Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Stemming from these observations, a worthwhile future goal in the treatment of HER2+ breast cancer is to promote combinatorial approaches that better eradicate HER2+ cancer cells via enhanced immunological mechanisms.…”
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Evaluating the Nolla Method for Dental Age Estimation in Children from Northwestern Romania by Ligia Ioana Moga, Abel Emanuel Moca, Raluca Iurcov, Dan Slăvescu, Ligia Luminița Vaida

“…Significant differences between chronological and dental ages were observed in 87.5% of the sample. Conclusions: The Nolla method consistently underestimated dental age in Romanian children, with greater discrepancies in older age groups and among girls. …”
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The vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China by Yinglin Leng, Yawen Zhao, Hong Zhou, Xia Ling, Xia Wang, Guiping Zhao, Wei Zhang

“…Statistical tests showed: (1) significantly higher Mainz Severity Score Index in patients with prolonged saccade latency [20(18,33) VS 13(9,22), p = 0.008] and vestibulo-oculomotor dysfunction [23(20,31) VS 9(5.5,12.5), p = 0.024], (2) significantly higher total small-vessel disease score in subgroups with prolonged saccade latency [2.5(1,3.5) VS 1(0,2), p = 0.038], defective smooth pursuit [3(2,4) VS 1(0,2), p = 0.003], defective optokinetic nystagmus [4(2,4) VS 1(0.2), p = 0.009] and vestibulo-oculomotor dysfunction [1(1,3) VS 0(0,1), p = 0.028], (3) significantly lower α-Gal A activity (μmol/L/h) in subgroups with defective saccades [0.44(0.25,1.93) VS 1.85(0.75,5.52), p = 0.015] and defective smooth pursuit [0.30(0.17,0.44) VS 0.96(0.39,2.40), p = 0.008], and (4) significantly elevated plasma globotriaosylsphingosine (ng/ml) in patients with defective saccades [74.16(11.05,89.18) VS 10.64(7.08,36.32), p = 0.034], than in patients without those abnormalities.Conclusion A high incidence of extensive vestibular and oculomotor dysfunction was observed in patients with FD, with the neuro-otological dysfunction being closely related to the disease burden and biomarkers like α-Gal A activity and lyso-Gb3.…”
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The added value and potential of long-term radio occultation data for climatological wind field monitoring by I. Nimac, J. Danzer, G. Kirchengast, G. Kirchengast

“…Their monitoring remains a challenging task given the shortcomings of available observations. One promising option for progress is the use of radio occultation (RO) satellite data, which enable deriving dynamics based on thermodynamic data. …”
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Efficacy and prognosis of dapagliflozin in the treatment of patients with acute myocardial infarction complicated with type 2 diabetes in Xining area by Jinping Chai, Delian Li, Yanmin Liu, Xiaoling Su

“…The basic data, laboratory examination indicators and long-term prognosis of the two groups were observed. Follow-up deadline is December 31, 2023, at the end of follow-up, including the primary endpoint and the secondary endpoint.Results245 patients were included in this study, age 34–94, the average age (61–11), 200 cases (81.63%) of men, women, 45 cases (18.37%), dapagliflozin group of men 92 cases (77.97%) and control group, 108 cases (85.04%). …”
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Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…We, here, examined that ectopic METTL7B expression abolished ferroptosis markers in cells raised by Erastin treatment, including the production of lipid ROS, the increased cellular iron and MDA content, the decreased gene expression of ACSL3, FANCD2, and FADS2, as well as the mitochondrial injury observed by electron microscopy. Mechanically, ectopic METTL7B expression promoted m6A modification on ACSL3 mRNA. …”
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Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease under General Anesthesia by Yu-Ting Ling, Qian-Qian Guo, Si-Min Wang, Li-Nan Zhang, Jin-Hua Chen, Yi Liu, Ruo-Heng Xuan, Bo Qu, Li-Ge Liu, Zhi-Shuang Wen, Jia-Kun Xu, Lu-Lu Jiang, Wen-Biao Xian, Bin Wu, Chang-Ming Zhang, Ling Chen, Jin-Long Liu, Nan Jiang

“…We conducted a retrospective observational cohort study on the data of 240 patients with Parkinson’s disease who underwent deep brain stimulation of the subthalamic nucleus under general anesthesia. …”
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Advanced Amperometric Microsensors for the Electrochemical Quantification of Quercetin in <i>Ginkgo biloba</i> Essential Oil from Regenerative Farming Practices by Elena Oancea, Ioana Adina Tula, Gabriela Stanciu, Raluca-Ioana Ștefan-van Staden, Jacobus (Koos) Frederick van Staden, Magdalena Mititelu

“…The minimum detectable concentration was observed with the G–CN and CoP/G–CN microsensors, achieving a threshold as low as 0.0001 μmol L⁻¹. …”
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Semifield Evaluation of Improved Passive Outdoor Host Seeking Device (POHD) for Outdoor Control of Anopheles arabiensis Mosquitoes by Stella T. Kessy, Bruno A. Nyundo, Ladslaus L. Mnyone, Issa N. Lyimo

“…The highest mortalities were observed when the POHD was baited with a combination of attractive blends and CO2. …”
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Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States by Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A. Marks, Katherine E. Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B. Araujo

