in Patients with Thyroid Nodules by Krupal B. Patel, Nicholas Cormier, James Fowler, Allison Partridge, Julie Theurer, Morgan Black, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, William Stecho, Christopher Howlett, Muriel Brackstone, John W. Barrett, Anthony Nichols

“…Given that a postoperative drop in BRAF (V600E) ctDNA levels was observed in all cases suggests its utility as a tumor marker.…”
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Influence of catheter ablation for atrial fibrillation on atrial and ventricular functional mitral regurgitation by Masaharu Masuda, Kimiko Sekiya, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Yasuhiro Matsuda, Yosuke Hata, Hiroyuki Uematsu, Taku Toyoshima, Naoko Higashino, Toshiaki Mano

“…The composite endpoint of all‐cause death and heart failure hospitalization during the 2 year follow‐up period was more frequently observed in the VFMR than in the AFMR group (22.6% vs. 3.7%, P < 0.0001). …”
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Beyond Dermatological Findings: Multisystem Involvement in Prolidase Deficiency by Ezgi Yalcin Gungoren, Zeynep Meric, Asena Pinar Sefer, Asuman Deveci Ozkan, Salim Can, Royala Babayeva, Nurhan Kasap, Ercan Nain, Esra Ozek Yucel, Ayca Kiykim, Sevgi Bilgic-Eltan, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

“…In prolidase deficiency, a broad spectrum of differences is observed in patients, ranging from asymptomatic to multisystem involvement. …”
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The INFLUENCE 3.0 model: Updated predictions of locoregional recurrence and contralateral breast cancer, now also suitable for patients treated with neoadjuvant systemic therapy by M.C. Van Maaren, T.A. Hueting, D.J.P. van Uden, M. van Hezewijk, L. de Munck, M.A.M. Mureau, P.A. Seegers, Q.J.M. Voorham, M.K. Schmidt, G.S. Sonke, C.G.M. Groothuis-Oudshoorn, S. Siesling

“…Regarding calibration, observed-predicted differences were all <1 %. Conclusion: This INFLUENCE 3.0 models showed moderate performance in LRR and CBC prediction. …”
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High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…In addition to the X-linked recessive inheritance pattern, the X-linked dominant inheritance pattern is also observed in AIFM1-related AN and affects females. In conclusion, we confirmed that AIFM1 is the primary related gene among late-onset AN cases, and the most common recurrent variant is p.Leu344Phe. …”
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