“…This study evaluates the effectiveness of mRNA-1273.815, a 2023–2024 Omicron XBB.1.5-containing mRNA COVID-19 vaccine in preventing COVID-19-related hospitalizations and medically attended COVID-19 in US adults aged ≥ 18 years. Methods This observational, matched cohort study used medical and pharmacy claims data from HealthVerity. …”
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Investigation of Potential Profiles and Influencing Factors of Voice Behavior among Chinese Nurses by Shuangying Huang, Hanwen Chen, Liyan Zhang, Xianming Weng, Lingming Zhou, Xiaoqin Ma, Weiyi Wang

“…Conclusion The voice behavior of nurses in China exhibits a moderate level. Heterogeneity was observed in the voice behavior of nurses, suggesting variations among individuals. …”
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Characterization and in vitro anticancer study of PEGylated liposome dually loaded with ferulic acid and doxorubicin by Andang Miatmoko, Patricia Kinanti Christy, Alfionita Isnaini, Berlian Sarasitha Hariawan, Devy Maulidya Cahyani, Margaret Ahmad, Nuzul Wahyuning Diyah, Mohamad Faris Adrianto, Ravi Kiran Deevi, Iwan Sahrial Hamid, Juni Ekowati

“…Moreover, changes to the DSC thermogram were observed following the incorporation of ferulic acid into the liposome, while the Lipo DOX-FA exhibited a relatively rapid drug release compared to Lipo DOX suggesting a slightly shorter period necessary to attain both therapeutic efficacy and the maintenance of a stable drug encapsulation in the systemic circulation. …”
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Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes by Zajeba Tabashsum, Michelle Angeles-Solano, Ashelyn E. Sidders, Joshua B. Parsons, Sarah E. Rowe

“…We previously showed that palmitoleic acid, a host-produced monounsaturated fatty acid, combined with vancomycin led to an accumulation of large fluid patches in the bacterial membrane, resulting in membrane destabilization and cell death. In this study, we observed that palmitoleic acid increases the rate of vancomycin killing by more than 50-fold, compared to vancomycin alone. …”
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Environmental PM2.5 Exposure: An Ignored Factor Associated with Blood Cadmium Level in Hemodialysis Patients by Hsu CW, Chan MJ, Weng CH, Tsai TY, Yen TH, Huang WH

“…Further studies are needed to confirm these observations and to explore the underlying mechanisms.Keywords: air pollution, cadmium, hemodialysis, particulate matter, PM2.5…”
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Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Ag... by Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn

“…Disruption of the cells with abnormal shapes was observed when trophozoites were treated with Kre. Trophozoites had lost their robust acanthopodia and began to shrink after treatment with Kre. …”
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Efficacy and safety of immune checkpoint inhibitors in elderly patients with advanced non-small cell lung cancer: a systematic review and meta-analysisResearch in context by Jiacheng Yao, Sihan Li, Lu Bai, Jun Chen, Chengbo Ren, Tingting Liu, Jingping Qiu, Jun Dang

“…However, significantly prolonged OS was not observed in subgroups of aged ≥ 75 years and PD-L1 < 1%. …”
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Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial st... by Aziz Eghbali, Aygin Eghbali, Neda Ashayeri, Fatemeh Fadayi, Kazem Ghaffari, Kazem Ghaffari, Kazem Ghaffari, Ali Ghasemi, Ali Ghasemi

“…BackgroundGiven that liver diseases and subsequent increases in liver enzymes are among the most frequent complications observed in leukemia patients treated with chemotherapeutic drugs, this study aimed to assess the impact of oral Lcarnitine supplementation on liver enzyme levels the maintenance phase of treatment for pediatric acute lymphoblastic leukemia (ALL) patients.MethodsIn this clinical trial, 100 pediatric patients aged &gt;5 years were divided into two groups after obtaining informed consent. …”
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Microstructure of the human metastatic vertebral body by Giulia Cavazzoni, Giulia Cavazzoni, Giulia Cavazzoni, Enrico Dall’Ara, Enrico Dall’Ara, Marco Palanca, Marco Palanca, Marco Palanca

“…Little is known about the microstructure of the metastatic tissue, the microstructure of the tissue surrounding the lesion, and how it does compare with vertebrae with no lesions observed on the biomedical images. A comprehensive assessment of the microstructural properties of the entire vertebral body can be obtained with micro computed tomography. …”
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A decomposition analysis of sociodemographic factors and non-cigarette tobacco use as contributors to the change in smoking rates in South Africa between 2017/18 and 2021 by K Kali, O Ayo-Yusuf

“…A Blinda-Oaxaca decomposition analysis was also used to explore the roles of various sociodemographic factors, including any differences in the use of TNPs, that may explain any observed differences in smoking rates between 2017/18 and 2021. …”
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A bacterial membrane-disrupting protein stimulates animal metamorphosis by Kyle E. Malter, Tiffany L. Dunbar, Carl Westin, Emily Darin, Josefa Rivera Alfaro, Nicholas J. Shikuma

“…This discovery sheds light on how a bacterial protein effector exerts its activity through membrane disruption, a phenomenon observed in various bacterial toxins affecting cellular functions, and elicits a developmental response. …”
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